The Evaluation Of New Antiarrhythmic Drugs
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The Evaluation Of New Antiarrhythmic Drugs
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Author : Joel Morganroth
language : en
Publisher:
Release Date : 1981
The Evaluation Of New Antiarrhythmic Drugs written by Joel Morganroth and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with Arrhythmia categories.
The Evaluation Of New Antiarrhythmic Drugs
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Author : J. Morganroth
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Evaluation Of New Antiarrhythmic Drugs written by J. Morganroth and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Thus, there are now several chronic canine myocardial infarction ventricular tachyarrhythmia models which are available for the evaluation of new antiarrhythmic drugs (Table I). The available models fulfill many, but not all of the requirements for an ideal chronic arrhythmia model (Table 11). The sustained arrhythmias initiated in these models using programmed pacing presumably have the same localized reentrant mechanism that characterizes chronic human myocardial infarction and chronic coronary 26 artery disease. However, these models are not suitable for determining whether a new drug will abolish spontaneous ly-occurring PVCs. In addition, these models are of unproven value in the study of acute spontaneously occurring sudden death; although recently initiated, provocative work may shed further light on this subject. Most importantly, the available models do seem well-suited to the evaluation of new drugs intended for use in chronic coronary artery disease patients at risk for sustained reentrant ventricular tachycardia or VF. Notably, the results of preliminary electropharmacologic studies in these canine models parallel closely those findings reported in human patients with sustained life-threatening ventricu lar tachyarrhythmias (Table Ill). Therefore, increased use of these chronic models for new antiarrhythmic drug testing is strongly recommended. TABLE II Ideal vs Available Chronic Canine - Arrhythmia Models Ideal Available 1. (a) Arrhythmia mechanism comparable to Yes patients with chronic CAD: Reentry (b) Pathophysiology similar (e. g. , atherogenic CAD) No 2. Susceptible to: (a) spontaneous PVCs No l No (b) spontaneous VT/VF (c) inducible VT/VF Yes 3.
The Evaluation Of New Antiarrhythmic Drugs
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Author :
language : en
Publisher:
Release Date : 1981
The Evaluation Of New Antiarrhythmic Drugs written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with Arrhythmia categories.
Cardiac Arrhythmias New Therapeutic Drugs And Devices
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Author : J. Morganroth
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cardiac Arrhythmias New Therapeutic Drugs And Devices written by J. Morganroth and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
In summary, there are many animal models that are useful in selecting new antiarrhythmic drugs. The selection of which model is most idea depends upon precisely what question is being asked. The large number of experimental models used to evaluate antiarrhythmic compounds points out the inability of anyone model to define the probability of antiarrhythmic efficacy in man. It has therefore become standard practice to utilize a batter of animal models for the evaluation of new antiarrhythmic agents. Each model has its own advantages and disadvantages and it is necessary to understand each model fully in oder to evaluate experimental findings and apply them to clinical settings. We believe that the availability of the chronic myocardial infarction ventricular tachyarrhythmia model provides 1) an excellent opportunity to more precisely understand arrhythmia mechanisms, 2) to develop new techniques such as signal averaging for evaluating late low level potentials identifying hearts at high risk of sudden death 3) to identify new antifibrillatory drugs versus drugs that are effective primarily against PVC's and ventricular tachycardia 4) to identify new surgical techniques to eliminate VT/VF, and 5) to evaluate new pacing modalities including implantable cardioverters. Although all animal models are wrong, many are very useful in furthering our knowledge directed at decreasing the distressingly high mortality from heart disease. NORMAL HtART TACHYCMDIA HtART , .. '" \ I I I I I I I I I .
Guidelines For The Clinical Evaluation Of Anti Arrhythmic Drugs
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Author : United States. Food and Drug Administration
language : en
Publisher:
Release Date : 1977
Guidelines For The Clinical Evaluation Of Anti Arrhythmic Drugs written by United States. Food and Drug Administration and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with Arrhythmia categories.
Antiarrhythmic Drugs
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Author : Richard N. Fogoros, MD
language : en
Publisher: Wiley-Blackwell
Release Date : 1997-03-14
Antiarrhythmic Drugs written by Richard N. Fogoros, MD and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-03-14 with Medical categories.
An introduction to cardiac arrythmias and their treatment, Antiarrhythmic Drugs: A Practical Guide offers a concise, easily understood framework enabling the reader to become confident in the evaluation and treatment of patients with cardiac arrhythmias. Because most clinicians, technicians and nurses find this area confusing, both in terms of diagnosis and management, this manual provides a route map for understanding mechanisms and selecting appropriate drug therapies. Focusing on the choice of drug for specific conditions, this book covers dosages, interactions and side effects.
Arrhythmia Treatment And Therapy
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Author : Raymond Woosley
language : en
Publisher: CRC Press
Release Date : 2000-02-25
Arrhythmia Treatment And Therapy written by Raymond Woosley and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-02-25 with Medical categories.
This vitally important reference traces the progress of antiarrhythmic drug trials and treatment methods-from the vantage point of the clinicians who designed and conducted the studies to objective views of the strengths and weaknesses of the results, identifying unresolved questions or newly created issues. Reviews significant studies in chronological order-providing a clear, informative account of how current thinking about arrhythmia treatment has evolved. Written by over 35 leading experts in the field, Clinical Trials on the Treatment of Arrhythmias emphasizes the need for science-based therapeutics and rigorously controlled clinical trials of drugs and implantable devices compares electrocardiographic monitoring with electrophysiological techniques for arrhythmia management analyzes the landmark Cardiac Arrhythmia Suppression Trial (CAST) evaluates the effectiveness of amiodarone describes sodium and potassium channel blockers and the development of drugs that slow conduction velocity and prolong repolarization and refractoriness investigates the effects of the d-isomer of sotalol on mortality critiques studies on the established efficacy of implantable devices versus amiodarone to benefit post-bypass surgery patients and more! Containing over 600 literature citations, Clinical Trials on the Treatment of Arrhythmias is an invaluable resource for cardiologists and cardiovascular specialists, pharmacologists, pharmaceutical researchers, and graduate and medical school students in these disciplines.
Cardiovascular Medicine
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Author : James T. Willerson
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-06
Cardiovascular Medicine written by James T. Willerson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-06 with Medical categories.
This book offers the most up-to-date, user-friendly guidance on the evaluation, diagnosis and medical and surgical treatment of heart and vascular disease. The book and DVD package is designed to provide comprehensive coverage of every aspect of cardiovascular medicine. The book has consistent chapter organization relevant to modern cardiovascular practice, clear design and engaging text. The reader will have all the guidance to diagnose and manage the full range of cardiovascular conditions in one textbook resource, while also benefiting from access to additional video material from the integral DVD-ROM. This includes over 100 individual heart sounds.
Pediatric Cardiac Surgery
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Author : Constantine Mavroudis
language : de
Publisher: John Wiley & Sons
Release Date : 2023-01-19
Pediatric Cardiac Surgery written by Constantine Mavroudis and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-19 with Medical categories.
Der Bereich der pädiatrischen Herz- und Gefäßchirurgie umfasst nicht nur die Herzchirurgie bei Säuglingen und Kindern, sondern auch die Herzchirurgie bei Erwachsenen zur Korrektur von angeborenen Herzfehlern. Da die Kindersterblichkeit aufgrund von Herzfehlern zurückgeht und Patienten mit angeborenen Herzfehlern zunehmend ein langes, gesundes Leben führen, ergeben sich neue Herausforderungen. Somit war der Bedarf an Einführungen in diesen lebensrettenden Bereich noch nie so groß. Pediatric Cardiac Surgery ist ein gut verständliches, umfassendes Lehrbuch, das diesen Bedarf seit über dreißig Jahren erfüllt und von Fachleuten auf allen Ebenen genutzt wird. Das Lehrwerk, das zahlreiche farbige Abbildungen enthält, bietet zunächst eine wissenschaftliche Einführung in die kardiovaskuläre Entwicklung und dann detaillierte Analysen von Defekten in verschiedenen Bereichen des Herzens mit den entsprechenden Verfahren zur Korrektur dieser Defekte. Die aktualisierte fünfte Auflage berücksichtigt die neuesten wissenschaftlichen Erkenntnisse und bleibt damit ein unverzichtbares Werk zu diesem Thema. Die fünfte Auflage von Pediatric Cardiac Surgery enthält unter anderem: * Beiträge von über 75 nationalen und internationalen Experten auf dem Gebiet * Beeindruckende anatomische Illustrationen von Rachid Idriss * Neue Kapitel, in denen der neueste Stand der Forschung dargestellt wird, sowie neue Inhalte in Bezug auf die kardiale Bildgebung und die medizinische Ausbildung Pediactric Cardiac Surgery ist ein wichtiges Nachschlagewerk für Herzchirurgen, die sich auf Kinder und Erwachsene spezialisiert haben, Kardiologen und alle medizinischen Fachkräfte, die mit pädiatrischen oder erwachsenen Herzpatienten arbeiten.
Early Phase Drug Evaluation In Man
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Author : O'grady
language : en
Publisher: CRC Press
Release Date : 2020-02-03
Early Phase Drug Evaluation In Man written by O'grady and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-03 with Medical categories.
Early Phase Drug Evaluation in Man is a comprehensive, practical guide that covers pre-clinical information relevant to early human studies, including pharmaceutical, metabolic, toxicological, and regulatory aspects, as well as the general considerations relevant to all early human studies. Each major therapeutic area is considered by class of activity of drug. The chapters describe what measurements of drug activity are available in healthy human subjects and in patients, how to make the measurements, their value and their limitations. The contributors have been drawn internationally from the pharmaceutical industry and academia. Early Phase Drug Evaluation in Man will provide an important reference guide for industry and academic professionals involved in the development of new drugs.