Complex Enzymes In Microbial Natural Product Biosynthesis Part A Overview Articles And Peptides
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Complex Enzymes In Microbial Natural Product Biosynthesis Part A Overview Articles And Peptides
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Author :
language : en
Publisher: Academic Press
Release Date : 2009-04-10
Complex Enzymes In Microbial Natural Product Biosynthesis Part A Overview Articles And Peptides written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-10 with Medical categories.
Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine. - Gathers tried and tested methods and techniques from top players in the field - In depth coverage of ribosomally-synthesised and Non-ribosomally-synthesised peptides - Provides an extremely useful reference for the experienced research scientist
Complex Enzymes In Microbial Natural Product Biosynthesis Part B Polyketides Aminocoumarins And Carbohydrates
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Author :
language : en
Publisher: Academic Press
Release Date : 2009-04-11
Complex Enzymes In Microbial Natural Product Biosynthesis Part B Polyketides Aminocoumarins And Carbohydrates written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-11 with Science categories.
Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine. Gathers tried and tested methods and techniques from top players in the field Provides an extremely useful reference for the experienced research scientist Covers biosynthesis of Polyketides, Tarpenoids, Aminocoumarins and Crabohydrates
Natural Product Biosynthesis By Microorganisms And Plants Part A
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Author :
language : en
Publisher: Academic Press
Release Date : 2012-12-31
Natural Product Biosynthesis By Microorganisms And Plants Part A written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-31 with Science categories.
This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The first of 3 volumes covering Natural product biosynthesis by microorganisms and plants, it has chapters on such topics as Kinetics of plant sesquiterpene synthases, Terpenoid biosynthesis in fungi, and plant Type III polyketide synthases. - Contains quality chapters authored by leaders in the field - The first of 3 volumes - Has chapters on such topics as kinetics of plant sesquiterpene synthases, terpenoid biosynthesis in fungi, and plant Type III polyketide synthases
Natural Product Biosynthesis By Microorganisms And Plants
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Author : D. A. Hopwood
language : en
Publisher: Academic Press
Release Date : 2012
Natural Product Biosynthesis By Microorganisms And Plants written by D. A. Hopwood and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Alkaloids categories.
Annotation This volume of 'Methods in Enzymology' continues the legacy of this premier serial by containing quality chapters authored by leaders in the field.
Natural Product Biosynthesis By Microorganisms And Plants Part C
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Author :
language : en
Publisher: Academic Press
Release Date : 2012-12-31
Natural Product Biosynthesis By Microorganisms And Plants Part C written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-31 with Science categories.
This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The third of 3 volumes covering Natural product biosynthesis by microorganisms and plants. - This new volume continues the legacy of this premier serial - Contains quality chapters authored by leaders in the field - The third of 3 volumes, it has chapters on such topics as metabolic pathways in Aspergillus oryzae, heterologous gene clusters and cyanobacteria as a source of natural products
Natural Product Biosynthesis By Microorganisms And Plants Part B
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Author :
language : en
Publisher: Academic Press
Release Date : 2012-10-01
Natural Product Biosynthesis By Microorganisms And Plants Part B written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-01 with Science categories.
This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The second of 3 volumes covering Natural product biosynthesis by microorganisms and plants. - This new volume continues the legacy of this premier serial - Contains quality chapters authored by leaders in the field - The second of 3 volumes it has chapters on such topics as biological chlorination, bromination and iodination, and phylogenetic approaches to natural product structure prediction
Cryo Em Part A Sample Preparation And Data Collection
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Author :
language : en
Publisher: Academic Press
Release Date : 2010-09-30
Cryo Em Part A Sample Preparation And Data Collection written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-30 with Science categories.
Cryo-EM Part A: Sample Preparation and Data Collection is dedicated to a description of the instruments, samples, protocols, and analyses that belong to cryo-EM. It emphasizes the relatedness of the ideas, instrumentation, and methods underlying all cryo-EM approaches, which allow practitioners to easily move between them. Within each section, the articles are ordered according to the most common symmetry of the sample to which their methods are applied. - Includes time-tested core methods and new innovations applicable to any researcher - Methods included are useful to both established researchers and newcomers to the field - Relevant background and reference information given for procedures can be used as a guide
Biophysical Chemical And Functional Probes Of Rna Structure Interactions And Folding Part A
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Author : Daniel Herschlag
language : en
Publisher: Academic Press
Release Date : 2009-11-16
Biophysical Chemical And Functional Probes Of Rna Structure Interactions And Folding Part A written by Daniel Herschlag and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-16 with Science categories.
This MIE volume provides laboratory techniques that aim to predict the structure of a protein which can have tremendous implications ranging from drug design, to cellular pathways and their dynamics, to viral entry into cells. - Expert researchers introduce the most advanced technologies and techniques in protein structure and folding - Includes techniques on tiling assays
Biophysical Chemical And Functional Probes Of Rna Structure Interactions And Folding Part B
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Author : Daniel Herschlag
language : en
Publisher: Academic Press
Release Date : 2009-11-16
Biophysical Chemical And Functional Probes Of Rna Structure Interactions And Folding Part B written by Daniel Herschlag and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-16 with Science categories.
This MIE volume provides laboratory techniques that aim to predict the structure of a protein which can have tremendous implications ranging from drug design, to cellular pathways and their dynamics, to viral entry into cells. - Expert researchers introduce the most advanced technologies and techniques in protein structure and folding - Includes techniques on tiling assays
Single Molecule Tools Part B Super Resolution Particle Tracking Multiparameter And Force Based Methods
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Author :
language : en
Publisher: Academic Press
Release Date : 2010-07-09
Single Molecule Tools Part B Super Resolution Particle Tracking Multiparameter And Force Based Methods written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-07-09 with Science categories.
Single molecule tools have begun to revolutionize the molecular sciences, from biophysics to chemistry to cell biology. They hold the promise to be able to directly observe previously unseen molecular heterogeneities, quantitatively dissect complex reaction kinetics, ultimately miniaturize enzyme assays, image components of spatially distributed samples, probe the mechanical properties of single molecules in their native environment, and "just look at the thing" as anticipated by the visionary Richard Feynman already half a century ago. Single Molecule Tools, Part B: Super-Resolution, Particle Tracking, Multiparameter, and Force Based Methods captures a snapshot of this vibrant, rapidly expanding field, presenting articles from pioneers in the field intended to guide both the newcomer and the expert through the intricacies of getting single molecule tools. - Includes time-tested core methods and new innovations applicable to any researcher employing single molecule tools - Methods included are useful to both established researchers and newcomers to the field - Relevant background and reference information given for procedures can be used as a guide to developing protocols in a number of disciplines