Targeting The Pd 1 Pd L1 Cancer Immune Evasion Axis Challenges And Emerging Strategies
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Targeting The Pd 1 Pd L1 Cancer Immune Evasion Axis Challenges And Emerging Strategies
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Author : Jie Xu
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-08
Targeting The Pd 1 Pd L1 Cancer Immune Evasion Axis Challenges And Emerging Strategies written by Jie Xu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-08 with Science categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Emerging Learnings In Cell Therapy Novel Binding Domains Universal Car T Cells And More
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Author : Anand Rotte
language : en
Publisher: Frontiers Media SA
Release Date : 2024-04-22
Emerging Learnings In Cell Therapy Novel Binding Domains Universal Car T Cells And More written by Anand Rotte and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-22 with Medical categories.
The Past decade has seen significant advances in cancer immunotherapy with the development of multiple strategies including monoclonal antibodies targeting checkpoint blockers, oncolytic viruses, fusion proteins and cell therapies such as tumor-specific chimeric antigen receptor (CAR-) T cell therapy, NK cell therapy and γδ-T-cell therapy. Multiple cell therapies including sipuleucel-T (Provange), axicabtagene ciloleucel (Yescarta), brexucabtagene autoleucel (Tecartus), tisagenlecleucel (Kymriah), lisocabtagene maraleucel (Breyanzi), idecabtagene vicleucel (Abecma) and ciltacabtagene autoleucel (Carvykti) have been approved by the US FDA for different hematological cancers and hormone-refractory prostate cancer (Provange). Impressive results were noted with CAR-T cell therapy with objective response rates (ORR) as high as 100% in certain hematological cancers and with responses durable over 10 years in some patients.
The Role Of Ubiquitination In Disease Development Progression And Prognosis
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Author : Wenyi Jin
language : en
Publisher: Frontiers Media SA
Release Date : 2025-05-08
The Role Of Ubiquitination In Disease Development Progression And Prognosis written by Wenyi Jin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-08 with Medical categories.
Ubiquitination, an essential post-translational modification, controls various cellular functions by attaching ubiquitin to proteins, dictating their fate from degradation to functional reorganization. This modification, catalyzed by a series of enzymes (E1, E2, E3), is crucial for maintaining cellular homeostasis and is highly involved in key processes such as signal transduction, DNA repair, and gene expression. Recent studies illustrate how ubiquitination dysfunction is linked to numerous diseases, highlighting its role in immune regulation, cancer progression, and other pathologies. However, despite significant advancements, the full mechanistic pathways and implications of ubiquitination in disease progression and immune system dysfunction remain incompletely understood. This Research Topic aims to deepen the understanding of how ubiquitination influences disease development, progression, and response to therapies. By focusing on the modulation of cell signaling and immune responses through ubiquitination, our goal is to uncover new mechanistic insights that could lead to more effective therapeutic strategies. Essential objectives include elucidating the non-degradative roles of ubiquitination in immune cell function and tumor microenvironment modulation, exploring the potential of ubiquitination as a biomarker, and advancing our understanding of its molecular mechanisms in disease contexts.
Targeting Oral Cancer
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Author : Andrew Fribley
language : en
Publisher: Springer
Release Date : 2016-02-29
Targeting Oral Cancer written by Andrew Fribley and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-29 with Medical categories.
This book provides research-oriented care providers with up-to-date information on the oral cancer patient population, the ways in which we are treating them, and the scientific approaches being pursued in order to improve survival and reduce treatment-related morbidity. The text is organized into three sections covering epidemiology and management, cancer development and biomarkers, and breaking developments and novel approaches for drug discovery. The first section includes discussion of the emerging role of HPV in oral cancer and explains the surgical, chemotherapy and radiation approaches to treatment. Aspects such as molecular progression, the role of cancer stem cells in tumor development, and the value of various biomarkers are then examined. The final section is devoted to the latest advances and covers, among other topics, current clinical trials, emerging drug targets, and targeting of the unfolded protein response and of mediators of coagulation.
Tumor Micro Environment And Drug Resistance
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Author : Wei Zhao
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-16
Tumor Micro Environment And Drug Resistance written by Wei Zhao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-16 with Science categories.
Immune Therapy For Pancreatic And Colon Cancers
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Author : Ganji Purnachandra Nagaraju
language : en
Publisher: Elsevier
Release Date : 2024-11-26
Immune Therapy For Pancreatic And Colon Cancers written by Ganji Purnachandra Nagaraju and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-26 with Science categories.
Immune Therapy for Pancreatic and Colon Cancer expands the knowledge on pathways, immune modulators, immune check points, and monoclonal antibodies that can lead to appropriate cancer treatment. With a strong focus on the development of immune therapies to improve the survival rates of pancreatic and colon cancer, this book also shows the latest trends in immune targeted approaches for cancer treatment. Sections describe the role of and the immune response to pancreatic and colon cancer, gives insights to past and current immunotherapies, including metabolic reprogramming, immune blockade therapy and immune modulation.This book is a valuable resource for health professionals, scientists and researchers, students, and all those who wish to broaden their knowledge of the advances in immunotherapy in pancreatic and colon cancer, inspire them and guide their design of novel experimental projects and translational studies. - Aims to incorporate diverse and novel immunotherapeutic strategies, targeting a wide array of tumor-induced immune escape mechanisms - Elucidates both past and current differences in immunotherapies, while also including strategies based on monoclonal antibodies' vaccine, and oncolytic virus-related immunotherapies - Provides an updated understanding of the how resistance breaks with immunotherapy in both pancreatic and colon cancer
Women In Breast Cancer 2022 Volume Ii
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Author : Margaret Gatti-Mays
language : en
Publisher: Frontiers Media SA
Release Date : 2023-11-08
Women In Breast Cancer 2022 Volume Ii written by Margaret Gatti-Mays and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-08 with Medical categories.
We are delighted to present the Frontiers in Oncology "Women in Breast Cancer” Volume II series of article collections. At present, less than 30% of researchers worldwide are women. Long-standing biases and gender stereotypes are discouraging girls and women away from science-related fields, and STEM research in particular. Science and gender equality are, however, essential to ensure sustainable development as highlighted by UNESCO. In order to change traditional mindsets, gender equality must be promoted, stereotypes defeated, and girls and women should be encouraged to pursue STEM careers.
Cancer Immunotherapies From Efficacy To Resistance Mechanisms
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Author : Morten Hansen
language : en
Publisher: Frontiers Media SA
Release Date : 2022-06-29
Cancer Immunotherapies From Efficacy To Resistance Mechanisms written by Morten Hansen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-29 with Medical categories.
Dr. Koguchi receives funding from Tesaro, a GSK company, Bristol-Myers Squibb, and Shimadzu Corporation.. Dr. Vujanovic is a co-inventor of a methodology licensed to INmune Bio, Inc. where a selective inhibitor of soluble TNF can be used to prevent or treat malignancies. Dr. Hansen is the recipient of a private grant from Eurostars Eureka. The other Topic Editors declare no competing interests.
The Intricate Innate Immune Cancer Cell Relationship In The Context Of Tumor Angiogenesis Immunity And Microbiota The Angiogenic Switch In The Tumor Microenvironment As A Key Target For Immunotherapies
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Author : Lorenzo Mortara
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-15
The Intricate Innate Immune Cancer Cell Relationship In The Context Of Tumor Angiogenesis Immunity And Microbiota The Angiogenic Switch In The Tumor Microenvironment As A Key Target For Immunotherapies written by Lorenzo Mortara and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-15 with Medical categories.
Gastrointestinal Cancer Immunotherapy From Drug Resistance Mechanisms To Overcoming Strategies
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Author : Xiaofang Che
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-15
Gastrointestinal Cancer Immunotherapy From Drug Resistance Mechanisms To Overcoming Strategies written by Xiaofang Che and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-15 with Medical categories.
Gastrointestinal (GI) cancers, including gastric cancer, colon cancer, liver cancer, esophageal cancer, and pancreatic cancer, seriously threaten the health of human beings worldwide with a high rate of morbidity and mortality. The clinical successes achieved with immune checkpoint inhibitors (ICIs) targeting PD-1/PD-L1 and CTLA-4 have opened a new cancer therapy era and brought new hope to cancer patients. However, the overall response rate (ORR) of ICI monotherapy in the non-selective population is only about 20%, in which some patients subsequently develop immunotherapy resistance. Moreover, the remaining 70-80% of patients displayed primary resistance to ICIs, and a few patients even experienced hyper progression disease (HPD). Although PD-L1 expression, mismatch repair deficient (MMRd), high tumor mutational burden (TMB-H) , high homologous recombination deficiency (HRD), and tumor infiltrated immune cells (TILs) are known as effective biomarkers for immunotherapy, growing studies have reported that ICIs could not improve the OS of all patients with PD-L1 expression higher than 50%, and the ORR of MSI-H patients was only about 60%, whereas some patients with low PD-L1 expression or MSS could still benefit from immunotherapy, indicating the complexity of ICI resistance. Therefore, it is of great importance and significance to explore the prediction biomarkers for primary or acquired immunotherapy resistance and elucidate their underlying molecular mechanisms and develop reversal strategies. Due to the multiple steps of the cancer immune cycle and complex immune microenvironment, any disorders of immune cell infiltration or T cell activation, such as lack of antigens and/or their presentation, lack of response to antigen presentation, and T cell priming, could contribute to ICI resistance. The combination with anti-angiogenesis therapy, radiotherapy, chemotherapy, and other ICIs has improved the efficacy of ICI therapy to some extent in the clinic. Although numerous studies related to ICI resistance were reported in GI cancers, due to the strong spatial/temporal heterogeneity and the complex immune microenvironment in different kinds of GI cancers and different individuals, many questions about ICI resistance and reversal strategies remain unsolved. The aim of this Research Topic is to provide a forum to exhibit the latest research achievement related to the exploration of biomarkers for immunotherapy resistance including HPD and the underlying molecular mechanisms, as well as the development of reversal strategies in GI cancers. We hope this Research Topic will lead to a better understanding of precision cancer immunotherapy and provide useful clues for clinical application to benefit more GI cancer patients with immunotherapy.