The Molecular Biology Of Adenoviruses I
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Molecular Biology Of Adenoviruses
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Author : L. Philipson
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular Biology Of Adenoviruses written by L. Philipson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
I. Introduction In his biography "Arrow in the Blue" the author Arthur Koestler suggests ironically that the fate of an individual may be predicted by examining the content of the newspapers at birth. Adenoviruses were discovered in 1953 (ROWE et al. , 1953; HILLEMAN and WERNER, 1954). At this time the Salk poliomyelitis vaccine was developed (SALK et al. , 1954) and in the same year the discovery of the double helical structure of DNA (WATSON and CRICK, 1953) and the plaque assay for one animal virus (DULBECCO and VOGT, 1953) was announced. Thus, this new group of viruses was born with great hopes for progress in molecular biology and for the control of animal virus infections. In the short interval be tween 1953 and 1956 the adenoviruses were discovered, methods for laboratory diagnosis and serotyping were established, the epidemiology was clarified and a highly effective vaccine was developed and approved (for a review see HILLE MAN, 1966). Succeeding years showed, however, that the vaccines were contami nated with the oncogenic SV 40 virus and that the adenoviruses themselves were tumorigenic. Since the discovery of adenoviruses animal virology was developed into a quantitative science offering explanation for viral functions at the molecular level. Precise biochemical tools to characterize the genome and its transcription products as well as the structural proteins of these viruses are now available.
The Molecular Biology Of Adenoviruses I
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Author : W. Doerfler
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Molecular Biology Of Adenoviruses I written by W. Doerfler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
A puzzling epidemiological problem was the driving force behind the discovery of human adenoviruses by Wallace Rowe and his colleagues 30 years ago. The de velopment of a plaque assay for poliomyelitis virus in 1953 led us to the threshold of quantitative virology, and in the same year the double-helical structure of DNA was discovered and became a cornerstone of mo lecular biology. The potential of adenoviruses as research tools in the molecular and cellular biology of eukaryotic cells was recognized as early as the late 1950s and early 1960s by several investigators. Structural and biochemical stu dies dominated the early years. In 1962, some of the adenoviruses were the first human viruses shown to be oncogenic in experimental animals. Thus adenovirology offered the investigator the entire gamut of host cell interactions, productive and abortive, as well as trans formed and tumor cell systems. The possibilities that adenoviruses afforded for the study of the molecular biology and genetics of eukaryotic cells were fully rea lized in the late 1960s and the 1970s.
Molecular Biology Of Adenoviruses
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Author : Carl Lennart Philipson
language : en
Publisher: Springer
Release Date : 1975-01-01
Molecular Biology Of Adenoviruses written by Carl Lennart Philipson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1975-01-01 with Adenoviruses categories.
The Molecular Biology Of Adenoviruses 2
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Author : W. Doerfler
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Molecular Biology Of Adenoviruses 2 written by W. Doerfler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Molecular Biology Of Adenoviruses
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Author : L. Philipson
language : en
Publisher:
Release Date : 2014-01-15
Molecular Biology Of Adenoviruses written by L. Philipson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-15 with categories.
The Molecular Repertoire Of Adenoviruses I
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Author : Walter Doerfler
language : en
Publisher: Springer
Release Date : 2011-12-22
The Molecular Repertoire Of Adenoviruses I written by Walter Doerfler and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-22 with Science categories.
For decades this virus system has served - and continues to do so - to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems. This three volume work presents an up-to-date account of recent basic research in one of the most important experimental systems for biochemical, cell biological, genetic, virological, and epidemiological investigations in mammalian molecular biology. In this, the first of the three volumes, an overview of adenovirus research is presented with emphasis on the structure and assembly of adenoviruses, viral infections, and viral gene products. The chapters have been written by an international group of leading experts in their respective fields of interest.
The Molecular Biology Of Adenoviruses 3
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Author : W. Doerfler
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Molecular Biology Of Adenoviruses 3 written by W. Doerfler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The Molecular Repertoire Of Adenoviruses Iii
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Author : Walter Doerfler
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Molecular Repertoire Of Adenoviruses Iii written by Walter Doerfler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
For decades this virus system has served--and continues to do so--to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems. This three volume work presents an up-to-date account of recent basic research in one of the most important experimental systems for biochemical, cell biological, genetic, virological and epidemiological investigation in mammalian molecular biology. In the first of the three volumes, we present an overview of adenovirus research. In the second volume, we turn our attention to such topics as DNA replication, recombination and integration and post-trans- criptional control. This, the third volume then looks at transformation and E1A, adenovirus genetics, pathogenesis and gene therapy.
The Molecular Repertoire Of Adenoviruses Ii
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Author : Walter Doerfler
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Molecular Repertoire Of Adenoviruses Ii written by Walter Doerfler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
For decades this virus system has served--and continues to do so--to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems. This three volume work presents an up-to-date account of recent basic research in one of the most important experimental systems for biochemical, cell biological, genetic, virological and epidemiological investigations in mammalian molecular biology. In this, the second of three volumes, the attention is turned to such topics as DNA replication, recombination and integration, and post-transcriptional control. The chapters have been written by an international group of leading experts in their respective fields of interest.
The Molecular Biology Of Adenoviruses
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Author : Walter Doerfler
language : en
Publisher:
Release Date : 1983
The Molecular Biology Of Adenoviruses written by Walter Doerfler and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with Adenoviruses categories.