Structural Correlates Of Carcinogenesis And Mutagenesis

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Structural Correlates Of Carcinogenesis And Mutagenesis

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Author : Irvin M. Asher
language : en
Publisher:
Release Date : 1978

Structural Correlates Of Carcinogenesis And Mutagenesis written by Irvin M. Asher and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Carcinogenicity testing categories.

Chemical Mutagens

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Author : Frederick J. De Serr
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Chemical Mutagens written by Frederick J. De Serr and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

Volume 8 of Chemical Mutagens covers a wide range of topics in this continuously changing field. This volume includes chapters on the detection of genetic damage in mammalian sperm both at specific loci and over the entire genome. The discussion of in vitro techniques for working with mammalian cells covers not only specific locus assays but also cellular activation systems. Another chapter extensively discusses the need for a revised protocol for the micronucleus assay. Structure activity relationships are investigated in a chapter dealing with hair dye constituents. One of the most comprehensive chapters deals with problems associated with the detection of mutagenic effects in defined human populations. Finally, there is a detailed presentation of a comprehensive study tabulating the genetic bioassay data on some known or suspected human carcinogens. In keeping with our policy of publishing important legislation in the area of chemical mutagens, we have also included the Council of the European Communities Directive of 18 September 1979. Frederick J. de Serres Research Triangle Park, North Carolina vii Contents Chapter 1 Detection of Effects of Mutagens in Human Populations George R. Hoffmann 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. Monitoring Progeny for Evidence of Germ-Cell Mutations. . . . . 3 2. 1. The Classical Approach: Phenotypic Monitoring . . . . . . . 3 2. 2. Monitoring for Changes in Gene Products . . . . . . . . . . . 7 3. Detection of Gene Mutations in Somatic Cells. . . . . . . . . . . . . 9 3. 1. Drug-Resistant Lymphocytes . . . . . . . . . . . . . . . . . . . . . . 9 3. 2. Hemoglobin Variants . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 4. Nongenetic Indicators of Mutagen Exposure .. . . . . . . . . . . . 21 4. 1. Alkylation of Proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 4. 2. DNA Damage . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Carcinogenesis Abstracts

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Author :
language : en
Publisher:
Release Date : 1979

Carcinogenesis Abstracts written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with Carcinogenesis categories.

Advances In Mutagenesis Research

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Author : Günter Obe
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Advances In Mutagenesis Research written by Günter Obe and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

Applied genetic research, genetic toxicology and mutation research investigate the mutagenicity and cancerogenicity of chemicals and other agents. Permanent mutation in genes and chromosomes, can be induced by aplethora of agents, including ionizing and nonionizing radiations, chemicals, and viruses. Among the aspects discused by Advances in Mutagenesis Research are (1) the understanding of the molecular mechanisms leading to mutations, and (2) the prevention of a thoughtless introduction of mutagenic agents into the environment. Contents: Nikolay W. Timofeeff-Ressovsky (1900-1981): An Essay on his Life and Scientific Achievements. - Arylnitrenium Ions and the Genotoxic Potency of Aromatic Amines and Nitro Compounds. - Analysisof Mutagenicity and Chemical Structure in Various Series of Related Compounds. - Formation of 8-Hydroxyguanine by Oxidative DNA Damage, its Repair and its Mutagenic Effects. - Exploring Genetic and Non-Genetic Relationships: The Induction of Micronuclei. - Mechanisms of Induced Mutagenesis by Ultraviolet Light in Escherichia coli. - Polytene Chromosomes in Mutagenesis. Three-Way Differential Stainingof Chromosomes for the Identification of SCEs per Cell Cycle: Fundamentals and Applications. - The Mammalian Centromere: Centromere Separation, Kinetochore Proteins and Aneuploidy. - Chorionic Villi Analysis. - ExploringGenetic and Non-Genetic Relationships: The Induction of Micronuclei.

Potential Industrial Carcinogens And Mutagens

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Author : L. Fishbein
language : en
Publisher: Elsevier
Release Date : 2011-08-30

Potential Industrial Carcinogens And Mutagens written by L. Fishbein and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-30 with Science categories.

Potential Industrial Carcinogens and Mutagens

Effects Of Foods And Drugs On The Development And Function Of The Nervous System

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Author : Rosa M. Gryder
language : en
Publisher:
Release Date : 1980

Effects Of Foods And Drugs On The Development And Function Of The Nervous System written by Rosa M. Gryder and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Neuropharmacology categories.

Inadvertent Modification Of The Immune Response

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Author : Irvin M. Asher
language : en
Publisher:
Release Date : 1980

Inadvertent Modification Of The Immune Response written by Irvin M. Asher and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Environmentally induced diseases categories.

Risk Benefit Decisions And The Public Health

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Author : Jeffrey A. Staffa
language : en
Publisher:
Release Date : 1980

Risk Benefit Decisions And The Public Health written by Jeffrey A. Staffa and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Medical care categories.

Structural Correlates Of Carcinogenesis And Mutagenesis

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Author :
language : en
Publisher:
Release Date : 1978

Structural Correlates Of Carcinogenesis And Mutagenesis written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with categories.

Non Animal Techniques In Biomedical And Behavioral Research And Testing

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Author : Michael Kapis
language : en
Publisher: CRC Press
Release Date : 1993-06-24

Non Animal Techniques In Biomedical And Behavioral Research And Testing written by Michael Kapis and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-06-24 with Medical categories.

Non-Animal Techniques in Biomedical and Behavioral Research and Testing features the contributions of noted experts describing the application of non-animal methods in a wide variety of research and testing situations, including computer modeling/graphics, protein sequence analysis, behavioral analysis, drug design/testing, cosmetic and household products testing, toxicological testing, clinical testing, chemical identification and analysis, and disease investigations. Many of the alternatives covered have applications in behavioral as well as biomedical research and testing. Topics examined include in vitro techniques, molecular genetics, structure-activity relationships, physicochemical methods, computer-assisted drug designs, nutrition, epidemiology, autopsies, neural networks, ethology, image scanning devices, and medical microbiology. Future applications for non-animal methods are also explored. The book will appeal to toxicologists, pharmacologists, cosmetic and household product researchers, epidemiologists, medical microbiologists, biopsychiatrists, biomedical and psychological educators, biochemists, molecular geneticists, and other scientists interested in alternative testing methods.