The Delivery Of Biologicals Across Endosomal Membranes By Ph Responsive Polymers
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The Delivery Of Biologicals Across Endosomal Membranes By Ph Responsive Polymers
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Author : Franziska Hausig-Punke
language : de
Publisher:
Release Date : 2023*
The Delivery Of Biologicals Across Endosomal Membranes By Ph Responsive Polymers written by Franziska Hausig-Punke and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023* with categories.
The efficient and safe delivery of complex biological agents offers great potential for the challenges of our time. Polymers offer considerable advantages in this regard, not only because of their low risk for immunogenic reactions, their comparatively inexpensive large-scale production and their long shelf life. The biological properties of organisms, organs, tissues and cells determine the design of safe and efficient delivery systems and should be considered as inspiration for new attempts to create effective materials. In addition to the balance between hydrophobicity and hydrophilicity, the degree of charge of a nanocarrier is also critical for efficient delivery and overcoming the endosome. Cationic charges do not only enhance cellular uptake but can also mediate a crossing of the endosomal barrier due to membrane interactions. The introduction of hydrophobic or even lipophilic components can further significantly increase membrane interactions. Besides the interaction with the cell membrane, it is important to consider that both the degree of charge and the hydrophobic-hydrophilic balance also affect the packaging and protection of sensitive biological cargo such as genetic material. However, cationic charges and hydrophobic components introduce some disadvantages, as electrostatic and hydrophobic interactions may disrupt the integrity of other cellular membranes, triggering toxic effects. Fine adjustment of the degree of charge and the hydrophobic-hydrophilic balance offer the possibility of balancing the requirements for a safe, yet efficient delivery process. In the present dissertation, various polymer systems with adjustable charge density and hydrophobic-hydrophilic balance were investigated with respect to their delivery efficiencies. A particular focus was set on the key step in delivery, the endosomal release.
Ph Responsive Polymers For Nucleic Acid And Vaccine Delivery
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Author : David James Peeler
language : en
Publisher:
Release Date : 2019
Ph Responsive Polymers For Nucleic Acid And Vaccine Delivery written by David James Peeler and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Biomacromolecules such as nucleic acids and peptides have great potential as therapeutics but must overcome many challenging biological barriers to succeed in the clinic. In this work, we present several investigations of stimulus-responsive polymers developed to navigate both extracellular and intracellular barriers to biologic drug delivery. We begin with a review of past applications of pH-responsive chemistries in nucleic acid delivery (Chapter 1). After screening a panel of lytic peptides in a pH-sensitive polymer conjugate system that mediates endosomal escape of plasmid cargo (Chapter 2), we evaluate the most promising gene delivery vector in a mouse model of traumatic brain injury (Chapter 3). Our efforts to develop engineered stem cells transplants as alternatives to gene delivery are then discussed (Chapter 4). Finally, we adapt our pH-responsive polymer for the delivery of peptide vaccine cargo (Chapter 5) and detail future directions to further improve antigen and adjuvant delivery with polymers (Chapter 6).
Biomaterials Science
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Author : William R Wagner
language : en
Publisher: Academic Press
Release Date : 2020-05-23
Biomaterials Science written by William R Wagner and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-23 with Medical categories.
The revised edition of the renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science from principles to applications. Biomaterials Science, fourth edition, provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine.This new edition incorporates key updates to reflect the latest relevant research in the field, particularly in the applications section, which includes the latest in topics such as nanotechnology, robotic implantation, and biomaterials utilized in cancer research detection and therapy. Other additions include regenerative engineering, 3D printing, personalized medicine and organs on a chip. Translation from the lab to commercial products is emphasized with new content dedicated to medical device development, global issues related to translation, and issues of quality assurance and reimbursement. In response to customer feedback, the new edition also features consolidation of redundant material to ensure clarity and focus. Biomaterials Science, 4th edition is an important update to the best-selling text, vital to the biomaterials’ community. The most comprehensive coverage of principles and applications of all classes of biomaterials Edited and contributed by the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials Fully revised and updated to address issues of translation, nanotechnology, additive manufacturing, organs on chip, precision medicine and much more. Online chapter exercises available for most chapters
Nanomedicine And Tissue Engineering
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Author : Nandakumar Kalarikkal
language : en
Publisher: CRC Press
Release Date : 2016-03-30
Nanomedicine And Tissue Engineering written by Nandakumar Kalarikkal and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-30 with Medical categories.
This book focuses on the recent advances in nanomedicine and tissue engineering. It outlines the basic tools and novel approaches that are becoming available in nanomedicine and tissue engineering and considers the full range of nanomedical applications which employ molecular nanotechnology inside the human body, from the perspective of a future pr
Molecular Regulation Of Endocytosis
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Author : Brian Ceresa
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-07-06
Molecular Regulation Of Endocytosis written by Brian Ceresa and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-06 with Science categories.
Molecular Regulation of Endocytosis is a compilation of scientific "short stories" about the entry of external substances into cells. As one can see from the chapters, endocytosis regulates diverse processes such as homeostasis of the cell, signal transduction, entry of pathogens and viruses. In addition to the experimental techniques embedded in each chapter, entire chapters are dedicated to experimental approaches that will be useful to all scientists and their model systems. For those more clinically oriented, the final chapters look to the future and ways of utilizing endocytic pathways for therapeutic purposes.
Bioresponsive Polymers
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Author : Deepa H. Patel
language : en
Publisher: CRC Press
Release Date : 2020-10-08
Bioresponsive Polymers written by Deepa H. Patel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-08 with Science categories.
This volume, Bioresponsive Polymers: Design and Application in Drug Delivery, focuses on recent advancements in bioresponsive polymers and their design, characterization, and applications in varied fields, such as drug delivery and gene delivery. It looks at several carriers for drug delivery and biological molecules using different bioresponsive polymers. To address the many difficulties in existing dosage forms, this book provides information on recent developments to overcome drawbacks of conventional forms of the drug delivery. The chapters cover most areas of bioresponsive polymers, starting with a basic introduction to bioresponsive polymers, followed by chapters on design, characterization, and mechanism of bioresponsive polymers; and applications of drug and gene delivery using bioresponsive polymers via oral, topical, nasal, ocular, and parenteral methods. The book also reviews recent advancements in bioresponsive polymers and advanced applications, such as engineering particulate moieties, biomedical applications, hydrogels as emerging therapy, and electrochemical responses, bioresponsive nanoparticles, and bioresponsive hydrogels.
Comprehensive Biomaterials
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Author : Paul Ducheyne
language : en
Publisher: Elsevier
Release Date : 2015-08-28
Comprehensive Biomaterials written by Paul Ducheyne and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-28 with Technology & Engineering categories.
Comprehensive Biomaterials brings together the myriad facets of biomaterials into one, major series of six edited volumes that would cover the field of biomaterials in a major, extensive fashion: Volume 1: Metallic, Ceramic and Polymeric Biomaterials Volume 2: Biologically Inspired and Biomolecular Materials Volume 3: Methods of Analysis Volume 4: Biocompatibility, Surface Engineering, and Delivery Of Drugs, Genes and Other Molecules Volume 5: Tissue and Organ Engineering Volume 6: Biomaterials and Clinical Use Experts from around the world in hundreds of related biomaterials areas have contributed to this publication, resulting in a continuum of rich information appropriate for many audiences. The work addresses the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, and strategic insights for those entering and operational in diverse biomaterials applications, research and development, regulatory management, and commercial aspects. From the outset, the goal was to review materials in the context of medical devices and tissue properties, biocompatibility and surface analysis, tissue engineering and controlled release. It was also the intent both, to focus on material properties from the perspectives of therapeutic and diagnostic use, and to address questions relevant to state-of-the-art research endeavors. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance as well as future prospects Presents appropriate analytical methods and testing procedures in addition to potential device applications Provides strategic insights for those working on diverse application areas such as R&D, regulatory management, and commercial development
The Chemical Engineer
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Author :
language : en
Publisher:
Release Date : 2007
The Chemical Engineer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Chemical engineering categories.
Applications Of Polymers In Drug Delivery
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Author : Ambikanandan Misra
language : en
Publisher: Elsevier
Release Date : 2020-10-02
Applications Of Polymers In Drug Delivery written by Ambikanandan Misra and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-02 with Technology & Engineering categories.
Applications of Polymers in Drug Delivery, Second Edition, provides a comprehensive resource for anyone looking to understand how polymeric materials can be applied to current, new, and emerging drug delivery applications. Polymers play a crucial role in modulating drug delivery and have been fundamental in the successful development of many novel drug delivery systems. This book describes the development of polymeric systems, ranging from conventional dosage forms to the most recent smart systems. Regulatory and intellectual property aspects as well as the clinical applicability of polymeric drug delivery systems are also discussed. The chapters are organized by specific delivery route, offering methodical and detailed coverage throughout. This second edition has been thoroughly revised to include the latest developments in the field. This is an essential book for researchers, scientists, and advanced students, in polymer science, drug delivery, pharmacology/pharmaceuticals, materials science, tissue engineering, nanomedicine, chemistry, and biology. In industry, this book supports scientists, R&D, and other professionals, working on polymers for drug delivery applications. Explains how polymers can be prepared and utilized for all major drug delivery routes Presents the latest advances, including drug targeting, polymeric micelles and polymersomes, and the delivery of biologicals and nucleic acid therapeutics Includes appendices with in-depth information on pharmaceutical properties of polymers and regulatory aspects
Drug Delivery Systems Advanced Technologies Potentially Applicable In Personalised Treatment
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Author : Jorge Coelho
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-15
Drug Delivery Systems Advanced Technologies Potentially Applicable In Personalised Treatment written by Jorge Coelho and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-15 with Medical categories.
This book is part of a series dedicated to recent advances on preventive, predictive and personalised medicine (PPPM). It focuses on the theme of “Drug delivery systems: advanced technologies potentially applicable in personalised treatments”. The critical topics involving the development and preparation of effective drug delivery systems, such as: polymers available, self-assembly, nanotechnology, pharmaceutical formulations, three dimensional structures, molecular modeling, tailor-made solutions and technological tendencies, are carefully discussed. The understanding of these areas constitutes a paramount route to establish personalised and effective solutions for specific diseases and individuals.