Systems Metabolic Engineering Of Corynebacterium Glutamicum Towards Improved Lysine Production
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Systems Metabolic Engineering Of Corynebacterium Glutamicum Towards Improved Lysine Production
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Author : Judith Becker
language : en
Publisher:
Release Date : 2010
Systems Metabolic Engineering Of Corynebacterium Glutamicum Towards Improved Lysine Production written by Judith Becker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Metabolic Engineering Of Corynebacterium Glutamicum For L Lysine Production On Silage
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Author : Andreas Neuner
language : en
Publisher:
Release Date : 2012
Metabolic Engineering Of Corynebacterium Glutamicum For L Lysine Production On Silage written by Andreas Neuner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Corynebacterium Glutamicum
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Author : Masayuki Inui
language : en
Publisher: Springer Nature
Release Date : 2020-04-13
Corynebacterium Glutamicum written by Masayuki Inui and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-13 with Science categories.
This updated second edition covers the molecular biology, genome engineering tools and comprehensive analysis techniques for Corynebacterium glutamicum. Aside from modern omics-based approaches, the authors also focus on cell physiology, including cell division, central carbon metabolic pathways, and the respiratory chain. Readers will learn how primary mechanisms like energy metabolism can be applied in processes like biorefinery. Newly added topics include cell envelope structures and aromatic compound metabolism in C. glutamicum. These chapters will be particularly useful for those interested in the microbial production of commodity chemicals, fuels, and proteins. Corynebacteriacea are already some of the most important industrial microorganisms. Understanding the cell physiology of C. glutamicum will help manufacturers to increase their product range and productivity through efficient metabolic engineering.
Metabolic Engineering Of C Glutamicum For Amino Acid Production Improvement
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Author : Mattheos A. G. Koffas
language : en
Publisher:
Release Date : 2000
Metabolic Engineering Of C Glutamicum For Amino Acid Production Improvement written by Mattheos A. G. Koffas and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with categories.
Systems Metabolic Engineering
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Author : Christoph Wittmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-15
Systems Metabolic Engineering written by Christoph Wittmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-15 with Medical categories.
Systems Metabolic Engineering is changing the way microbial cell factories are designed and optimized for industrial production. Integrating systems biology and biotechnology with new concepts from synthetic biology enables the global analysis and engineering of microorganisms and bioprocesses at super efficiency and versatility otherwise not accessible. Without doubt, systems metabolic engineering is a major driver towards bio-based production of chemicals, materials and fuels from renewables and thus one of the core technologies of global green growth. In this book, Christoph Wittmann and Sang-Yup Lee have assembled the world leaders on systems metabolic engineering and cover the full story – from genomes and networks via discovery and design to industrial implementation practises. This book is a comprehensive resource for students and researchers from academia and industry interested in systems metabolic engineering. It provides us with the fundaments to targeted engineering of microbial cells for sustainable bio-production and stimulates those who are interested to enter this exiting research field.
Metabolic Engineering In The Post Genomic Era
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Author : Boris N. Kholodenko
language : en
Publisher: Garland Science
Release Date : 2004
Metabolic Engineering In The Post Genomic Era written by Boris N. Kholodenko and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Biochemical engineering categories.
The Horizon Scientific Press titles focus on high-level microbiology and molecular biology topics. Written by internationally renowned and highly respected leaders in the field, titles in this series comprise of review manuals, practical manuals, and reference texts for research scientists, bioscience professionals and graduate students. Engineering living cells continues to pose immense challenges to the researcher. In fact many bioengineers have only just started to appreciate the full extent of the hierarchical control used by living systems: upon attempts to increase the activity of a "rate-limiting" step, the multiple feedbacks at the metabolic, signaling and genetic levels result in the rate limiting step shifting to elsewhere in that pathway or even to elsewhere in the whole organism. The advent of full-force genomics should enable preventing this response, however, it has been difficult for researchers to know where to turn for guidance. This book aims to help the reader understand and deal with the plasticity of living cell factories and to turn the plasticity into the desired rather than the adverse direction. The book brings together all the recent, most important breakthroughs in this exciting field: Internationally renowned key scientists have reviewed each topic in detail. In the Introduction, the editors give an overview of new approaches and spell out what the engineer and the industry may now really begin to aim for; they even adapt the definition of metabolic engineering to befit the post-genomics era. Other topics included are: the experimental approaches necessary to understand cellular regulation at all of its hierarchical levels, including proteomics [Chapter 2], metabolomics [Chapter 3] and fluxomics [Chapter 4]; new tools that help metabolic engineering [Chapters 5-7]; modeling of living cells, e.g. finding metabolic pathways [Chapter 8] and comparing the actual and predicted use of these in living organisms such as E. coli and Corynebacteria [Chapters 9, 10]; the optimization of cell factories as production organisms (e.g., use of whole cell models, silicon cells, and coordinate manipulation of multiple genes [Chapters 12-15]). A chapter on future perspectives directs further developments of the field in the near future. Metabolic Engineering in the Post Genomic Erais an essential reading for everyone with an interest in engineering living cells including: Metabolic egnineers, bioengineers, biotechnologists, molecular biologists, and pharmaceutical and biotechnology companies.
Metabolic Engineering Of Amino Acid Production In Corynebacterium Glutamicum
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Author : Grace Eileen Colón
language : en
Publisher:
Release Date : 1995
Metabolic Engineering Of Amino Acid Production In Corynebacterium Glutamicum written by Grace Eileen Colón and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.
Improved L Lysine Production In Corynebacterium Glutamicum By Rational Strain Engineering
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Author : Sarah Schiefelbein
language : en
Publisher:
Release Date : 2015
Improved L Lysine Production In Corynebacterium Glutamicum By Rational Strain Engineering written by Sarah Schiefelbein and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Bio Based Production Of L Methionine In Corynebacterium Glutamicum
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Author :
language : en
Publisher: Cuvillier Verlag
Release Date : 2010-09-21
Bio Based Production Of L Methionine In Corynebacterium Glutamicum written by and has been published by Cuvillier Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-21 with Science categories.
In the present work, Corynebacterium glutamicum pathways of the central metabolism were investigated from a systems-oriented view regarding a detailed understanding of the underlying reaction network towards future biotechnological production of L-methionine. The physiological characterization of the anabolic network of mutants, specifically designed for these studies, was achieved by combining fluxomics and metabolomics after rigorous validation of existing technologies, especially for metabolite analysis, and development of novel efficient protocols adapted to C. glutamicum. Above all, a lack of suitable sampling methods in the field of metabolomics was identified by validation of common protocols, not only for C. glutamicum, but also for various microorganisms including biotechnological important bacteria and yeasts. Based on these findings, a novel differential approach was developed and validated, whereby intracellular levels are determined via differential analysis of total broth and culture filtrate without cells. Applying this method, the existence of a novel threonine-independent pathway for isoleucine biosynthesis starting from homolanthionine was identified in C. glutamicum ΔmcbR. This pathway withdraws significant amounts of carbon from the methionine biosynthesis. Subsequent studies identified the availability of NADPH as additional limiting step. In C. glutamicum ΔmcbR, a deletion mutant with a deregulated methionine and cysteine pathway, the ADPH/NADP+ ratio was only 0.29 and thus much lower as that of the wild-type (2.35). Engineering of the NADPH metabolism via increased pentose phosphate pathway activity by enhancement of the transketolase operon resulted in a significantly increased NADPH/NADP+ ratio (1.40). Moreover, the utilization of the reduced sulfur sources methanethiol and dimethyldisulfide was investigated. Both sulfur compounds are utilized by C. glutamicum as source of sulfide and C1 carbon. This opens new possibilities to pass the high energy and NADPH demanding pathways of sulfate reduction and C1 metabolism for methionine biosynthesis. Using an isotope labeling study, the conversion of methionine to S-adenosylmethionine was found to be highly active. Thus, this reaction competes with the export of methionine and displays a target to be downregulated in a future production strain.
Metabolic Engineering Of Corynebacterium Glutamicum For Production Of L Lysine From Mannitol And Mannitol Rich Seaweed Extracts
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Author : Sarah Lisa Hoffmann
language : en
Publisher:
Release Date : 2020
Metabolic Engineering Of Corynebacterium Glutamicum For Production Of L Lysine From Mannitol And Mannitol Rich Seaweed Extracts written by Sarah Lisa Hoffmann and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.