The Crf Signal

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The Crf Signal

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Author : Jay Schulkin
language : en
Publisher: Oxford University Press
Release Date : 2017

The Crf Signal written by Jay Schulkin and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Medical categories.

"Information molecules such as corticotropin-releasing factor (CRF) are ancient and widely distributed across diverse organs. The scientific community is beginning to realize that CRF is a dynamic and diversely widespread peptide hormone (e.g. placenta) with many functions (parturtion, metamorphosis, circadian rhythmicity) beyond acting as a releasing factor in the brain. Indeed, CRF has been associated with a range of states of the brain, including fear and anxiety, social contact, and incentive salence and addiction. Examining the evolutionary origins of CRF, its diverse endocrine and neural functions, this book provides insights into CRF that will be of interest to students and researchers in the biological, medical and behavioral sciences."--Page 4 of cover.

Amyloid And Related Disorders

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Author : Maria M. Picken MD, PhD, FASN
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-04-03

Amyloid And Related Disorders written by Maria M. Picken MD, PhD, FASN and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-03 with Medical categories.

Abnormal proteins are known to be associated with various pathologies. Most notably, these include amyloidoses, monoclonal protein deposits associated with plasma cell dyscrasia/multiple myeloma, cryoglobulins and various related organized and non-organized deposits. Amyloid and Related Disorders presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue and bone marrow pathology is covered. This approach provides a unifying concept of these pathologic processes, which have systemic involvement, and which have, hitherto, not been universally appreciated. Awareness of these diseases among a wider audience of pathologists may increase the rate of their diagnosis as well as that of earlier diagnosis. This volume will be invaluable to specialized and general pathologists as well as cytopathologists; other medical professionals may also benefit from this concise update on the systemic amyloidoses.

Modelling Biomedical Signals

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Author : Giuseppe Nardulli
language : en
Publisher: World Scientific
Release Date : 2002-05-24

Modelling Biomedical Signals written by Giuseppe Nardulli and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-05-24 with Technology & Engineering categories.

In the last few years, concepts and methodologies initially developed in physics have found high applicability in many different areas. This book, a result of cross-disciplinary interaction among physicists, biologists and physicians, covers several topics where methods and approaches rooted in physics are successfully applied to analyze and to model biomedical data. Included are papers on physiological rhythms and synchronization phenomena, gene expression patterns, the immune system, decision support systems in medical science, protein folding and protein crystallography. The volume can be used as a valuable reference for graduate students and researchers at the interface of physics, biology and medicine.The proceedings have been selected for coverage in:• Index to Scientific & Technical Proceedings (ISTP CDROM version / ISI Proceedings)

Trafficking Of Gpcrs

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Author : Guangyu Wu
language : en
Publisher: Academic Press
Release Date : 2015-06-05

Trafficking Of Gpcrs written by Guangyu Wu and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-05 with Science categories.

G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell surface receptors that regulate a variety of cell functions. Over the past few decades great progress has been made in defining the roles of intracellular trafficking in controlling the functionality of the receptors as well as in the development of various human diseases. This volume of Progress in Molecular Biology and Translational Science reviews the recent understanding of GPCR trafficking regulators and molecular mechanisms. - Written by future leaders in the pain field - Covers a wide range of targets - Contains provocative ideas about GPCR trafficking

Metabolism And Behavior In The Corticotropin Releasing Factor Family Of Peptides

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Author : James A. Carr
language : en
Publisher: Frontiers Media SA
Release Date : 2015-08-03

Metabolism And Behavior In The Corticotropin Releasing Factor Family Of Peptides written by James A. Carr and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-03 with Corticotropin releasing hormone categories.

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Hormone Action And Signal Transduction In Endocrine Physiology And Disease

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Author : László Hunyady
language : en
Publisher: Frontiers Media SA
Release Date : 2020-10-30

Hormone Action And Signal Transduction In Endocrine Physiology And Disease written by László Hunyady and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-30 with Medical categories.

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Sensing The Environment Regulation Of Local And Global Homeostasis By The Skin S Neuroendocrine System

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Author : Andrzej T. Slominski
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-02

Sensing The Environment Regulation Of Local And Global Homeostasis By The Skin S Neuroendocrine System written by Andrzej T. Slominski and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-02 with Medical categories.

The skin, the body’s largest organ, is strategically located at the interface with the external environment where it detects, integrates and responds to a diverse range of stressors, including solar radiation. It has already been established that the skin is an important peripheral neuroendocrine-immune organ that is closely networked with central regulatory systems. These capabilities contribute to the maintenance of peripheral homeostasis. Specifically, epidermal and dermal cells produce and respond to classical stress neurotransmitters, neuropeptides and hormones, production which is stimulated by ultraviolet radiation (UVR), biological factors (infectious and non-infectious) and other physical and chemical agents. Examples of local biologically active products are cytokines, biogenic amines (catecholamines, histamine, serotonin and N-acetyl-serotonin), melatonin, acetylocholine, neuropeptides including pituitary (proopiomelanocortin-derived ACTH, b-endorphin or MSH peptides, thyroid stimulating hormone) and hypothalamic (corticotropin-releasing factor and related urocortins, thyroid-releasing hormone) hormones, as well as enkephalins and dynorphins, thyroid hormones, steroids (glucocorticoids, mineralocorticoids, sex hormones, 7-δ steroids), secosteroids, opioids and endocannabinoids. The production of these molecules is hierarchical, organized along the algorithms of classical neuroendocrine axes such as the hypothalamic pituitary adrenal axis (HPA), hypothalamic-thyroid axis (HPT), serotoninergic, melatoninergic, catecholaminergic, cholinergic, steroid/secosteroidogenic, opioid and endocannabinoid systems. Disruptions of these axes or of communication between them may lead to skin and/or systemic diseases. These local neuroendocrine networks also serve to limit the effect of noxious environmental agents to preserve local and consequently global homeostasis. Moreover, the skin-derived factors/systems can also activate cutaneous nerve endings to alert the brain to changes in the epidermal or dermal environments, or alternatively to activate other coordinating centers by direct (spinal cord) neurotransmission without brain involvement. Furthermore, rapid and reciprocal communications between epidermal and dermal and adnexal compartments are also mediated by neurotransmission including antidromic modes of conduction. Lastly, skin cells and the skin as an organ coordinate and/or regulate not only peripheral but also global homeostasis.

Hormonal Signaling In Biology And Medicine

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Author : Gerald Litwack
language : en
Publisher: Academic Press
Release Date : 2019-10-24

Hormonal Signaling In Biology And Medicine written by Gerald Litwack and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-24 with Medical categories.

Hormonal Signaling in Biology and Medicine: Comprehensive Modern Endocrinology covers the endocrine secretions produced by every organ. This extensive collection of knowledge is organized by tissue, addressing how certain hormones are synthesized in multiple tissues, along with their structure, function and pathways, which are very applicable for researchers in drug design who need to focus on a specific step along the pathway. This is a must have reference for researchers in endocrinology and practicing endocrinologists, but it is also ideal for biochemists, pharmacologists, biologists and students. - Serves as a valuable desk reference for researchers - Provides information on the structure of a given hormone, its receptor(s), and the pathways that become activated - Includes extensive citations to the literature that will enable the reader to dig more deeply into the effects of a given hormone

G Protein Coupled Receptor Dimers

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Author : Katharine Herrick-Davis
language : en
Publisher: Springer
Release Date : 2017-08-31

G Protein Coupled Receptor Dimers written by Katharine Herrick-Davis and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-31 with Medical categories.

G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses. They dimerize (form a pair of macromolecules) with a wide variety of other receptors. The proposed book will provide a comprehensive overview of GPCR dimers, starting with a historical perspective and including, basic information about the different dimers, how they synthesize, their signaling properties, and the many diverse physiological processes in which they are involved. In addition to presenting information about healthy GPCR dimer activity, the book will also include a section on their pathology and therapeutic potentials.

The Brain As A Drug Target

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Author : Shafiqur Rahman
language : en
Publisher: Academic Press
Release Date : 2011-01-12

The Brain As A Drug Target written by Shafiqur Rahman and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-12 with Business & Economics categories.

The brain is protected by the blood-brain barrier and this barrier prevents many drugs from entering the brain. This volume discusses various drug delivery and targeting strategies that are being developed to enhance the transport and distribution of drugs into the brain. Discusses new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields