Sphingolipid Biology
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Sphingolipid Biology
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Author : Y. Hirabayashi
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-31
Sphingolipid Biology written by Y. Hirabayashi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-31 with Science categories.
Sphingolipids are fundamental to the structures of cell membranes, lipoproteins, and the stratum cornea of the skin. Many complex sphingolipids, as well as simpler sphingoid bases and derivatives, are highly bioactive as extra- and intracellular regulators of growth, differentiation, migration, survival, senescence, and numerous cellular responses to stress. This book reviews exciting new developments in sphingolipid biology/sphingolipidology that challenge our understanding of how multicellular organisms grow, develop, function, age, and die.
Sphingolipids As Signaling And Regulatory Molecules
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Author : Charles Chalfant
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-01-12
Sphingolipids As Signaling And Regulatory Molecules written by Charles Chalfant and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-12 with Science categories.
This book attempts to analyze the latest discoveries in sphingolipid biology and how the alteration of their metabolism leads to altered signaling events and to the development of pathobiological disorders, such as cancer, cardiovascular diseases, asthma, diabetes, inflammation and infectious diseases.
Sphingolipids Basic Science And Drug Development
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Author : Erich Gulbins
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-11
Sphingolipids Basic Science And Drug Development written by Erich Gulbins and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-11 with Medical categories.
Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. They have an important function in signaling mechanisms in the cell. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide. In the first part basic functions of sphingolipids are described, as well as the genetics of important enzymes, sphingolipid metabolism and synthesis. The second part of this first volume focuses on drug development and pharmacology. The book is intended for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians working in pharmacology, oncology, cardiology, neurology and infectious disease. Together with Volume 216 by the same editors, the collection represents a unique, comprehensive work on sphingolipids, providing information on both sphingolipids’ basic biology (including synthesis, metabolism and cell biology) and their important function in a (patho-)physiological context.
Sphingolipids
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Author : Angel Catalá
language : en
Publisher: Nova Science Publishers
Release Date : 2015
Sphingolipids written by Angel Catalá and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Sphingolipids categories.
This book presents an overview of sphingolipids: biology, synthesis and functions. The topics analysed in this book cover a broad spectrum of functions played by sphingolipids including: the role of sphingomyelin in the regulation of membrane physical state; tricyclic antidepressants as modulators of sphingolipid turnover and cell sensitivity to insulin action; sphingolipid diversity, biosynthesis and regulation; metabolism of glycolipids at the cell's surface: modulation and functional implications; the specific role of sphingomyelins in cell physiology; the role of sphingosine-based lipids using sphingolipidomics; sphingolipids and ceramides of aqueous humor and trabecular meshwork; the effect of membrane microdomains containing sphingolipids on lipid peroxidation; and roles of sphingolipids in skeletal development and homeostasis.
Bioactive Ceramides In Health And Disease
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Author : Johnny Stiban
language : en
Publisher: Springer Nature
Release Date : 2019-09-09
Bioactive Ceramides In Health And Disease written by Johnny Stiban and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-09 with Science categories.
This book is about the various roles of bioactive ceramides and other sphingolipids in cellular biology. The enigmatic biophysical and biochemical properties of ceramides and their propensity to influence membranes whether as rafts or protein-permeable channels are heavily discussed. Metabolism of ceramides and their metabolites is also focused with ceramide synthase family of proteins being a target of extensive review. Ceramide 1-phosphate and other sphingolipids are also presented in cellular physiology and pathophysiology. Prokaryotic origins of mitochondria at the level of membranes and the occurrence of apoptosis in bacteria are presented. Many aspects of ceramide and sphingolipid biology are addressed in this book. Its focus is the metabolism of ceramide in normal and diseased states and the biophysical and biochemical mechanisms governing the bioactivity of these molecules. Sphingolipid research has surged over the past thirty years and this book gathers the recent findings of various aspects of sphingolipid biochemistry. World-renowned scientists from the field of lipid biology, specifically sphingolipid biochemistry, were gathered to write this book. Scholars from most continents of the globe committed to write diligently about their expertise and the newest findings in the relevant fields. This book came to fruition after almost a year and a half of laborious preparation and diligent writings. This book is targeted to the experienced reader who is looking to read about the various aspects of bioactive ceramide signaling, as well as to the newcomer into the field, as the topics are explained in concise yet very informative manner. The authors and editor wish all readers a pleasant time reading this volume, and are adamant that this book will meet all expectations.
Sphingolipids In Disease
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Author : Erich Gulbins
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-06
Sphingolipids In Disease written by Erich Gulbins and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-06 with Medical categories.
Sphingolipids are lipid components of the plasma membrane of eukaryotic cells with an important function in signaling mechanisms in the cell. This book provides insight into the physiological and pathophysiological role of sphingolipids and in particular its derivative ceramide. The function of Sphingolipids in cell signaling with regard to infectious and lung diseases, cancer, cardiovascular diseases and neuropsychiatric disorders are described and treated in distinct parts. Together with Volume 215 from the same Editors, the collection represents a unique, comprehensive work on Sphingolipids, providing information on both: Sphingolipid basic biology as well as its important function in a (patho)physiological context. The book is written for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians in pharmacology, oncology, cardiology, neurology and infectious disease.
Bioactive Sphingolipids In Cancer Biology And Therapy
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Author : Yusuf A. Hannun
language : en
Publisher: Springer
Release Date : 2015-08-28
Bioactive Sphingolipids In Cancer Biology And Therapy written by Yusuf A. Hannun and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-28 with Medical categories.
This volume presents information on both the basic and clinical aspects of sphingolipid-metabolizing enzymes in various cancers. The volume also includes discussions of the innovative techniques and approaches for quantitative analysis and imaging that could significantly impact the general understanding of this topic, and the potential benefit of targeting sphingolipid enzymes to develop novel cancer therapeutics. As well, the volume includes a critical examination of the specific pathways and pathobiologies associated with the altered regulation of sphingolipid metabolism as a contributor to the development and/or maintenance of pathological conditions such as cancer.
Sphingolipid Biochemistry
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Author : Julian N. Kanfer
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Sphingolipid Biochemistry written by Julian N. Kanfer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Sphingolipids In Cancer
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Author :
language : en
Publisher: Academic Press
Release Date : 2018-07-27
Sphingolipids In Cancer written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-27 with Medical categories.
Sphingolipids in Cancer, Volume 140, the latest release in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Topics discussed in this updated volume include Mechanisms of ceramide-dependent cancer cell death, Sphingolipids as regulators of autophagy and endocytic trafficking, The role and function of sphingomyelin biosynthesis in the development of cancer, Neutral sphingomyelinases in cancer: Friend or foe?, Sphingolipid rendezvous at the crossroad of NAFLD and senescence, Ceramide signaling and p53 pathways, Sphingolipid regulation of RNA Biology in cancer phenotypes, The role of ceramide-1-phosphate in tumor cell survival and dissemination, and more. Provides information on cancer research, with this release focusing on sphingolipids Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike
Sphingolipid Metabolism And Metabolic Disease
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Author : Xian-Cheng Jiang
language : en
Publisher: Springer Nature
Release Date : 2022-05-03
Sphingolipid Metabolism And Metabolic Disease written by Xian-Cheng Jiang and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-03 with Medical categories.
This book provides an up-to-date review of the fundamentals of sphingolipid metabolism and its role in metabolic diseases. Focusing on the sphingolipid de novo synthesis pathway, the effect of sphingomyelin, ceramide, and sphingosine-1-phosphate, and linkage between sphingolipids and other lipids, such as cholesterol, it covers serine palmitoyltransferase, ceramide synthases, ceramidases, sphingosine kinases, and sphingomyelin synthases, and more. While highlighting how rare diseases related to abnormal glycosphingolipid metabolism, this publication introduces sphingolipid metabolism-related diseases, such as lung diseases and cancers, as well as sphingolipid circadian regulation. The book demonstrates advances and limitations of research on sphingolipid metabolism and its roles in metabolic diseases and other diseases. It offers graduate students and researchers a coherent overview of sphingolipids, as well as the limitations of current research in the field, and promotes further studies on metabolic diseases, as well as pharmaceutical research on drug discovery based on sphingolipid de novo synthase.
