Tertiary Lymphoid Structures
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Tertiary Lymphoid Structures
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Author : Marie-Caroline Dieu-Nosjean
language : en
Publisher: Springer Nature
Release Date : 2024-11-11
Tertiary Lymphoid Structures written by Marie-Caroline Dieu-Nosjean and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-11 with Medical categories.
This second edition details new and updated chapters on technologies related to tertiary lymphoid structures( TLS). Chapters guide readers through TLS in cancers, different stages of TLS development, immune function of TLS, molecular, cellular, and imaging methods, and preclinical methods to uncover the function of cells composing TLS in inflammatory situations in humans. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Tertiary Lymphoid Structures: Methods and Protocols, Second Edition aims to guide you through techniques and methods used to study the biology of TLS.
Tertiary Lymphoid Structures From Basic Biology To Translational Impact In Cancer
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Author : Vivek Verma
language : en
Publisher: Frontiers Media SA
Release Date : 2022-04-06
Tertiary Lymphoid Structures From Basic Biology To Translational Impact In Cancer written by Vivek Verma and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-06 with Medical categories.
Tertiary Lymphoid Structures Tls In The Tumor Immune Microenvironment
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Author : Ying Ma
language : en
Publisher: Frontiers Media SA
Release Date : 2025-02-06
Tertiary Lymphoid Structures Tls In The Tumor Immune Microenvironment written by Ying Ma and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-06 with Medical categories.
Cancer has become the most common disease worldwide. With their extremely aggressive nature of growth, many cancer types portend dismal 5-year survival rates. Chemotherapy, as the conventional treatment option, is the mainstay of treatment for these malignancies, and while some patients derive remarkable clinical response, ultimately chemoresistance prevails. This resistance highlights the self-renewal of tumor cells and reflects its notorious capacity to mediate a microenvironment that is tumor protective. Recently, immunotherapy achieved great successes in tumors with abundant lymphocytes influx, such as melanoma and lung cancer. But, none of the immunotherapeutic regimens have been effective in immune-privileged cancers, reflecting an immune suppressive microenvironment that is lack of immune cell infiltration along with the tumor initiation, development, and progression, as known as ‘cold’ tumor.
Inducible Lymphoid Organs
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Author : Kenji Kabashima
language : en
Publisher: Springer Nature
Release Date : 2020-08-17
Inducible Lymphoid Organs written by Kenji Kabashima and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-17 with Medical categories.
This book sheds new light on “inducible” lymphoid organs (ILOs): antigen presentation sites that are generated de novo in peripheral tissues under various pathogenic conditions. Accomplished immunologists demonstrate that the physiological role of these ILOs is completely different from that of central lymphoid organs, i.e., the lymph nodes or spleen. In addition to the central organs, the ILOs are considered essential structures for the efficient elicitation of adaptive immune responses in lesions. The respective chapters highlight examples from multiple sites, e.g. the skin, lung, intestinal tract, genital tract, the synovial membrane of the joints and artificial lymph nodes. Accordingly, readers will learn that ILO structure and function can vary substantially, depending on the context. Presenting the results of the latest immunological research, the book offers a fascinating and insightful read for both scientists and clinicians in the areas of infectious and immune-associated diseases.
Immunopathology In Toxicology And Drug Development
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Author : George A. Parker
language : en
Publisher: Springer
Release Date : 2017-03-28
Immunopathology In Toxicology And Drug Development written by George A. Parker and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-28 with Medical categories.
This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 2, Organ Systems, offers summaries of organ-specific immunobiology and immunopathology as well as common responses to xenobiotics. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.
Tumor Ecosystem
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Author : Erwei Song
language : en
Publisher: Springer Nature
Release Date : 2023-07-20
Tumor Ecosystem written by Erwei Song and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-20 with Medical categories.
This book intends to report new concept of onco-spheres in cancer ecosystem. Onco-spheres are defined as where cancer cells (living organisms) dynamically interact with nontumor cellular (other living organisms) and noncellular components (non-living environmental factors) in the ‘host’ internal environment (habitat) to construct a self-sustainable cancer ecosystem, which can be scoped at three different levels: primary/regional, distal and systemic onco-spheres. Cancer cells should be conceived as ‘living organisms’, interacting with cellular or noncellular components in the host internal environment, not only with the local tumor microenvironment (TME) but also constantly communicating with a distant organ niche as well interacting with the host’s nervous, endocrine and immune systems, to construct a self-sustainable ‘biosphere’, as we termed the tumor ecosystem. By looking at the interaction of cancer and host as a unique ecosystem, we will use ecology principles to further delineate the features of the dynamics of the tumor ecosystem. As the pioneer in proposing this concept, we feel that this full-scale overview of the tumor ecosystem is able to inform the readers about this concept, and to pave the way for designing novel therapeutic strategies on actionable targets within tumor ecosystem. The book is likely to be of interest to immunologist, biologist, medical students, researchers and general public who wish to learn more on this new concept of tumor ecosystem, and how this could be applied in many fields of research.
Therapeutic Mechanism Of Osteosarcoma
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Author : Yang Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2025-04-28
Therapeutic Mechanism Of Osteosarcoma written by Yang Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-28 with Science categories.
Osteosarcoma (OS) is the most common primary bone tumor, with a bimodal age distribution. The highest incidence is in children and adolescents, and the second highest is among older adults (>60 years). Surgery and neoadjuvant chemotherapy are the main clinical treatments for OS, yet the 5-year survival rate is just 20% for individuals with metastases or recurrent OS. Most standard treatments were established in the 1980s, which can achieve long-term survival in approximately 60% of patients with localized OS. However, in the face of inoperable surgery, we are still limited in what we can do for OS patients who are insensitive or intolerant to chemotherapy drugs. Resistance to chemotherapeutic drugs is also a problem that hinders breakthroughs in OS treatment. Although survival rates have not improved during the past four decades, the heterogeneity and potential molecular aberrations of OS have been revealed as the biology of OS has come to be better understood. With the recent advancements in molecular profiling technology for OS, new technologies and concepts are undergoing sublimation.
Wintrobe S Clinical Hematology
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Author : Robert J. Means, Jr.
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2023-05-22
Wintrobe S Clinical Hematology written by Robert J. Means, Jr. and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-22 with Medical categories.
Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.
Immune Responses Against Tumors From The Bench To The Bedside
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Author : Tiezheng Hou
language : en
Publisher: Frontiers Media SA
Release Date : 2024-07-29
Immune Responses Against Tumors From The Bench To The Bedside written by Tiezheng Hou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-29 with Medical categories.
Traditionally, surgery, radiotherapy, chemotherapy and hormonal therapy have been used in clinical practice to treat cancer patients. However, these methods are either not completely tumor free or without collateral damage to health tissues. Therefore, tumor recurrence, partial remission, treatment side effect and poor tolerance in elderly patients, and lack of effective strategy to treat late-stage cancers have been the major hurdles faced by clinicians in health care. Although cancer immunotherapy including checkpoint blockade, CAR-T, oncolytic viruses, and recombinant cytokines has taken center stage in mainstream oncology because of its specifically targeting tumor cells without affecting surrounding normal cells, only a proportion of patients receiving treatment respond and others relapse after an initial response. Different tumor indications respond differently, and even in cancer types that respond, unresponsiveness are still observed. This resistance suggests that either lack of sufficient host recognition and immunity (intrinsic) or active immune suppression by tumor complex (acquired).
Lymphatic System
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Author : Gaia Favero
language : en
Publisher: BoD – Books on Demand
Release Date : 2024-02
Lymphatic System written by Gaia Favero and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02 with Science categories.