Targeting The Broadly Pathogenic Kynurenine Pathway
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Targeting The Broadly Pathogenic Kynurenine Pathway
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Author : Sandeep Mittal
language : en
Publisher: Springer
Release Date : 2015-11-18
Targeting The Broadly Pathogenic Kynurenine Pathway written by Sandeep Mittal and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-18 with Science categories.
Tryptophan metabolism via kynurenine pathway plays a critical role in both health and a variety of human diseases. This book highlights the known associations between kynurenine pathway and various disease states, as well as examines the current status of drug development and clinical trials of compounds known to alter tryptophan metabolism. The research plays a critical role in molecular targeted therapies directed at altering the kynurenine pathway of tryptophan metabolism. The initial and rate-limiting step of tryptophan metabolism is mediated by one of two enzymes, tryptophan-2,3-dioxygenase (TDO; predominantly in the liver, but also in the brain) and indoleamine-2,3-dioxygenase (IDO; in a host of tissues in response to immune activation). Targeting the enzymes IDO and TDO, as well as other downstream effectors would therefore be likely to generate novel treatment options that would be helpful in a wide variety of clinical settings. This book provides a unique bridge between basic mechanistic understanding of the role of the kynurenine pathway with translational applications and clinical relevance. It will explore the indications that tryptophan metabolism is a potential biomarker of disease activity, can contribute to local and possibly systemic immune suppression in cancer, and is an attractive target for which a variety of inhibitors are readily available.
Immunomodulatory Roles Of Tryptophan Metabolites In Inflammation And Cancer
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Author : Juliane Günther
language : en
Publisher: Frontiers Media SA
Release Date : 2020-09-03
Immunomodulatory Roles Of Tryptophan Metabolites In Inflammation And Cancer written by Juliane Günther and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-03 with Medical categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Comparative Endocrine Stress Responses In Vertebrates
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Author : Lluis Tort
language : en
Publisher: Frontiers Media SA
Release Date : 2020-01-02
Comparative Endocrine Stress Responses In Vertebrates written by Lluis Tort and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-02 with categories.
Novel Targets For Chronic Inflammatory Diseases Focus On Therapeutic Drugs And Natural Compounds Volume Ii
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Author : Yan Huang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-03-18
Novel Targets For Chronic Inflammatory Diseases Focus On Therapeutic Drugs And Natural Compounds Volume Ii written by Yan Huang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-18 with Science categories.
This Research Topic is part of a series with: Novel Targets for Chronic Inflammatory Diseases: Focus On Therapeutic Drugs and Natural Compounds Chronic inflammation is a component of many disease conditions that affect a large group of individuals worldwide, which is characterized by persistent, low-grade inflammation and is increased in the aging population. It occurs when an initiating stimulus is not removed or if the resolution process is disrupted, resulting in a state of low-grade inflammation. It is acknowledged that chronic inflammatory diseases are involved in cardiovascular diseases, endocrine disease, neurodegenerative disease, hepatic disease, pulmonary disease, gastrointestinal disease, and cancer et al., including but not limited to atherosclerosis, diabetes, multiple sclerosis, fibrosis, NAFLD, COPD, inflammatory bowel disease, autoimmune disorders(like SLE, RA), which are major causes of death worldwide. Immunity is a physiological function of the human body, which maintains health by destroying and rejecting foreign substances including antigens, damaged cells, and tumors et al. There is a close relationship between inflammation and immunity, whether they are both protective mechanisms against invasion or injury responses. Therefore, the important role of inflammatory and immune responses should be noted, it is necessary to explore novel targets and therapeutic drugs for chronic inflammatory diseases.
Autoimmune Endocrinopathies
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Author : Robert Volpé
language : en
Publisher: Springer Science & Business Media
Release Date : 1999-06-04
Autoimmune Endocrinopathies written by Robert Volpé and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-06-04 with Medical categories.
Dr. Robert Volpé and his distinguished contributors comprehensively review the latest thinking about the theoretical, experimental, and clinical aspects of autoimmune endocrine disorders. These world-renowned experts examine the pathogenesis and immunogenetics of these diseases, discuss the role of sex hormones in autoimmunity, and elucidate the nature of autoantigens. They also provide clinical detail on a wide variety of autoimmune endocrinopathies, including autoimmune thyroid disease, Graves' ophthalmopathy and dermopathy, human insulin-dependent diabetes mellitus, and autoimmune adrenocortical failure. Postpartum autoimmune endocrine syndromes, autoimmune hypophysitis, and the polyglandular autoimmune syndromes are also discussed in detail. Comprehensive and authoritative, Autoimmune Endocrinopathies provides today's most up-to-date understanding of the etiology and pathogenesis of autoimmune endocrine diseases.
Targeting Indoleamine 2 3 Dioxygenases And Tryptophan Dioxygenase For Cancer Immunotherapy
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Author : Lieve Brochez
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-08
Targeting Indoleamine 2 3 Dioxygenases And Tryptophan Dioxygenase For Cancer Immunotherapy written by Lieve Brochez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-08 with Medical categories.
Topic Editor Dr. Alexander J. Muller receives financial support by IO Biotech company. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Tumor Induced Immune Suppression
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Author : Dmitry I. Gabrilovich
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-02-10
Tumor Induced Immune Suppression written by Dmitry I. Gabrilovich and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-10 with Medical categories.
Tumor-Induced Immune Suppression - Prospects and Progress in Mechanisms and Therapeutic Reversal presents a comprehensive overview of large number of different mechanisms of immune dysfunction in cancer and therapeutic approaches to their correction. This includes the number of novel mechanisms that has never before been discussed in previous monographs. The last decades were characterized by substantial progress in the understanding of the role of the immune system in tumor progression. Researchers have learned how to manipulate the immune system to generate tumor specific immune response, which raises high expectations for immunotherapy to provide breakthroughs in cancer treatment. It is increasingly clear that tumor-induced abnormalities in the immune system not only hampers natural tumor immune surveillance, but also limits the effect of cancer immunotherapy. Therefore, it is critically important to understand the mechanisms of tumor-induced immune suppression to make any progress in the field and this monograph provides these important insights.
Molecular Mechanisms In Chronic Kidney Disease
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Author : Claudia Torino
language : en
Publisher: Frontiers Media SA
Release Date : 2021-09-02
Molecular Mechanisms In Chronic Kidney Disease written by Claudia Torino and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-02 with Science categories.
Biomarkers To Enable Therapeutics Development In Neurodevelopmental Disorders
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Author : Mustafa Sahin
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-31
Biomarkers To Enable Therapeutics Development In Neurodevelopmental Disorders written by Mustafa Sahin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-31 with Science categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
The Handbook Of Microbial Metabolism Of Amino Acids
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Author : J. P. Felix D'Mello
language : en
Publisher: Cab International
Release Date : 2017
The Handbook Of Microbial Metabolism Of Amino Acids written by J. P. Felix D'Mello and has been published by Cab International this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Amino acids categories.