Study Of Dynamic Functional Br
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Dynamic Functional Connectivity In Neuropsychiatric Disorders Methods And Applications
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Author : Wenbin Guo
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-03
Dynamic Functional Connectivity In Neuropsychiatric Disorders Methods And Applications written by Wenbin Guo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-03 with Science categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Study Of Dynamic Functional Br
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Author : Zening Fu
language : en
Publisher: Open Dissertation Press
Release Date : 2017-01-26
Study Of Dynamic Functional Br written by Zening Fu and has been published by Open Dissertation Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-26 with Technology & Engineering categories.
This dissertation, "A Study of Dynamic Functional Brain Connectivity Using Functional Magnetic Resonance Imaging (fMRI): Method and Applications" by Zening, Fu, 傅泽宁, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Identifying the statistical interdependence (functional connectivity, FC) between brain regions using functional magnetic resonance imaging (fMRI)is an important approach towards understanding how brain system is organized. Most fMRI studies assumed temporal stationarity of FC, so that the dynamic fluctuations of FC were overlooked. Emerging evidence has shown that FC fluctuates significantly across time and such fluctuations are physiologically relevant. The objectives of this work were (1) to develop novel methods for estimating dynamic FC from non-stationary fMRI signals, and (2) to apply new methods on real-life fMRI datasets for exploring dynamic patterns of FC in tasks and at rest. In particular, new methods were introduced to tackle two key issues in dynamic FC estimation: how to adaptively select window size to estimate dynamic FC and how to estimate dynamic FC networks with sparse architecture and sparse evolution. Firstly, a local polynomial regression (LPR) method was introduced to estimate time-varying covariance (TVCOV) for the inference of dynamic FC. The asymptotic analysis of this covariance estimator was performed and then a data-driven method, intersection of confidence intervals (ICI), was adopted to adaptively determine the window size. Simulation results showed that the LPR-ICI method could achieve robust and reliable performance in estimating TVCOV, making it a powerful tool for studying the dynamic FC from fMRI signals. Secondly, the LPR-ICI method was applied to a visual task fMRI dataset for studying the changes of FC in a block-designed visual checkerboard experiment. Reliable task-related FC changes were identified among activated visual regions during the task block. The results suggested that characterizing the task-related FC dynamics might provide greater insight into condition shifts and coordination between brain regions. Thirdly, the LPR-ICI method was applied to a resting-state fMRI dataset for exploring FC dynamics across the whole brain and investigating their relationships with dynamics of local brain activities. Converging results demonstrated that resting-state FC exhibited remarkable different dynamic patterns across the brain and these dynamic patterns were significantly correlated with the dynamic patterns of brain activities. These findings suggested that the brain might bean adaptive network, in which brain activities and their FC coevolve across time. Lastly, a novel dual l0-penalized (DLP) time-varying in verse covariance estimation method was introduced for estimating sparse dynamic FC networks. This DLP method was able to estimate dynamic networks with sparse architecture and sparse evolution by minimizing a log-likelihood function regularized by two l0-penalties (to enforce sparse architecture and sparse evolution, respectively).A coordinate descent algorithm was developed for searching the local minimizers of the objective function. Extensive simulation results showed that the DLP method could achieve better performance than conventionall1-penalized methods. In summary, two newly-developed methods (LPR-ICI and DLP) could be effective tools for studying dynamic brain FC and our results have advanced the knowledge of how brain regions dynamically coordinate. This study was also clinically relevant, as the quantification of altered FC dynamics in clinical populations of neuropsyc
A Study Of Dynamic Functional Brain Connectivity Using Functional Magnetic Resonance Imaging Fmri
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Author : Zening Fu
language : en
Publisher:
Release Date : 2017-01-26
A Study Of Dynamic Functional Brain Connectivity Using Functional Magnetic Resonance Imaging Fmri written by Zening Fu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-26 with Brain categories.
Dynamic Functional Connectivity In Neuropsychiatric Disorders Methods And Applications Volume Ii
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Author : Zaicu Cui
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-07
Dynamic Functional Connectivity In Neuropsychiatric Disorders Methods And Applications Volume Ii written by Zaicu Cui and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-07 with Science categories.
Neuropsychiatric disorders have a huge impact on individuals, families and societies. However, the neuropathology underlying cognitive deficits in neuropsychiatric disorders remains unclear. Resting-state functional connectivity provides a powerful way to investigate functional alterations underlying cognitive deficits in neuropsychiatric disorders. Traditional FC analysis measures the correlations of signals with an assumption that functional connectivity remains constant during the observation period. In recent years, several studies have demonstrated the feasibility of dynamic methods in characterization of functional brain changes, such as dynamic functional connectivity investigated by a sliding window method. However, selection of window size, window stepsize and window type are open areas of research and an important parameter to capture the resting-state FC dynamics.
Dynamic Functional Studies In Nuclear Medicine In Developing Countries
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Author : International Atomic Energy Agency
language : en
Publisher:
Release Date : 1989
Dynamic Functional Studies In Nuclear Medicine In Developing Countries written by International Atomic Energy Agency and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Medical categories.
Proceedings of a symposium, Vienna, 15-19 August 1988. The papers deal mainly with clinical applications of dynamic functional studies and document some of the problems involved in setting up nuclear medicine facilities in general, and specifically for the diagnosis of the diseases prevalent in less developed countries. Other topics covered are quality control of equipment and the transfer of medical technology.
Neuroimaging Approaches To The Study Of Cognitive Aging
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Author : Ronald Cohen
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-29
Neuroimaging Approaches To The Study Of Cognitive Aging written by Ronald Cohen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-29 with categories.
Mr Imaging In White Matter Diseases Of The Brain And Spinal Cord
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Author : Massimo Filippi
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-12-29
Mr Imaging In White Matter Diseases Of The Brain And Spinal Cord written by Massimo Filippi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-29 with Medical categories.
In recent decades, the use of neuroimaging techniques has resulted in outstanding progress in the diagnosis and management of neurological diseases, and this is particularly true of those diseases that affect the white matter of the brain and spinal cord. This book, written by internationally acclaimed experts, comprises a series of comprehensive and up-to-date reviews on the use of MR imaging in these major neurological conditions. The diverse available MR techniques, such as magnetization transfer MRI, diffusion-weighted MRI, MR spectroscopy, functional MRI, cell-specific MRI, perfusion MRI, and microscopic imaging with ultra-high field MRI, offer an extraordinarily powerful means of gaining fundamental in vivo insights into disease processes. The strengths and weaknesses of all these techniques in the study of multiple sclerosis and other relevant diseases are extensively considered. After an introductory section on neuroimaging technology, subsequent sections address disorders of myelination, demyelinating diseases, immune-mediated disorders, and white matter disorders related to aging and other conditions. This book provides a valuable summary of the state of the art in the field, and defines important areas for future research.
Stability Periodicity And Boundedness In Functional Dynamical Systems On Time Scales
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Author : Murat Adıvar
language : en
Publisher: Springer Nature
Release Date : 2020-04-23
Stability Periodicity And Boundedness In Functional Dynamical Systems On Time Scales written by Murat Adıvar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-23 with Mathematics categories.
Motivated by recent increased activity of research on time scales, the book provides a systematic approach to the study of the qualitative theory of boundedness, periodicity and stability of Volterra integro-dynamic equations on time scales. Researchers and graduate students who are interested in the method of Lyapunov functions/functionals, in the study of boundedness of solutions, in the stability of the zero solution, or in the existence of periodic solutions should be able to use this book as a primary reference and as a resource of latest findings. This book contains many open problems and should be of great benefit to those who are pursuing research in dynamical systems or in Volterra integro-dynamic equations on time scales with or without delays. Great efforts were made to present rigorous and detailed proofs of theorems. The book should serve as an encyclopedia on the construction of Lyapunov functionals in analyzing solutions of dynamical systems on time scales. The book is suitable for a graduate course in the format of graduate seminars or as special topics course on dynamical systems. The book should be of interest to investigators in biology, chemistry, economics, engineering, mathematics and physics.
Molecular Imaging Basic Principles And Applications In Biomedical Research 3rd Edition
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Author : Markus Rudin
language : en
Publisher: World Scientific
Release Date : 2020-04-04
Molecular Imaging Basic Principles And Applications In Biomedical Research 3rd Edition written by Markus Rudin and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-04 with Technology & Engineering categories.
The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full biological context. Due to the high specificity of the molecular readouts the approach bears a high potential for diagnostics. It is fair to say that molecular imaging has become an indispensable tool for biomedical research and drug discovery and development today.This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities, and the design of targeted probes are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events in the living organism. Topics covered include the studies of the biodistribution of reporter probes and drugs, visualization of the expression of biomolecules such as receptors and enzymes, and how imaging can be used for analyzing consequences of the interaction of a ligand or a drug with its molecular target by visualizing signal transduction, or assessing the metabolic, physiological, or structural response of the organism studied.The third edition has been extended considerably. This holds for the chapter on imaging modalities, which now includes sections on intravital microscopy and mass spectrometric imaging. All chapters have been updated and a new chapter on the challenges of translating molecular imaging solutions for clinical use has been added.
Neutrons In Soft Matter
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Author : Toyoko Imae
language : en
Publisher: John Wiley & Sons
Release Date : 2011-05-23
Neutrons In Soft Matter written by Toyoko Imae and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-23 with Science categories.
Neutron and synchrotron facilities, which are beyond the scale of the laboratory, and supported on a national level in countries throughout the world. These tools for probing micro- and nano-structure research and on fast dynamics research of atomic location in materials have been key in the development of new polymer-based materials. Different from several existing professional books on neutron science, this book focuses on theory, instrumentation, an applications. The book is divided into five parts: Part 1 describes the underlying theory of neutron scattering. Part 2 describes the various instruments that exist and the various techniques used to achieve neutron scattering or bombardment. Part 3 discusses data treatment and simulation methods as well as how to assess the environment of the sample (temperature, pressure, shear, and external fields). Part 4 addresses the myriad applications of small and large molecules, biomolecules, and gels. Part 5 describes the various global neutron sources that exist and provides an overview of the different reactors.