Targeted Molecular Imaging

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Targeted Molecular Imaging

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Author : Michael J. Welch
language : en
Publisher: CRC Press
Release Date : 2012-02-24

Targeted Molecular Imaging written by Michael J. Welch and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-24 with Science categories.

Targeted Molecular Imaging covers the development of novel diagnostic approaches that use an imaging probe and agent to noninvasively visualize cellular processes in normal and disease states. It discusses the concept, development, preclinical studies, and, in many cases, translation to the clinic of targeted imaging agents. The many case studies that form the core of this book deal with the development and translation of non-nuclear probes and radiotracers; other sections address critical topics such as In vitro studies, small animal research, and the application of targeted probes for nuclear, optical and MRI imaging. The chapters use a common format to demonstrate how various investigators approach the comprehensive task of validating a new targeted probe. Targeted Molecular Imaging is a timely resource for a rapidly advancing field, and addresses: Various methods of validating a new targeted probe through examples from human studies with imaging of breast cancer, cardiovascular disease, and neurodegenerative diseases Basic principles, disease models, imaging studies in animals, imaging in initial human studies, and the application of molecular imaging in pharmacy and drug discovery In vitro studies, small animal studies, and targeted radiopharmaceuticals Using these case studies, investigators can generalize and apply the information to their own specific targeted probe. The insights provided by the contributors, experts who have developed these approaches in their own groups, help guide scientists planning to translate imaging agents from the concept stage to clinical application.

Targeted Molecular Imaging In Oncology

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Author : E. Edmund Kim
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29

Targeted Molecular Imaging In Oncology written by E. Edmund Kim and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.

Cancer cells dedifferentiate with repect to cell function; their vascularity is more leaky, but perfusion is heterogenerously reduced, and interstitial fluid pressure is high, severely retarding delivery of agents from the blood. Targeted imaging is designed to produce a detectable difference between tissue that is visualized with single photon and positron emission tomography, magnetic resonance imaging, computed tomography, or ultrasonography. This book uniquely reports strategies for the application of molecular targeted imaging agents such as antibodies, peptides, receptors and contrast agents in the biologic grading of tumors, differential diagnosis of tumors, prediction of therapeutic response and monitoring tumor response to treatment. This book also describes updated information about the imaging of tumor angiogenesis, hypoxia, apoptosis and gene delivery as well as expression in the understanding and utility of tumor molecular biology for better cancer management.

Nanobiomaterials

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Author : Jorddy Neves Cruz
language : en
Publisher: Materials Research Forum LLC
Release Date : 2023-06-05

Nanobiomaterials written by Jorddy Neves Cruz and has been published by Materials Research Forum LLC this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-05 with Technology & Engineering categories.

The book provides a comprehensive overview of the synthesis, characterization and potential applications of nanobiomaterials. Emphasis is placed on antimicrobial action, bone regeneration, wound treatment, cancer diagnosis, environmental cleanup and the ethical considerations of nanomedicine. Keywords: Nanomaterials, Green Chemistry, Synthesis of Nanoparticles, Characterization of Silver Nanoparticles, Antimicrobial Action, Bone Regeneration, Wound Treatment, Molecular Targets, Cancer Diagnosis, Environmental Clean-up, Ethics of Nanomedicine.

Nanoplatform Based Molecular Imaging

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Author : Xiaoyuan Chen
language : en
Publisher: John Wiley & Sons
Release Date : 2011-04-20

Nanoplatform Based Molecular Imaging written by Xiaoyuan Chen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-20 with Technology & Engineering categories.

The cutting-edge guide on advancing the science of molecular imaging using nanoparticles Nanoplathform-Based Molecular Imaging provides rationale for using nanoparticle-based probes for molecular imaging, then discusses general strategies for this underutilized, yet promising, technology. It addresses general strategies of particle synthesis and surface chemistry, applications in computed tomography optical imaging, magnetic resonance imaging, ultrasound, multimodality imaging, theranostics, and finally, the clinical perspectives of nanoimaging. This comprehensive volume summarizes the opinions of those in the forefront of research and describes the latest developments by emphasizing fundamentals and initiating hands-on application.

Nanotechnology Based Approaches For Targeting And Delivery Of Drugs And Genes

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Author : Vijay Mishra
language : en
Publisher: Academic Press
Release Date : 2017-05-23

Nanotechnology Based Approaches For Targeting And Delivery Of Drugs And Genes written by Vijay Mishra and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-23 with Medical categories.

Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes provides an overview of the important aspects of nanomedicine in order to illustrate how to design and develop novel and effective drug delivery systems using nanotechnology. The book is organized into three sections, beginning with an introduction to nanomedicine and its associated issues. Section two discusses the latest technologies in nanomedicine, while the third section covers future developments and challenges in the field. By focusing on the design, synthesis, and application of a variety of nanocarriers in drug and gene delivery, this book provides pharmaceutical and materials science students, professors, clinical researchers, and industry scientists with a valuable resource aimed at tackling the challenges of delivering drugs and genes in a more targeted manner. - Explores a wide range of promising approaches for the diagnosis and treatment of diseases using the latest advances in cutting-edge nanomedical technologies - Contains contributions from world-renowned experts and researchers working in the area of nanomedicine and drug delivery - Covers the associated challenges and potential solutions to working with nanotechnology in drug delivery - Highlights crucial topics, such as biopharmaceutical and toxicity issues, quality by design, drug targeting, and more

Targeted Cancer Imaging

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Author : Mehdi Azizi
language : en
Publisher: Academic Press
Release Date : 2021-11-24

Targeted Cancer Imaging written by Mehdi Azizi and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-24 with Science categories.

Targeted Cancer Imaging: Design and Synthesis of Nanoplatforms based on Tumour Biology reviews and categorizes imaging and targeting approaches according to cancer type, highlighting new and safe approaches that involve membrane-coated nanoparticles, tumor cell-derived extracellular vesicles, circulating tumor cells, cell-free DNAs, and cancer stem cells, all with the goal of pointing the way to developing precise targeting and multifunctional nanotechnology-based imaging probes in the future. This book is highly multidisciplinary, bridging the knowledge gap between tumor biology, nanotechnology, and diagnostic imaging, and thus making it suitable for researchers ranging from oncology to bioengineering. Although considerable efforts have been conducted to diagnose, improve and treat cancer in the past few decades, existing therapeutic options are insufficient, as mortality and morbidity rates remain high. One of the best hopes for substantial improvement lies in early detection. Recent advances in nanotechnology are expected to increase our current understanding of tumor biology, allowing nanomaterials to be used for targeting and imaging both in vitro and in vivo experimental models. - Gives understanding of cancer biology that is appropriate for students and researchers in engineering and nanotechnology - Demonstrates cancer targeting strategies of multifunctional nanotechnology-based imaging probes - Shows how to design, synthesize and apply cancer imaging nanostructures

Nanobody

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Author : Ulrich Rothbauer
language : en
Publisher: MDPI
Release Date : 2021-03-30

Nanobody written by Ulrich Rothbauer and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-30 with Science categories.

Nanobodies have become outstanding tools for biomedical research, diagnostics and therapy. Recent advances in the identification and functionalization of target-specific nanobodies now make nanobody-based approaches broadly available to many researches in the field. This book provides a compilation of original research articles and comprehensive reviews covering important and up to date aspects of research on nanobodies and their applications for immunoassays, proteomics, protein crystallization and in vitro and in vivo imaging.

Synthesis Of Single Modal And Dual Modal Targeted Molecular Imaging Agents For Mri Nir Imaging Of Breast Cancer

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Author : Basant Kaur
language : en
Publisher:
Release Date : 2021

Synthesis Of Single Modal And Dual Modal Targeted Molecular Imaging Agents For Mri Nir Imaging Of Breast Cancer written by Basant Kaur and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Breast categories.

"Our research is focused on the early and accurate detection of breast cancer (BrCa) by molecular imaging. Breast cancer is the most common type of cancer among women. Each year about one in eight women will be diagnosed, and over 500,000 deaths occur from breast cancer globally. To improve chances of survival, breast cancer must be diagnosed and treated at an early stage. Conventional imaging uses mammography, magnetic resonance imaging (MRI), and ultrasound. Limitations in these can result in false-positive results or undetected tumors. It is vital to create more sensitive imaging methods to diagnose BrCa, to reduce false-positives and to guide therapy. A new approach to targeted molecular imaging agents (TMIAs) for BrCa will be described for single-modal and dual-modal imaging by fluorescence and MRI. To target these imaging agents, we employed a new BrCa-targeting peptide called 18-4. This peptide was synthesized by solid phase peptide synthesis (SPPS) followed by conjugation of a near infrared dye, Cy5.5-1S, utilizing a new modular method developed in our lab, to form M3, an imaging agent for BrCa. The modular method was then utilized to construct a single-modal agent containing the MRI-contrast agent metal gadolinium. Lastly, a dual modal targeted imaging agent containing both Gd and Cy5.5-1S for dual modal fluorescence-MRI of BrCa was synthesized. This is the first example of a dual-modal TMIA that is synthesized entirely by SPPS, where the imaging agents are brought in on the side chain of amino acids that coupled as part of the solid phase synthetic approach."--Abstract.

Essential Bioimaging Methods

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Author : P. Michael Conn
language : en
Publisher: Academic Press
Release Date : 2009-10-05

Essential Bioimaging Methods written by P. Michael Conn and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-05 with Medical categories.

Need a tested, reliable method that works? Put Essential Bioimaging Methods to work for you. Editor Michael Conn has hand-picked the most robust methods from his previously-published volumes in the Methods in Enzymology series. Many of these methods have been briefly updated by the authors that created them and use them in their research, and this book further refines and organizes existing content and focuses on methods that work, including MRI, fMRI, PET, Microscopic optical imaging and other. Part of the Reliable Lab Solution series, this volume provides clear advice and explicit protocols, providing updates to classic, tried-and-true methods and an essential addition to the bookshelf or workbench of any researcher in the field. * Highlights usefulness of techniques in basic research detailing MRI imaging of small animals, fMRI of Macaque monkeys, and baboon model of reperfused stroke * Built from volumes in the flagship brand, Methods in Enzymology * Provides tricks, tips and different approaches

Ligands For Targeted Drug Delivery

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Author : Vikas Pandey
language : en
Publisher: Academic Press
Release Date : 2025-05-23

Ligands For Targeted Drug Delivery written by Vikas Pandey and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-23 with Medical categories.

Ligands for Targeted Drug Delivery: Basic Fundamentals and Applications is a comprehensive reference focused on the many ways drug carriers can be functionalized to target specific organs, tissues, cells, and sub-cellular compartments. Chapters cover the basic concepts of targeted drug delivery, describing multiple levels of targets and challenges, along with approaches for target-specific drug delivery and a thorough overview of the challenges in design and application of ligands. Following sections discuss nanoparticles and the main ligand classes with their respective applications. The final chapters discuss future prospects of the technology and clinical aspects of ligand modified drug delivery systems.This is a key reference to drug delivery researchers dealing with the application of ligands to overcome challenges in delivering their active principles to the target structure. Biomedical engineers, materials scientists, and chemists can also benefit from the through description of ligand classes and their potential to improve drug delivery efficiency. - Provides foundational information on targeted drug delivery at organ, tissue, cellular, and sub-cellular levels - Compares active and passive targeting and their applications - Summarizes the wider classes of ligands used for drug delivery - Presents a strategic thinking framework for pairing nanocarriers with appropriate ligands for enhanced therapeutic efficacy