Targeting The Immune Modulating Enzyme Ido1 Using Anticancer Agents
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Targeting The Immune Modulating Enzyme Ido1 Using Anticancer Agents
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Author : Hollie Elizabeth Flick
language : en
Publisher:
Release Date : 2013
Targeting The Immune Modulating Enzyme Ido1 Using Anticancer Agents written by Hollie Elizabeth Flick and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Oncoimmunology
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Author : Laurence Zitvogel
language : en
Publisher: Springer
Release Date : 2017-12-13
Oncoimmunology written by Laurence Zitvogel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-13 with Medical categories.
In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.
The Heterogeneity Of Cancer Metabolism
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Author : Anne Le
language : en
Publisher: Springer
Release Date : 2018-06-26
The Heterogeneity Of Cancer Metabolism written by Anne Le and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-26 with Medical categories.
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Unmasking Metabolic Dependencies For Anti Cancer Treatment In Cancer
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Author : Johannes Fahrmann
language : en
Publisher: Frontiers Media SA
Release Date : 2024-05-27
Unmasking Metabolic Dependencies For Anti Cancer Treatment In Cancer written by Johannes Fahrmann and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-27 with Medical categories.
Over the last decade, our understanding of metabolism in the context of cancer has evolved greatly. It is now evident that altered cellular metabolism is an integral effector of tumorigenesis that is intricately intertwined with cell signaling as well as genetic and epigenetic regulation of diverse tumor programs. Recognizing the dysregulation of cellular metabolism as an important aspect of tumor function has offered new potential direction to seek clinical benefit by providing targets for the development of novel therapeutics. To-date, several small molecule inhibitors that target tumor or immune cell metabolism are being explored in active clinical trials as either preventive, stand-alone, or adjuvant therapies for various malignancies. Thus, identifying critical metabolic vulnerabilities in pre-neoplastic cells, cancer cells, and immune cells has direct and timely relevance for developing additional treatment and preventative strategies against cancer.
Tumor Immune Microenvironment In Cancer Progression And Cancer Therapy
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Author : Pawel Kalinski
language : en
Publisher: Springer
Release Date : 2017-12-22
Tumor Immune Microenvironment In Cancer Progression And Cancer Therapy written by Pawel Kalinski and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-22 with Medical categories.
The tumor microenvironment has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the normal cells, molecules, and blood vessels that surround and feed a tumor cell. As many scientists have realized, studying the tumor microenvironment has become critical to moving the field forward, since there are many players in a tumor’s localized and surrounding area, which can significantly change cancer cell behavior. There is a dual relationship wherein the tumor can change its microenvironment and the microenvironment can affect how a tumor grows and spreads. Tumor Microenvironment in Cancer Progression and Cancer Therapy aims to shed light on the mechanisms, factors, and mediators that are involved in the cancer cell environment. Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics. Thus, the dual role of the tumor microenvironment is the integral focus of the volume. The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. It also focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells. These three groups are discussed under the lens of their role in promoting tumor growth, shielding the tumor from rejection and from standard forms of cancer therapies. They are emerging as targets and mediators of standard and new forms of potential therapy.
Frontiers In Clinical Drug Research Anti Cancer Agents Volume 8
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Author : Atta-ur-Rahman
language : en
Publisher: Bentham Science Publishers
Release Date : 2021-12-03
Frontiers In Clinical Drug Research Anti Cancer Agents Volume 8 written by Atta-ur-Rahman and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-03 with Science categories.
Frontiers in Clinical Drug Research - Anti-Cancer Agents is a book series intended for pharmaceutical scientists, postgraduate students and researchers seeking updated and critical information for developing clinical trials and devising research plans in anti-cancer research. Reviews in each volume are written by experts in medical oncology and clinical trials research and compile the latest information available on special topics of interest to oncology and pharmaceutical chemistry researchers. The eighth volume of the book features reviews on these topics: - Key data management elements in clinical trials for oncological therapeutics - Prospects for therapeutic targeting of microRNAs in brain tumors - Breast cancer vaccines: current status and future approach - Desmocollin-3 and cancer - MDM2-p53 antagonists under clinical evaluation: a promising cancer targeted therapy for cancer patients harbouring wild-type tp53 - Towards targeted therapy: anticancer agents targeting cell organelle mitochondria - Anticancer therapeutic strategies in gliomas: chemotherapy, immunotherapy, and molecularly targeted therapy in adults.
Metronomic Chemotherapy
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Author : Guido Bocci
language : en
Publisher: Springer
Release Date : 2014-09-04
Metronomic Chemotherapy written by Guido Bocci and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-04 with Medical categories.
This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.
Anticancer Agents
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Author : Qiao-Hong Chen
language : en
Publisher: MDPI
Release Date : 2021-03-02
Anticancer Agents written by Qiao-Hong Chen and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-02 with Business & Economics categories.
This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers.
Eosinophils In Health And Disease
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Author : James J. Lee
language : en
Publisher: Academic Press
Release Date : 2012-11-02
Eosinophils In Health And Disease written by James J. Lee and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-02 with Health & Fitness categories.
Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance.
Modulation Of Human Immune Parameters By Anticancer Therapies
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Author : Ulrich Sack
language : en
Publisher: Frontiers Media SA
Release Date : 2021-01-18
Modulation Of Human Immune Parameters By Anticancer Therapies written by Ulrich Sack and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-18 with Medical categories.