Role Of Molecular Chaperones In Structural Folding Biological Functions And Drug Interactions Of Client Proteins
DOWNLOAD
Download Role Of Molecular Chaperones In Structural Folding Biological Functions And Drug Interactions Of Client Proteins PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Role Of Molecular Chaperones In Structural Folding Biological Functions And Drug Interactions Of Client Proteins book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Role Of Molecular Chaperones In Structural Folding Biological Functions And Drug Interactions Of Client Proteins
DOWNLOAD
Author : Mario D. Galigniana
language : en
Publisher: Bentham Science Publishers
Release Date : 2018-04-26
Role Of Molecular Chaperones In Structural Folding Biological Functions And Drug Interactions Of Client Proteins written by Mario D. Galigniana and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-26 with Science categories.
The book provides an updated panorama of the functional relevance of molecular chaperones in the proper folding of client factors, protein-protein interactions, the regulation of key biological functions, the development of ligand-based structural complexes and the consequent pharmacological or biotechnological applications of these processes. The involvement of molecular chaperones in several processes ranging from regulation of transcription factors and protein-protein interactions in bacteria to proteostasis, signaling pathways and cancer are also addressed. The book is an essential consulting tool for researchers, working professionals in academia or industry, and students of all levels who wish to obtain the most relevant and updated information currently available about protein folding and chaperones.
Role Of Molecular Chaperones On Structural Folding Biological Functions And Drug Interactions Of Client Proteins
DOWNLOAD
Author : Mario D. Galigniana
language : en
Publisher:
Release Date : 2018-04-26
Role Of Molecular Chaperones On Structural Folding Biological Functions And Drug Interactions Of Client Proteins written by Mario D. Galigniana and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-26 with categories.
"The book provides an updated panorama of the functional relevance of molecular chaperones in the proper folding of client factors, protein-protein interactions, the regulation of key biological functions, the development of ligand-based structural complexes and the consequent pharmacological or biotechnological applications of these processes. The involvement of molecular chaperones in several processes ranging from regulation of transcription factors and protein-protein interactions in bacteria to proteostasis, signaling pathways and cancer are also addressed. The book is an essential consulting tool for researchers, working professionals in academia or industry, and students of all levels who wish to obtain the most relevant and updated information currently available about protein folding and chaperones. "
Heat Shock Proteins In Inflammatory Diseases
DOWNLOAD
Author : Alexzander A. A. Asea
language : en
Publisher: Springer Nature
Release Date : 2021-10-13
Heat Shock Proteins In Inflammatory Diseases written by Alexzander A. A. Asea and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-13 with Science categories.
The book Heat Shock Proteins in Inflammatory Diseases provides the most comprehensive highlight and insight of the expression, function and therapeutic activity of Heat Shock Proteins in inflammatory diseases including sepsis, psoriasis, neurodegenerative diseases, cancers, viral infection and autoimmune rheumatic diseases. Using an integrative approach, the contributors provide a synopsis of the most current updates on the state of HSP in inflammatory diseases. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Fundamentals Of Protein Structure And Function
DOWNLOAD
Author : Engelbert Buxbaum
language : en
Publisher: Springer
Release Date : 2015-11-27
Fundamentals Of Protein Structure And Function written by Engelbert Buxbaum and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-27 with Science categories.
This book serves as an introduction to protein structure and function. Starting with their makeup from simple building blocks, called amino acids, the 3-dimensional structure of proteins is explained. This leads to a discussion how misfolding of proteins causes diseases like cancer, various encephalopathies, or diabetes. Enzymology and modern concepts of enzyme kinetics are then introduced, taking into account the physiological, pharmacological and medical significance of this often neglected topic. This is followed by thorough coverage of hæmoglobin and myoglobin, immunoproteins, motor proteins and movement, cell-cell interactions, molecular chaperones and chaperonins, transport of proteins to various cell compartments and solute transport across biological membranes. Proteins in the laboratory are also covered, including a detailed description of the purification and determination of proteins, as well as their characterisation for size and shape, structure and molecular interactions. The book emphasises the link between protein structure, physiological function and medical significance. This book can be used for graduate and advanced undergraduate classes covering protein structure and function and as an introductory text for researchers in protein biochemistry, molecular and cell biology, chemistry, biophysics, biomedicine and related courses. About the author: Dr. Buxbaum is a biochemist with interest in enzymology and protein science. He has been working on the biochemistry of membrane transport proteins for nearly thirty years and has taught courses in biochemistry and biomedicine at several universities.
The Molecular Chaperones Interaction Networks In Protein Folding And Degradation
DOWNLOAD
Author : Walid A. Houry
language : en
Publisher: Springer
Release Date : 2014-09-01
The Molecular Chaperones Interaction Networks In Protein Folding And Degradation written by Walid A. Houry and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-01 with Science categories.
Molecular chaperones are a fundamental group of proteins that have been identified only relatively recently. They are key components of a protein quality machinery in the cell which insures that the folding process of any newly-synthesized polypeptide chain results in the formation of a properly folded protein and that the folded protein is maintained in an active conformation throughout its functional lifetime. Molecular chaperones have been shown to play essential roles in cell viability under both normal and stress conditions. Chaperones can also assist in the unfolding and degradation of misfolded proteins and in disaggregating preformed protein aggregates. Chaperones are also involved in other cellular functions including protein translocation across membranes, vesicle fusion events, and protein secretion. In recent years, tremendous advances have been made in our understanding of the biology, biochemistry, and biophysics of function of molecular chaperones. In addition, recent technical developments in the fields of proteomics and genomics allowed us to obtain a global view of chaperone interaction networks. Finally, there is now a growing interest in the role of molecular chaperones in diseases. This book will provide a comprehensive analysis of the structure and function of the diverse systems of molecular chaperones and their role in cell stress responses and in diseases from a global network perspective.
Molecular Chaperones In Human Disorders
DOWNLOAD
Author :
language : en
Publisher: Academic Press
Release Date : 2019-01-09
Molecular Chaperones In Human Disorders written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-09 with Science categories.
Molecular Chaperones in Human Disorders, Volume 114 in the Advances in Protein Chemistry and Structural Biology series, provides an overview of current developments in mechanisms underlying DNA repair and their involvement in maintaining chromatin repair, the balance between chromosomal repair pathways, tumorigenesis, immune signaling and infection-induced inflammation. Chapters in this new release cover Functional principles and regulation of molecular chaperones, Chaperones and retinal disorders, Protein misfolding and degradation in genetic diseases, Chaperone dysfunction in hereditary myopathic diseases, Diseases caused by functional disorder of molecular chaperones residing in the endoplasmic reticulum, and many other timely topics. - Describes advances in our understanding on DNA repair mechanisms and the involvement of their dysregulation in promoting diseases - Provides an ideal resource for a very wide audience of specialists, researchers and students - Contains timely chapters written by well-renown authorities in their field - Presents information that is well supported by a number of high quality illustrations, figures and tables
Biophysics Of Molecular Chaperones
DOWNLOAD
Author : Sebastian Hiller
language : en
Publisher: Royal Society of Chemistry
Release Date : 2023-11-01
Biophysics Of Molecular Chaperones written by Sebastian Hiller and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-01 with Science categories.
Molecular chaperones are critical to control protein quality in all living cells. Understanding chaperone function at the atomic level, and in particular its mode of interaction with client proteins, is crucial to understanding the fundamental roles chaperones play in biology. This book fills a gap in the literature by comprehensively summarizing and discussing new advanced experimental techniques for their analysis. Providing a comprehensive overview of advanced biophysical methods for the characterization of molecular mechanisms of molecular chaperones, the majority of the contributions are NMR methodology. This is the method of choice for atomic resolution studies of such systems. Additional notable biophysical approaches are considered to present all relevant current developments in exploring chaperone function and the transient and dynamic interactions with their client proteins. The book is targeted at both current practitioners of structural biology and biophysical chemistry and scientists who are interested in entering the field. It could be useful for graduate students as supplementary reading.
Handbook Of Biomarkers And Precision Medicine
DOWNLOAD
Author : Claudio Carini
language : en
Publisher: CRC Press
Release Date : 2019-04-16
Handbook Of Biomarkers And Precision Medicine written by Claudio Carini and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-16 with Medical categories.
"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.
Heat Shock Protein 90 In Human Diseases And Disorders
DOWNLOAD
Author : Alexzander A. A. Asea
language : en
Publisher: Springer Nature
Release Date : 2019-11-04
Heat Shock Protein 90 In Human Diseases And Disorders written by Alexzander A. A. Asea and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-04 with Science categories.
The book Heat Shock Protein 90 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP90. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, previously unknown signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding Oncogenic Aspects of HSP90; Section II, focuses on Bimolecular Aspects of HSP90; Section III, emphasizes and HSP90 in Natural Products Development and Section IV; give the most up to date reviews on Clinical Aspects of HSP90. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Natural Products, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Molecular Chaperones And Human Disease
DOWNLOAD
Author : Graham Chakafana
language : en
Publisher: Frontiers Media SA
Release Date : 2022-12-19
Molecular Chaperones And Human Disease written by Graham Chakafana and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-19 with Science categories.