The Genetics And Molecular Biology Of Neural Tumors
DOWNLOAD
Download The Genetics And Molecular Biology Of Neural Tumors PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get The Genetics And Molecular Biology Of Neural Tumors book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
The Genetics And Molecular Biology Of Neural Tumors
DOWNLOAD
Author : Avery A. Sandberg
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-05-06
The Genetics And Molecular Biology Of Neural Tumors written by Avery A. Sandberg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-05-06 with Medical categories.
Collecting an extensive amount of information from thousands of publications by leading investigators in this rapidly developing field, this book provides a convenient and up-to-date one volume source for research in neural tumors of various cellular origins. With over 3,500 references, 110 figures and 120 tables, this volume gathers an astonishing body of knowledge regarding human neural tumors. This book is the first of its kind, encyclopedic and wide-ranging.
Evolution Of The Molecular Biology Of Brain Tumors And The Therapeutic Implications
DOWNLOAD
Author : Terry Lichtor
language : en
Publisher: BoD – Books on Demand
Release Date : 2013-02-27
Evolution Of The Molecular Biology Of Brain Tumors And The Therapeutic Implications written by Terry Lichtor and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-27 with Medical categories.
A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular recent new avenues regarding the role of stem cells and microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to chemotherapeutic agents and radiation therapy has been developed. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided.
Advances In Molecular Genetics Of Brain Tumors
DOWNLOAD
Author : Nives Pecina-Slaus
language : en
Publisher: Mdpi AG
Release Date : 2023-02-23
Advances In Molecular Genetics Of Brain Tumors written by Nives Pecina-Slaus and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-23 with Science categories.
This book encompasses a number of articles that focus on the molecular blueprint of brain tumors. A collection of relevant papers in the rapidly expanding field of brain tumor molecular genetics broadens our knowledge about the biology of brain tumors, and inspires further studies that will improve the diagnosis and clinical management of brain tumors. Due to the great heterogeneity of brain tumors it is important to research and understand every aspect of their initiation, progression and metastasis in order to design better diagnostic and therapeutic approaches for their clinical management and patient benefit.
The Genetics Of Cancer
DOWNLOAD
Author : Gajanan V. Sherbet
language : en
Publisher: Academic Press
Release Date : 1997-06-22
The Genetics Of Cancer written by Gajanan V. Sherbet and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-06-22 with Medical categories.
Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, and molecular biology. Clonal evolution of the metastasis phenotype Cell Cycle regulation Apoptosis in tumour growth and metastasis Angiogenesis in cancer Cell surface glycoproteins and their receptors Proteinases and their inhibitors in cancer invasion Oncogenes and cancer metastasis Developmental genes Tumour suppressor genes Metastasis suppressor genes Dominant metastasis-associated genes
Neurofibromatosis Type 1
DOWNLOAD
Author : Meena Upadhyaya
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-01-29
Neurofibromatosis Type 1 written by Meena Upadhyaya and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-29 with Medical categories.
Neurofibromatosis type 1 (NF1), caused by mutational inactivation of the NF1 tumour suppressor gene, is one of the most common dominantly inherited human disorders, affecting 1 in 3000 individuals worldwide. This book presents in concise fashion, but as comprehensively as possible, our current state of knowledge on the molecular genetics, molecular biology and cellular biology of this tumour predisposition syndrome. Written by internationally recognized experts in the field, the 44 chapters that constitute this edited volume provide the reader with a broad overview of the clinical features of the disease, the structure and expression of the NF1 gene, its germ line and somatic mutational spectra and genotype-phenotype relationships, the structure and function of its protein product (neurofibromin), NF1 modifying loci, the molecular pathology of NF1-associated tumours, animal models of the disease, psycho-social aspects and future prospects for therapeutic treatment.
Molecular Neuro Oncology And Its Impact On The Clinical Management Of Brain Tumors
DOWNLOAD
Author : O.D. Wiestler
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular Neuro Oncology And Its Impact On The Clinical Management Of Brain Tumors written by O.D. Wiestler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Tumors of the nervous system represent a difficult therapeutic challenge. During recent years, substantial progress has been made in characterizing genetic mechnisms involved in the formation of brain tumors. There is a lot of hope that an understanding of the molecular basis of transformation will eventually lead to specific therapeutic approaches. In this volume, leading authorities in both molecular and clinical neuro-oncology summarize recent developments in their respective fields. The first part of the book will focus on specific molecular genetic defects in neural tumors and their potential clinical significance. Part two gives an update on established and novel treatment regimens for patients with brain tumors. Several contributions will demonstrate that molecular and clinical neuro-oncology are already entangled. With its unique combination of molecular biological and clinical data, this volume provides basic researchers and clinical neuroscientists with a comprehensive update in both disciplines.
Genomics And Models Of Nerve Sheath Tumors
DOWNLOAD
Author : Angela C. Hirbe
language : en
Publisher: MDPI
Release Date : 2020-11-18
Genomics And Models Of Nerve Sheath Tumors written by Angela C. Hirbe and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-18 with Science categories.
Nerve sheath tumors can be a significant cause of morbidity for many patients. These include benign tumors such as schwannomas, diffuse and plexiform neurofibromas, and atypical neurofibromas, as well as the aggressive soft tissue sarcoma known as the malignant peripheral nerve sheath tumor (MPNST). Nerve sheath tumors occur sporadically and in the context of the clinical neuro-genetic tumor predisposition syndromes neurofibromatosis type 1 (NF1) and type 2 (NF2). Historically, the mainstay of treatment for nerve sheath tumors has been surgery. However, for both benign and malignant nerve sheath tumors, there is a high recurrence rate, highlighting the pressing need for novel therapies. As we have entered the genomic era, the hope is that an improved understanding of the genetics, and therefore the biology, of these tumors will ultimately lead to therapies that result in better outcomes. In this Special Issue, we include both review articles and original research related to the genomic understanding and modeling of schwannomas, plexiform and diffuse neurofibromas, atypical neurofibromas, and malignant peripheral nerve sheath tumors as well as genomic methods being developed and applied to advance our understanding of these tumors.
Brain Tumor Invasion
DOWNLOAD
Author : Tom Mikkelsen
language : en
Publisher: Wiley-Liss
Release Date : 1998-05-05
Brain Tumor Invasion written by Tom Mikkelsen and has been published by Wiley-Liss this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-05-05 with Medical categories.
Brain Tumor Invasion Biological, Clinical, and Therapeutic Considerations Edited by Tom Mikkelsen Rolf Bjerkvig Ole Didrik Laerum Mark L. Rosenblum Recent advances in molecular biology have given us profound new insights into the behavior of primary brain tumors. Not only are such tumors more diffuse in their infiltration of brain tissue and therefore less amenable to surgery than brain tumors originating elsewhere in the body—it now appears that the central nervous system and the normal brain itself constitute a biological environment conducive to the uncontrolled spread of primary tumors. Brain Tumor Invasion is the first comprehensive reference devoted to the invasive behavior of primary brain tumors. It examines the biological mechanisms responsible for the increased ability of gliomas to metastasize in the central nervous system, and discusses the role of chemical carcinogens, growth factors, oncogenes, and tumor suppressors in the progression of such metastases. This book surveys the latest research in the field, reviews present and future prospects of anti-invasive brain tumor therapy, and even translates preclinical trials and other research results into potential new therapies. The material is divided into five main categories: Developmental biology and molecular neuro-oncology Pathological and clinical features of malignant brain tumors Models for the study of brain tumor invasion in vivo and in vitro Mechanisms of invasion New therapeutic strategies Brain Tumor Invasion offers dozens of maps and photographs that illustrate topics under discussion. This in-depth introduction to one of the most difficult problems in the management of brain tumors is indispensable to neuro-oncologists involved in brain tumor research and therapy. It is also useful to researchers in cancer biology, neuroscience, cell biology, and molecular genetics.
Brain Tumors
DOWNLOAD
Author : Francis Ali-Osman
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-10-28
Brain Tumors written by Francis Ali-Osman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-28 with Medical categories.
Exciting new developments and discoveries of the last two decades are beginning to shed light on the complex biology of brain tumors and are advancing our understa- ing of the cellular and molecular processes involved in their initiation, progression, and clinical and biological behavior. The disease process in brain tumors is quite complex and the resulting tumors are characterized by a high degree of biological and clinical diversity. Thus, despite the advances of the last two decades, prognosis for patients with malignant brain tumors remains abysmal. Significant progress in the diagnosis, treatment and, ultimately, prevention of these tumors will require both the timely h- nessing of the advances in basic and clinical brain tumor research, and a continuing concerted effort at increasing our understanding of brain tumor biology, in particular, the molecular genetic changes and perturbations of cellular pathways involved in brain oncogenesis and which drive the biological and clinical behavior of the tumors. Brain tumor diagnosis and prognosis, which is still largely based on histopathology and other clinical criteria, will, in the future, acquire a significant molecular component, with the incorporation of knowledge of genes that are mutated, over-expressed, deleted, silenced, or functionally altered in the tumors. Treatment strategies for brain tumors, rather than being empirical, will be rationally developed based on an understanding of the cellular and molecular mechanisms and targets that have been activated, suppressed, or otherwise altered.
Evolution By Tumor Neofunctionalization
DOWNLOAD
Author : Andrei P. Kozlov
language : en
Publisher: Academic Press
Release Date : 2014-02-15
Evolution By Tumor Neofunctionalization written by Andrei P. Kozlov and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-15 with Science categories.
Evolution by Tumor Neofunctionalization explores the possibility of the positive role of tumors in evolution of multicellular organisms. This unique perspective goes beyond recent publications on how evolution may influence tumors, to consider the possible role of tumors in evolution. Widespread in nature tumors represent a much broader category than malignant tumors only. The majority of tumors in humans and other animals may never undergo malignant transformation. Tumors may differentiate with the loss of malignancy, and malignant tumors may spontaneously regress. Cellular oncogenes and tumor suppressor genes play roles in normal development. Many features of tumors could be used in evolution, and there are examples of tumors that have played a role in evolution. This book will stimulate thinking on this topic by specialists in the fields of evolutionary biology, oncology, molecular biology, molecular evolution, embryology, evo-devo, tumor immunology, pathology and clinical oncology. Covers the role that tumors might play in evolution. Provides multidisciplinary approach that will appeal to a wide circle of professionals in the fields of evolutionary biology, oncology, molecular biology, and more