The Centrosome And Its Functions And Dysfunctions
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The Centrosome And Its Functions And Dysfunctions
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Author : Heide Schatten
language : en
Publisher:
Release Date : 2022
The Centrosome And Its Functions And Dysfunctions written by Heide Schatten and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
The book provides a comprehensive overview of classic and modern approaches of centrosome research, including new aspects of centrosome functions focusing on primary cilia and their implications in numerous diseases. In addition, several chapters raise awareness of centrosomes in areas that have not yet fully considered the centrosome as an organelle that impacts other organelle functions directly or indirectly. It further relates centrosome functions to other research areas such as aging and stem cell research. Since its discovery almost 150 years ago the centrosome is increasingly being recognized as a most impactful organelle for its role, not only as primary microtubule organizing center (MTOC) but also as a major communication center for signal transduction pathways and as a center for proteolytic activities. Its significance for cell cycle regulation has been well studied and we now also know that centrosome dysfunctions are implicated in numerous diseases and disorders including cancer, cystic diseases of the kidney, liver fibrosis, cardiac defects, obesity and several other diseases and disorders. This new volume reviews the latest advances in the field and provides valuable background information that is readily understandable for the newcomer and the experienced centrosome researcher alike. Due to the interdisciplinary of the subject, it is a valuable resource for researchers and clinicians working in biomedical research, cell biology, cancer biology, reproduction and developmental biology, neuroscience and stem cell research. .
The Centrosome
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Author :
language : en
Publisher:
Release Date : 2012
The Centrosome written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
The Centrosome
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Author : Heide Schatten
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-07-13
The Centrosome written by Heide Schatten and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-13 with Science categories.
The Centrosome: Cell and Molecular Mechanisms of Functions and Dysfunctions in Disease includes chapters on classic and modern aspects of centrosome research to cover topics of current interest that have not been covered in depth in most books on the market so far. It extends on previous topics and includes new exciting aspects of centrosome research focused on primary cilia and their dysfunctions that are implicated in numerous diseases. Each chapter will be written by experts in their fields who will contribute their unique expertise in specific research fields and include cell and molecular details that are important for the specific subtopics. The book will be comprehensive, concise and will include reviews of key topics in the field. Cutting edge new information will be balanced with background information that will be readily understandable for the newcomer and the experienced centrosome researcher alike.
The Centrosome And Its Functions And Dysfunctions
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Author : Heide Schatten
language : en
Publisher: Springer Nature
Release Date : 2022-12-16
The Centrosome And Its Functions And Dysfunctions written by Heide Schatten and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-16 with Science categories.
The book provides a comprehensive overview of classic and modern approaches of centrosome research, including new aspects of centrosome functions focusing on primary cilia and their implications in numerous diseases. In addition, several chapters raise awareness of centrosomes in areas that have not yet fully considered the centrosome as an organelle that impacts other organelle functions directly or indirectly. It further relates centrosome functions to other research areas such as aging and stem cell research. Since its discovery almost 150 years ago the centrosome is increasingly being recognized as a most impactful organelle for its role, not only as primary microtubule organizing center (MTOC) but also as a major communication center for signal transduction pathways and as a center for proteolytic activities. Its significance for cell cycle regulation has been well studied and we now also know that centrosome dysfunctions are implicated in numerous diseases and disorders including cancer, cystic diseases of the kidney, liver fibrosis, cardiac defects, obesity and several other diseases and disorders. This new volume reviews the latest advances in the field and provides valuable background information that is readily understandable for the newcomer and the experienced centrosome researcher alike. Due to the interdisciplinary of the subject, it is a valuable resource for researchers and clinicians working in biomedical research, cell biology, cancer biology, reproduction and developmental biology, neuroscience and stem cell research.
Cell Division Machinery And Disease
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Author : Monica Gotta
language : en
Publisher: Springer
Release Date : 2017-06-09
Cell Division Machinery And Disease written by Monica Gotta and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-09 with Science categories.
This book critically evaluates the causal link between cell division machinery and disease. Further, it identifies key open questions in the field and the means for exploring them. Throughout the various chapters, internationally known contributors present the evidence for and against a causal link between key elements of the cell division machinery and diseases such as cancer, neuropathologies, aging, and infertility. A more clinically oriented chapter further discusses the current and future applications of anti-mitotic drugs in these diseases. Cell Division Machinery and Disease is essential reading for graduate or advanced graduate students, researchers or scientists working on cell division as well as clinicians interested in the molecular mechanisms of the discussed diseases.
The Golgi Apparatus And Centriole
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Author : Malgorzata Kloc
language : en
Publisher: Springer
Release Date : 2020-09-04
The Golgi Apparatus And Centriole written by Malgorzata Kloc and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-04 with Science categories.
This volume takes a closer look how the cell organelles Golgi apparatus (also known as the Golgi complex or Golgi body), and centriole are structurally and functionally intertwined. Initially, it was believed that the role of Golgi complex is limited to the packaging and preparation for secretion of various cellular proteins, while the centriole participates in cell division and cilia formation. However, since their discovery nearly 200 years ago, it became clear that these two organelles are interacting, and that their functions are much more complex and far reaching than previously thought. Recent findings indicate that the Golgi–Centriole relationship may be important for directional protein transport, cell polarization and cell cycle progression. Current studies indicate that Golgi and centriole also participate in development and act as cellular and immunological sensors, and that their abnormalities lead to cell and developmental abnormalities, Alzheimer, cancer, various lipid disorders and neurological and immunological diseases in humans. This volume combines the latest information on the structure, molecular composition, and roles of Golgi and centriole in various cellular functions and diseases. The better understanding of the Golgi–centriole interactions may lead to the development of novel therapies for the treatment of various diseases, including cancer.
Centrosome And Centriole
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Author :
language : en
Publisher: Academic Press
Release Date : 2015-09-10
Centrosome And Centriole written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-10 with Science categories.
This new volume of Methods in Cell Biology looks at methods for analyzing centrosomes and centrioles. Chapters cover such topics as methods to analyze centrosomes, centriole biogenesis and function in multi-ciliated cells, laser manipulation of centrosomes or CLEM, analysis of centrosomes in human cancers and tissues, proximity interaction techniques to study centrosomes, and genome engineering for creating conditional alleles in human cells. Covers sections on model systems and functional studies, imaging-based approaches and emerging studies Chapters are written by experts in the field Cutting-edge material
The Cytoskeleton In Health And Disease
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Author : Heide Schatten
language : en
Publisher: Springer
Release Date : 2015-08-21
The Cytoskeleton In Health And Disease written by Heide Schatten and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-21 with Science categories.
This volume addresses the structural and functional roles of the cytoskeleton and its dysfunctions which often lead to disease. It provides thorough discussion of microtubules, microfilaments, intermediate filaments, and cytoskeletal functions and dysfunctions in different organ systems. Comprehensive yet concise. The Cytoskeleton In Health And Disease presents cutting-edge discoveries balanced with background information and highlights the new aspects of the research and its impact on the design of new strategies or the identification of new targets for therapeutic intervention. There is a significant need for a book on this topic, as interest in the cytoskeleton continues to grow as causes and cures for cytoskeletal diseases are further explored in biomedical research. This book is essential reading for scientists, students, and teachers interested in expanding their knowledge related to the cytoskeleton. New researchers entering the field will find classic and well as contemporary information not easily found in the current literature or internet resources.
The Microtubule Cytoskeleton
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Author : Jens Lüders
language : en
Publisher: Springer
Release Date : 2016-04-08
The Microtubule Cytoskeleton written by Jens Lüders and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-08 with Science categories.
This book provides an overview on the organization and function of the microtubule cytoskeleton, which is essential to many cellular processes and profoundly linked to a range of human diseases. Covering basic concepts as well as molecular details, the book discusses how microtubules are nucleated and organized into ordered arrays, at different cell cycle stages and in distinct cell types. In addition, the book highlights how defects in the microtubule cytoskeleton are linked to diseases such as neurodevelopmental disorders. The book is intended for students, graduates and more senior researchers in cell and developmental biology as well as for medical doctors.
Factors Affecting Neurological Aging
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Author : Colin R Martin
language : en
Publisher: Academic Press
Release Date : 2021-06-01
Factors Affecting Neurological Aging written by Colin R Martin and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-01 with Psychology categories.
Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. Finally, this comprehensive resource examines the use of animal modeling of aging and neurological disease. Provides the most comprehensive coverage on a broad range of topics related to the neuroscience of aging Features sections on the genetic components that influence aging and diseases of aging Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations Includes more than 500 illustrations and tables