The Networking Of Chaperones By Co Chaperones

DOWNLOAD eBooks

Download The Networking Of Chaperones By Co Chaperones PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get The Networking Of Chaperones By Co Chaperones book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page

The Networking Of Chaperones By Co Chaperones

DOWNLOAD eBooks

Author : Gregory L. Blatch
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-06-07

The Networking Of Chaperones By Co Chaperones written by Gregory L. Blatch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-07 with Science categories.

The Networking of Chaperones by Co-chaperones updates the current understanding of how chaperones are regulated and networked. It is a resource for those in the specialized field of cell stress and chaperones. The book will also be of interest to those in broader cross-cutting field such as cellular networks and systems biology.

The Networking Of Chaperones By Co Chaperones

DOWNLOAD eBooks

Author : Adrienne L. Edkins
language : en
Publisher: Springer Nature
Release Date : 2022-12-15

The Networking Of Chaperones By Co Chaperones written by Adrienne L. Edkins and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-15 with Science categories.

Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is the dynamic integration of the processes of protein folding, degradation and translocation to ensure that cellular function is finely tuned in space and time. This third edition of the book The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by co-chaperones, a diverse cohort of non-client proteins. Since the second edition was released, not only has knowledge deepened on how co-chaperones act as nodes to network and functionalise chaperones, but an understanding of their broader biological function has started to emerge. The third edition provides new and updated chapters highlighting recent developments and emerging themes on co-chaperones, such as their extracellular functions, their role in human disease and their status as putative drug targets. The book is a useful resource for both newcomers and established researchers in the field of cell stress and chaperones, as well as those interested in cross-cutting disciplines such as cellular networks and systems biology.

The Networking Of Chaperones By Co Chaperones

DOWNLOAD eBooks

Author : Gregory Lloyd Blatch
language : en
Publisher: Springer
Release Date : 2014-12-08

The Networking Of Chaperones By Co Chaperones written by Gregory Lloyd Blatch and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-08 with Medical categories.

Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is a dynamic balance between the integrated processes of protein folding, degradation and translocation. The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by a cohort of diverse non-client proteins, known as co-chaperones. The second edition includes the current status of the field and descriptions of a number of novel co-chaperones that have been recently identified. This new edition has a strong focus on the role of co-chaperones in human disease and as putative drug targets. The book will be a resource for both newcomers and established researchers in the field of cell stress and chaperones, as well as those interested in cross-cutting disciplines such as cellular networks and systems biology.

The Networking Of Chaperones By Co Chaperones

DOWNLOAD eBooks

Author : Gregory L. Blatch
language : en
Publisher: Springer
Release Date : 2011-09-17

The Networking Of Chaperones By Co Chaperones written by Gregory L. Blatch and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-17 with Science categories.

The Networking of Chaperones by Co-chaperones updates the current understanding of how chaperones are regulated and networked. It is a resource for those in the specialized field of cell stress and chaperones. The book will also be of interest to those in broader cross-cutting field such as cellular networks and systems biology.

The Molecular Chaperones Interaction Networks In Protein Folding And Degradation

DOWNLOAD eBooks

Author : Walid A. Houry
language : en
Publisher: Springer
Release Date : 2014-09-01

The Molecular Chaperones Interaction Networks In Protein Folding And Degradation written by Walid A. Houry and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-01 with Science categories.

Molecular chaperones are a fundamental group of proteins that have been identified only relatively recently. They are key components of a protein quality machinery in the cell which insures that the folding process of any newly-synthesized polypeptide chain results in the formation of a properly folded protein and that the folded protein is maintained in an active conformation throughout its functional lifetime. Molecular chaperones have been shown to play essential roles in cell viability under both normal and stress conditions. Chaperones can also assist in the unfolding and degradation of misfolded proteins and in disaggregating preformed protein aggregates. Chaperones are also involved in other cellular functions including protein translocation across membranes, vesicle fusion events, and protein secretion. In recent years, tremendous advances have been made in our understanding of the biology, biochemistry, and biophysics of function of molecular chaperones. In addition, recent technical developments in the fields of proteomics and genomics allowed us to obtain a global view of chaperone interaction networks. Finally, there is now a growing interest in the role of molecular chaperones in diseases. This book will provide a comprehensive analysis of the structure and function of the diverse systems of molecular chaperones and their role in cell stress responses and in diseases from a global network perspective. ​

Role Of Molecular Chaperones In Structural Folding Biological Functions And Drug Interactions Of Client Proteins

DOWNLOAD eBooks

Author : Mario D. Galigniana
language : en
Publisher: Bentham Science Publishers
Release Date : 2018-04-26

Role Of Molecular Chaperones In Structural Folding Biological Functions And Drug Interactions Of Client Proteins written by Mario D. Galigniana and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-26 with Science categories.

The book provides an updated panorama of the functional relevance of molecular chaperones in the proper folding of client factors, protein-protein interactions, the regulation of key biological functions, the development of ligand-based structural complexes and the consequent pharmacological or biotechnological applications of these processes. The involvement of molecular chaperones in several processes ranging from regulation of transcription factors and protein-protein interactions in bacteria to proteostasis, signaling pathways and cancer are also addressed. The book is an essential consulting tool for researchers, working professionals in academia or industry, and students of all levels who wish to obtain the most relevant and updated information currently available about protein folding and chaperones.

Molecular Aspects Of The Stress Response Chaperones Membranes And Networks

DOWNLOAD eBooks

Author : Peter Csermely
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-08-09

Molecular Aspects Of The Stress Response Chaperones Membranes And Networks written by Peter Csermely and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-09 with Science categories.

This book makes a novel synthesis of the molecular aspects of the stress response and long term adaptation processes with the system biology approach of biological networks. Authored by an exciting mixture of top experts and young rising stars, it provides a comprehensive summary of the field and identifies future trends.

Hsf1 And Molecular Chaperones In Biology And Cancer

DOWNLOAD eBooks

Author : Marc Laurence Mendillo
language : en
Publisher: Springer Nature
Release Date : 2020-04-15

Hsf1 And Molecular Chaperones In Biology And Cancer written by Marc Laurence Mendillo and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-15 with Medical categories.

Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease. The chapter “Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Molecular Targets In Protein Misfolding And Neurodegenerative Disease

DOWNLOAD eBooks

Author : Pierfausto Seneci
language : en
Publisher: Academic Press
Release Date : 2014-10-07

Molecular Targets In Protein Misfolding And Neurodegenerative Disease written by Pierfausto Seneci and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-07 with Science categories.

Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc. Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases Provides a “drug discovery application oriented perspective, evaluating targets and candidates for their overall therapeutic potential Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets

The Proteasomal System In Aging And Disease

DOWNLOAD eBooks

Author : Tilman Grune
language : en
Publisher: Academic Press
Release Date : 2012-07-05

The Proteasomal System In Aging And Disease written by Tilman Grune and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-05 with Medical categories.

This volume of Progress in Molecular Biology and Translational Science discusses cutting-edge research of proteasomes and proteasome-associated proteins and cellular systems. The volume is split into two sections. The first part discusses the current knowledge of the structure, function, and regulation of the proteasomal system. The second part describes the role of the proteasome in aging and disease. Contributions from leading authorities Informs and updates on all the latest developments in the field