Inflammatory Cells And Mediators In Bronchial Asthma
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Inflammatory Cells And Mediators In Bronchial Asthma
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Author : Devendra K. Agrawal
language : en
Publisher: CRC Press
Release Date : 2020-10-28
Inflammatory Cells And Mediators In Bronchial Asthma written by Devendra K. Agrawal and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-28 with Medical categories.
Inflammatory Cells and Mediators in Bronchial Asthma provides reviews and summaries regarding state-of-the-art articles that examine the role of various inflammatory cells and their mediators in the pathogenesis of asthma. Topics include pharmacological and biochemical regulation of the airways; involvement of key inflammatory cells and the release and effect of their mediators in airway function; and the characteristics of receptors for leukotriene B4, C4, and D4, adenosine, platelet-activating factor, sensory and inflammatory peptides, and the effect of various anti-asthmatic drugs on airway inflammation. Physicians, allergists, immunologists, and pulmonary disease research scientists will find this book to be an invaluable reference resource.
Inflammatory Mechanisms In Asthma
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Author : Stephen Holgate
language : en
Publisher: Routledge
Release Date : 2018-12-07
Inflammatory Mechanisms In Asthma written by Stephen Holgate and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-07 with Medical categories.
This timely volume brings together the latest basic and clinical insights on the cellular and mediator mechanisms involved in the induction and persistence of airway dysfunction of asthma by over 90 experts in the field-paving the way for developing novel and more effective antiinflammatory therapeutic agents and strategies. Furnishing a comprehensive and up-to-date view of the expanding and interrelated components underlying asthma pathogenesis, Inflammatory Mechanisms in Asthma describes how evidence on airway inflammation is obtained with invasive and noninvasive procedures, such as bronchoalveolar lavage and sputum analysis reviews the complex interactions of inflammatory cells that contribute to chronic inflammation and bronchial hyperreactivity, including eosinophils, basophils, neutrophils, fibroblasts, epithelial cells, and macrophages considers mast cells, cytokines, neural factors, leukotrienes, kinins, and other mediators that regulate the development, establishment, or resolution of asthma exacerbations presents new information suggesting that airway changes in asthma can lead to remodeling or airway fibrosis and more! Enhanced with over 4700 references, tables, drawings, and photographs, this compelling investigation into the pathophysiology of asthma is an indispensable resource for pulmonologists, physiologists, immunologists, allergists, epidemiologists, biochemists, molecular biologists, and graduate and medical school students in these disciplines.
T Lymphocyte And Inflammatory Cell Research In Asthma
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Author : G. Jolles
language : en
Publisher: Academic Press
Release Date : 2012-12-02
T Lymphocyte And Inflammatory Cell Research In Asthma written by G. Jolles and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
It is well established that asthma is an inflammatory disease of the airway mucosa and drugs like inhaled glucocorticoids are now commonly introduced early in therapy. A characteristic feature of this disease is the vast number of eosinophils in airway tissue, although many other migratory and resident inflammatory cells with the capacity to synthesize and release cytokines and putative asthma mediators are present in the inflamed mucosa. The cross-talk between lymphocytes and these cells and the role of cytokines in complex biological networks are currently areas of intense research. This volume gathers together chapters and discussions on the biology of immunocompetent and inflammatory cells, cellular interplay and communication, and on the relative importance of cells and mediators in disease. It should help contribute to further insights into the pathology of asthma and to the development of novel efficacious drugs for the treatment of asthma and related respiratory disorders.
Therapeutic Targets In Airway Inflammation
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Author : N. Tony Eissa
language : en
Publisher: CRC Press
Release Date : 2003-05-13
Therapeutic Targets In Airway Inflammation written by N. Tony Eissa and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-05-13 with Medical categories.
This reference examines the cellular, molecular, and genetic mechanisms involved in airway inflammation, as well as the pathophysiology, epidemiology, and aetiology of asthma. It explores strategies to prevent cellular injury and oxidative tissue damage, inhibit key inflammatory pathways and identify disease-specific targets to reduce the induction
Asthma
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Author : Thomas A.E. Platts-Mills
language : en
Publisher: CRC Press
Release Date : 1999-04-27
Asthma written by Thomas A.E. Platts-Mills and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-04-27 with Medical categories.
Asthma is a disease which, beginning in the 1980s, increased in the United States and other countries in both its prevalence and mortality. According to reports by the Center for Disease Control, the number of people with asthma increased by 42% in the last decade, with children, ethnic minorities and the urban poor being most at risk. Timely research on the causes and mechanisms behind the dramatic increase of asthma in the United States and other nations-to epidemic proportions-is presented in this volume. Investigators heading up eight research groups in asthma and/or allergy present their most recent findings, funded by the Center for Indoor Air Research. In addition to the work underway and discussions/suggestions on present research problems, ASTHMA: Causes and Mechanisms of an Epidemic Inflammatory Disease provides a chapter on the causes of asthma-and the reasons for its recent spread, so hotly discussed in the current literature. Researchers in the fields of asthma and allergy, health care providers, and others who follow research in either of these two developing areas will benefit from this book. The book is written at the level of one investigator to another.
Role Of Cd4 T Cell Sub Populations In Allergic Asthma
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Author : Shakti P. Pattanayak
language : en
Publisher: GRIN Verlag
Release Date : 2016-07-27
Role Of Cd4 T Cell Sub Populations In Allergic Asthma written by Shakti P. Pattanayak and has been published by GRIN Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-27 with Medical categories.
Scientific Essay from the year 2016 in the subject Medicine - Pharmacology, Pharmacy, , language: English, abstract: Asthma is a chronic disorder specifically characterized by severe inflammation and constriction, mucus hyper-secretion and hyper-responsiveness in the airway. Allergic Asthma (AA) is characterized by discontinuous airway obstruction that may cause temporary to severe asphyxiation and can consequence into death. Airway obstruction in asthma is because of rigorous inflammation concerning multi-cellular components together with eosinophils, neutrophils, CD4+T lymphocytes & mast cells, with eosinophilic infiltration being the most conspicuous feature. The multifaceted phenotype of AA suggested being elevated from multiple interactions of infiltrating and structural cells that is coordinated by T helper 2 (TH2) cells consequential in chronic airway inflammation. By extremely secreting convinced mediators like interleukin (IL)-4, IL-5, and IL-13, which grasps a key point in asthma pathogenesis cause erratic degree of broncho-obstruction, increased mucus production, and airway remodeling. There are a variety of T cell which plays a significant role in AA that is TH1, TH2, TH17, regulatory T cell, TH3 TH22, TH25, TH9 and others. There are various molecular signaling molecules such as STAT4, FOXp3, GATA-3 and T-bet which regulates CD4+T cells in AA. Nowadays the approach to manage asthma is based on inhaled bronchodilator and corticosteroids. But the research is on the mechanism of some promising phytomedicines. we summarized here with some mechanisms of some flavonoids to alleviate AA through CD4+T cells. In conclusion, we found that the CD4+T-cell subpopulations played some major contribution in regulating/modulating the AA and interestingly, the natural potent anti-oxidant & anti- inflammatory compounds such as flavonoids could able to attenuate the AA by regulating these subpopulations of CD4+T-cells or the signaling molecules involved in the pathogenesis.
Cellular Mechanisms In Airways Inflammation
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Author : Clive P. Page
language : en
Publisher: Birkhäuser
Release Date : 2013-03-11
Cellular Mechanisms In Airways Inflammation written by Clive P. Page and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-11 with Medical categories.
Airways inflammation is a complex biological phenomenon resulting from the recruitment and activation of numerous cell types. Airways inflammation contributes to the pathophysiology of airways disease. An understanding of the mechanisms that regulate inflammatory cell function is essential for the development of novel anti-inflammatory drugs for the treatment of common respiratory diseases such as asthma and COPD. This book provides a collection of valuable reviews on the major inflammatory cells involved in airways disease and examines the pharmacology of current anti-inflammatory drugs used in the treatment of airways disease. Moreover, an insight into the development of emerging drug therapies is also highlighted. This book is a must for the library of any researcher or clinician interested in the pathophysiology of airways disease.
The Immunological Basis Of Asthma
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Author : Bart Lambrecht
language : en
Publisher: CRC Press
Release Date : 2003-02-26
The Immunological Basis Of Asthma written by Bart Lambrecht and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-02-26 with Medical categories.
This text assesses the role of dendritic cells, T and B lymphocytes, epithelial and mast cells, eosinophils, neutrophils, macrophages, and their products in the initiation and progression of airway inflammation, regulation, and repair. It unveils advances in immunology and cell biology to generate new therapeutic regimens for inflammatory and aller
Asthma
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Author : Celso Pereira
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-10-02
Asthma written by Celso Pereira and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-02 with Medical categories.
Asthma is a prevalent disease in all age groups that results from different pathogenic mechanisms, cells, and mediators engaged in innumerous clinical phenotypes and endotypes. This book exhaustively and didactically explores the biological expression of numerous cells and mediators involved in bronchial inflammation. The information provided aims at identifying the diversity and complexity of the interrelationships between the different players, drawing attention to critical mechanisms in asthma. It also highlights the requirement of new tools to identify strong biomarkers absolutely critical for managing asthma.
Biotherapeutic Approaches To Asthma
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Author : Jan Agosti
language : en
Publisher: CRC Press
Release Date : 2002-07-22
Biotherapeutic Approaches To Asthma written by Jan Agosti and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-07-22 with Medical categories.
Addressing the need for enhanced drug selectivity and efficacy, Biotherapeutic Approaches to Asthma is an authoritative and timely guide for respiratory specialists, clinical immunologists, allergists, physiologists, pulmonologists, otolaryngologists, and medical school students in these disciplines. It contains emerging data on the importance of c