Synaptic Plasticity And The Mechanism Of Alzheimer S Disease
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Synaptic Plasticity And The Mechanism Of Alzheimer S Disease
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Author : Dennis J. Selkoe
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-01-08
Synaptic Plasticity And The Mechanism Of Alzheimer S Disease written by Dennis J. Selkoe and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-08 with Medical categories.
A biochemical hypothesis - that Alzheimer’s disease (AD) is a progressive cerebral amyloidosis caused by the aggregation of the amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies. This volume serves as a record focused on bringing together investigators at the forefront of elucidating the structure and function of hippocampal synapses with investigators focused on understanding how early assemblies of Ab may compromise some of these synapses.
Synaptic Plasticity And The Mechanism Of Alzheimer S Disease
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Author : Dennis J. Selkoe
language : en
Publisher: Springer
Release Date : 2009-09-02
Synaptic Plasticity And The Mechanism Of Alzheimer S Disease written by Dennis J. Selkoe and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-02 with Medical categories.
A biochemical hypothesis - that Alzheimer’s disease (AD) is a progressive cerebral amyloidosis caused by the aggregation of the amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies. This volume serves as a record focused on bringing together investigators at the forefront of elucidating the structure and function of hippocampal synapses with investigators focused on understanding how early assemblies of Ab may compromise some of these synapses.
The Molecular Mechanisms Of Synaptic Plasticity Impairments In Alzheimer S Disease
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Author : Gong-Ping Liu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-16
The Molecular Mechanisms Of Synaptic Plasticity Impairments In Alzheimer S Disease written by Gong-Ping Liu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-16 with Science categories.
The Effects Of Alzheimer S Disease On Synaptic Plasticity And The Camp Pka Pathway
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Author : Dalya Cohen
language : en
Publisher:
Release Date : 2018
The Effects Of Alzheimer S Disease On Synaptic Plasticity And The Camp Pka Pathway written by Dalya Cohen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Alzheimer's Disease (AD) is a physiologically devastating form of dementia, yet an understanding of AD pathology remains elusive. One promising avenue of research is to examine synaptic plasticity within the brain centres of learning and memory in animal models of AD. Long-term potentiation (LTP) is a model of learning and memory at the synaptic level, and deficits in LTP have been proposed in AD. The aim of this work is to examine whether synaptic defects in AD involve a neuronal signalling cascade: the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) pathway. This research uses novel modes of LTP induction which manipulate the course of LTP induction. Examinations reveal alterations in basal synaptic transmission in AD mouse models. The use of a cAMP/PKA enhancing drug revealed a potential dysregulation in the cAMP/PKA cascade. Lastly, coastline analysis showed potentiation induced hyperexcitability at synapses of an AD mouse model.
Molecular And Cellular Mechanisms Of Neuronal Plasticity
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Author : Yigal H. Ehrlich
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular And Cellular Mechanisms Of Neuronal Plasticity written by Yigal H. Ehrlich and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Numerous studies have proven the biological basis of memory formation and have begun to identify the biochemical traces and cellular circuits that are formed by experience, and which participate int the storage of information in the brain, its retention for long durations, and its retrieval upon demand. Cells in the nervous system have the capability of undergoing extremely long-lasting alterations in response to hormonal, pharmacological, and environmental stimulations. The mechanisms underlying this neuronal plasticity are activated by experiential inputs and operate in the process of learning and the formation of memories in the brain. This volume presents research areas which have not been highlighted in the past. In addition to studies on the involement of functional proteins in neuronal adaptation, this volume presents recent developments on the critical roles of bioactive lipids and nucleotides in these processes. In addition to the widely studied role of second messengers, a review of studies on extracellular phosphorylation systems operating on the surface of brain neurons is presented.The first section of the volume presents studies of basic mechanisms operating in a wide range of adaptive processes. The second section presents recent advances in investigations that have demonstrated the clinical implications of this research. These include: state of the art use of transgenic models in studies of molecular and cellular mechanisms implicated in familial Alzheimer's disease and Amyotrophic Lateral Sclerosis; studies of specific proteins implicated in Alzheimer's disease, including an adapter that binds to the beta-amyloid precurser protein (beta-APP) and the microtubular protein Tau and its membrane-bound counterpart. The advantages of using cell culture models for elucidating the causes of neuronal degeneration and for identifying mechanisms of neuroprotection are also presented among the chapters in the section on clinical implications.
Genes Environment And Alzheimer S Disease
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Author : Orly Lazarov
language : en
Publisher: Academic Press
Release Date : 2016-02-25
Genes Environment And Alzheimer S Disease written by Orly Lazarov and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-25 with Psychology categories.
Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline. It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer’s disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease. Provides the first volume to link genetic and environmental risk factors for Alzheimer’s disease and dementia Aids researchers and clinicians in understanding the basic mechanisms of Alzheimer’s disease and cognitive decline Brings the basic science and clinical perspectives together in a single volume, facilitating translational possibilities Includes a range of molecular to behavioral components assembled into a single volume that creates an excellent resource for basic and clinical neuroscientists
Alzheimer S Disease Pathogenesis
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Author : Suzanne De La Monte
language : en
Publisher: BoD – Books on Demand
Release Date : 2011-09-12
Alzheimer S Disease Pathogenesis written by Suzanne De La Monte and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-12 with Medical categories.
Alzheimer's Disease Pathogenesis: Core Concepts, Shifting Paradigms, and Therapeutic Targets, delivers the concepts embodied within its title. This exciting book presents the full array of theories about the causes of Alzheimer's, including fresh concepts that have gained ground among both professionals and the lay public. Acknowledged experts provide highly informative yet critical reviews of the factors that most likely contribute to Alzheimer's, including genetics, metabolic deficiencies, oxidative stress, and possibly environmental exposures. Evidence that Alzheimer's resembles a brain form of diabetes is discussed from different perspectives, ranging from disease mechanisms to therapeutics. This book is further energized by discussions of how neurotransmitter deficits, neuro-inflammation, and oxidative stress impair neuronal plasticity and contribute to Alzheimer's neurodegeneration. The diversity of topics presented in just the right depth will interest clinicians and researchers alike. This book inspires confidence that effective treatments could be developed based upon the expanding list of potential therapeutic targets.
Emerging Drugs And Targets For Alzheimer S Disease
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Author : Ana Martinez
language : en
Publisher: Royal Society of Chemistry
Release Date : 2010-05-07
Emerging Drugs And Targets For Alzheimer S Disease written by Ana Martinez and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-07 with Medical categories.
Alzheimer's disease is the most prevalent type of neurodegenerative disorder in the elderly. A recent study from Bloomberg School of Public Health estimated that more than 26 million people worldwide were living with the disease in 2006 and that the global prevalence of the disease will grow to more than 106 million by 2050. By that time, 43 per cent of those living with the disease will need high-level care, equivalent to that of a nursing home. However, even if modest advances in preventing or delaying the disease's progression were made, it could have a huge impact on global public health. According to this study, interventions that could delay the onset of the disease by as little as one year would reduce the prevalence of the disease by 12 million fewer cases in 2050. These figures reinforce how important it is to find an effective therapeutic intervention for Alzheimer's disease. Emerging Drugs and Targets for Alzheimer's Disease collects some of the most outstanding examples of new drugs currently in pharmaceutical development or new targets under the validation process that will reach the Alzheimer's drug market over the next few years as disease modifying drugs. Written by a team of distinguished experts these books are an essential resource for scientists in the pharmaceutical and biotechnology industries and academics working in the drugs for neurodegeneration field.
Learning Memory And Synaptic Plasticity In Alzheimer S Model Mice
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Author : Jason Knight Clark
language : en
Publisher:
Release Date : 2016
Learning Memory And Synaptic Plasticity In Alzheimer S Model Mice written by Jason Knight Clark and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Alzheimer's disease (AD) is a neurodegenerative disease of aging thought to be initiated by production of Amyloid-[beta] peptide, which leads to synaptic dysfunction and progressive memory loss, and the eventual formation of [beta]-Amyloid plaques and neurofibrillary Tau tangles. Working memory is one of the first cognitive impairments in AD. We therefore wanted to explore the cellular mechanisms underlying working memory impairments in AD utilizing a well-known triple transgenic mouse model of Alzheimer's disease (3xTg-AD) carrying mutations in APP, PS1, and Tau. We evaluated working memory using an 8-arm radial maze, and synaptic transmission and plasticity using an ex vivo hippocampal slice preparation to measure field Excitatory Post-Synaptic Potentials (fEPSP) in the CA1 region of ventral hippocampus. Unexpectedly, young 3xTg-AD mice at 3 months of age, typically considered to be presymptomatic, were significantly impaired in the spatial working memory task compared to Nontransgenic (NonTg) control mice. Measurements of fEPSPs to evaluate Long-Term Potentiation (LTP) as an indicator of long-term synaptic plasticity showed the NMDA receptor-dependent component of LTP (NMDAR LTP) was reduced in 3xTg-AD mice compared to NonTg mice. The remaining non-NMDA receptor-dependent component of LTP (non-NMDAR LTP) however was increased, resulting in a total LTP that was not different between 3xTg-AD and NonTg mice. At 8 months of age, 3xTg-AD mice were again significantly impaired in the spatial working memory task, and NMDAR LTP was again reduced in 3xTg-AD mice. The non-NMDAR LTP however was also reduced in 3xTg-AD mice, resulting in a total LTP that was now reduced in 3xTg-AD mice. The majority (>90%) of non-NMDAR LTP is mediated by Voltage-Dependent Calcium Channels (VDCC), and attempts to block LTP using NMDAR and VDCC antagonists were unsuccessful, indicating 3xTg-AD mice have compensatory mechanisms for LTP expression that occur independently of NMDAR or non-NMDAR dependent mechanisms. In addition, 3xTg-AD mice also showed impairments in short-term synaptic plasticity and basal synaptic transmission at both 3 and 8 months of age. These impairments in synaptic transmission and plasticity coincide with impairments in spatial working memory, and understanding the nature of these altered mechanisms may lead to therapeutic targets for disorders such as AD.
Neuroplasticity
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Author : Victor Chaban
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-06-06
Neuroplasticity written by Victor Chaban and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-06 with Medical categories.
This book provides comprehensive and up-to-date insights into emerging research trends on neuroplasticity with current or future treatments for neurodevelopment and neurodegenerative diseases. The authors discuss structural and functional changes associated with cortical remapping, sensory substitution, synaptic and non-synaptic compensatory plasticity due to brain damage, brain training, chronic pain, meditation, music, exercise and related states. Key features include pathogenesis, and existing and new therapies together with a pharmacological and non-pharmacological approach in clinical treatment and management. The authors are established experts that contributed significantly to a better understanding of the etiology of neuroplasticity. This book is recommended to healthcare providers, clinical scientists, students and patients.