Structural Biophysical And Enzymatic Characterization Of A Piezo Thermophilic Peptidase Complex From The Deep Sea Archaeon Pyrococcus Horikoshii Anglais
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Structural Biophysical And Enzymatic Characterization Of A Piezo Thermophilic Peptidase Complex From The Deep Sea Archaeon Pyrococcus Horikoshii Anglais
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Author : Eva Rosenbaum
language : en
Publisher:
Release Date : 2008
Structural Biophysical And Enzymatic Characterization Of A Piezo Thermophilic Peptidase Complex From The Deep Sea Archaeon Pyrococcus Horikoshii Anglais written by Eva Rosenbaum and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Recently Franzetti et al. discovered a new type of energy-independent self-compartmentalized proteases in Archaea. The particles were named TET for their tetrahedral three-dimensional structure. The TETs self assemble as large molecular weight complexes of about 500kDa. Their role in the organism is yet unknown. In P. horikoshii, a hyperthermophilic Archaea from the deep sea, three TET proteases have been identified (PhTET1, 2 and 3). We have expressed and purified recombinant PhTET3. The enzyme was characterized biochemically and we determined the structure of a PhTET3 12 subunit complex by x-ray crystallography. In order to gain insight into its potential physiological role and to ascertain why there are three TET proteases in P. horikoshii, the structure and the enzymatic properties of PhTET3 have been compared to the two other TET proteases that were characterized before. As self-compartmentalization plays an important role in functioning and regulation of proteases, the factors controlling PhTET3 oligomerization in vitro have been studied by analytical ultracentrifugation and small angle neutron scattering. Finally, under physiological deep sea conditions, the enzyme is exposed to high temperature (up to 100°C) and high pressure. In order to study the limits of stability of large molecular weight assemblies, the low-resolution structure and the enzymatic activity of PhTET3 have been monitored under high pressures and temperatures using small angle x-ray scattering and high-pressure spectrophotometry. Taken together, these studies revealed that the TET proteases of P.horikoshii form an integrated peptide degradation systems and that PhTET3 exhibits unusual stability under high pressure and temperature as well as environment-associated enzymatic properties.
Physiological And Biotechnological Aspects Of Extremophiles
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Author : Richa Salwan
language : en
Publisher: Academic Press
Release Date : 2020-06-04
Physiological And Biotechnological Aspects Of Extremophiles written by Richa Salwan and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-04 with Science categories.
Physiological and Biotechnological Aspects of Extremophiles highlights the current and topical areas of research in this rapidly growing field. Expert authors from around the world provide the latest insights into the mechanisms of these fascinating organisms use to survive.The vast majority of extremophiles are microbes which include archaea, bacteria and some eukaryotes. These microbes live under chemical and physical extremes that are usually lethal to cellular molecules, yet they manage to survive and even thrive. Extremophiles have important practical uses. They are a valuable source of industrially important enzymes and recent research has revealed novel mechanisms and biomolecular structures with a broad range of potential applications in biotechnology, biomining, and bioremediation.Aimed at research scientists, students, microbiologists, and biotechnologists, this book is an essential reading for scientists working with extremophiles and a recommended reference text for anyone interested in the microbiology, bioprospecting, biomining, biofuels, and extremozymes of these organisms. Shows the implications of the physiological adaptations of microbes from extreme habitats that are largely contributed by their biomolecules from basic to applied research Provides in-depth knowledge of genomic plasticity and proteome of different extremophiles Gives detailed and comprehensive insight about use of genetic engineering as well as genome editing for industrial applications
Industrial Pharmaceutical Biotechnology
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Author : Heinrich Klefenz
language : en
Publisher: Wiley-VCH
Release Date : 2002-04-22
Industrial Pharmaceutical Biotechnology written by Heinrich Klefenz and has been published by Wiley-VCH this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-04-22 with Medical categories.
This volume focuses on pharmaceutical biotechnology as a key area of life sciences. The complete range of concepts, processes and technologies of biotechnology is applied in modern industrial pharmaceutical research, development and production. The results of genome sequencing and studies of biological-genetic function are combined with chemical, micro-electronic and microsystem technology to produce medical devices and diagnostic biochips. A multitude of biologically active molecules is expanded by additional novel structures created with newly arranged gene clusters and bio-catalytic chemical processes. New organisational structures in the co-operation of institutes, companies and networks enable faster knowledge and product development and immediate application of the results of research and process development. This book is the ideal source of information for scientists and engineers in research and development, for decision-makers in biotech, pharma and chemical corporations, as well as for research institutes, but also for founders of biotech companies and people working for venture capital corporations.
Physiological Molecular And Genetic Perspectives Of Wheat Improvement
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Author : Shabir H Wani
language : en
Publisher: Springer Nature
Release Date : 2020-12-17
Physiological Molecular And Genetic Perspectives Of Wheat Improvement written by Shabir H Wani and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-17 with Technology & Engineering categories.
World population is growing at an alarming rate and may exceed 9.7 billion by 2050, whereas agricultural productivity has been negatively affected due to yield limiting factors such as biotic and abiotic stresses as a result of global climate change. Wheat is a staple crop for ~20% of the world population and its yield needs be augmented correspondingly in order to satisfy the demands of our increasing world population. “Green revolution”, the introduction of semi-dwarf, high yielding wheat varieties along with improved agronomic management practices, gave rise to a substantial increase in wheat production and self-sufficiency in developing countries that include Mexico, India and other south Asian countries. Since the late 1980’s, however, wheat yield is at a standoff with little fluctuation. The current trend is thus insufficient to meet the demands of an increasing world population. Therefore, while conventional breeding has had a great impact on wheat yield, with climate change becoming a reality, newer molecular breeding and management tools are needed to meet the goal of improving wheat yield for the future. With the advance in our understanding of the wheat genome and more importantly, the role of environmental interactions on productivity, the idea of genomic selection has been proposed to select for multi-genic quantitative traits early in the breeding cycle. Accordingly genomic selection may remodel wheat breeding with gain that is predicted to be 3 to 5 times that of crossbreeding. Phenomics (high-throughput phenotyping) is another fairly recent advancement using contemporary sensors for wheat germplasm screening and as a selection tool. Lastly, CRISPR/Cas9 ribonucleoprotein mediated genome editing technology has been successfully utilized for efficient and specific genome editing of hexaploid bread wheat. In summary, there has been exciting progresses in the development of non-GM wheat plants resistant to biotic and abiotic stress and/or wheat with improved nutritional quality. We believe it is important to highlight these novel research accomplishments for a broader audience, with the hope that our readers will ultimately adopt these powerful technologies for crops improvement in order to meet the demands of an expanding world population.
Thermoregulation And Human Performance
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Author : Frank E. Marino
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2008-01-01
Thermoregulation And Human Performance written by Frank E. Marino and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-01 with Medical categories.
Over the last decades, our understanding of the relationship between thermoregulation, performance and fatigue has changed dramatically. New advances in technology and methodology permitted the study of rising and decreasing body temperature on metabolism and provided insights into the role the nervous system plays in determining human performance under thermally stressful situations. Further analysis of previous research has been necessary in addition to considering theories derived from complimentary areas of research such as evolutionary biology, anthropology and cellular and molecular biology. This publication provides different interpretations of recent research for a better understanding of the limitations of thermoregulation. In particular, it presents evidence for the human's ability to anticipate thermal limits and adjust their performance accordingly so that cellular homeostasis is preserved. Further, the book is featuring the inclusion of the effect of reduced body temperature on muscular performance and endurance which today is a popular method for providing avenues of reduced thermal strain and recovery from exercise. This publication will be an essential read for those working in thermal medicine, exercise physiology and human performance.
Pharmaceutical Biotechnology
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Author : Adalberto Pessoa
language : en
Publisher: CRC Press
Release Date : 2021-07-16
Pharmaceutical Biotechnology written by Adalberto Pessoa and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-16 with Medical categories.
Pharmaceutical Biotechnology: A Focus on Industrial Application covers the development of new biopharmaceuticals as well as the improvement of those being produced. The main purpose is to provide background and concepts related to pharmaceutical biotechnology, together with an industrial perspective. This is a comprehensive text for undergraduates, graduates and academics in biochemistry, pharmacology and biopharmaceutics, as well as professionals working on the interdisciplinary field of pharmaceutical biotechnology. Written with educators in mind, this book provides teachers with background material to enhance their classes and offers students and other readers an easy-to-read text that examines the step-by-step stages of the development of new biopharmaceuticals. Features: Discusses specific points of great current relevance in relation to new processes as well as traditional processes Addresses the main unitary operations used in the biopharmaceutical industry such as upstream and downstream Includes chapters that allow a broad evaluation of the production process Dr. Adalberto Pessoa Jr. is Full Professor at the School of Pharmaceutical Sciences of the University of São Paulo and Visiting Senior Professor at King’s College London. He has experience in enzyme and fermentation technology and in the purification processes of biotechnological products such as liquid–liquid extraction, cross-flow filtration and chromatography of interest to the pharmaceutical and food industries. Dr. Michele Vitolo is Full Professor at the School of Pharmaceutical Sciences of the University of São Paulo. He has experience in enzyme technology, in immobilization techniques (aiming the reuse of the biocatalyst) and in the operation of membrane reactors for obtaining biotechnological products of interest to the pharmaceutical, chemical and food industries. Dr. Paul F. Long is Professor of Biotechnology at King's College London and Visiting International Research Professor at the University of São Paulo. He is a microbiologist by training and his research uses a combination of bioinformatics, laboratory and field studies to discover new medicines from nature, particularly from the marine environment.
Green Bio Processes
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Author : Binod Parameswaran
language : en
Publisher: Springer
Release Date : 2018-11-03
Green Bio Processes written by Binod Parameswaran and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-03 with Technology & Engineering categories.
This volume discusses recent advancements to the age old practice of using microbial enzymes in the preparation of food. Written by leading experts in the field, it discusses novel enzymes and their applications in the industrial preparation of food to improve taste and texture, while reducing cost and increasing consistency. This book will be of interest to both researchers and students working in food technology.