Targeting Distinct Tumor Infiltrating Myeloid Cells By Inhibiting Csf 1receptor In Solid Tumors
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Targeting Distinct Tumor Infiltrating Myeloid Cells By Inhibiting Csf 1receptor In Solid Tumors
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Author : Saul Jonathan Priceman
language : en
Publisher:
Release Date : 2009
Targeting Distinct Tumor Infiltrating Myeloid Cells By Inhibiting Csf 1receptor In Solid Tumors written by Saul Jonathan Priceman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
Revisiting The Metastatic Cascade Putting Myeloid Cells Into Context
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Author : George S. Karagiannis
language : en
Publisher: Frontiers Media SA
Release Date : 2021-02-09
Revisiting The Metastatic Cascade Putting Myeloid Cells Into Context written by George S. Karagiannis and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-09 with Science categories.
Nk Cells In Cancer Immunotherapy Successes And Challenges
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Author : Anahid Jewett
language : en
Publisher: Academic Press
Release Date : 2022-12-06
Nk Cells In Cancer Immunotherapy Successes And Challenges written by Anahid Jewett and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-06 with Science categories.
NK Cells in Cancer Immunotherapy: Successes and Challenges explains the latest immunotherapeutic strategies, focusing on NK cells to allow the best and precise combination treatments to cancer patients. The book provides existing background knowledge in the field of immunotherapy and discusses future areas of research required to carry out cutting-edge, validated therapies. Chapters cover advances in immunotherapeutic strategies, in particular, the use of NK cells with and without T-cell therapy in the treatment of cancer. The book is a valuable resource for cancer researchers, oncologists, graduate students and those interested in learning more about novel strategies to treat cancer patients. Immunotherapy is fast becoming the method of choice for cancer therapy. Although remarkable advances have been made in the field of immunotherapy, there are significant challenges and difficulties ahead since many of the current immunotherapeutic strategies do not provide long-lasting treatment strategies, and therefore are not very effective. - Covers CAR/T and CAR/NK and adoptive NK cell therapy with and without T cell therapies - Discusses basic biology of NK cells and mouse models of human cancers and the role of NK cells in metastatic cancer and in cancer stem cells - Encompasses information on combination therapies using check point inhibition, adoptive transfer of cytotoxic effector cells, chemotherapeutic drugs and activating and inhibitory antibodies
M1 M2 Macrophages The Arginine Fork In The Road To Health And Disease
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Author : Charles Dudley Mills
language : en
Publisher: Frontiers Media SA
Release Date : 2015-03-23
M1 M2 Macrophages The Arginine Fork In The Road To Health And Disease written by Charles Dudley Mills and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-23 with Immunologic diseases categories.
Macrophages have unique and diverse functions necessary for survival. And, in humans (and other species), they are the most abundant leukocytes in tissues. The Innate functions of macrophages that are best known are their unusual ability to either “Kill” or “Repair”. Since killing is a destructive process and repair is a constructive process, it was stupefying how one cell could exhibit these 2 polar – opposite functions. However, in the late 1980’s, it was shown that macrophages have a unique ability to enzymatically metabolize Arginine to Nitric Oxide (NO, a gaseous non – specific killer molecule) or to Ornithine (a precursor of polyamines and collagen for repair). The dual Arginine metabolic capacity of macrophages provided a functional explanation for their ability to kill or repair. Macrophages predominantly producing NO are called M1 and those producing Ornithine are called M2. M1 and M2 – dominant responses occur in lower vertebrates, and in T cell deficient vertebrates being directly driven by Damage and Pathogen Associated Molecular Patterns (DAMP and PAMP). Thus, M1 and M2 are Innate responses that protect the host without Adaptive Immunity. In turn, M1/M2 is supplanting previous models in which T cells were necessary to “activate” or “alternatively activate” macrophages (the Th1/Th2 paradigm). M1 and M2 macrophages were named such because of the additional key findings that these macrophages stimulate Th1 and Th2 – like responses, respectively. So, in addition to their unique ability to kill or repair, macrophages also govern Adaptive Immunity. All of the foregoing would be less important if M1 or M2 – dominant responses were not observed in disease. But, they are. The best example to date is the predominance of M2 macrophages in human tumors where they act like wound repair macrophages and actively promote growth. More generally, humans have become M2 – dominant because sanitation, antibiotics and vaccines have lessened M1 responses. And, M2 dominance seems the cause of ever - increasing allergies in developed countries. Obesity represents a new and different circumstance. Surfeit energy (e.g., lipoproteins) causes monocytes to become M1 dominant in the vessel walls causing plaques. Because M1 or M2 dominant responses are clearly causative in many modern diseases, there is great potential in developing the means to selectively stimulate (or inhibit) either M1 or M2 responses to kill or repair, or to stimulate Th1 or Th2 responses, depending on the circumstance. The contributions here are meant to describe diseases of M1 or M2 dominance, and promising new methodologies to modulate the fungible metabolic machinery of macrophages for better health.
Encyclopedia Of Immunobiology
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Author :
language : en
Publisher: Academic Press
Release Date : 2016-04-27
Encyclopedia Of Immunobiology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-27 with Medical categories.
Encyclopedia of Immunobiology, Five Volume Set provides the largest integrated source of immunological knowledge currently available. It consists of broad ranging, validated summaries on all of the major topics in the field as written by a team of leading experts. The large number of topics covered is relevant to a wide range of scientists working on experimental and clinical immunology, microbiology, biochemistry, genetics, veterinary science, physiology, and hematology. The book is built in thematic sections that allow readers to rapidly navigate around related content. Specific sections focus on basic, applied, and clinical immunology. The structure of each section helps readers from a range of backgrounds gain important understanding of the subject. Contains tables, pictures, and multimedia features that enhance the learning process In-depth coverage allows readers from a range of backgrounds to benefit from the material Provides handy cross-referencing between articles to improve readability, including easy access from portable devices
The Tumor Microenvironment Recent Advances And Novel Therapeutic Approaches
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Author : Sandra Orsulic
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-03
The Tumor Microenvironment Recent Advances And Novel Therapeutic Approaches written by Sandra Orsulic and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-03 with Science categories.
Approaches To Advance Cancer Vaccines To Clinical Utility
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Author : An M. T. Van Nuffel
language : en
Publisher: Frontiers Media SA
Release Date : 2019-12-27
Approaches To Advance Cancer Vaccines To Clinical Utility written by An M. T. Van Nuffel and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-27 with categories.
Although cancer vaccines have yielded promising results both in vitro and in animal models, their translation into clinical application has not been very successful so far. Through the success of immune checkpoint inhibitors, the tumor immunotherapy field revived and led to important new insights. A better understanding of the functional capacity of different dendritic cell (DC) subsets and the immunogenicity of tumor antigens, more particularly of neoantigens, have important implications for the improvement of cancer vaccines. These insights can guide the development of novel strategies, to enhance the clinical utility of cancer vaccines. The aim of this Research Topic is therefore to provide a comprehensive overview of current issues regarding cancer vaccine development with an emphasis on novel approaches toward enhancing their efficacy.
Systemic Drug Delivery Strategies
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Author : Mansoor M. Amiji
language : en
Publisher: Academic Press
Release Date : 2021-08-21
Systemic Drug Delivery Strategies written by Mansoor M. Amiji and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-21 with Medical categories.
Systemic Drug Delivery Strategies: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, Volume 2 examines the challenges of delivering immuno-oncology therapies, focusing specifically on the multiple technologies of affective drug delivery strategies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. This volume of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy discusses methods of targeting tumors, CRISPR technology, and vaccine delivery among many other delivery strategies. Systemic Drug Delivery Strategies: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, Volume 2 creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. - Comprehensive treaty covering all aspects of immuno-oncology (IO) - Novel strategies for delivery of IO therapeutics and vaccines - Forecasting on the future of nanotechnology and drug delivery for IO
The Tumor Stroma
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Author : Jai Prakash
language : en
Publisher: CRC Press
Release Date : 2022-01-27
The Tumor Stroma written by Jai Prakash and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-27 with Medical categories.
The identification of the role of tumor stroma—the tissue in the surroundings of cancer cells—in cancer development, progression, and metastasis has revolutionized the fields of cancer biology as well as cancer therapeutics. This book provides a comprehensive overview of this rapidly-evolving field including tumor stroma biology, therapeutic targets, molecular imaging, and advanced tumor stroma in vitro models. The book will serve as a handbook for graduate students, postgraduate researchers, pharmaceutical scientists, and biomedical engineers.
Cancer Vaccines Time To Think Differently
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Author : Stephanie E. B. McArdle
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-30
Cancer Vaccines Time To Think Differently written by Stephanie E. B. McArdle and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-30 with Medical categories.