Test No 455 Performance Based Test Guideline For Stably Transfected Transactivation In Vitro Assays To Detect Estrogen Receptor Agonists And Antagonists
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Test No 455 Performance Based Test Guideline For Stably Transfected Transactivation In Vitro Assays To Detect Estrogen Receptor Agonists And Antagonists
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2015-07-28
Test No 455 Performance Based Test Guideline For Stably Transfected Transactivation In Vitro Assays To Detect Estrogen Receptor Agonists And Antagonists written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-28 with categories.
This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists and Antagonists (ER TA assays).
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 455 Performance Based Test Guideline For Stably Transfected Transactivation In Vitro Assays To Detect Estrogen Receptor Agonists And Antagonists
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2021-06-17
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 455 Performance Based Test Guideline For Stably Transfected Transactivation In Vitro Assays To Detect Estrogen Receptor Agonists And Antagonists written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-17 with categories.
This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists and Antagonists (ER TA assays).
Animal Models In Research
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Author : Harikrishnan Vijayakumar Sreelatha
language : en
Publisher: Springer Nature
Release Date : 2024-04-03
Animal Models In Research written by Harikrishnan Vijayakumar Sreelatha and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-03 with Medical categories.
This book describes the development of animal models widely used in biomedical research using step-wise instructions and photographs. Showcasing a wide range of species from zebra fishes, birds, rodents, rabbits, dogs, and pigs, the book includes detailed methodology on how to work with these species and to develop various models. The animal models in neurology including stroke, Alzheimer’s disease, Parkinson’s disease, and Schizophrenia; Animal models in cancer research, sleep disorders, and cardiovascular diseases are described to meet the understanding of researchers who plan to replicate these models in their laboratories. In depth detailing on the development of targeted gene knockouts and transgenics, implantation models that are used in toxicology studies, and pharmacokinetic studies in pigs and dogs are a highlight. Further, the book describes pharmacologic, chemically induced, surgically induced, microbiologically induced, infectious models, models for neurobehavioral studies, oncology research, and pain research. The book has dedicated sections on anesthesia and analgesia and teaches procedures like venous cut-downs and cannulations in pigs and dogs, and endotracheal intubation, mechanical ventilation and thoracotomy in rodents and will serve as a self-training tool. Concepts in the field of animal model development are explained using examples. Sample size selection, study design, and statistical evaluation of experiments involving laboratory animals are explained to enable young researchers to practically understand the nuances. This book will be a valuable tool for academicians, students, scientists, and veterinarians and will benefit equally who are new to the field and who are already working with laboratory animals.
Handbook Of Cosmetic Science And Technology
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Author : Frank Dreher
language : en
Publisher: CRC Press
Release Date : 2022-08-11
Handbook Of Cosmetic Science And Technology written by Frank Dreher and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-11 with Medical categories.
With chapters from experienced and internationally renowned contributors holding positions in research, industry, and clinical practice, this is the fifth edition of what has become the standard reference for cosmetic scientists and dermatologists seeking the latest innovations and technology for the formulation, design, testing, use, and production of cosmetic products for the skin. *Offers in-depth analysis of specific topics in cosmetic science and research *Presents the latest in international research and its translation to practice *Gives an indispensable guide to a hotly competitive area for research and practice
A Handbook Of Environmental Toxicology
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Author : J.P.F. D'Mello
language : en
Publisher: CABI
Release Date : 2019-12-04
A Handbook Of Environmental Toxicology written by J.P.F. D'Mello and has been published by CABI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-04 with Science categories.
Written by an international team of authors from a range of educational, medical and research establishments, this book is an essential reference for advanced students and researchers in the areas of environmental sciences, ecology, agriculture, environmental health and medicine, in addition to industry and government personnel responsible for environmental regulations and directives. A Handbook of Environmental Toxicology focuses on two key aspects: human disorders and ecotoxicology as affected by major toxins originating from biological sources and pollutants, as well as radiation generated spontaneously or as a result of anthropogenic activity. A diverse array of these potentially harmful agents regularly appear in the atmosphere, soil, water and food, compromising both human health and biodiversity in natural and managed ecosystems.
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 250 Easzy Assay Detection Of Endocrine Active Substances Acting Through Estrogen Receptors Using Transgenic Tg Cyp19a1b Gfp Zebrafish Embryos
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2021-06-17
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 250 Easzy Assay Detection Of Endocrine Active Substances Acting Through Estrogen Receptors Using Transgenic Tg Cyp19a1b Gfp Zebrafish Embryos written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-17 with categories.
The EASZY assay is a mechanism-based in vivo screening assay designed to detect endocrine active chemicals acting as agonist through estrogen receptors (ERs), by inducing the expression of the green fluorescent protein (GFP) driven by the cyp19a1b promoter. The EASZY assay allows for the detection of estrogenic activity of chemicals on transgenic tg(cyp19a1b:GFP) Zebrafish embryos exposed for 96 hours during the embryonic stages of development.
Oecd Series On Testing And Assessment Guidance Document On Good In Vitro Method Practices Givimp
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2018-12-10
Oecd Series On Testing And Assessment Guidance Document On Good In Vitro Method Practices Givimp written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-10 with categories.
In the past several decades, there has been a substantial increase in the availability of in vitro test methods for evaluating chemical safety in an international regulatory context. To foster confidence in in vitro alternatives to animal testing, the test methods and conditions under which ...
In Vitro Environmental Toxicology Concepts Application And Assessment
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Author : Georg Reifferscheid
language : en
Publisher: Springer
Release Date : 2017-05-16
In Vitro Environmental Toxicology Concepts Application And Assessment written by Georg Reifferscheid and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-16 with Science categories.
This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science.Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification.In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.
Hayes Principles And Methods Of Toxicology
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Author : A. Wallace Hayes
language : en
Publisher: CRC Press
Release Date : 2014-10-10
Hayes Principles And Methods Of Toxicology written by A. Wallace Hayes and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-10 with Medical categories.
Hayes' Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chap
Adverse Effects Of Engineered Nanomaterials
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Author : Bengt Fadeel
language : en
Publisher: Academic Press
Release Date : 2017-02-14
Adverse Effects Of Engineered Nanomaterials written by Bengt Fadeel and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-14 with Medical categories.
Adverse Effects of Engineered Nanomaterials: Exposure, Toxicology, and Impact on Human Health, Second Edition, provides a systematic evaluation of representative engineered nanomaterials (ENM) of high volume production and their high economic importance. Each class of nanomaterials discussed includes information on what scientists, industry, regulatory agencies, and the general public need to know about nanosafety. Written by leading international experts in nanotoxicology and nanomedicine, this book gives a comprehensive view of the health impact of ENM, focusing on their potential adverse effects in exposed workers, consumers, and patients. All chapters have been updated with new sections on the endocrine system and other organ systems. In addition, other newly added sections include introductory chapters on the physio-chemical characterization of nanomaterials and interactions between nanomaterials and biological systems, as well as a new chapter that explores risk assessment and management of nanomaterials. This book fills an important need in terms of bridging the gap between experimental findings and human exposure to ENM, also detailing the clinical and pathological consequences of such exposure in the human population. - Uses a schematic, non-exhaustive approach to summarizes the most important research data in this field - Discusses the health implications of experimental data in nanotoxicology - Presents a completely revised edition that focuses on the human health impacts of engineered nanomaterials, including many organ-specific chapters