Tandem Mass Spectrometry Of Sphingolipids Application In Metabolic Studies And Diagnosis Of Inherited Disorders Of Sphingolipid Metabolism
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Tandem Mass Spectrometry Of Sphingolipids Application In Metabolic Studies And Diagnosis Of Inherited Disorders Of Sphingolipid Metabolism
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Author : Ladislav Kuchař
language : en
Publisher:
Release Date : 2012
Tandem Mass Spectrometry Of Sphingolipids Application In Metabolic Studies And Diagnosis Of Inherited Disorders Of Sphingolipid Metabolism written by Ladislav Kuchař and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Science categories.
Tandem Mass Spectrometry of Sphingolipids: Application in Metabolic Studies and Diagnosis of Inherited Disorders of Sphingolipid Metabolism.
Sphingolipids And Metabolic Disease
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Author : L. Ashley Cowart
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-09-15
Sphingolipids And Metabolic Disease written by L. Ashley Cowart and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-15 with Science categories.
Current thinking holds that obesity derives primarily from overnutrition (though compelling arguments for other mechanisms, like endocrine disruption by environmental pollutants, also gain support from the literature). In animals, overnutrition is initially handled by adipose tissue expansion; however, exhaustion of this route of lipid sequestering results in oversupply of lipid to other tissues including skeletal muscle, heart, liver, and others. Failure of these tissues to clear excess lipids through either metabolism or sequestration into putatively inert triacylglycerols results in perturbation of bioactive lipid metabolism in cells. In particular, aberrant generation of bioactive sphingolipids is implicated in a multitude of pathological outcomes of metabolic disease including insulin resistance, inflammation, cardiomyopathy, and others. This volume addresses not only the fundamentals of sphingolipid metabolism and analysis, but also the roles of sphingolipids in these disease processes.
Advances In Clinical Chemistry
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Author :
language : en
Publisher: Academic Press
Release Date : 2016-10-04
Advances In Clinical Chemistry written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-04 with Science categories.
Advances in Clinical Chemistry, Volume 77, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry and is the benchmark for novel analytical approaches in the clinical laboratory. Provides the most up-to-date technologies in Clinical Chemistry and Clinical Laboratory Science Authored by world renowned clinical laboratory scientists, physicians, and research scientist Presents the international benchmark for novel analytical approaches in the clinical laboratory
Inborn Disorders Of Sphingolipid Metabolism
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Author : Stanley M. Aronson
language : en
Publisher: Elsevier
Release Date : 2017-01-31
Inborn Disorders Of Sphingolipid Metabolism written by Stanley M. Aronson and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-31 with Health & Fitness categories.
Inborn Disorders of Sphingolipid Metabolism is a collection of papers presented at the Third International Symposium on the Cerebral Sphingolipidoses and Allied Diseases, held at the Isaac Albert Research Institute of the Jewish Chronic Disease Hospital and at the State University of New York, Downstate Medical Center, on October 25 and 26, 1965. This book is organized into three parts encompassing 35 chapters. Part I deals first with electron microscopic, histochemical, and morphological investigations of certain sphingolipid metabolism disorders. This part also examines several case reports on the features and symptoms of spongy degeneration of the central nervous system, familial leukodystrophy, adrenal insufficiency, and cutaneous melanosis. Part II surveys the metabolism, biosynthesis, and structure of gangliosides and sialic acids. This part also considers the nature of the lipophilic portions of the brain gangliosides. This part particularly looks into the features and clinical manifestation of Tay-Sachs disease. The third part covers the genetic and clinical aspects of the Tay-Sachs disease. This part also evaluates the genetics of the Hurler-Hunter syndrome, Batten-Spielmeyer-Vogt disease, and lipogranulomatosis syndrome. This book is of value to biochemists, histochemists, geneticists, and researchers in the allied fields of lipidosis.
Sphingolipid Metabolism And Metabolic Disease
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Author : Xian-Cheng Jiang
language : en
Publisher: Springer
Release Date : 2022-05-04
Sphingolipid Metabolism And Metabolic Disease written by Xian-Cheng Jiang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-04 with Medical categories.
This book provides an up-to-date review of the fundamentals of sphingolipid metabolism and its role in metabolic diseases. Focusing on the sphingolipid de novo synthesis pathway, the effect of sphingomyelin, ceramide, and sphingosine-1-phosphate, and linkage between sphingolipids and other lipids, such as cholesterol, it covers serine palmitoyltransferase, ceramide synthases, ceramidases, sphingosine kinases, and sphingomyelin synthases, and more. While highlighting how rare diseases related to abnormal glycosphingolipid metabolism, this publication introduces sphingolipid metabolism-related diseases, such as lung diseases and cancers, as well as sphingolipid circadian regulation. The book demonstrates advances and limitations of research on sphingolipid metabolism and its roles in metabolic diseases and other diseases. It offers graduate students and researchers a coherent overview of sphingolipids, as well as the limitations of current research in the field, and promotes further studies on metabolic diseases, as well as pharmaceutical research on drug discovery based on sphingolipid de novo synthase.
Sphingolipids As Signaling And Regulatory Molecules
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Author : Charles Chalfant
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-01-12
Sphingolipids As Signaling And Regulatory Molecules written by Charles Chalfant and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-12 with Science categories.
This book attempts to analyze the latest discoveries in sphingolipid biology and how the alteration of their metabolism leads to altered signaling events and to the development of pathobiological disorders, such as cancer, cardiovascular diseases, asthma, diabetes, inflammation and infectious diseases.
Sphingolipid Biology
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Author : Y. Hirabayashi
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-31
Sphingolipid Biology written by Y. Hirabayashi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-31 with Science categories.
Sphingolipids are fundamental to the structures of cell membranes, lipoproteins, and the stratum cornea of the skin. Many complex sphingolipids, as well as simpler sphingoid bases and derivatives, are highly bioactive as extra- and intracellular regulators of growth, differentiation, migration, survival, senescence, and numerous cellular responses to stress. This book reviews exciting new developments in sphingolipid biology/sphingolipidology that challenge our understanding of how multicellular organisms grow, develop, function, age, and die.
Index Medicus
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Author :
language : en
Publisher:
Release Date : 2002
Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Medicine categories.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Methodologies For Metabolomics
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Author : Norbert W. Lutz
language : en
Publisher: Cambridge University Press
Release Date : 2013-01-21
Methodologies For Metabolomics written by Norbert W. Lutz and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-21 with Medical categories.
Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites, including nuclear magnetic resonance and mass spectrometry, are highlighted. The integration of these techniques with classical biological methods is also addressed. Furthermore, the book presents statistical and chemometric methods for evaluation of the resultant data. The broad spectrum of topics includes a vast variety of organisms, samples and diseases, ranging from in vivo metabolomics in humans and animals to in vitro analysis of tissue samples, cultured cells and biofluids.
Sphingolipid Metabolism And Cell Signaling
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Author :
language : en
Publisher: Academic Press
Release Date : 1999-11-05
Sphingolipid Metabolism And Cell Signaling written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-11-05 with Science categories.
Sphingolipids are found in all eukaryotic and in some prokaryotic organisms and provide structure for cell membranes, lipoproteins, and other biological materials as well as participate in the regulation of cell growth, differentiation, and diverse cell functions, including cell-cell communication, cell-substratum interactions, and intracellular signal transduction. This volume presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. Its companion Volume 312 will contain information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.