Studies On Key Developmental Regulatory Mechanisms Associated With Dopaminergic Neuron During Degeneration And Regeneration
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Studies On Key Developmental Regulatory Mechanisms Associated With Dopaminergic Neuron During Degeneration And Regeneration
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Author : Tippabathani Jayakrishna S
language : en
Publisher: Independent Author
Release Date : 2023-03-19
Studies On Key Developmental Regulatory Mechanisms Associated With Dopaminergic Neuron During Degeneration And Regeneration written by Tippabathani Jayakrishna S and has been published by Independent Author this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-19 with Education categories.
Dopamine (DA) is involved in many metabolic and regulating functions such as reward, motivation, memory, attention, and regulating body movements. In the mammalian central nervous system (CNS), mesencephalic dopaminergic (mDA) neurons are the main source of dopamine (Holzschuh et al., 2001). The selective loss of mDA neurons of the substantia nigra pars compacta (SNpc) is the hallmark of Parkinson's disease (PD) (DeMaagd and Philip, 2015). PD is associated with impairment of cognitive capabilities and symptoms like bradykinesia, tremor, and akinesia. Scientific reports are working to decipher the cellular and molecular mechanisms driving PD pathogenesis, as it is not well understood. Symptoms manifest only after 70-80% of mDA neurons have been degenerated (Cheng et al., 2010) and may be devastating because the adult CNS has extremely limited intrinsic regeneration to replace the lost neurons (Horner and Gage, 2000). Unfortunately, the loss of DA neurons cannot be rescued or reversed by drug administration. It is mandatory to decipher the neurogenesis and their mechanism, as they assist the scientific community towards inducing human stem cells to express a dopaminergic phenotype.
Apoptosis And Beyond
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Author : James A. Radosevich
language : en
Publisher: John Wiley & Sons
Release Date : 2018-09-18
Apoptosis And Beyond written by James A. Radosevich and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-18 with Science categories.
These volumes teach readers to think beyond apoptosis and describes all of the known processes that cells can undergo which result in cell death This two-volume source on how cells dies is the first, comprehensive collection to cover all of the known processes that cells undergo when they die. It is also the only one of its kind to compare these processes. It seeks to enlighten those in the field about these many processes and to stimulate their thinking at looking at these pathways when their research system does not show signs of activation of the classic apoptotic pathway. In addition, it links activities like the molecular biology of one process (eg. Necrosis) to another process (eg. apoptosis) and contrasts those that are close to each. Volume 1 of Apoptosis and Beyond: The Many Ways Cells Die begins with a general view of the cytoplasmic and nuclear features of apoptosis. It then goes on to offer chapters on targeting the cell death mechanism; microbial programmed cell death; autophagy; cell injury, adaptation, and necrosis; necroptosis; ferroptosis; anoikis; pyronecrosis; and more. Volume 2 covers such subjects as phenoptosis; pyroptosis; hematopoiesis and eryptosis; cyclophilin d-dependent necrosis; and the role of phospholipase in cell death. Covers all known processes that dying cells undergo Provides extensive coverage of a topic not fully covered before Offers chapters written by top researchers in the field Provides activities that link and contrast processes to each other Apoptosis and Beyond: The Many Ways Cells Die will appeal to students and researchers/clinicians in cell biology, molecular biology, oncology, and tumor biology.
Development And Engineering Of Dopamine Neurons
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Author : Jeroen Pasterkamp
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-16
Development And Engineering Of Dopamine Neurons written by Jeroen Pasterkamp and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-16 with Medical categories.
Theneurotransmitter dopamine has just celebrated its 50thbirthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransm- ter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (mdDA) system, previously designated as midbraindopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and theirprojections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has been marked by the cloning and characterization ofNurrl and Pitx3. These transcription factors were shown to have a critical function during mdDA development. These initial studies have been followed by the identification of many other proteins, which have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminaldifferent- tion and finally maintenance of the mdDA neuronal pool.
Axon Degeneration
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Author : Elisabetta Babetto
language : en
Publisher: Humana
Release Date : 2020-06-11
Axon Degeneration written by Elisabetta Babetto and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-11 with Science categories.
This book is a collection of classical as well as innovative methods used to investigate axon degeneration with a particular focus on addressing the common challenges encountered while performing these procedures. Particular attention is devoted to the study of axon loss in several model organisms, as each poses unique challenges and provides powerful advantages. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Axon Degeneration: Methods and Protocols is an ideal guide for facilitating the application and further development of these protocols, which will help the scientific community tackle important questions regarding axon degeneration. Chapters 2, 3, and 20 are available Open Access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Cajal S Degeneration And Regeneration Of The Nervous System
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Author : Santiago Ramón y Cajal
language : en
Publisher: History of Neuroscience
Release Date : 1991
Cajal S Degeneration And Regeneration Of The Nervous System written by Santiago Ramón y Cajal and has been published by History of Neuroscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Nervous system categories.
This book is a reprint of an English translation of Cajal's original work, with abundant notes and commentaries by the editor. This text describes Cajal's fundamental contributions to neuroscience, which continue to be important today. It accurately details Cajal's ideas and data, and providesreaders with the opportunity to learn what Cajal thought about his research career and the significance of his observations. Excerpts from Tello's memorial lectures also provide a contemporary view of Cajal's work.
Connecting Form And Function Recent Advances In Understanding Dendrite Morphogenesis And Plasticity
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Author : Quan Yuan
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-03
Connecting Form And Function Recent Advances In Understanding Dendrite Morphogenesis And Plasticity written by Quan Yuan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-03 with Science categories.
Translational Research In Traumatic Brain Injury
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Author : Daniel Laskowitz
language : en
Publisher: CRC Press
Release Date : 2015-12-01
Translational Research In Traumatic Brain Injury written by Daniel Laskowitz and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-01 with Medical categories.
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.
Degeneration And Regeneration In The Nervous System
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Author : Norman Saunders
language : en
Publisher: CRC Press
Release Date : 2003-09-02
Degeneration And Regeneration In The Nervous System written by Norman Saunders and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-02 with Medical categories.
Degeneration and Regeneration in the Nervous System brings together an international team of contributors to produce a series of critical reviews appraising key papers in the field. The pace of research on brain and spinal cord injury quickened considerably in the last ten years and there is much that is new and important that is covered in this book. However, there is still a long way to go before our knowledge will explain fully why the central nervous system has such a limited capacity for regeneration, and before experimental solutions can be applied to the patient. With emphasis on actual and therapeutic importance of the work reviewed, Degeneration and Regeneration in the Nervous System is a useful overview for graduate students, their teachers and researchers working in this field.
Molecular Mechanisms Of Neurodegenerative Diseases
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Author : Marie-Francoise Chesselet
language : en
Publisher: Springer Science & Business Media
Release Date : 2000-10-19
Molecular Mechanisms Of Neurodegenerative Diseases written by Marie-Francoise Chesselet and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-10-19 with Medical categories.
With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.
Cell Therapy For Neurological Disorders
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Author : Zhiguo Chen
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-04
Cell Therapy For Neurological Disorders written by Zhiguo Chen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-04 with Science categories.
