Structure And Insight
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Structure And Insight
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Author : Pierre M. van Hiele
language : en
Publisher:
Release Date : 1986
Structure And Insight written by Pierre M. van Hiele and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Education categories.
Structures And Algorithms
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Author : Jens Erik Fenstad
language : en
Publisher: Springer
Release Date : 2018-03-10
Structures And Algorithms written by Jens Erik Fenstad and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-10 with Philosophy categories.
This book explains exactly what human knowledge is. The key concepts in this book are structures and algorithms, i.e., what the readers “see” and how they make use of what they see. Thus in comparison with some other books on the philosophy (or methodology) of science, which employ a syntactic approach, the author’s approach is model theoretic or structural. Properly understood, it extends the current art and science of mathematical modeling to all fields of knowledge. The link between structure and algorithms is mathematics. But viewing “mathematics” as such a link is not exactly what readers most likely learned in school; thus, the task of this book is to explain what “mathematics” should actually mean. Chapter 1, an introductory essay, presents a general analysis of structures, algorithms and how they are to be linked. Several examples from the natural and social sciences, and from the history of knowledge, are provided in Chapters 2–6. In turn, Chapters 7 and 8 extend the analysis to include language and the mind. Structures are what the readers see. And, as abstract cultural objects, they can almost always be seen in many different ways. But certain structures, such as natural numbers and the basic theory of grammar, seem to have an absolute character. Any theory of knowledge grounded in human culture must explain how this is possible. The author’s analysis of this cultural invariance, combining insights from evolutionary theory and neuroscience, is presented in the book’s closing chapter. The book will be of interest to researchers, students and those outside academia who seek a deeper understanding of knowledge in our present-day society.
Structure And Insight
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Author : Pierre M. van Hiele
language : en
Publisher:
Release Date : 1986
Structure And Insight written by Pierre M. van Hiele and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Education categories.
From the Preface: The goal of this book is to contribute to the improvement of teaching. Yet there is, of necessity, considerable theory in it: an understanding of how the levels can be used in practice requires an understanding of the theory behind it. There are ways to ascend from one level to the next and the teacher can help the pupil to find these ways. To be able to do this we need a theory, and practice follows from it. I was never much interested in the question of how many levels can be identified in a certain topic because it is possible to improve teaching without answering this question. * This text includes: * Structure-based theory of geometric thought development * Context-effected theory of cognitive change * Theory based on the structure of and insight into mathematical thought processes * New theory of mathematics instruction in geometry * New insights into the language of mathematics development * Provides mathematics educators, educational psychologists, test planners, and educational researchers with a forum for instructional thought and development in mathematics, in general, and geometry, in particular * The levels of thinking that are manifested in the ways children learn geometry provide a basis for a new theory of the development of thought and instruction * The teacher-based knowledge, experience, and conception of these levels of thinking are represented in the ways geometric thinking undergoes change as a function of instruction
Structural Insights Into Gene Expression And Protein Synthesis
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Author : Thomas A Steitz
language : en
Publisher: World Scientific
Release Date : 2020-08-18
Structural Insights Into Gene Expression And Protein Synthesis written by Thomas A Steitz and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-18 with Science categories.
Several years ago, Thomas Steitz agreed to contribute a volume to the 'World Scientific Series in Structural Biology' that would deal with the contributions he and his coworkers have made to structural biology during his remarkable career. Sadly, Tom died in the fall of 2018 before he had had time to do more than produce an outline for this book, and a list of the reprints he wanted it to contain.Fortunately, Tom's colleagues and coworkers responded enthusiastically when they were informed later that fall that if they were willing to help out, a volume would be published to commemorate his career. It fell to Anders Liljas, Peggy Eatherton, Tom's longtime administrative assistant, and Peter Moore, a close colleague, to oversee their efforts. Thomas Steitz is best known for the work he and his coworkers did to elucidate the biochemical basis of gene expression. The structures of a large number of the macromolecules involved in transcription and translation emerged from his laboratory over the course of his career. This book includes reprints of the most important papers he had published, grouped according to the structures they relate to, and commentaries written by the scientists who collaborated with him to solve each of them. It thus summarizes the achievements of one of the most distinguished biochemists of the second half of the 20th century.
Insights In Structural Biology 2021
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Author : Annalisa Pastore
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-15
Insights In Structural Biology 2021 written by Annalisa Pastore and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-15 with Science categories.
Structure Based Design Of Drugs And Other Bioactive Molecules
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Author : Arun K. Ghosh
language : en
Publisher: John Wiley & Sons
Release Date : 2014-08-11
Structure Based Design Of Drugs And Other Bioactive Molecules written by Arun K. Ghosh and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-11 with Medical categories.
Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary structure-based design. This practical approach provides the tools to develop a high-affinity ligand with drug-like properties for a given drug target for which a high-resolution structure exists. The authors use numerous examples of recently developed drugs to present "best practice" methods in structurebased drug design with both newcomers and practicing researchers in mind. By way of a carefully balanced mix of theoretical background and case studies from medicinal chemistry applications, readers will quickly and efficiently master the basic skills of successful drug design. This book is aimed at new and active medicinal chemists, biochemists, pharmacologists, natural product chemists and those working in drug discovery in the pharmaceutical industry. It is highly recommended as a desk reference to guide students in medicinal and chemical sciences as well as to aid researchers engaged in drug design today.
Ion Channel Structure And Drug Discovery Accelerated By Cryo Em
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Author : Shujia Zhu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-30
Ion Channel Structure And Drug Discovery Accelerated By Cryo Em written by Shujia Zhu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-30 with Science categories.
Antiviral Drug Discovery And Development
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Author : Xinyong Liu
language : en
Publisher: Springer Nature
Release Date : 2021-07-13
Antiviral Drug Discovery And Development written by Xinyong Liu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-13 with Medical categories.
This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting protein–protein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.
Structure Based Drug Discovery
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Author : Roderick E Hubbard
language : en
Publisher: Royal Society of Chemistry
Release Date : 2007-10-31
Structure Based Drug Discovery written by Roderick E Hubbard and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-31 with Medical categories.
Structure-based drug discovery is a collection of methods that exploits the ability to determine and analyse the three dimensional structure of biological molecules. These methods have been adopted and enhanced to improve the speed and quality of discovery of new drug candidates. After an introductory overview of the principles and application of structure-based methods in drug discovery, this book then describes the essential features of the various methods. Chapters on X-ray crystallography, NMR spectroscopy, and computational chemistry and molecular modelling describe how these particular techniques have been enhanced to support rational drug discovery, with discussions on developments such as high throughput structure determination, probing protein-ligand interactions by NMR spectroscopy, virtual screening and fragment-based drug discovery. The concluding chapters complement the overview of methods by presenting case histories to demonstrate the major impact that structure-based methods have had on discovering drug molecules. Written by international experts from industry and academia, this comprehensive introduction to the methods and practice of structure-based drug discovery not only illustrates leading-edge science but also provides the scientific background for the non-expert reader. The book provides a balanced appraisal of what structure-based methods can and cannot contribute to drug discovery. It will appeal to industrial and academic researchers in pharmaceutical sciences, medicinal chemistry and chemical biology, as well as providing an insight into the field for recent graduates in the biomolecular sciences.
Structures And Architecture
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Author : Mario Rinke
language : en
Publisher: CRC Press
Release Date : 2025-06-23
Structures And Architecture written by Mario Rinke and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-23 with Technology & Engineering categories.
Structures and Architecture - REstructure REmaterialize REthink REuse contains the contributions to the 6th International Conference on Structures and Architecture (ICSA 2025, Antwerp, Belgium, 8-11 July 2025). As a response to the pressing global climate and energy crisis, and with new settings and tools, the design and construction of our built environment needs reconsideration and extension. The papers call for a re-imagination of current practices regarding structures and architecture. The volumes of the series are published every three years, in tandem with the conferences organised by the International Association of Structures and Architecture. They aim to reach a global audience of researchers, practitioners, and students, including architects, structural and construction engineers, builders and building consultants, constructors, material suppliers, planners, urban designers, anthropologists, economists, sociologists, artists, product manufacturers, and other professionals involved in the design and realisation of architectural, structural, and infrastructural projects.