Teratogenic Mechanisms
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Teratogenic Mechanisms
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Author : T.V.N. Persaud
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Teratogenic Mechanisms written by T.V.N. Persaud and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The study of birth defects has assumed an importance even greater now than in the past because mortality rates attributed to congenital anomalies have declined far less than those for other causes of death, such as infectious and nutritional diseases. It is estimated that as many as 50% of all pregnancies terminate as miscarriages. In the majority of cases this is the result of faulty development. Major congenital malformations are found in at least 2% of all liveborn infants, and 22% of all stillbirths and infant deaths are associated with severe congenital anomalies. Teratological studies of an experimental nature are neither ethical nor justifiable in humans. Numerous investigations have been carried out in laboratory animals and other experimental models in order to improve our understanding of abnormal intra-uterine development. In less than two decades the field of experimental teratology has advanced phenomenally. As a result of the wide range of information that is now accumulating, it has become possible to obtain an insight into the causes, mechanisms and prevention of birth defects. However, considerable work will be needed before these problems can be resolved. This book brings together some of the more recent and important research findings related to the mechanisms and pathogenesis of abnormal develop ment. It is not only a documentation of the latest experimental work, but it also points out future directions that seem productive and challenging.
Mechanisms And Pathogenesis
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Author : James Wilson
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Mechanisms And Pathogenesis written by James Wilson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Science categories.
Teratogenic Mechanisms Of Retinoic Acid
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Author :
language : en
Publisher:
Release Date : 1982
Teratogenic Mechanisms Of Retinoic Acid written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with Chondrogenesis categories.
Teratogens
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Author : V. Kolb Meyers
language : en
Publisher: Elsevier
Release Date : 1988-01-01
Teratogens written by V. Kolb Meyers and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988-01-01 with Medical categories.
This multi-author work deals with the practical aspects of teratogens - chemicals which cause birth defects. It is designed for use as a unique guide to these chemicals in which one can find all relevant information. The issues covered include: how to obtain information about the teratogenic potential of chemicals; teratogenic chemicals in undergraduate chemistry laboratories; safe handling of teratogenic chemicals; teratogenicity of pesticides and other pollutants in the environment; occupational exposure and pregnancy outcome; identification and prevention of reproductive hazards in industry; and the long-term effects of chemicals on the developing brain. A list of approximately 5,000 chemicals known to cause reproductive effects is given. A comprehensive bibliography is included with each chapter providing up-to-date references for more in-depth coverage. The monograph will be of interest to academic and industrial chemists, health professionals, as well as both undergraduate and graduate students in health and related sciences.
Teratogens
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Author : Vera M. Kolb
language : en
Publisher: Elsevier
Release Date : 2013-10-22
Teratogens written by Vera M. Kolb and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Health & Fitness categories.
Teratogens Chemicals Which Cause Birth Defects, 2nd Revised Edition is a collection of papers that discusses the practical aspect of teratogens, particularly regarding information on the teratogenic potential of chemicals. This book describes the principles and mechanism of teratogenesis, including the initiating mechanisms during the subcellular or molecular level and the role of bio-activation in teratogenesis. Investigations have been done on the relationship between spontaneous abortion in women exposed to organic solvents, antineoplastic agents, and chemicals in plastics. Other studies also show that teratogenicity depends in part on enzymatic bio-activation to an embryotoxic reactive intermediate. This text also explains the legal and ethical aspects of fetal protection policies with emphasis on fetal protection. Protection to expecting women extends to pregnant students exposed to teratogenic chemicals in chemistry laboratories. The book explains how and where to get information about the teratogenic potential of chemicals and how to properly handle these chemicals in the laboratory. The book also provides a list from RTECs of toxic chemicals which can cause reproductive effects. This book can prove useful for chemists, pharmacologists, obstetricians, gynecologists, and practitioners of general medicine.
Teratogenesis And Reproductive Toxicology
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Author : E.M. Johnson
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Teratogenesis And Reproductive Toxicology written by E.M. Johnson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The resolution of links between exposure to components of our complex environmental and causation of reproductive effects in the population constitutes an important problem in the field of toxicology. The focus of this volume is developmental toxicology, which represents one aspect of reproductive toxicology dealing with the study of adverse effects on the developing conceptus. Developmental toxicology, which includes teratogenesis as one of its manifesta tions, provides a fertile field for research in several basic and clinical disciplines; this field also receives input from several disoiplines such as developmental and molecu lar biology, pathology, pharmacology and toxicology, pediatrics and neonatology, and epidemiology. More recently we h~ve seen an emergence of interest in other fields such as perinatal physiology and postnatal behavior which have now become incorporated into the mainstream of research in this discipline. The present volume is an effort to provide a sampling of concepts currently under active investigation in several of the above fields. The authors have endeavored to provide up-to-date in formation on the following topics: detection and analysis of potential hazards to the conceptus in the workplace, pharmacokinetic aspects of the maternal/placental! fetal complex and its relationship to human birth defects, and probable mechanisms of teratogenesis as uncovered in certain well-defined situations. Also included are summaries of newer investigations on the emerging field of postnatal functional evaluations, i. e. , adverse effects on adult activities resultant from in utero exposure to toxic substances.
Catalog Of Teratogenic Agents
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Author : Thomas H. Shepard
language : en
Publisher: JHU Press
Release Date : 2004
Catalog Of Teratogenic Agents written by Thomas H. Shepard and has been published by JHU Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Teratogenic agents categories.
Links information on experimental teratogenic agents with the congenital defects in human beings.
Drug Toxicity In Embryonic Development Ii
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Author : Robert J. Kavlock
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Drug Toxicity In Embryonic Development Ii written by Robert J. Kavlock and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Having received the invitation from Springer-Verlag to produce a volume on drug-induced birth defects for the Handbook of Experimental Pharmacology, we asked ourselves what new approach could we offer that would capture the state of the science and bring a new synthesis of the information on this topic to the world's literature. We chose a three-pronged approach, centered around those particular drugs for which we have a relatively well established basis for understanding how they exert their unwanted effects on the human embryo. We then supplemented this information with a series of reviews of critical biological processes involved in the established normal developmental patterns, with emphasis on what happens to the embryo when the processes are perturbed by experimental means. Knowing that the search for mechanisms in teratology has often been inhibited by the lack of understanding of how normal development proceeds, we also included chapters describing the amazing new discoveries related to the molecular control of normal morphogenesis for several organ systems in the hope that experimental toxicologists and molecular biologists will begin to better appreciate each others questions and progress. Several times during the last two years of developing outlines, issuing invitations, reviewing chapters, and cajoling belated contributors, we have wondered whether we made the correct decision to undertake this effort.
Potter S Pathology Of The Fetus Infant And Child
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Author : Edith Louise Potter
language : en
Publisher: Mosby
Release Date : 2007
Potter S Pathology Of The Fetus Infant And Child written by Edith Louise Potter and has been published by Mosby this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Abnormalities, Human categories.
This comprehensive reference addresses all aspects of fetal and neonatal pathology, including complicated pregnancies, multiple pregnancies, abortion, placental pathology, and disorders affecting the full-term neonate. A consistent organization allows for quick access to specific guidance, and nearly 2,500 illustrations - 2,350 in full color - depict conditions and abnormalities as they present in practice, facilitating diagnosis. An Image Bank on CD-ROM - new to this edition - features all of the illustrations from the 2-volume set, downloadable for presentations.
Dictionary Of Toxicology
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Author : Ernest Hodgson
language : en
Publisher: Academic Press
Release Date : 2014-10-08
Dictionary Of Toxicology written by Ernest Hodgson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-08 with Medical categories.
Dictionary of Toxicology, Third Edition presents a compendium of definitions of all current toxicological terminology. This authoritative reference illustrates and describes words, concepts, acronyms and symbols for both the toxicological theory and applied risk assessment, as well as providing guidance on the correct selection of problematic, similar and frequently-misused terms. Written by one of the world’s foremost experts in toxicology, and with each entry peer reviewed, Dictionary of Toxicology, Third Edition is an essential reference for all scientific, medical and legal professionals who work with or encounter the toxicological effects of contaminants on biological systems. New to this edition: an update on every entry and the inclusion of all terminology and concepts relating to molecular toxicology, nanotoxicology and computational toxicology. Presents peer-reviewed definitions on the most up-to-date toxicological terms and concepts. New edition includes definitions within the fields of molecular toxicology, nanotoxicology, computational toxicology and risk assessment.