Successful Randomized Trials
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Successful Randomized Trials
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Author : Michael J. Domanski
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2009
Successful Randomized Trials written by Michael J. Domanski and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Medical categories.
This handbook is a ready reference on the theory and operation of modern large, multicenter randomized clinical trials, which have come to be the basis of evidence-based medicine. Written in a concise, engaging style geared to physicians, the book explains the rationale and theoretical foundations for clinical trials, the components of modern clinical trials including their functions and interactions, and practical considerations in the design and implementation of these studies including an introduction to the economics and business aspects.
Randomization In Clinical Trials
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Author : William F. Rosenberger
language : en
Publisher: John Wiley & Sons
Release Date : 2015-11-23
Randomization In Clinical Trials written by William F. Rosenberger and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-23 with Mathematics categories.
Praise for the First Edition “All medical statisticians involved in clinical trials should read this book...” - Controlled Clinical Trials Featuring a unique combination of the applied aspects of randomization in clinical trials with a nonparametric approach to inference, Randomization in Clinical Trials: Theory and Practice, Second Edition is the go-to guide for biostatisticians and pharmaceutical industry statisticians. Randomization in Clinical Trials: Theory and Practice, Second Edition features: Discussions on current philosophies, controversies, and new developments in the increasingly important role of randomization techniques in clinical trials A new chapter on covariate-adaptive randomization, including minimization techniques and inference New developments in restricted randomization and an increased focus on computation of randomization tests as opposed to the asymptotic theory of randomization tests Plenty of problem sets, theoretical exercises, and short computer simulations using SAS® to facilitate classroom teaching, simplify the mathematics, and ease readers’ understanding Randomization in Clinical Trials: Theory and Practice, Second Edition is an excellent reference for researchers as well as applied statisticians and biostatisticians. The Second Edition is also an ideal textbook for upper-undergraduate and graduate-level courses in biostatistics and applied statistics. William F. Rosenberger, PhD, is University Professor and Chairman of the Department of Statistics at George Mason University. He is a Fellow of the American Statistical Association and the Institute of Mathematical Statistics, and author of over 80 refereed journal articles, as well as The Theory of Response-Adaptive Randomization in Clinical Trials, also published by Wiley. John M. Lachin, ScD, is Research Professor in the Department of Epidemiology and Biostatistics as well as in the Department of Statistics at The George Washington University. A Fellow of the American Statistical Association and the Society for Clinical Trials, Dr. Lachin is actively involved in coordinating center activities for clinical trials of diabetes. He is the author of Biostatistical Methods: The Assessment of Relative Risks, Second Edition, also published by Wiley.
Field Trials Of Health Interventions
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Author : Peter G. Smith
language : en
Publisher:
Release Date : 2015
Field Trials Of Health Interventions written by Peter G. Smith and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Health & Fitness categories.
This is an open access title available under the terms of a CC BY-NC 4.0 International licence. It is free to read at Oxford Scholarship Online and offered as a free PDF download from OUP and selected open access locations. Before new interventions are released into disease control programmes, it is essential that they are carefully evaluated in field trials'. These may be complex and expensive undertakings, requiring the follow-up of hundreds, or thousands, of individuals, often for long periods. Descriptions of the detailed procedures and methods used in the trials that have been conducted have rarely been published. A consequence of this, individuals planning such trials have few guidelines available and little access to knowledge accumulated previously, other than their own. In this manual, practical issues in trial design and conduct are discussed fully and in sufficient detail, that Field Trials of Health Interventions may be used as a toolbox' by field investigators. It has been compiled by an international group of over 30 authors with direct experience in the design, conduct, and analysis of field trials in low and middle income countries and is based on their accumulated knowledge and experience. Available as an open access book via Oxford Medicine Online, this new edition is a comprehensive revision, incorporating the new developments that have taken place in recent years with respect to trials, including seven new chapters on subjects ranging from trial governance, and preliminary studies to pilot testing.
Randomized Controlled Trials
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Author : Alejandro R. Jadad
language : en
Publisher:
Release Date : 2007
Randomized Controlled Trials written by Alejandro R. Jadad and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Clinical trials categories.
Designing Randomised Trials In Health Education And The Social Sciences
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Author : D. Torgerson
language : en
Publisher: Springer
Release Date : 2008-03-13
Designing Randomised Trials In Health Education And The Social Sciences written by D. Torgerson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-13 with Social Science categories.
The book focuses on the design of rigorous trials rather than their statistical underpinnings, with chapters on: pragmatic designs; placebo designs; preference approaches; unequal allocation; economics; analytical approaches; randomization methods. It also includes a detailed description of randomization procedures and different trial designs.
Introduction To Randomized Controlled Clinical Trials
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Author : John N.S. Matthews
language : en
Publisher: CRC Press
Release Date : 2006-06-26
Introduction To Randomized Controlled Clinical Trials written by John N.S. Matthews and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-06-26 with Mathematics categories.
Evidence from randomized controlled clinical trials is widely accepted as the only sound basis for assessing the efficacy of new medical treatments. Statistical methods play a key role in all stages of these trials, including their justification, design, and analysis. This second edition of Introduction to Randomized Controlled Clinical Trials prov
Randomized Control Trials In The Field Of Development
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Author : Florent Bédécarrats
language : en
Publisher:
Release Date : 2020
Randomized Control Trials In The Field Of Development written by Florent Bédécarrats and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Business & Economics categories.
Randomized Control Trials in the Field of Development provides a critical perspective on the use of randomized control trials in development and poverty alleviation policies, warning against their excessive use and proposing improvements and alternatives.
Randomized Controlled Trials
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Author : Phyllis Solomon
language : en
Publisher: Oxford University Press
Release Date : 2009-02-02
Randomized Controlled Trials written by Phyllis Solomon and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-02-02 with Social Science categories.
Randomized controlled trials (RCTs) are considered by many researchers and providers to be the gold standard of health and social service effectiveness research. However, there exist scant resources that deal with the complex nature of designing and implementing RCTs in community-based settings. This clearly written pocket guide provides researchers and social service practitioners insight into each step of an RCT. The goal of this text is to enable readers to understand, design, and implement a community-based RCT. From the initial stage of planning the RCT and developing its conceptual foundations through implementation, the authors provide a wealth of detail and case studies from social work practice research that assist readers to comprehend the detailed information provided. Accessible, concrete advice is woven throughout the text and tackles the many design and implementation challenges that arise in community practice settings. The importance of utilizing a mix of qualitative and quantitative methods is encouraged due to the intricate nature of RCT research in community-based environments. Through utilizing practical case examples, this pocket guide reviews the essentials of RCTs in a manner that will appeal to researchers, practitioners and students alike who are seeking the necessary tools to build the empirical knowledge base for community-based psychosocial interventions for social work.
Handbook Of Statistical Methods For Randomized Controlled Trials
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Author : KyungMann Kim
language : en
Publisher: CRC Press
Release Date : 2021-08-23
Handbook Of Statistical Methods For Randomized Controlled Trials written by KyungMann Kim and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-23 with Mathematics categories.
Statistical concepts provide scientific framework in experimental studies, including randomized controlled trials. In order to design, monitor, analyze and draw conclusions scientifically from such clinical trials, clinical investigators and statisticians should have a firm grasp of the requisite statistical concepts. The Handbook of Statistical Methods for Randomized Controlled Trials presents these statistical concepts in a logical sequence from beginning to end and can be used as a textbook in a course or as a reference on statistical methods for randomized controlled trials. Part I provides a brief historical background on modern randomized controlled trials and introduces statistical concepts central to planning, monitoring and analysis of randomized controlled trials. Part II describes statistical methods for analysis of different types of outcomes and the associated statistical distributions used in testing the statistical hypotheses regarding the clinical questions. Part III describes some of the most used experimental designs for randomized controlled trials including the sample size estimation necessary in planning. Part IV describe statistical methods used in interim analysis for monitoring of efficacy and safety data. Part V describe important issues in statistical analyses such as multiple testing, subgroup analysis, competing risks and joint models for longitudinal markers and clinical outcomes. Part VI addresses selected miscellaneous topics in design and analysis including multiple assignment randomization trials, analysis of safety outcomes, non-inferiority trials, incorporating historical data, and validation of surrogate outcomes.
Textbook Of Pharmacoepidemiology
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Author : Brian L. Strom
language : en
Publisher: John Wiley & Sons
Release Date : 2013-05-13
Textbook Of Pharmacoepidemiology written by Brian L. Strom and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-13 with Medical categories.
The Textbook of Pharmacoepidemiology provides a streamlined text for evaluating the safety and effectiveness of medicines. It includes a brief introduction to pharmacoepidemiology as well as sections on data sources, methodology and applications. Each chapter includes key points, case studies and essential references. One-step resource to gain understanding of the subject of pharmacoepidemiology at an affordable price Gives a perspective on the subject from academia, pharmaceutical industry and regulatory agencies Designed for students with basic knowledge of epidemiology and public health Includes many case studies to illustrate pharmacoepidemiology in real clinical setting