The Neutral Theory Of Molecular Evolution
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The Neutral Theory Of Molecular Evolution
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Author : Motoo Kimura
language : en
Publisher: Cambridge University Press
Release Date : 1983
The Neutral Theory Of Molecular Evolution written by Motoo Kimura and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with Science categories.
This book is the first comprehensive treatment of this subject.
My Thoughts On Biological Evolution
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Author : Motoo Kimura
language : en
Publisher: Springer Nature
Release Date : 2020-07-29
My Thoughts On Biological Evolution written by Motoo Kimura and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-29 with Science categories.
This book, written by Motoo Kimura (1924–94), is a classic in evolutionary biology. In 1968, Kimura proposed the “neutral theory of molecular evolution”, which became the theoretical basis of modern evolutionary studies. After publishing his work in 1983 in the book “Neutral Theory of Molecular Evolution”, Kimura wrote this book in 1988 for the general public. It was originally written in Japanese and is translated here for the first time. In the book, Kimura first summarizes the development of evolutionary theory since Lamarck and Darwin. He then shows how the search for mechanisms of evolution developed into population genetics and describes how the study of molecular evolution matured by taking in the fruits of molecular biology. Kimura proceeds to carefully explain his neutral evolution theory at the molecular level. Finally, he presents his view of the world from an evolutionary perspective. The book has long served as an in-depth introduction to evolutionary biology for students and young researchers in Japan. There has been remarkably rapid progress in the field of bioscience at the molecular level over the past 30 years. Nevertheless, the book remains an important contribution that laid the foundations for what followed in molecular evolutionary studies.
Theoretical Population Genetics
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Author : J.S. Gale
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Theoretical Population Genetics written by J.S. Gale and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The rise of the neutral theory of molecular evolution seems to have aroused a renewed interest in mathematical population genetics among biologists, who are primarily experimenters rather than theoreticians. This has encouraged me to set out the mathematics of the evolutionary process in a manner that, I hope, will be comprehensible to those with only a basic knowledge of calculus and matrix algebra. I must acknowledge from the start my great debt to my students. Equipped initially with rather limited mathematics, they have pursued the subject with much enthusiasm and success. This has enabled me to try a number of different approaches over the years. I was particularly grateful to Dr L. J. Eaves and Professor W. E. Nance for the opportunity to give a one-semester course at the Medical College of Virginia, and I would like to thank them, their colleagues and their students for the many kindnesses shown to me during my visit. I have concentrated almost entirely on stochastic topics, since these cause the greatest problems for non-mathematicians. The latter are particularly concerned with the range of validity of formulae. A sense of confidence in applying these formulae is, almost certainly, best gained by following their derivation. I have set out proofs in fair detail, since, in my experience, minor points of algebraic manipulation occasionally cause problems. To avoid loss of continuity, I have sometimes put material in notes at the end of chapters.
Bioinformatics For Beginners
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Author : Supratim Choudhuri
language : en
Publisher: Elsevier
Release Date : 2014-05-09
Bioinformatics For Beginners written by Supratim Choudhuri and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-09 with Science categories.
Bioinformatics for Beginners: Genes, Genomes, Molecular Evolution, Databases and Analytical Tools provides a coherent and friendly treatment of bioinformatics for any student or scientist within biology who has not routinely performed bioinformatic analysis. The book discusses the relevant principles needed to understand the theoretical underpinnings of bioinformatic analysis and demonstrates, with examples, targeted analysis using freely available web-based software and publicly available databases. Eschewing non-essential information, the work focuses on principles and hands-on analysis, also pointing to further study options. - Avoids non-essential coverage, yet fully describes the field for beginners - Explains the molecular basis of evolution to place bioinformatic analysis in biological context - Provides useful links to the vast resource of publicly available bioinformatic databases and analysis tools - Contains over 100 figures that aid in concept discovery and illustration
The Causes Of Molecular Evolution
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Author : John H. Gillespie
language : en
Publisher: Oxford University Press
Release Date : 1994-05-26
The Causes Of Molecular Evolution written by John H. Gillespie and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-05-26 with Science categories.
This work provides a unified theory that addresses the important problem of the origin and maintenance of genetic variation in natural populations. With modern molecular techniques, variation is found in all species, sometimes at astonishingly high levels. Yet, despite these observations, the forces that maintain variation within and between species have been difficult subjects of study. Because they act very weakly and operate over vast time scales, scientists must rely on indirect inferences and speculative mathematical models. However, despite these obstacles, many advances have been made. The author's research in molecular genetics, evolution, and bio-mathematics has enabled him to draw on this work, and present a coherent and valuable view of the field. The book is divided into three parts. The first consists of three chapters on protein evolution, DNA evolution, and molecular mechanisms. This section reviews the experimental observations on genetic variation. The second part gives a unified treatment of the mathematical theory of selection in a fluctuating environment. The final two chapters combine the earlier assessments in a treatment of the scientific status of two competing theories for the maintenance of genetic variation. Steeped in the enormous advances population genetics has made over the past 25 years, this book has proven highly popular among human geneticists, biologists, evolutionary theorists, and bio-mathematicians.
Computational Molecular Evolution
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Author : Ziheng Yang
language : en
Publisher: OUP Oxford
Release Date : 2006-10-05
Computational Molecular Evolution written by Ziheng Yang and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-10-05 with Science categories.
The field of molecular evolution has experienced explosive growth in recent years due to the rapid accumulation of genetic sequence data, continuous improvements to computer hardware and software, and the development of sophisticated analytical methods. The increasing availability of large genomic data sets requires powerful statistical methods to analyse and interpret them, generating both computational and conceptual challenges for the field. Computational Molecular Evolution provides an up-to-date and comprehensive coverage of modern statistical and computational methods used in molecular evolutionary analysis, such as maximum likelihood and Bayesian statistics. Yang describes the models, methods and algorithms that are most useful for analysing the ever-increasing supply of molecular sequence data, with a view to furthering our understanding of the evolution of genes and genomes. The book emphasizes essential concepts rather than mathematical proofs. It includes detailed derivations and implementation details, as well as numerous illustrations, worked examples, and exercises. It will be of relevance and use to students and professional researchers (both empiricists and theoreticians) in the fields of molecular phylogenetics, evolutionary biology, population genetics, mathematics, statistics and computer science. Biologists who have used phylogenetic software programs to analyze their own data will find the book particularly rewarding, although it should appeal to anyone seeking an authoritative overview of this exciting area of computational biology.
Crumbling Genome
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Author : Alexey S. Kondrashov
language : en
Publisher: John Wiley & Sons
Release Date : 2017-05-16
Crumbling Genome written by Alexey S. Kondrashov and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-16 with Science categories.
A thought-provoking exploration of deleterious mutations in the human genome and their effects on human health and wellbeing Despite all of the elaborate mechanisms that a cell employs to handle its DNA with the utmost care, a newborn human carries about 100 new mutations, originated in their parents, about 10 of which are deleterious. A mutation replacing just one of the more than three billion nucleotides in the human genome may lead to synthesis of a dysfunctional protein, and this can be inconsistent with life or cause a tragic disease. Several percent of even young people suffer from diseases that are caused, exclusively or primarily, by pre ]existing and new mutations in their genomes, including both a wide variety of genetically simple Mendelian diseases and diverse complex diseases such as birth anomalies, diabetes, and schizophrenia. Milder, but still substantial, negative effects of mutations are even more pervasive. As of now, we possess no means of reducing the rate at which mutations appear spontaneously. However, the recent flood of genomic data made possible by next-generation methods of DNA sequencing, enabled scientists to explore the impacts of deleterious mutations on humans with previously unattainable precision and begin to develop approaches to managing them. Written by a leading researcher in the field of evolutionary genetics, Crumbling Genome reviews the current state of knowledge about deleterious mutations and their effects on humans for those in the biological sciences and medicine, as well as for readers with only a general scientific literacy and an interest in human genetics. Provides an extensive introduction to the fundamentals of evolutionary genetics with an emphasis on mutation and selection Discusses the effects of pre-existing and new mutations on human genotypes and phenotypes Provides a comprehensive review of the current state of knowledge in the field and considers crucial unsolved problems Explores key ethical, scientific, and social issues likely to become relevant in the near future as the modification of human germline genotypes becomes technically feasible Crumbling Genome is must-reading for students and professionals in human genetics, genomics, bioinformatics, evolutionary biology, and biological anthropology. It is certain to have great appeal among all those with an interest in the links between genetics and evolution and how they are likely to influence the future of human health, medicine, and society.
Population Genetics
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Author : John H. Gillespie
language : en
Publisher: JHU Press
Release Date : 2004-08-06
Population Genetics written by John H. Gillespie and has been published by JHU Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-08-06 with Medical categories.
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Molecular Evolution
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Author : Roderick D.M. Page
language : en
Publisher: John Wiley & Sons
Release Date : 2009-07-14
Molecular Evolution written by Roderick D.M. Page and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-07-14 with Science categories.
The study of evolution at the molecular level has given the subject of evolutionary biology a new significance. Phylogenetic 'trees' of gene sequences are a powerful tool for recovering evolutionary relationships among species, and can be used to answer a broad range of evolutionary and ecological questions. They are also beginning to permeate the medical sciences. In this book, the authors approach the study of molecular evolution with the phylogenetic tree as a central metaphor. This will equip students and professionals with the ability to see both the evolutionary relevance of molecular data, and the significance evolutionary theory has for molecular studies. The book is accessible yet sufficiently detailed and explicit so that the student can learn the mechanics of the procedures discussed. The book is intended for senior undergraduate and graduate students taking courses in molecular evolution/phylogenetic reconstruction. It will also be a useful supplement for students taking wider courses in evolution, as well as a valuable resource for professionals. First student textbook of phylogenetic reconstruction which uses the tree as a central metaphor of evolution. Chapter summaries and annotated suggestions for further reading. Worked examples facilitate understanding of some of the more complex issues. Emphasis on clarity and accessibility.
Population Genetics Molecular Evolution And The Neutral Theory
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Author : Motoo Kimura
language : en
Publisher: University of Chicago Press
Release Date : 1994
Population Genetics Molecular Evolution And The Neutral Theory written by Motoo Kimura and has been published by University of Chicago Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Science categories.
One of this century's leading evolutionary biologists, Motoo Kimura revolutionized the field with his random drift theory of molecular evolution—the neutral theory—and his groundbreaking theoretical work in population genetics. This volume collects 57 of Kimura's most important papers and covers forty years of his diverse and original contributions to our understanding of how genetic variation affects evolutionary change. Kimura's neutral theory, first presented in 1968, challenged the notion that natural selection was the sole directive force in evolution. Arguing that mutations and random drift account for variations at the level of DNA and amino acids, Kimura advanced a theory of evolutionary change that was strongly challenged at first and that eventually earned the respect and interest of evolutionary biologists throughout the world. This volume includes the seminal papers on the neutral theory, as well as many others that cover such topics as population structure, variable selection intensity, the genetics of quantitative characters, inbreeding systems, and reversibility of changes by random drift. Background essays by Naoyuki Takahata examine Kimura's work in relation to its effects and recent developments in each area.