Structure Of Antigens
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Structure Of Antigens
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Author : Marc H. V. Van Regenmortel
language : en
Publisher: CRC Press
Release Date : 1992-12-07
Structure Of Antigens written by Marc H. V. Van Regenmortel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-12-07 with Medical categories.
Structure of Antigens discusses a variety of topics dealing with the structural basis of antigenicity. Topics include the analytical methods used to elucidate the structure of antigens, the structure of antibodies, the principles underlying modern immunoassays and the measurement of antibody binding affinity, and physicochemical principles and methodological aspects. The book also considers major groups of antigens distinguished by their functional activity and biological role (e.g., drugs, autoantigens, snake toxins, allergens) or by their association with particular biological systems (e.g., antigens of microorganisms). Structure of Antigens will provide a current, useful, reference for researchers and graduate students in all fields of biological science who need an overview of antigenic specificity. VOLUME II
Sructure Of Antigens
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Author : Marc H. V. Van Regenmortel
language : en
Publisher: CRC Press
Release Date : 1992-02-03
Sructure Of Antigens written by Marc H. V. Van Regenmortel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-02-03 with Medical categories.
Structure of Antigens discusses a variety of topics dealing with the structural basis of antigenicity. Topics include the analytical methods used to elucidate the structure of antigens, the structure of antibodies, the principles underlying modern immunoassays and the measurement of antibody binding affinity, and physicochemical principles and methodological aspects. The book also considers major groups of antigens distinguished by their functional activity and biological role (e.g., drugs, autoantigens, snake toxins, allergens) or by their association with particular biological systems (e.g., antigens of microorganisms). Structure of Antigens will provide a current, useful, reference for researchers and graduate students in all fields of biological science who need an overview of antigenic specificity. VOLUME 1
Structure Of Antigens
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Author : Marc H. V. van Regenmortel
language : en
Publisher: CRC-Press
Release Date : 1992-12-07
Structure Of Antigens written by Marc H. V. van Regenmortel and has been published by CRC-Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-12-07 with Science categories.
Structure of Antigens discusses a variety of topics dealing with the structural basis of antigenicity. Topics include the analytical methods used to elucidate the structure of antigens, the structure of antibodies, the principles underlying modern immunoassays and the measurement of antibody binding affinity, and physicochemical principles and methodological aspects. The book also considers major groups of antigens distinguished by their functional activity and biological role (e.g., drugs, autoantigens, snake toxins, allergens) or by their association with particular biological systems (e.g., antigens of microorganisms). Structure of Antigens will provide a current, useful, reference for researchers and graduate students in all fields of biological science who need an overview of antigenic specificity. VOLUME II
Structure Of Antigens
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Author : Marc H. V. van Regenmortel
language : en
Publisher: CRC-Press
Release Date : 1995-12-20
Structure Of Antigens written by Marc H. V. van Regenmortel and has been published by CRC-Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-12-20 with Medical categories.
Volume 3 of Structure of Antigens presents analytical methods used to elucidate the structure of antigens. As in the first two volumes, this reference focuses on the structure and analysis of antibody binding sites. It brings together the structural basis of major types of antigens, including lysozyme, cytochrome c, muscle proteins, cereal and milk proteins, carbohydrate antigens, and more. Major groups of antigens associated with particular biological systems, such as the cytoskeleton, muscle proteins, and viral antigens, are discussed. This reference analyzes the molecular basis of antibody specificity and the structure of T cell epitopes.
Structure And Function Of Antibodies
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Author : Roy Jefferis
language : en
Publisher: MDPI
Release Date : 2021-02-05
Structure And Function Of Antibodies written by Roy Jefferis and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-05 with Science categories.
This book provides a detailed description of all kinds of therapeutic antibodies including IgGs, IgAs, IgEs, and IgMs, bispecific antibodies, chimeric antigen receptor antibodies, and antibody fragments. Details about how each of these antibodies interact with their ligands, the immune system, and their targets are provided. Additionally, this book delves into the details of antibody, Fc, and variable chain structures, and how subtle changes in structure, charge, flexibility, post-translational modification, and the ability to bind to natural antibody ligands can result in a significant impact on antibody activity and functionality. Finally, the book explains the critical quality attributes of modern therapeutic antibodies and how to ensure that antibodies entering development have the best possible chance of success.
The Immunoglobulins
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Author : Roald Nezlin
language : en
Publisher: Academic Press
Release Date : 1998-05-06
The Immunoglobulins written by Roald Nezlin and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-05-06 with Science categories.
This book provides comprehensive up-to-date information on the structure and function of immunoglobulins. It describes the basic features of these molecules, which assists the reader in understanding how they function as an integral part of the immune system. The Immunoglobulins describes the localization and structure of different binding sites of immunoglobulin molecules, including the antigen-binding site, on the basis of latest x-ray crystallography studies. It discusses recently developed biotechnological methods that allow scientists to obtain fully active antibody molecules in vitro even without immunization and to construct new variants of immunoglobulins and their fragments by fusing with various other active molecules. A survey of recent knowledge on immunoglobulin-binding molecules other than antigens and on flexibility of immunoglobulin molecules concludes the discussion of functional aspects of the problem. Describes recent reviews on the structure and function of immunoglobulin molecules of various species Summarizes in detail recent findings on the fine structure of the antigen-combining site Presents comparative data on the antigen-recognizing sites of other molecules such as MHC proteins and T-cell receptors Summarizes growing data on immunoglobulin binding sites responsible for the reaction of immunoglobulins with molecules other than antigens Explores the rapid advance of recent biotechnological methods used for the construction of antibody molecules and their fragments with new properties Presents extensive references and is lavishly illustrated
The Antigens
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Author : Michael Sela
language : en
Publisher: Academic Press
Release Date : 2014-05-10
The Antigens written by Michael Sela and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-10 with Science categories.
The Antigens, Volume I is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology, structure and function, their initiation of the immune response, and the nature of the products of this response. The nature of the reaction of antigens with antibodies and with sensitized cells is also explored. Comprised of seven chapters, this volume begins with a discussion on the antigenic functions of nucleic acids as well as their immunogenicity, hapten functions, and serologic reactions. The reader is then introduced to the immunochemistry and antigenic determinants of enzymes, along with the structure and phylogeny of immunoglobulins and immunoglobulin allotypes. The evolution of proteins and their structure and function is also considered, paying particular attention to evolution by the random fixation of selectively neutral alleles, the rates of protein evolution, gene duplication, and divergence or convergence. The final chapter is devoted to the chemistry and biology of immunoglobulin E as well as the regulation of formation of their antibodies. This book will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.
Structure And Function Of Antibodies
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Author : Leonard Eleazar Glynn
language : en
Publisher: John Wiley & Sons
Release Date : 1981
Structure And Function Of Antibodies written by Leonard Eleazar Glynn and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with Antibodies categories.
Histocompatibility Antigens
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Author : B. Parham
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Histocompatibility Antigens written by B. Parham and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Science categories.
The Major Histocompatibility Complex (MHC) was discovered as a con sequence of the chronic problem encountered by cancer biologists in the early years of this century: the failure to maintain tumor lines by serial passage in outbred mice. A number of observations pointed to genetic similarity being a prerequisite for successful transplantation and they were incorporated into a genetic theory of transplantation by C.C. Little. This prompted scientists like Little to initiate breeding experiments designed to test his hypothesis and produce genetically identical mice which would permit the growth of trans planted tumors. Most inbred strains of mice commonly used in immunology derive from those efforts. Transplantation of normal tissues obeyed the same rules found for malignant tissues and rejection was shown to be an immunological phenomenon. G.D. Snell showed that a single genetic locus determined rapid rejection of skin grafts. This was initially called the Major Histocompatibility Locus but was subsequently shown to include many functionally related genes and renamed the Major Histocompatibility Complex (MHC). In mouse this is the H-2 complex and man the HLA complex. During this same period P.A.
Hla Class Ii Antigens
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Author : Bjarte G. Solheim
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Hla Class Ii Antigens written by Bjarte G. Solheim and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This volume deals with the structure and function of molecules that have, during the last decade, turned out to have a central role in immune responses. Trans plantation antigens were discovered and characterized by Gorer about 50 years ago, and the biological basis for the unequalled complexity of their variability between individuals within a species, in spite of extreme conservation between species, was the subject of intense research and discussion for many years. During the days of belief in "immune surveillance" against spontaneously developing tumors, it was suggested that histoincompatibility between members of one species would prevent cancer from being a contagious disease and thus a threat to the species. Immunologists involved in human transplantation had to learn and care about the complexity, especially after 1967, when it was found that HLA antigens were the products of the human MHC. Rejection of HLA-identical sib kidney grafts was so rare, even in those days, that cases of rejection were described in scientific papers.