The Molecular Basis Of Sex And Differentiation
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The Molecular Basis Of Sex And Differentiation
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Author : Milton H. Saier
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Molecular Basis Of Sex And Differentiation written by Milton H. Saier and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Man's mind stretched to a new idea never goes back to its original dimensions Oliver Wendell Holmes Our current understanding of sex and biological differentiation results from the application of three principal experimental approaches to these subjects: those of the physiologist, the biochemist, and the geneticist. These three approaches are illustrated by the materials presented in the chapters of this volume. Chapters 1-5 emphasize conceptualization of developmental processes, describing systems principally from the standpoint of the physiologist. Structures and functions are defined with only occasional reference to specific molecular details. Chapters 6- 10 present the views of the biochemist, attempting to describe functions influ encing or regulating cellular behavior at the molecular level. And Chapters 11- 14 illustrate the approaches of the modem-day geneticist in his attempts to gain a detailed understanding of processes controlling gene expression. While it is possible to delineate these three major sections, each emphasizing a distinct experimental approach, it must be realized that the yield of knowledge increases exponentially with the number of experimental approaches available to the investigator. Information resulting from the application of each of these approaches must converge to give the same answers for anyone biological phenomenon in anyone experimental system. Further, if we can learn of details regarding a particular process by applying different experimental approaches, our postulates concerning the underlying molecular mechanisms are likely to be more accurate. But biological systems are not unrelated.
Sex Determination Differentiation And Intersexuality In Placental Mammals
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Author : R. H. F. Hunter
language : en
Publisher: Cambridge University Press
Release Date : 1995-03-09
Sex Determination Differentiation And Intersexuality In Placental Mammals written by R. H. F. Hunter and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-03-09 with Science categories.
How do males become male and females become female? And what are the consequences if the decision is not incisive? Drawing upon interests in animal genetics and molecular biology, the author endeavours to answer these difficult yet fascinating questions. Originally published in 1995, this book describes the genetic determination of sex and examines how sexual organs are differentiated. Using examples of intersexuality, chimaeras and asymmetries, the book describes the underlying molecular basis of sex determination and sexual differentiation, and focuses on the critical role of the rate of embryonic development in these vital processes. Male precocity is a recurrent theme, as is the involvement of Sertoli cells and their secretion of anti-Müllerian hormone. An invaluable book for reproductive physiologists, geneticists and developmental biologists whose interests may extend from animal science through veterinary medicine to human clinical medicine.
Genetics Of Sex Differentiation
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Author : Ursula Mittwoch
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Genetics Of Sex Differentiation written by Ursula Mittwoch and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Genetics of Sex Differentiation intends to help readers understand the genetic basis of sex differentiation. The book focuses on explaining how the sex chromosomes affect the process of sex differentiation by influencing the rates at which cells divide. The book is composed of seven chapters. It provides overviews of classical genetics and structure of cells. It also explains the chromosomal basis of sex determination and sex determination using Drosophila. Polygenetics and continuous and quasicontinuous variations are also discussed. The book also discusses sex factors, determination, and disorders. Moreover, it explains the heterochromatin, embryological basis of sex differentiation, and triploidy and autosomal effects. In addition, it discusses the relationship of genes, chromosomes, growth, and sex. The book is an excellent ""bedside book"" for students in biology, specifically in genetics and developmental biology. Lecturers and professionals in biology and genetics will also find this book invaluable for their practice.
The Genetics And Biology Of Sex Determination
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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2002-04-26
The Genetics And Biology Of Sex Determination written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-04-26 with Science categories.
Nature employs a wide variety of sex determining mechanisms and it is only comparatively recently that the tools have become available for these to be explored at the cellular and molecular levels. A major landmark was the discovery in 1990 of the SRY gene and the subsequent demonstration of its key role in triggering male sex determination in transgenic mice. This book reviews and discusses our current understanding of the molecular genetic pathways of sex determination, with special emphasis on vertebrates. It features comparisons with other modes of sex determination, consideration of the biology of sexual development and discussion of the evolution of sex-determining mechanisms. By bringing together an international and interdisciplinary group of experts who study many different aspects of the problem, the book highlights much new and exciting work in this area and serves to identify and stimulate promising new research directions.
Disorders Of Sex Development
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Author : John M. Hutson
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-01-14
Disorders Of Sex Development written by John M. Hutson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-14 with Medical categories.
The rapid advances in medicine over the last 50 years have totally changed the outlook for children with disorders of sex development (DSD), but there is still much to learn. This book crystallizes the combined experience of a leading dedicated unit over 25 years in delivering expert medical and surgical care to children with DSD in a holistic environment. It documents the most recent advances in the molecular biology and embryology of sex development, and describes each disorder in detail. The clinical presentation and approach to diagnosis are described both for babies and for children presenting later in childhood or at adolescence. The chapters on management highlight all the latest knowledge and include the shared wisdom of the authors on current controversies, such as the timing of surgical treatment. Finally, the authors describe their short-, medium-, and long-term outcomes, which demonstrate the strengths of holistic team management.
Molecular Genetics Of Sex Determination
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Author : Stephen S. Wachtel
language : en
Publisher: Academic Press
Release Date : 2014-07-23
Molecular Genetics Of Sex Determination written by Stephen S. Wachtel and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-23 with Science categories.
In this era of accelerated discovery and prolific output, Molecular Genetics of Sex Determination keeps readers abreast of this fields fast-moving biology. Its chapters were completed by experts in eacharea only months before publication. The text is organized into two parts. First, it reviews the basic biology of sex determination and summarizes ground-breaking work in mouse, marsupial, and Drosophila systems. Second, it covers current human genetics, clinical studies, and the syndromes of abnormal sex differentiation. With chapters by preeminent reproductive biologists, this is a capital work. Ohno's law is described by Ohno; the Lyon hypothesis, by Lyon; Sinclair tells how he cloned the testis-determining gene; and so on. Molecular Genetics of Sex Determination is authoritative, comprehensive, and current. It is prime reading for geneticists, developmental biologists, graduate students in these and related fields, clinical researchers, physicians, and medical students. Reviews the genetics of sex determination in 19 up-to-date chapters Features research on sex chromosomes and sex-determining genes Includes abnormalities of sex determination and clinical genetics Written by scientists who pioneered work in this field
Hormonal And Genetic Basis Of Sexual Differentiation Disorders And Hot Topics In Endocrinology Proceedings Of The 2nd World Conference
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Author : Maria I. New
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-06-21
Hormonal And Genetic Basis Of Sexual Differentiation Disorders And Hot Topics In Endocrinology Proceedings Of The 2nd World Conference written by Maria I. New and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-21 with Medical categories.
Proceedings of the 2nd World Conference – Hormonal and Genetic Basis of Sexual Differentiation Disorders and Hot Topics in Endocrinology. The meeting took place at The Eden Roc Hotel in Miami Beach, Florida, 1/15/10 – 1/17-10. Endocrinology and more specifically, the area of sexual differentiation disorders is an evolving field of medicine. The diagnosis and treatment of Disorders of Sex Development (DSD) is multi-faceted.
Exploring The Biological Contributions To Human Health
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2001-07-02
Exploring The Biological Contributions To Human Health written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-07-02 with Medical categories.
It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.
Genetic Markers Of Sex Differentiation
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Author : Florence P. Haseltine
language : en
Publisher: Springer
Release Date : 1987-11-30
Genetic Markers Of Sex Differentiation written by Florence P. Haseltine and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987-11-30 with Psychology categories.
Genetics Of Sex Determination
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Author : Ram S. Verma
language : en
Publisher: Elsevier Science Limited
Release Date : 1996
Genetics Of Sex Determination written by Ram S. Verma and has been published by Elsevier Science Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Science categories.
The Genetical Theory of Natural Selection by R.A. Fisher (1930) dictated that sexual dimorphisms may depend upon a single medelian factor. This could be true for some species but his suggestion could not take off the ground as gender in Drosophila is determined by the number of X chromosomes. Technical advances in molecular biology have revived the initial thinking of Fisher and dictate that TDF or SRY genes in humans or Tdy in mice are sex determining genes. The fortuitous findings of XX males and XY female, which are generally termed sex reversal phenomenon, are quite bewildering traits that have caused much amazement concerning the pairing mechanism(s) of the pseudoautosomal regions of human X and Y chromosomes at meiosis. These findings have opened new avenues to explore further the genetic basis of sex determination at the single gene level. The aim of the fourth volume, titled Genetics of Sex Determination is to reflect on the latest advances and future investigative directions, encompassing 10 chapters. Commissioned several distinguished scientists, all pre-eminent authorities in each field to shed their thoughts concisely but epitomise their chapters with an extended bibliography. Obviously, during the past 60 years, the metoric advances are voluminous and to cover every account of genes, chromosomes, and sex in a single volume format would be a herculean task. Therefore, a few specific topics are chosen, which may be of great interest to scientists and clinicians. The seasoned scientists who love to inquire about the role of genes in sex determination should find the original work of these notable contributors very enlightening. This volume is intended for advanced students who want to keep abreast as well as for those who indulge in the search for genes of sex determination.