Thalassemia Syndromes
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The Thalassaemia Syndromes
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Author : David J. Weatherall
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-30
The Thalassaemia Syndromes written by David J. Weatherall and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Medical categories.
In the new edition of this successful and authoritative book, the thalassaemias are reviewed in detail with respect to their clinical features, cellular pathology, molecular genetics, prevention and treatment. It is aimed at specialists in haematology in the laboratory or clinical setting, particularly in areas where thalassaemia is common either in the native population or in immigrant communities. The fourth edition has been both updated and re-organized. Three new chapters have been added on the link between alpha-thalassaemia and mental retardation, on avoidance and population control and on global epidemiology. Considerable emphasis is placed on molecular pathology reflecting the huge burst of information to have come out of this field in the last few years.
The Thalassaemia Syndromes
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Author : D. J. Weatherall
language : en
Publisher:
Release Date : 1965
The Thalassaemia Syndromes written by D. J. Weatherall and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1965 with Thalassemia categories.
Fast Facts Thalassemia Syndromes
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Author : Ali T. Taher
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2023-07-31
Fast Facts Thalassemia Syndromes written by Ali T. Taher and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-31 with Medical categories.
'Fast Facts: Thalassemia Syndromes' provides a concise, comprehensive introduction to the thalassemia syndromes and current approaches to treating them and their associated morbidities. It also offers an insight into some of the novel therapies that are currently in clinical trials or that have recently been approved, which have the potential to transform the lives of patients with thalassemia.
Molecular Genetics Of Thalassemia Syndromes
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Author : Reena Das
language : en
Publisher: Biota Publishing
Release Date : 2016-08-01
Molecular Genetics Of Thalassemia Syndromes written by Reena Das and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-01 with Science categories.
This book reviews the molecular genetics of the thalassemia syndromes, inherited hemoglobin disorders that comprise the commonest monogenic disorders globally. Thalassemias are found in high frequencies in tropical regions corresponding to the malaria belt. Beta thalassemia traits show high HbA2 by HPLC, and β-globin mutations (commonly point mutations) are detected by using ARMS-PCR, reverse dot-blot analysis and β-globin gene sequencing. Globally >300 β globin gene mutations exist, however regional mutations are limited to 5-6 common ones. Alpha globin gene defects can only be identified by molecular tests, the exception being HbH disease that shows "golf ball" appearance in HbH preparation, pre-integration peaks on HPLC and a fast-moving band on hemoglobin electrophoresis. Multiplex Gap-PCR identifies common α-globin gene deletions. Specific PCR across the junction caused by the unequal crossing over can detect α-gene triplication. However, heterozygosity or homozygous triplication cannot be resolved by this technique. Non-deletional α-thalassemia can be characterized by specific α-globin gene sequencing. Identification of unusual deletions requires Multiplex Ligation-dependent Probe Amplification. In conclusion, the molecular characterization of human globin gene disorders is required to resolve the phenotypically heterogeneous thalassemia syndromes. Molecular analysis is also an important tool to prevent these disorders by offering prenatal screening in regions with a high disease burden.
The Thalassaemia Syndromes
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Author : David John Weatherall
language : en
Publisher:
Release Date : 1972
The Thalassaemia Syndromes written by David John Weatherall and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1972 with Thalassemia categories.
In the new edition of this successful and authoritative book, the thalassaemias are reviewed in detail with respect to their clinical features, cellular pathology, molecular genetics, prevention and treatment. It is aimed at specialists in haematology in the laboratory or clinical setting, particularly in areas where thalassaemia is common either in the native population or in immigrant communities. The fourth edition has been both updated and re-organized. Three new chapters have been added on the link between alpha-thalassaemia and mental retardation, on avoidance and population control and on global epidemiology. Considerable emphasis is placed on molecular pathology reflecting the huge burst of information to have come out of this field in the last few years.
Thalassemia Syndromes
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Author : Marwa Zakaria
language : en
Publisher: BoD – Books on Demand
Release Date : 2023-11-22
Thalassemia Syndromes written by Marwa Zakaria and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-22 with Medical categories.
The thalassemia syndromes are a diverse group of hereditary anemias caused by decreased or absent production of one type of globin chain. Genetic counseling, prenatal diagnosis, and newborn screening are all issues of importance in these inherited disorders. This book provides a comprehensive overview of thalassemia, including information on its mechanisms and treatment modalities. Chapters elucidate the mechanism of disordered synthesis of hemoglobin in thalassemia and present recent studies of the genetic mechanisms that underlie this abnormal biosynthetic process.
Conference On Hemoglobin 2 3 May 1957
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Author : National Research The Division of Medical Sciences the National Heart Institute National Institutes of Health
language : en
Publisher: National Academies
Release Date : 1958
Conference On Hemoglobin 2 3 May 1957 written by National Research The Division of Medical Sciences the National Heart Institute National Institutes of Health and has been published by National Academies this book supported file pdf, txt, epub, kindle and other format this book has been release on 1958 with Hemoglobin categories.
Thalassemia
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Author : Bernard G. Forget
language : en
Publisher: Clinics: Internal Medicine
Release Date : 2010
Thalassemia written by Bernard G. Forget and has been published by Clinics: Internal Medicine this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
Thalassemia is discussed comprehensively by the authors in this issue.' Topics discussed include the population genetics and dynamimcs of thalassemia, alpha thalassemia, HbE/beta thalassemia, management of iron overload in thalassemia syndromes, allogeneic cellular gene therapy for hemoglobinopathies, cord blood transplantation for beta thalassemia major, and gene therapy for hemoglobin disorders.
Thalassemia An Issue Of Hematology Oncology Clinics Of North America E Book
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Author : Edward J. BenzJr
language : en
Publisher: Elsevier Health Sciences
Release Date : 2023-03-16
Thalassemia An Issue Of Hematology Oncology Clinics Of North America E Book written by Edward J. BenzJr and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-16 with Medical categories.
In this issue of Hematology/Oncology Clinics, guest editors Drs. Edward J. Benz, Jr. and Vijay G. Sankaran bring their considerable expertise to the topic of Thalassemia. Top experts in the field provide an overview of the history, epidemiology, pathogenic mechanisms, and clinical management of the thalassemia syndromes. Contains 16 practice-oriented topics including molecular basis and genetic modifiers of thalassemia; fetal hemoglobin in thalassemia; clinical complications and their management; iron chelation in thalassemia; fertility and pregnancy in women with transfusion-dependent thalassemia; gene therapy and genome editing in thalassemia; emerging medical therapies for thalassemia; and more. Provides in-depth clinical reviews on thalassemia, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Guidelines For The Clinical Management Of Thalassaemia
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Author : Maria-Domenica Cappellini
language : en
Publisher:
Release Date : 2008
Guidelines For The Clinical Management Of Thalassaemia written by Maria-Domenica Cappellini and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.