The Nerve Growth Cone
DOWNLOAD
Download The Nerve Growth Cone PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get The Nerve Growth Cone book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
The Nerve Growth Cone
DOWNLOAD
Author : Paul C. Letourneau
language : en
Publisher: Raven Press (ID)
Release Date : 1991
The Nerve Growth Cone written by Paul C. Letourneau and has been published by Raven Press (ID) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.
Describes research on nerve growth cones, (the dynamic cell structure that plays a key role in establishing the specific neuronal interconnections that determine neural circuitry, and thus behaviour), from their individual molecular components to their behaviour within intact living animals.
Biology Of The Nerve Growth Cone
DOWNLOAD
Author : Stanley B. Kater
language : en
Publisher:
Release Date : 1985
Biology Of The Nerve Growth Cone written by Stanley B. Kater and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Medical categories.
Biology Of The Nerve Growth Cone
DOWNLOAD
Author : Kater
language : en
Publisher: John Wiley & Sons
Release Date : 1985-09-18
Biology Of The Nerve Growth Cone written by Kater and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985-09-18 with categories.
Neuronal Growth Cones
DOWNLOAD
Author : Phillip R. Gordon-Weeks
language : en
Publisher: Cambridge University Press
Release Date : 2000-07-03
Neuronal Growth Cones written by Phillip R. Gordon-Weeks and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-07-03 with Medical categories.
'I had the good fortune to behold for the first time that fantastic ending of the growing axon. In my sections of the spinal cord of the three day chick embryo, this ending appeared as a concentration of protoplasm of conical form, endowed with amoeboid movements. It could be compared with a living battering ram, soft and flexible, which advances, pushing aside mechanically the obstacles which it finds in its path, until it reaches the region of its peripheral termination. This curious terminal club, I christened the growth cone.' (Santiago Ramón y Cajal, Recollections of My Life, 1937). In Neuronal Growth Cones, Phillip Gordon-Weeks presents the molecular biology of the behavior of growth cones. The book covers the basic morphology and behavior of growth cones, motility and neurite extension via the growth cone cytoskeleton, pathfinding, intracellular signalling, and synaptogenesis. It is the first detailed, critical analysis of all aspects of growth cone biology.
Intrinsic And Extrinsic Forces That Guide Growth Cone Motility
DOWNLOAD
Author : Robert Henry Nichol
language : en
Publisher:
Release Date : 2017
Intrinsic And Extrinsic Forces That Guide Growth Cone Motility written by Robert Henry Nichol and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Nerve growth cones are sensory-motile structures that guide developing neurites to form of trillions of synapses in the human brain. Growth cones interact with the extracellular matrix (ECM), such as laminin (LN), through integrin receptors at adhesion sites. Adhesions link ECM proteins to the actin cytoskeleton through numerous adaptor and signaling proteins. One presumed function of growth cone adhesions is to restrain or "clutch" myosin-II-based filamentous actin (F-actin) retrograde flow (RF) to promote leading edge membrane protrusion. In motile non-neuronal cells, myosin-II binds and exerts force upon actin filaments at the leading edge, where clutching forces occur. However, in growth cones, it is unclear whether similar F-actin-clutching forces affect axon outgrowth and guidance. I found in Xenopus spinal neurons RF is reduced in rapidly migrating growth cones on laminin (LN) compared with non-integrin-binding poly-D-lysine (PDL). I further illustrate this relationship between adhesion and RF locally via two-channel imaging of RF and paxillin, as well as on micropatterns of PDL and LN. Finally, I showed that RF is significantly attenuated in vivo, suggesting that it is restrained by molecular clutching forces within the spinal cord. In the second part of my thesis I investigated how extracellular mechanical forces influence neuritogenesis. I examined the role of mechanical forces on neurite development of human forebrain (hFBs) neurons and human motor neurons (hMNs) derived from induced pluripotent stem cells (iPSCs). These two populations of neurons extend axons into distinct environments. Using polyacrylamide (PAA) and collagen substrata of varying elasticity I found that the extension of hFB neurites exhibit little differential outgrowth, while hMN neuritogenesis was strongly promoted on more rigid substrata. I found that the observed differential growth rates are in part due to greater adhesion of the growth cone leading edge to more rigid environments, suggesting hMN growth cones form more stable adhesions leading to greater motility. Furthermore, I found RhoA, an important adhesion regulating GTPase, activity was higher on stiffer substrata in hMNs. Taken together, these data illustrate the mechanistic role of intrinsic and extrinsic forces during neurite outgrowth
The Actin Cytoskeleton And Myosin I Alpha In Nerve Growth Cones
DOWNLOAD
Author : Annette Karen Lewis
language : en
Publisher:
Release Date : 1994
The Actin Cytoskeleton And Myosin I Alpha In Nerve Growth Cones written by Annette Karen Lewis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with categories.
Axon Growth And Guidance
DOWNLOAD
Author : Dominique Bagnard
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-10
Axon Growth And Guidance written by Dominique Bagnard and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-10 with Medical categories.
This book proposes an updated view of the current knowledge of the molecular and cellular mechanisms ensuring axon growth and guidance. The introductory chapter will remind the readers of all the features of a growth cone and the mechanisms controlling its growth. From there, one enters a fabulous journey with a growth cone, a Tom Thumb story filled with molecular encounters and complex interactions leading to one of the most fantastic developmental achievements: the nervous system wiring.
Regulation Of Nerve Growth Cone Motility By Extracellular Matrix Proteins And Intracellular Calcium Dynamics
DOWNLOAD
Author : Timothy Matthew Gomez
language : en
Publisher:
Release Date : 1995
Regulation Of Nerve Growth Cone Motility By Extracellular Matrix Proteins And Intracellular Calcium Dynamics written by Timothy Matthew Gomez and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Brain categories.
Eicosanoid Mediated Repellent Signaling In The Nerve Growth Cone
DOWNLOAD
Author : Jesse C. Gatlin
language : en
Publisher:
Release Date : 2005
Eicosanoid Mediated Repellent Signaling In The Nerve Growth Cone written by Jesse C. Gatlin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
Molecular Biology Of The Cell
DOWNLOAD
Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.