Supercritical Fluid Extraction And Its Use In Chromatographic Sample Preparation
DOWNLOAD
Download Supercritical Fluid Extraction And Its Use In Chromatographic Sample Preparation PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Supercritical Fluid Extraction And Its Use In Chromatographic Sample Preparation book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Supercritical Fluid Extraction And Its Use In Chromatographic Sample Preparation
DOWNLOAD
Author : S.A. Westwood
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Supercritical Fluid Extraction And Its Use In Chromatographic Sample Preparation written by S.A. Westwood and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
by Professor D. E. Games, Mass Spectrometry Research Unit, University College of Swansea Sample preparation can be viewed as occupying a Cinderella role in analytical science. However, the quality of sample preparation plays a key role in high In the past decade, there has been quality analysis and deserves higher stature. considerable interest in the use of supercritical fluid extraction (SFE) as an alternative to conventional procedures for the preparation of samples for ana lysis. The driving force for this development is the need for automated, sim pler, faster, non-destructive and selective methods for extraction, preferably using non-toxic extraction media which are easily disposed of. Utilization of supercritical fluids for extraction fulfils these requirements because of their unique physical chemical properties and usually low toxicity. Selectivity can be achieved by suitable selection of pressure (density), temperature and modi fier conditions which enable solvating power to be varied. The high diffusivity of supercritical fluids provides rapid sample penetration and extraction. Use of fluids with low critical temperatures enables extraction to be conducted under mild thermal conditions ensuring that thermally labile compounds do not decompose. The technique can be used off-line, and the extracts analysed by appropriate techniques, or it can be used on-line, by coupling with a variety of chromatographic techniques. These can then, if necessary, be coupled fur ther with spectroscopic techniques, such as Fourier transform infrared, ultra violet or mass spectrometry, to provide specific identification or structural information.
Practical Supercritical Fluid Chromatography And Extraction
DOWNLOAD
Author : Thomas Caudell
language : en
Publisher: Routledge
Release Date : 2018-05-08
Practical Supercritical Fluid Chromatography And Extraction written by Thomas Caudell and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-08 with Science categories.
An exploration of fundamental as well as practical aspects of supercritical fluid chromatography and extraction. It addresses topics such as: packed columns in SFC; detection in SFC; supercritical fluid chromatography/mass spectroscopy; and evaporative light scattering detection in SFC.
Analytical Supercritical Fluid Extraction Techniques
DOWNLOAD
Author : E.D. Ramsey
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Analytical Supercritical Fluid Extraction Techniques written by E.D. Ramsey and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
During the past decade supercritical fluid extration (SFE) has attracted considerable attention as a sample preparation procedure in analytical chemistry. The successful implementation of this technique can lead to improved sample throughput, more efficient recovery of analytes, cleaner extracts, economic replacement of halogenated solvents and a high level of automation, compared to conventional sample preparation procedures. This book provides an overview of basic principles of SFE as well as in-depth reviews of both on- and off-line SFE methods. The on-line coupling of SFE with both chromatographic and spectroscopics techniques has been the subject of a great deal of research effort and is dealt with in detail. Newer developments, such as off-line SFE of solid and liquid matrices, are starting to attract a great deal of interest, and the coverage of these areas will prove of particular value to the analytical chemist. The international team of authors has illustrated these topics with many `state-of-the-art' applications, and each chapter provides a comprehensive list of references. For the convenience of the reader, an appendix which contains pressure conversion scales and supercritical fluid carbon dioxide density tables appears at the end of the book. The volume's extensive coverage of both on-line and off-line extraction will be particularly useful to analytical chemists, in a wide range of environments, seeking to develop high quality, simple and robust SFE methods.
Analysis With Supercritical Fluids Extraction And Chromatography
DOWNLOAD
Author : Bernd Wenclawiak
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Analysis With Supercritical Fluids Extraction And Chromatography written by Bernd Wenclawiak and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The use of supercritical fluids in analytical chemistry is still grow ing. More and more analysts are discovering the favorable advan tages for a number of applications. Especially supercritical fluid extraction (SFE) has attracted a lot of interest in recent years due to its simplicity. Supercritical fluid chromatography (SFC) has become better established and the development of this technique has been accelerated by the many applications with capillary col umns which have been published in the literature. At first SFC equipment was based on instruments commonly used for liquid chromatography, and the first commercial in struments were derived from this technology. However, capillary columns can be much more easily interfaced to gas chromatogra phy equipment especially to the detectors commonly used for Oc. Many stationary phases both for packed micro columns and capillary columns have been designed for SFC purposes extending this technology to LC and OC. The most common fluid applied in SFC and SFE is carbon dioxide. The advantages of supercritical CO , such as having dif 2 fusivity like a gas and solvating power depending on temperature and pressure, are also valid for other fluids and modified fluids. Both properties are valuable for sample extraction and extraction selectivity.
Supercritical Fluid Methods And Protocols
DOWNLOAD
Author : John R. Williams
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-05
Supercritical Fluid Methods And Protocols written by John R. Williams and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-05 with Science categories.
Over the last 15 years, there has been renewed interest in supercritical fluids owing to their unique properties and relatively low environmental impact. Greatest attention has been given to the extraction and separation of organic compounds. Supercritical fluids have also been successfully used for particle production, as reaction media, and for the destruction of toxic waste. Supercritical carbon dioxide has been the most widely used supercritical fluid, mainly because it is cheap, relatively nontoxic, and has convenient critical values. Supercritical fluids have also been used on analytical and preparative scales for many biological and other applications. Many papers have been published on the use of supercritical fluids. However, few have acted as a detailed instruction manual for those wanting to use the techniques for the first time. We anticipate that this Methods in Biotechnology volume, Supercritical Fluid Methods and Protocols will s- isfy the need for such a book. Every chapter has been written by experienced workers and should, if closely followed, enable workers with some or no previous experience of supercritical fluids to conduct experiments successfully at the first attempt.
Practical Application Of Supercritical Fluid Chromatography For Pharmaceutical Research And Development
DOWNLOAD
Author :
language : en
Publisher: Elsevier
Release Date : 2022-12-02
Practical Application Of Supercritical Fluid Chromatography For Pharmaceutical Research And Development written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-02 with Science categories.
Practical Application of Supercritical Fluid Chromatography for Pharmaceutical Research and Development provides a valuable "go-to reference for many difficult-to-solve challenges using pertinent chromatographic theory, first-hand case studies, and examples provided from academic and industry experts. This text also enables professors teaching an analytical instrumental course to introduce and instruct students about one of the most sustainable and powerful separation methods currently available. While the text has broad applicability across industrial sectors, it focuses primarily on application in the pharmaceutical industry. The book is designed to allow readers to align current HPLC/UHPLC capabilities with SFC as an orthogonal tool for project specific methods in the pharmaceutical industry. It highlights where SFC falls on the spectrum of useful chromatographic tools for routine and challenging separative methods. Experienced HPLC users who are interested in developing knowledge in orthogonal separation techniques, as well as newcomers to the field of separation science, will find this text particularly useful. Chapters address where SFC may fit the analytical needs of the pharmaceutical industry and alert the readers as to where the technique will not fit. Readers will gain an understanding of how and where SFC may be applied and adapted more routinely across the pharmaceutical industry as a 'green' way of undertaking separation opportunities and challenges. Areas within the pharmaceutical industry include early drug discovery, process chemistry, and late stage development and manufacturing. - Describes approaches to SFC column and mobile phase selection for method development for both analytical and preparative tasks - Gives practical examples of how analytical SFC enables the monitoring of synthetic reactions including unstable intermediates, chiral and achiral polar reactants and products across small and large modalities - Provides need-focused case studies for pharmaceutical analysts, process chemists, and contract chemistry facilities that can benefit from monitoring or purifying polar intermediates, mutagenic impurities, nitrosamines and other reaction by-products including excipients and metabolites
Applications Of Supercritical Fluids In Industrial Analysis
DOWNLOAD
Author : J.R. Dean
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Applications Of Supercritical Fluids In Industrial Analysis written by J.R. Dean and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The continued search for rapid, efficient and cost-effective means of analytical measurement has introduced supercritical fluids into the field of analytical chemistry. Two areas are common: supercritical fluid chroma tography and supercritical fluid extraction. Both seek to exploit the unique properties of a gas at temperatures and pressures above the critical point. The most common supercritical fluid is carbon dioxide, employed because of its low critical temperature (31 °C), inertness, purity, non-toxicity and cheapness. Alternative supercritical fluids are also used and often in conjunction with modifiers. The combined gas-like mass transfer and liquid-like solvating characteristics have been used for improved chroma tographic separation and faster sample preparation. Supercritical fluid chromatography (SFC) is complementary to gas chro matography ( GC) and high performance liquid chromatography (HPLC), providing higher efficiency than HPLC, together with the ability to analyse thermally labile and high molecular weight analytes. Both packed and open tubular columns can be employed, providing the capability to analyse a wide range of sample types. In addition, flame ionization detection can be used, thus providing 'universal' detection.
Principles And Practice Of Modern Chromatographic Methods
DOWNLOAD
Author : Kevin Robards
language : en
Publisher: Academic Press
Release Date : 2021-12-03
Principles And Practice Of Modern Chromatographic Methods written by Kevin Robards and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-03 with Science categories.
Principles and Practice of Modern Chromatographic Methods, Second Edition takes a comprehensive, unified approach in its presentation of chromatographic techniques. Like the first edition, the book provides a scientifically rigid, but easy-to-follow presentation of chromatography concepts that begins with the purpose and intent of chromatographic theory - the "what and why that are left out of other books attempting to cover these principles. This fully revised second edition brings the content up-to-date, covering recent developments in several new sections and an additional chapter on composite methods. New topics include sample profiling, sample preparation, sustainable green chemistry, 2D chromatography, miniaturization/nano-LC, HILIC, and more. - Contains thorough chapters that begin with an updated schematic overview and a visual representation of the content - Avoids the obfuscation of different terminologies and classification systems that are prevalent in the area, such as the relationship between liquid chromatography and column chromatography - Provides integrated and comprehensive topic coverage based on chromatographic bibliometrics and survey reports on the relative usage of chromatographic techniques
Countercurrent Chromatography
DOWNLOAD
Author : A. Berthod
language : en
Publisher: Elsevier
Release Date : 2002-10-10
Countercurrent Chromatography written by A. Berthod and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-10-10 with Science categories.
Countercurrent chromatography (CCC) is a separation technique in which the stationary phase is a liquid. The mobile phase is also a liquid, so biphasic liquid systems with at least two solvents are used. Centrifugal fields are used to hold the liquid stationary phase while pushing the liquid mobile phase through it.This comprehensive reference covers recent advancements in the two types of CCC machines: the high speed CCCs without rotary seals and with coiled spools and centrifugal partition chromatographs (CPC) with rotary seals and interconnected channels. Written by leading international experts in the CCC field, the book focuses on the liquid nature of the stationary phase: giving newcomers the basis to do CCC efficiently and rapidly; explaining the art of obtaining a biphasic liquid system; describing the flow patterns in both CPC and high speed CCC machines; showing possible other uses of a liquid stationary phase; presenting a wealth of applications in the separation of organic, pharmaceutical and inorganic mixtures; and demonstrating that even supercritical fluids can be used in CCC.
Additives In Polymers
DOWNLOAD
Author : Jan C. J. Bart
language : en
Publisher: John Wiley & Sons
Release Date : 2005-04-08
Additives In Polymers written by Jan C. J. Bart and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-04-08 with Technology & Engineering categories.
This industrially relevant resource covers all established and emerging analytical methods for the deformulation of polymeric materials, with emphasis on the non-polymeric components. Each technique is evaluated on its technical and industrial merits. Emphasis is on understanding (principles and characteristics) and industrial applicability. Extensively illustrated throughout with over 200 figures, 400 tables, and 3,000 references.