Structure Function Relationships In Chinese Hamster Adenine Phoshoribosyl Transferase
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Structure Function Relationships In Chinese Hamster Adenine Phoshoribosyl Transferase
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Author : Barry Noel Ford
language : en
Publisher:
Release Date : 1998
Structure Function Relationships In Chinese Hamster Adenine Phoshoribosyl Transferase written by Barry Noel Ford and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.
Adenine phosphoribosyl transferase is a ubiquitous enzyme which salvages endogenous adenine, via the nucleotide AMP, for use by the cell. This activity, inconjunction with other interconnected purine salvage mechanisms is an energy-efficientway for the cell to satisfy its purine requirements. APRT is a target molecule in certain human diseases, for chemotherapeutics, and in vivo mutagenesis studies. There is little known about structure-function relationships in APRT. In the absence of solved three-dimensionalcrystal structures, we have explored structure-function relationships in APRT by sequence comparison, in vitro mutagenesis and kinetic analysis, protein crosslinking,and in vivo selection of mutant enzymes with altered substrate affinities. Chinese hamster APRT shares identifiable sequence similarities to all other phosphoribosyl transferases, and many other nucleotide binding proteins, in regions which probably serve closely similar functions across diverse protein families. Predicted secondary structures of CHO APRT are very similar to other APRT molecules, and to a lesser degree to other phosphoribosyl transferases. Residues of part of the generalized nucleotide binding motif of APRT were found to have specific roles in binding substrate, which can be extrapolated to the same functional elements in other nucleotide binding proteins. In addition, mutants identified by selection for altered substrate affinities are widely dispersed in the primary sequence. Although APRT is thought to exist as a dimer in its native context, certain mutants of APRT which have impaired ability to form dimers appear to have near-wildtype activity.
Gout
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Author : David S. Newcombe
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-10-12
Gout written by David S. Newcombe and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-12 with Medical categories.
Gout: Basic Science and Clinical Practice is a thoroughly researched comprehensive text which covers all important aspects of gout, including its genetics, pathophysiology, diagnosis, and management. Gout is probably the most common rheumatic disease after osteoarthritis and is becoming more common with the prevalence of the metabolic syndrome in the US, and in many other countries. Only about 10% of patients with gout are treated by rheumatologists and this often leads to inadequate diagnosis and treatment in general medical practice. Written by an expert in the field this book is valuable reference for rheumatologists and others in the medical profession who are interested in understanding and managing this important disease.
Proceedings Of The National Academy Of Sciences Of The United States Of America
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Author : National Academy of Sciences (U.S.)
language : en
Publisher:
Release Date : 1989
Proceedings Of The National Academy Of Sciences Of The United States Of America written by National Academy of Sciences (U.S.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Science categories.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1991
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medicine categories.
Micrornas As Tools In Biopharmaceutical Production
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Author : Niall Barron
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-15
Micrornas As Tools In Biopharmaceutical Production written by Niall Barron and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-15 with Medical categories.
Focused manuscript on the potential use/role of miRNAs in bioprocessing, specifically the production of complex proteins in mammalian cells. With that in mind I propose a draft list of topics/chapters along the following lines: Intro on CHO/bioprocessing/engineering challenges to set scene, Genomic organization, biogenesis and mode of action, Identifying miRNA targets: Computational prediction, transcriptomics, proteomices, UTR analysis, etc., miRNA expression in Chinese Hamster Ovary cells, miRNAs as engineering targets: pathway manipulation to impact bioprocess phenotypes, miRNAs as biomarkers, Detection methods: Northern, PCR, hybridization arrays, Next Gen Seq, Manipulation of expression in cultured cells: Transient/stable disregulation, Knockout.
Molecular Structure Of Human Chromosomes
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Author : Jorge Yunis
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Molecular Structure Of Human Chromosomes written by Jorge Yunis and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.
Molecular Structure of Human Chromosomes is an authoritative guide to genetics, focusing on human genome. This reference compiles contributions covering available knowledge on human genome structure and organization, which the previous researches fail to encompass. This text provides a comprehensive discussion of cytogenetic techniques, emphasizing their application to human genome studies and examinations. The book is divided into nine chapters. It explains the molecular organization and function of the human genome and the DNA sequences in man. It also discusses the localization of human gene by in situ hybridization and the approaches to gene mapping. The book describes the structure of the chromosomes and the trends in chromosome techniques; banding and polymorphism; and repetitive DNA and primate evolution. Various practitioners in genetics and biology will find this book a good reference. Students and novices in these fields will also find this book an excellent guide.
Veterans At Risk
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 1993-02-01
Veterans At Risk written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-02-01 with Medical categories.
Recently, World War II veterans have come forward to claim compensation for health effects they say were caused by their participation in chemical warfare experiments. In response, the Veterans Administration asked the Institute of Medicine to study the issue. Based on a literature review and personal testimony from more than 250 affected veterans, this new volume discusses in detail the development and chemistry of mustard agents and Lewisite followed by interesting and informative discussions about these substances and their possible connection to a range of health problems, from cancer to reproductive disorders. The volume also offers an often chilling historical examination of the use of volunteers in chemical warfare experiments by the U.S. militaryâ€"what the then-young soldiers were told prior to the experiments, how they were "encouraged" to remain in the program, and how they were treated afterward. This comprehensive and controversial book will be of importance to policymakers and legislators, military and civilian planners, officials at the Department of Veterans Affairs, military historians, and researchers.
Genetics Abstracts
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Author :
language : en
Publisher:
Release Date : 1995
Genetics Abstracts written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Genetics categories.
Science Citation Index
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Author :
language : en
Publisher:
Release Date : 1994
Science Citation Index written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Science categories.
Vols. for 1964- have guides and journal lists.
Dissertation Abstracts International
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Author :
language : en
Publisher:
Release Date : 2000
Dissertation Abstracts International written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Dissertations, Academic categories.
