Targeting Indoleamine 2 3 Dioxygenases And Tryptophan Dioxygenase For Cancer Immunotherapy
DOWNLOAD
AUDIOBOOK
Download Targeting Indoleamine 2 3 Dioxygenases And Tryptophan Dioxygenase For Cancer Immunotherapy PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Targeting Indoleamine 2 3 Dioxygenases And Tryptophan Dioxygenase For Cancer Immunotherapy book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Targeting Indoleamine 2 3 Dioxygenases And Tryptophan Dioxygenase For Cancer Immunotherapy
DOWNLOAD
AUDIOBOOK
Author : Lieve Brochez
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-08
Targeting Indoleamine 2 3 Dioxygenases And Tryptophan Dioxygenase For Cancer Immunotherapy written by Lieve Brochez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-08 with Medical categories.
Topic Editor Dr. Alexander J. Muller receives financial support by IO Biotech company. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Targeting The Broadly Pathogenic Kynurenine Pathway
DOWNLOAD
AUDIOBOOK
Author : Sandeep Mittal
language : en
Publisher: Springer
Release Date : 2015-11-18
Targeting The Broadly Pathogenic Kynurenine Pathway written by Sandeep Mittal and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-18 with Science categories.
Tryptophan metabolism via kynurenine pathway plays a critical role in both health and a variety of human diseases. This book highlights the known associations between kynurenine pathway and various disease states, as well as examines the current status of drug development and clinical trials of compounds known to alter tryptophan metabolism. The research plays a critical role in molecular targeted therapies directed at altering the kynurenine pathway of tryptophan metabolism. The initial and rate-limiting step of tryptophan metabolism is mediated by one of two enzymes, tryptophan-2,3-dioxygenase (TDO; predominantly in the liver, but also in the brain) and indoleamine-2,3-dioxygenase (IDO; in a host of tissues in response to immune activation). Targeting the enzymes IDO and TDO, as well as other downstream effectors would therefore be likely to generate novel treatment options that would be helpful in a wide variety of clinical settings. This book provides a unique bridge between basic mechanistic understanding of the role of the kynurenine pathway with translational applications and clinical relevance. It will explore the indications that tryptophan metabolism is a potential biomarker of disease activity, can contribute to local and possibly systemic immune suppression in cancer, and is an attractive target for which a variety of inhibitors are readily available.
The Heterogeneity Of Cancer Metabolism
DOWNLOAD
AUDIOBOOK
Author : Anne Le
language : en
Publisher: Springer
Release Date : 2018-06-26
The Heterogeneity Of Cancer Metabolism written by Anne Le and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-26 with Medical categories.
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Protein Kinase Mediated Decisions Between Life And Death
DOWNLOAD
AUDIOBOOK
Author : Ayse Basak Engin
language : en
Publisher: Springer Nature
Release Date : 2021-02-04
Protein Kinase Mediated Decisions Between Life And Death written by Ayse Basak Engin and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-04 with Medical categories.
Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life. As “Protein Kinases” are related to many health problems, clinicians, basic science researchers and students need this information. Chapter “Signal Transduction in Immune Cells and Protein Kinases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Eosinophils In Health And Disease
DOWNLOAD
AUDIOBOOK
Author : James J. Lee
language : en
Publisher: Academic Press
Release Date : 2012-11-02
Eosinophils In Health And Disease written by James J. Lee and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-02 with Health & Fitness categories.
Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance.
Translational Immunotherapy Of Brain Tumors
DOWNLOAD
AUDIOBOOK
Author : John H. Sampson
language : en
Publisher: Academic Press
Release Date : 2017-02-06
Translational Immunotherapy Of Brain Tumors written by John H. Sampson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-06 with Science categories.
Translational Immunotherapy of Brain Tumors gives researchers and practitioners an up-to-date and comprehensive overview of the field. Chapters include adoptive immunotherapy, immunosuppression, CAR therapy of brain tumors, and dendritic cell therapy for brain tumors. Very few agents have been shown to be efficacious in the treatment of malignant gliomas. Recently, there have been a number of studies demonstrating the potential success of immunotherapy for brain tumors. Immunotherapeutics are becoming the most frequent drugs to be used in cancer therapy. These new breakthroughs, now approved by the FDA, are a part of multiple phase III international trials and ongoing research in malignant glioma, meaning that the information in this cutting-edge book will be of great importance to practitioners and researchers alike. Comprehensive overview, providing an update on immunology, translational immunotherapy, and clinical trials relating to malignant gliomas Edited by a prominent neurosurgeon with contributions by leading researchers in the field Ideal resource for researchers and practitioners interested in learning about mechanisms that use the immune system to treat brain tumors
B Vitamins And Folate
DOWNLOAD
AUDIOBOOK
Author : Victor R. Preedy
language : en
Publisher: Royal Society of Chemistry
Release Date : 2013
B Vitamins And Folate written by Victor R. Preedy and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Health & Fitness categories.
Written by an expert team, this research compilation provides a fascinating insight into the scientific knowledge around these compounds for health and nutritional scientists.
Inflammation Associated Depression Evidence Mechanisms And Implications
DOWNLOAD
AUDIOBOOK
Author : Robert Dantzer
language : en
Publisher: Springer
Release Date : 2016-12-28
Inflammation Associated Depression Evidence Mechanisms And Implications written by Robert Dantzer and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-28 with Medical categories.
Inflammation has invaded the field of psychiatry. The finding that cytokines are elevated in various affective and psychotic disorders brings to the forefront the necessity of identifying the precise research domain criteria (RDoCs) that inflammation is responsible for. This task is certainly the most advanced in major depressive disorders. The reason is that a dearth of clinical and preclinical studies has demonstrated that inflammation can cause symptoms of depression and conversely, cytokine antagonists can attenuate symptoms of depression in medical and psychiatric patients with chronic low grade inflammation. Important knowledge has been gained on the symptom dimensions that inflammation is driving and the mechanisms of action of cytokines in the brain, providing new targets for drug research and development. The aim of the book “Inflammation-Associated Depression” is to present this field of research and its implications in a didactic and comprehensive manner to basic and clinical scientists, psychiatrists, physicians, and students at the graduate level.
Autoimmune Endocrinopathies
DOWNLOAD
AUDIOBOOK
Author : Robert Volpé
language : en
Publisher: Springer Science & Business Media
Release Date : 1999-06-04
Autoimmune Endocrinopathies written by Robert Volpé and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-06-04 with Medical categories.
Dr. Robert Volpé and his distinguished contributors comprehensively review the latest thinking about the theoretical, experimental, and clinical aspects of autoimmune endocrine disorders. These world-renowned experts examine the pathogenesis and immunogenetics of these diseases, discuss the role of sex hormones in autoimmunity, and elucidate the nature of autoantigens. They also provide clinical detail on a wide variety of autoimmune endocrinopathies, including autoimmune thyroid disease, Graves' ophthalmopathy and dermopathy, human insulin-dependent diabetes mellitus, and autoimmune adrenocortical failure. Postpartum autoimmune endocrine syndromes, autoimmune hypophysitis, and the polyglandular autoimmune syndromes are also discussed in detail. Comprehensive and authoritative, Autoimmune Endocrinopathies provides today's most up-to-date understanding of the etiology and pathogenesis of autoimmune endocrine diseases.
Early Detection And Treatment Of Head Neck Cancers
DOWNLOAD
AUDIOBOOK
Author : Rami El Assal
language : en
Publisher: Springer Nature
Release Date : 2021-05-07
Early Detection And Treatment Of Head Neck Cancers written by Rami El Assal and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-07 with Medical categories.
Head and neck cancer (HNC) is a heterogeneous group of cancers that, if combined, represent one of the most common cancer types. Patients with HNC suffer significant morbidity and mortality due to the importance of the structures involved. Over two-thirds of these patients are diagnosed at a late stage, leading to a poor prognosis. Therefore, advancements in early detection and treatment of HNC are crucial. Volume I begins with a general overview, including the industry landscape, of HNC detection, diagnosis, and treatment. Next, it covers the applications of innovative technologies such as microfluidics, nanotechnology, and deep learning to early detect as well as study HNC. For example, studying the cellular features at a single-cell level became possible with the advancement of technologies such as mass cytometry or specifically, Cytometry by Time Of Flight Mass Spectrometry (CyTOF), which has revolutionized the way we can study complex human diseases such as HNC. Finally, the last few chapters are dedicated to describing the standard of care of HNC. The first volume of Early Detection and Treatment of Head & Neck Cancers is highly pertinent to the next generation of interdisciplinary clinicians, scientists, residents, and students who are particularly interested in HNC and in the translation of early detection methods, technologies, and research to clinical practice.