The Molecular Biology Of Adenoviruses 3
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The Molecular Biology Of Adenoviruses 3
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Author : W. Doerfler
language : en
Publisher: Springer
Release Date : 2011-12-06
The Molecular Biology Of Adenoviruses 3 written by W. Doerfler and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-06 with Medical categories.
The Molecular Repertoire Of Adenoviruses Iii
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Author : Walter Doerfler
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Molecular Repertoire Of Adenoviruses Iii written by Walter Doerfler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
For decades this virus system has served--and continues to do so--to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems. This three volume work presents an up-to-date account of recent basic research in one of the most important experimental systems for biochemical, cell biological, genetic, virological and epidemiological investigation in mammalian molecular biology. In the first of the three volumes, we present an overview of adenovirus research. In the second volume, we turn our attention to such topics as DNA replication, recombination and integration and post-trans- criptional control. This, the third volume then looks at transformation and E1A, adenovirus genetics, pathogenesis and gene therapy.
The Molecular Biology Of Adenoviruses 2
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Author : W. Doerfler
language : en
Publisher: Springer
Release Date : 1984-05-01
The Molecular Biology Of Adenoviruses 2 written by W. Doerfler and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984-05-01 with Medical categories.
The data summarized in this chapter show that morphological transformation and oncogenesis by adenoviruses are brought about by the coordinated activity of regions E1A and E1B. Gene products of each of these subregions appear to fulfill distinct roles in oncogenic transformation, with the possible exception of the product(s) encoded by the O. 9-kb E1A mRNA. Also unclear is the func tion of the 20-kd E1B protein, which has a small role, if any, in morphological transformation, but appears to be essential for the development of the oncogenic phenotype, as defined by the ability of transformed cells to grow in immuno deficient nude mice. The differences in biological properties of oncogenic and nononcogenic adenoviruses must be attributed to differences in the primary structure of the respective E1A and E1B gene products, in particular of the product(s) of the 1. 0-kb E1A mRNA and of the 55-kd protein encoded by the 2. 2-kb EiB mRNA. The availability of cold-sensitive adenovirus mutants has enabled us to conclude that the transformed phenotype is maintained as a result of continuous expression of at least region E1A gene products, and is therefore not the result of a hit-and-run mechanism. Despite the progress in our understanding of adenovirus transformation and oncogenesis, virtually nothing is known about the precise mechanism by which the viral gene products bring about the neoplastic changes in cells. The only exception is the demonstration that Ad12 region E1A (1.
Molecular Biology Of Adenoviruses
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Author : L. Philipson
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular Biology Of Adenoviruses written by L. Philipson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
I. Introduction In his biography "Arrow in the Blue" the author Arthur Koestler suggests ironically that the fate of an individual may be predicted by examining the content of the newspapers at birth. Adenoviruses were discovered in 1953 (ROWE et al. , 1953; HILLEMAN and WERNER, 1954). At this time the Salk poliomyelitis vaccine was developed (SALK et al. , 1954) and in the same year the discovery of the double helical structure of DNA (WATSON and CRICK, 1953) and the plaque assay for one animal virus (DULBECCO and VOGT, 1953) was announced. Thus, this new group of viruses was born with great hopes for progress in molecular biology and for the control of animal virus infections. In the short interval be tween 1953 and 1956 the adenoviruses were discovered, methods for laboratory diagnosis and serotyping were established, the epidemiology was clarified and a highly effective vaccine was developed and approved (for a review see HILLE MAN, 1966). Succeeding years showed, however, that the vaccines were contami nated with the oncogenic SV 40 virus and that the adenoviruses themselves were tumorigenic. Since the discovery of adenoviruses animal virology was developed into a quantitative science offering explanation for viral functions at the molecular level. Precise biochemical tools to characterize the genome and its transcription products as well as the structural proteins of these viruses are now available.
The Molecular Repertoire Of Adenoviruses I
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Author : Walter Doerfler
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Molecular Repertoire Of Adenoviruses I written by Walter Doerfler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
For decades this virus system has served - and continues to do so - to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems. This three volume work presents an up-to-date account of recent basic research in one of the most important experimental systems for biochemical, cell biological, genetic, virological, and epidemiological investigations in mammalian molecular biology. In this, the first of the three volumes, an overview of adenovirus research is presented with emphasis on the structure and assembly of adenoviruses, viral infections, and viral gene products. The chapters have been written by an international group of leading experts in their respective fields of interest.
Molecular Biology Of Adenoviruses
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Author : L. Philipson
language : en
Publisher:
Release Date : 2014-01-15
Molecular Biology Of Adenoviruses written by L. Philipson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-15 with categories.
The Molecular Repertoire Of Adenoviruses Ii
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Author : Walter Doerfler
language : en
Publisher: Springer
Release Date : 2011-12-22
The Molecular Repertoire Of Adenoviruses Ii written by Walter Doerfler and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-22 with Science categories.
For decades this virus system has served--and continues to do so--to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems. This three volume work presents an up-to-date account of recent basic research in one of the most important experimental systems for biochemical, cell biological, genetic, virological and epidemiological investigations in mammalian molecular biology. In this, the second of three volumes, the attention is turned to such topics as DNA replication, recombination and integration, and post-transcriptional control. The chapters have been written by an international group of leading experts in their respective fields of interest.
The Molecular Biology Of Adenoviruses I
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Author : W. Doerfler
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Molecular Biology Of Adenoviruses I written by W. Doerfler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
A puzzling epidemiological problem was the driving force behind the discovery of human adenoviruses by Wallace Rowe and his colleagues 30 years ago. The de velopment of a plaque assay for poliomyelitis virus in 1953 led us to the threshold of quantitative virology, and in the same year the double-helical structure of DNA was discovered and became a cornerstone of mo lecular biology. The potential of adenoviruses as research tools in the molecular and cellular biology of eukaryotic cells was recognized as early as the late 1950s and early 1960s by several investigators. Structural and biochemical stu dies dominated the early years. In 1962, some of the adenoviruses were the first human viruses shown to be oncogenic in experimental animals. Thus adenovirology offered the investigator the entire gamut of host cell interactions, productive and abortive, as well as trans formed and tumor cell systems. The possibilities that adenoviruses afforded for the study of the molecular biology and genetics of eukaryotic cells were fully rea lized in the late 1960s and the 1970s.
Molecular Biology Of Adenoviruses
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Author : Carl Lennart Philipson
language : en
Publisher: Springer
Release Date : 1975-01-01
Molecular Biology Of Adenoviruses written by Carl Lennart Philipson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1975-01-01 with Adenoviruses categories.
The Adenoviruses
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Author : Harold S. Ginsberg
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-08
The Adenoviruses written by Harold S. Ginsberg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-08 with Medical categories.
The discovery of adenoviruses naturally induced a new interest in viruses of the human upper respiratory tract since previously unknown viruses infecting this portion of the human body had not been identified in 20 years, and their unique characteristics stimulated investigations into the biochemical events essential for replication of animal viruses. Indeed, the field of molecular virology has evolved during the period since their dis covery, and adenoviruses have played a major role in this development. The exciting discoveries made with adenoviruses have had such a pro found effect on knowledge in basic virology, molecular biology, viral ge netics, human and animal infections, and cell transformation that this seemed a propitious time to have some of the major contributors review this field. This volume pays tribute to the late Wallace Rowe, Robert Huebner, and Maurice Hilleman whose initial discoveries of adenoviruses have tremendously enriched virology. Harold S. Ginsberg vii Contents Chapter 1 An Overview 1 Harold S. Ginsberg Chapter 2 The Architecture of Adenoviruses M. V. Nermut I. Introduction ................................... . 5 II. Chemical and Physical Properties ................... . 6 III. Virus Capsid: Composition and Organization .......... . 7 A. Hexon ..................................... . 10 B. Penton .................................... . 12 C. Other Virus Polypeptides Associated with the Capsid 13 D. Organization of the Capsid ..................... . 14 IV. Virus Core .................................... . 15 A. Evidence for the Core Shell ..................... . 17 B. Organization of the DNA-Protein Complex (Nucleoc- sid) ....................................... . 18 C. Tentative Model of the Adenovirus Nucleocapsid ... . 22 V. Model of the Adenovirion ......................... . 29 32 References .......................................... .