Teratological Testing
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Teratological Testing
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Author : T.V.N. Persaud
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Teratological Testing written by T.V.N. Persaud and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The study of birth defects has assumed an importance even greater now than in the past because mortality rates attributed to congenital anomalies have declined far less than those for other causes of death, such as infectious and nutritional diseases. It is estimated that as many as 50% of all pregnancies terminate as miscarriages. In the majority of cases this is the result of faulty development. Major congenital malformations are found in at least 2% of all liveborn infants, and 22% of all stillbirths and infant deaths are associated with severe congenital anomalies. Teratological studies of an experimental nature are neither ethical nor justifiable in humans. Numerous investigations have been carried out in laboratory animals and other experimental models in order to improve our understanding of abnormal intra-uterine development. In less than two decades the field of experimental teratology has advanced phenomenally. As a result of the wide range of information that is now accumulating, it has become possible to obtain an insight into the causes, mec.;hanisms and prevention of birth defects. However, considerable work will be needed before these problems can be resolved. The· contributions in this volume deal primarily with the areas of terato logical evaluation and the use of selected animal models for the study of con genital anomalies. It is not only a documentation of the latest experimental work, but it also indicates new and important areas for future research.
Advances In The Study Of Birth Defects
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Author : T. V. N. Persaud
language : en
Publisher:
Release Date : 1979
Advances In The Study Of Birth Defects written by T. V. N. Persaud and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with Abnormalities, Human categories.
Teratogenicity Testing
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Author : Paul C. Barrow
language : en
Publisher: Humana Press
Release Date : 2012-11-09
Teratogenicity Testing written by Paul C. Barrow and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-09 with Medical categories.
Teratology is the study of chemical-induced birth defects. This book is a comprehensive guide to the procedures and methods commonly employed in the safety testing of all classes of chemical for teratogenicity (also referred to as embryotoxicity, developmental toxicity or prenatal toxicity). The various international regulatory requirements are explained in detail, in order that the reader may perform all of the necessary studies for the successful registration or marketing authorisation of a new pharmaceutical, industrial chemical, crop protection product or food additive. Written in the highly successful Methods in Molecular BiologyTM series format, each chapter gives clear complete instructions on how to perform the task in hand. The authors are respected experts in their field, all with hands-on experience of the procedures described. Teratogenicity Testing: Methods and Protocols gives crucial guidance and tips on how to deal with unexpected results and overcome regulatory difficulties.
Teratological Testing Volume 2
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Author : TVN Persaud (Ed)
language : en
Publisher:
Release Date : 1979
Teratological Testing Volume 2 written by TVN Persaud (Ed) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with categories.
Teratology
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Author : C.L. Berry
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Teratology written by C.L. Berry and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
In the fifteen years since the thalidomide disaster teratology has become a science in its own right, distinct from its progenitors, experimental embryology and develop mental biology, but bearing many of the familiar features of both parents. In this growth period there have been contributions from many different scientific disciplines as diverse as molecular biology and obstetrics, which have united in the field of study of congenital malformations. Scientists in academic departments, government research institutes and industrial pharmacology have all explored ways of evaluating the potential of drugs and chem icals to damage the embryo; strict methods of screening for teratogenicity have be come mandatory in most parts of the world. Despite a wealth of basic information in the fields of genetics and embryology, there is little concrete knowledge of the causal mechanisms of malformation in Man, and even less concerning the relevance to Man of those laboratory and animal tests which decide the fate of potentially useful drugs. It is timely, therefore, that in 1975 a group of young and active sci entists and clinicians concerned with the broader implications of teratology should review the past and look to the future of this emerging speciality. In this volume the editors have blended the opinions of teratologists; their message presages change in many of the old and accepted areas of investigative teratology.
Issues And Reviews In Teratology
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Author : Harold Kalter
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Issues And Reviews In Teratology written by Harold Kalter and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Teratology is at once among the oldest and youngest of human preoccupations. Coincident with man's first observations of the stars were his recordings of human and animal deformities. But, such aberrancies must have occurred even earlier, for although it is one of those things-like evolution-that cannot be proven, it is nevertheless indisputable that dysmorphogenesis must have occurred from the time complex forms of life first arose on our planet; and that from the beginnings of human awareness our species was conscious of such happenings. From the earliest recordings of this fascination with the form and meaning of abnormality a tortuous but continuous line extends to modern struggles to understand and control these manifestations. And now, after long occupying an honorable but peripheral place in the halls of philosophical and scientific pursuits, teratology has quite suddenly come to take a prominent position at the hub of a complex crossroads of human concerns. This shift in its fortune has taken several forms. Fetal maldevelopment has become the concern of environmentalists, activists of various persuasions, indus trial organizations, government agencies, ethicists, parents-i. e. , individuals and groups whose actions are impelled by apprehension. Such motives are of course not without basis; the trauma of thalidomide left a scar yet raw. For still others clinicians, academics, experimentalists-the upsurge in the interest in fetal mal development is at a different level, and their pursuits are broad, taking external agents as but one of the causes of defective development.
Basic Concepts In Teratology
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Author : T. V. N. Persaud
language : en
Publisher: Alan R. Liss
Release Date : 1985
Basic Concepts In Teratology written by T. V. N. Persaud and has been published by Alan R. Liss this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Medical categories.
Issues And Reviews In Teratology
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Author : H. Kalter
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Issues And Reviews In Teratology written by H. Kalter and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Why Efforts to Expand the Meaning of "Teratogen" Are Unacceptable Disagreement about nomenclature in teratology is not new. Dissent even about the very fabric of the discipline-what congenital malformations consist of-has often been voiced. Time, instead of resolving such diffi culties, has sometimes worsened them. For example, in the past it was agreed that congenital malforma tions are abnormalities of structure present at birth, but differences of opinion concerning where the line between normal and abnormal was to be drawn prevailed. It was obvious that, in order to discover the causes of congenital malformations and cast strategies for their prevention, it would be necessary to have knowledge of the baseline of their frequency, and that this required uniformity of definition of terms. Since malfor mations of primary social concern are those having grave outcomes (and are, paradoxically, also the commonest ones), it is logical that such condi tions were the first consideration of investigators and were the defects whose frequency was considered to comprise the required baseline.
Interspecies Comparison In Teratology Testing
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Author : David W. Natella
language : en
Publisher:
Release Date : 1984
Interspecies Comparison In Teratology Testing written by David W. Natella and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Teratogenicity testing categories.
Scientific Rationale For The Selection Of Toxicity Testing Methods
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Author : Michael G. Ryon
language : en
Publisher:
Release Date : 1985
Scientific Rationale For The Selection Of Toxicity Testing Methods written by Michael G. Ryon and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Toxicity testing categories.