T Lymphocyte And Inflammatory Cell Research In Asthma
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T Lymphocyte And Inflammatory Cell Research In Asthma
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Author : G. Jolles
language : en
Publisher: Academic Press
Release Date : 2012-12-02
T Lymphocyte And Inflammatory Cell Research In Asthma written by G. Jolles and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
It is well established that asthma is an inflammatory disease of the airway mucosa and drugs like inhaled glucocorticoids are now commonly introduced early in therapy. A characteristic feature of this disease is the vast number of eosinophils in airway tissue, although many other migratory and resident inflammatory cells with the capacity to synthesize and release cytokines and putative asthma mediators are present in the inflamed mucosa. The cross-talk between lymphocytes and these cells and the role of cytokines in complex biological networks are currently areas of intense research. This volume gathers together chapters and discussions on the biology of immunocompetent and inflammatory cells, cellular interplay and communication, and on the relative importance of cells and mediators in disease. It should help contribute to further insights into the pathology of asthma and to the development of novel efficacious drugs for the treatment of asthma and related respiratory disorders.
Inflammatory Cells And Mediators In Bronchial Asthma
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Author : Devendra K. Agrawal
language : en
Publisher: CRC Press
Release Date : 2020-10-28
Inflammatory Cells And Mediators In Bronchial Asthma written by Devendra K. Agrawal and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-28 with Medical categories.
Inflammatory Cells and Mediators in Bronchial Asthma provides reviews and summaries regarding state-of-the-art articles that examine the role of various inflammatory cells and their mediators in the pathogenesis of asthma. Topics include pharmacological and biochemical regulation of the airways; involvement of key inflammatory cells and the release and effect of their mediators in airway function; and the characteristics of receptors for leukotriene B4, C4, and D4, adenosine, platelet-activating factor, sensory and inflammatory peptides, and the effect of various anti-asthmatic drugs on airway inflammation. Physicians, allergists, immunologists, and pulmonary disease research scientists will find this book to be an invaluable reference resource.
The Immunological Basis Of Asthma
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Author : Bart Lambrecht
language : en
Publisher: CRC Press
Release Date : 2019-08-30
The Immunological Basis Of Asthma written by Bart Lambrecht and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-30 with categories.
This text assesses the role of dendritic cells, T and B lymphocytes, epithelial and mast cells, eosinophils, neutrophils, macrophages, and their products in the initiation and progression of airway inflammation, regulation, and repair. It unveils advances in immunology and cell biology to generate new therapeutic regimens for inflammatory and allergic diseases, and offers unparalleled research from nearly 60 international contributors
Role Of Cd4 T Cell Sub Populations In Allergic Asthma
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Author : Shakti P. Pattanayak
language : en
Publisher: GRIN Verlag
Release Date : 2016-07-27
Role Of Cd4 T Cell Sub Populations In Allergic Asthma written by Shakti P. Pattanayak and has been published by GRIN Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-27 with Medical categories.
Scientific Essay from the year 2016 in the subject Medicine - Pharmacology, Pharmacy, , language: English, abstract: Asthma is a chronic disorder specifically characterized by severe inflammation and constriction, mucus hyper-secretion and hyper-responsiveness in the airway. Allergic Asthma (AA) is characterized by discontinuous airway obstruction that may cause temporary to severe asphyxiation and can consequence into death. Airway obstruction in asthma is because of rigorous inflammation concerning multi-cellular components together with eosinophils, neutrophils, CD4+T lymphocytes & mast cells, with eosinophilic infiltration being the most conspicuous feature. The multifaceted phenotype of AA suggested being elevated from multiple interactions of infiltrating and structural cells that is coordinated by T helper 2 (TH2) cells consequential in chronic airway inflammation. By extremely secreting convinced mediators like interleukin (IL)-4, IL-5, and IL-13, which grasps a key point in asthma pathogenesis cause erratic degree of broncho-obstruction, increased mucus production, and airway remodeling. There are a variety of T cell which plays a significant role in AA that is TH1, TH2, TH17, regulatory T cell, TH3 TH22, TH25, TH9 and others. There are various molecular signaling molecules such as STAT4, FOXp3, GATA-3 and T-bet which regulates CD4+T cells in AA. Nowadays the approach to manage asthma is based on inhaled bronchodilator and corticosteroids. But the research is on the mechanism of some promising phytomedicines. we summarized here with some mechanisms of some flavonoids to alleviate AA through CD4+T cells. In conclusion, we found that the CD4+T-cell subpopulations played some major contribution in regulating/modulating the AA and interestingly, the natural potent anti-oxidant & anti- inflammatory compounds such as flavonoids could able to attenuate the AA by regulating these subpopulations of CD4+T-cells or the signaling molecules involved in the pathogenesis.
Asthma
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Author : Thomas A.E. Platts-Mills
language : en
Publisher: CRC Press
Release Date : 1999-04-27
Asthma written by Thomas A.E. Platts-Mills and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-04-27 with Medical categories.
Asthma is a disease which, beginning in the 1980s, increased in the United States and other countries in both its prevalence and mortality. According to reports by the Center for Disease Control, the number of people with asthma increased by 42% in the last decade, with children, ethnic minorities and the urban poor being most at risk. Timely research on the causes and mechanisms behind the dramatic increase of asthma in the United States and other nations-to epidemic proportions-is presented in this volume. Investigators heading up eight research groups in asthma and/or allergy present their most recent findings, funded by the Center for Indoor Air Research. In addition to the work underway and discussions/suggestions on present research problems, ASTHMA: Causes and Mechanisms of an Epidemic Inflammatory Disease provides a chapter on the causes of asthma-and the reasons for its recent spread, so hotly discussed in the current literature. Researchers in the fields of asthma and allergy, health care providers, and others who follow research in either of these two developing areas will benefit from this book. The book is written at the level of one investigator to another.
Crc Desk Reference For Allergy And Asthma
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Author : Hans-Uwe Simon
language : en
Publisher: CRC Press
Release Date : 2000-04-26
Crc Desk Reference For Allergy And Asthma written by Hans-Uwe Simon and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-04-26 with Medical categories.
As the prevalence of allergic diseases and asthma has increased in recent years, scientists have intensified research efforts to understand the pathogenesis of these sometimes debilitating conditions. Indeed, researchers have provided key insights-and new concepts-that have changed therapeutic strategies. Moreover, allergic inflammation has served as something of a model in furthering our understanding of regulatory mechanisms of inflammation in general. Presented in an encyclopedic format, the CRC Desk Reference for Allergy and Asthma provides the latest scientific information on allergic diseases and asthma. It combines knowledge from clinical immunology with basic immunology, pharmacology, biochemistry, and molecular biology to examine new treatment strategies for allergic diseases and asthma. Highlights of the CRC Desk Reference for Allergy and Asthma include: EASE OF USE. This desk reference presents topics in alphabetical order so that they are easy to find. CROSS-REFERENCING. Utilizes cross-referencing to aid in the rapid switch between basic and clinical science. UNIFIED NOMENCLATURE. Greatly assists those readers who are new in the field. HIGHLIGHTS VITAL INFORMATION. Vital information is highlighted in boxes, allowing rapid identification of key concepts. Written by leading authorities in the field, the CRC Desk Reference for Allergy and Asthma serves as a timely reference for anyone interested in this area of research. Not only does it present information in an easy-to-use format, but it addresses many hot topics and views that will have sustaining value for years to come.
Asthma
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Author : Peter J. Barnes
language : en
Publisher:
Release Date : 1992
Asthma written by Peter J. Barnes and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medical categories.
The Second Edition of this highly successful text includes all the virtues of the first--all aspects of research on the causative mechanisms of asthma and its treatment as well as exhaustive and extensive chapter references. The book has expanded in line with recent research findings. Of special note is the inclusion of important advances in the understanding of the basic inflammatory process in asthma--the role of individual cells, and the role of multiple inflammatory mediators. Comprehensive coverage of both basic science and clinical aspectrs of asthma Exhaustively referenced throughout
Asthma Pathophysiology Herbal And Modern Therapeutic Interventions
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Author : Sheikh Rayees
language : en
Publisher: Springer Nature
Release Date : 2021-03-26
Asthma Pathophysiology Herbal And Modern Therapeutic Interventions written by Sheikh Rayees and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-26 with Medical categories.
Asthma is a chronic airway disease affecting over 300 million people worldwide with an expected increase of an additional 100 million by 2025. Past decade has observed a notable increase in asthma prevalence on both national and global levels with highest rates observed in western countries (about 30%). Over the past 40 years, a drastic increase in global prevalence, morbidity, mortality, and economic burden have been observed due to asthma especially in children. The rising numbers of hospital admissions for asthma, especially young children, reflect an increase in severe asthma, poverty and lack of proper disease management. Worldwide, approximately 180,000 deaths annually are caused due to this condition. The financial burden on a single asthma patient per year in different western countries ranges from US$300–1,300. Asthma is an intricate respiratory disorder with differences in its severity, natural history and hence treatment response. These differences in intensities of various presentations such as bronchial hyper-responsiveness, airway inflammation, mucus production, airflow obstruction make asthma a heterogeneous disease. The mainstay of current therapies for asthma includes inhaled corticosteroids, phosphodiesterase inhibitors, leukotriene modifiers and β2-adrenoceptor agonists. Some of the currently available drugs are efficient in one or more aspects. However the associated side effects or heterogeneity of the disease limit their usefulness and efficacy, thereby putting a demand on development of new drugs and therapies. On the other hand, asthma has also been treated/managed via herbal medications. These approaches have been described in Unani, Ayurvedic or Chinese system of medicine since antiquity. In fact, several anti-asthmatic drugs were developed from herbs commonly utilized in the non-Western system of medicine. This book focuses on the pathophysiology of asthma, its medication (both herbal and modern), limitations and their future prospects.
T Cell Regulation In Allergy Asthma And Atopic Skin Diseases
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Author : Kurt Blaser
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2008-01-01
T Cell Regulation In Allergy Asthma And Atopic Skin Diseases written by Kurt Blaser and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-01 with Medical categories.
This book presents the state of the art in cellular and molecular mechanisms regulating the immune response in allergic inflammation. Special attention is given to the central role of regulatory T cells (Treg) in immune regulation and induction of peripheral tolerance, as well as to the relevance of Th17 cells in chronic inflammation. The importance of Treg and Th17 cells is demonstrated in bronchial asthma, atopic eczema, contact dermatitis and delayed-type hypersensitivity. Furthermore, T-cell-mediated regulatory mechanisms in helminthic infections and fungal allergy are discussed. Several chapters are devoted to the therapeutic consequences that these recently discovered T-cell functions may have. Their role as a potential target for specific immunotherapy is evaluated and novel approaches for peripheral tolerance induction and treatment of allergic and asthmatic diseases and inflammation are suggested. Stem cell transplantation as a future therapeutic intervention in regulatory T-cell disorders is also considered. Well edited and up to date, this volume is recommended reading for allergologists, immunologists, dermatologists and any scientist interested in the immunological events regulating allergic inflammation in general and allergic manifestations in different organs.
Asthma
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Author : Celso Pereira
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-10-02
Asthma written by Celso Pereira and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-02 with Medical categories.
Asthma is a prevalent disease in all age groups that results from different pathogenic mechanisms, cells, and mediators engaged in innumerous clinical phenotypes and endotypes. This book exhaustively and didactically explores the biological expression of numerous cells and mediators involved in bronchial inflammation. The information provided aims at identifying the diversity and complexity of the interrelationships between the different players, drawing attention to critical mechanisms in asthma. It also highlights the requirement of new tools to identify strong biomarkers absolutely critical for managing asthma.