Insights In Structural Biology 2021

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Molecular Level Atomistic And Structural Insights On Biological Macromolecules Inhibition And Dynamics Studies

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Author : Chandrabose Selvaraj
language : en
Publisher: Frontiers Media SA
Release Date : 2024-03-14

Molecular Level Atomistic And Structural Insights On Biological Macromolecules Inhibition And Dynamics Studies written by Chandrabose Selvaraj and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-14 with Science categories.

Everything in a living organism relies on biological macromolecules, which have the role of enzymatic chemical transformations, formation of structures, transportation, catalysis, and regulation of biological processes. They are complex biological structures that require an atomistic understanding. A molecular understanding of biological macromolecules has had a massive impact on the pharmaceutical, biotechnological, and chemical industries. Specifically, new enzymatic structures are being discovered through various experimental and computational methods, by describing an atomistic-level insight into function, mechanism, role in reactions and their inhibition. Those atom-level illustrations are mainly focused through enzyme kinetics, enzyme inhibition, mutational and conformational analysis through quantum mechanical and molecular dynamics methods.

Insights In Virology 2021

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Author : Chunfu Zheng
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-28

Insights In Virology 2021 written by Chunfu Zheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-28 with Science categories.

Cryo Electron Microscopy In Structural Biology

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Author : Krishnarao Appasani
language : en
Publisher: CRC Press
Release Date : 2024-10-17

Cryo Electron Microscopy In Structural Biology written by Krishnarao Appasani and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-17 with Science categories.

Cryo-electron microscopy, in combination with tomography, has emerged as a new technology for visualizing molecular structures at a resolution beyond even 1 Å. Using this technology has revealed the native molecular details of viruses, membranes, enzymes, ribosomes, and cells. This comprehensive volume brings together authoritative overviews of these methods from structural and biological perspectives. It is a must-have for researchers and graduate students, as well as those working in industry, primarily in the areas of biophysics, structural biology, crystallography, and genomics. Key Features • Focuses on the applications of cryo-EM to structural biology • Documents the importance of cryo-EM/ET approaches in studying the structural determinants of cellular organelle and membrane protein biochemistry • Reviews the applications of high-resolution structures of viruses • Emphasizes structural insights of nuclear and gene machineries • Includes a section focused entirely on the applications of cryo-EM/ET in drug discovery and therapeutic development

Insights In Structural Biology 2021

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Author : Annalisa Pastore
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-15

Insights In Structural Biology 2021 written by Annalisa Pastore and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-15 with Science categories.

Structural And Dynamic Aspects Of Protein Function And Allostery

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Author : George Lisi
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-28

Structural And Dynamic Aspects Of Protein Function And Allostery written by George Lisi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-28 with Science categories.

Insights In Systems Biology Research

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Author : Gary An
language : en
Publisher: Frontiers Media SA
Release Date : 2025-06-10

Insights In Systems Biology Research written by Gary An and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-10 with Science categories.

Summary of Topic: This collection represents an interdisciplinary exploration of systems biology and systems medicine, integrating advanced methodologies from computational modeling, deep neural networks, and multiomics to improve understanding and treatment of human diseases and biological mechanisms. Emphasis is placed on cutting-edge technologies, including deep learning for statistical inference from gene expression data and noncoding genetic variants, quantitative systems pharmacology for virtual patient generation, and semi-mechanistic modeling applied to novel therapies such as CAR T-cell interventions. The articles further highlight disease modeling across various scales, exemplified through multi-scale simulation frameworks applied to complex conditions such as COVID-19 long-term sequelae, rheumatoid arthritis, epilepsy, and tuberculosis. Additionally, the importance of modularity in biological networks, developments in functional annotation of microbial transporters, and new approaches towards bioengineered bacterial consortia through molecular communication are discussed. This collection informs us of the ongoing efforts to harness computational power and biological insights to advance personalized medicine, improve therapeutic strategies, and deepen our understanding of complex biological phenomena. ----- Systems Biology has undergone significant transformations due to the pioneering efforts of researchers worldwide. The discipline now spans several subfields, such as Neuroscience, Genetics and Genomics, Medicine, among others, each advancing the field in unique ways through innovative technologies and insightful discoveries. This evolution is celebrated in a curated collection by Frontiers in Systems Biology, which aims to highlight the state-of-the-art developments and set the stage for future inquiries and applications in the field. This collection actively showcases the overlap of technology with theoretical advancements, creating a broad framework from which new methodologies and strategies are born. This Research Topic aims to provide an overview of the most recent progress in Systems Biology. It seeks to outline the impacts that the integration of disparate biological research areas can have in solving complex biological problems and advancing human health. Without losing sight of the past achievements, the goal is to explore the potential of future advancements, addressing the challenges that remain at the forefront of this vibrant field. The scope of this Research Topic is broadly defined yet focused on areas where significant innovative strides have been made. We welcome contributions that emphasize: - Integrative approaches in Systems Neuroscience - Contemporary breakthroughs in Genetics and Genomics - The use of Multiscale Mechanistic Modelling to represent biological interfaces - Bridging gaps between experimental and computational biology in Translational Systems Biology - Enhancing methodologies in Data and Model Integration This collection welcomes contributions from Editorial Board Members or those referred by a board member, reflecting on current developments and plotting pathways for upcoming research endeavors. Authors are encouraged to engage critically with their fields, identifying current challenges and proposing novel solutions to advance the understanding of complex systems within biology.

Advanced Methods In Structural Biology

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Author : Ângela Sousa
language : en
Publisher: Springer Nature
Release Date : 2023-04-24

Advanced Methods In Structural Biology written by Ângela Sousa and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-24 with Science categories.

This volume explores the latest integrated bioprocesses and technologies used to study the production of the target recombinant protein of therapeutic or diagnostic interest; its isolation, purification, and stabilization; and the bio-interaction and structural analyses. The chapters in this book are organized into four parts. Part One covers production methods of soluble and membrane proteins in prokaryotic and eukaryotic expression systems, such as Lactococcus lactis and Escherichia coli. Part Two describes traditional and novel approaches for recombinant protein purification and stabilization, and buffers and additives. Part Three discusses automated methods in structural biology based on in silico approaches; and Part Four provides examples of advanced protein investigation methodologies to assess structural analysis such as high-throughput protein crystallization and time-resolved serial crystallography. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Advanced Methods in Structural Biology is a valuable resource to those in academia (i.e., graduate students and postdoctoral researchers) and researchers in the pharmaceutical industry who wish to learn more about this developing field. Chapter 5 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Integrative Structural Biology Of Proteins And Macromolecular Assemblies Bridging Experiments And Simulations

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Author : Paulo Ricardo Batista
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-26

Integrative Structural Biology Of Proteins And Macromolecular Assemblies Bridging Experiments And Simulations written by Paulo Ricardo Batista and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-26 with Science categories.

Insights In Ethnopharmacology 2021

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Author : Michael Heinrich
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-04

Insights In Ethnopharmacology 2021 written by Michael Heinrich and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-04 with Science categories.

Mononuclear Non Heme Iron Dependent Enzymes Part B

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Author :
language : en
Publisher: Elsevier
Release Date : 2024-09-17

Mononuclear Non Heme Iron Dependent Enzymes Part B written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-17 with Science categories.

Mononuclear Non-heme Iron Dependent Enzymes, Volume 703 PART B focuses on methods for studying, characterizing, and leveraging the chemistry of mononuclear non-heme iron dependent enzymes. Chapters in this new release include Photoreduction for Rieske oxygenase chemistry, Insights into the Mechanisms of Rieske Oxygenases from Studying the Unproductive Activation of Dioxygen, Non-heme iron and 2-oxoglutarate enzymes catalyze cyclopropane and azacyclopropane formations, Obtaining precise metrics of substrate positioning in Fe(II)/2OG dependent enzymes using Hyperfine Sublevel Correlation Spectroscopy, Xe-pressurization studies for revealing substrate-entrance tunnels, and much more.Additional chapters cover A tale of two dehydrogenases involved in NADH recycling, Rieske oxygenases and/or their partner reductase proteins, Expression, assay and inhibition of 9-cis-epoxycarotenoid dioxygenase (NCED) from Solanum lycopersicum and Zea mays, Biocatalysis and non-heme iron enzymes, In vitro analysis of the three-component Rieske oxygenase cumene dioxygenase from Pseudomonas fluorescens IP01, Structure and function of carbazole 1,9a-dioxygenase, Characterization of a Mononuclear Nonheme Iron-dependent Mono-oxygenase OzmD in Oxazinomycin Biosynthesis, and much more. - Provides detailed articles regarding how to study the structures and mechanisms of mononuclear non-heme iron dependent enzymes - Guides readers on how to use partner proteins in non-heme iron enzyme catalysis - Includes strategies to employ mononuclear non-heme iron enzymes in biocatalytic applications