The Nuclear Receptor Factsbook
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The Nuclear Receptor Factsbook
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Author : Vincent Laudet
language : en
Publisher: Gulf Professional Publishing
Release Date : 2002
The Nuclear Receptor Factsbook written by Vincent Laudet and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Medical categories.
The FactsBook Series has established itself as the best source of easily accessible and accurate facts about protein groups. They use an easy-to-follow format and are researched and compiled by experts in the field. This Factsbook is devoted to nuclear receptors. The first section presents an introduction and describes the mode of action of the receptors in general. The second section of the book contains detailed entries covering each type of receptor. Entries provide information on: Nomenclature and structure, Isolation, DNA binding properties, Ligands, Expression, Target genes, Knockouts, Disease association, Gene structure, promoter and isoforms, Chromosomal location, Amino acid sequences, Key references
Nuclear Receptor Factsbook
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Author : Vincent Laudet
language : en
Publisher: Turtleback
Release Date : 2001-11-01
Nuclear Receptor Factsbook written by Vincent Laudet and has been published by Turtleback this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-11-01 with Medical categories.
The FactsBook Series has established itself as the best source of easily accessible and accurate facts about protein groups. They use an easy-to-follow format and are researched and compiled by experts in the field. This Factsbook is devoted to nuclear receptors. The first section presents an introduction and describes the mode of action of the receptors in general. The second section of the book contains detailed entries covering each type of receptor. Entries provide information on: Nomenclature and structure Isolation DNA binding properties Ligands Expression Target genes Knockouts Disease association Gene structure, promoter and isoforms Chromosomal location Amino acid sequences Key references
Nuclear Receptors
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Author : Margaret K. Bates
language : en
Publisher: Nova Science Publishers
Release Date : 2011
Nuclear Receptors written by Margaret K. Bates and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Nuclear receptors (Biochemistry) categories.
Nuclear Receptors As Molecular Targets For Cardiometabolic And Central Nervous System Diseases
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Author : J.L. Junien
language : en
Publisher: IOS Press
Release Date : 2008-07-16
Nuclear Receptors As Molecular Targets For Cardiometabolic And Central Nervous System Diseases written by J.L. Junien and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-07-16 with Medical categories.
Nuclear receptors are a family of transcription factors consisting of 49 members identified in the human genome. Nuclear receptors regulate transcription by binding to response elements in the regulatory regions of target genes and thereby affect expression of genes involved in differentiation, growth, lipid homeostasis, inflammation and immunity. Over the past two decades significant advances have been made in the understanding of the regulation of gene expression by nuclear receptors. The knowledge on nuclear receptors has delivered novel therapies for lipid control and hormone replacement, and for management of cancer and diabetes. Therefore, nuclear receptors are attractive molecular targets for design of therapy for diabetes, obesity, atherosclerosis, cancer, inflammation and neurodegeneration. The focus of this volume is centered on the mechanistic involvement of nuclear receptors in cardiological, metabolic and neurological disorders, on possible explanation of pathways involved in pathogenesis, on susceptibility to and prevention of metabolic and neurological disorders and on the aspects of drug finding including chemistry and rational drug design. This volume reviews recent progress on nuclear receptors critically and will intrigue those pursuing interest in physiology, pathology and medicine.
Nuclear Receptors From Structure To The Clinic
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Author : Iain J. McEwan
language : en
Publisher: Springer
Release Date : 2015-08-20
Nuclear Receptors From Structure To The Clinic written by Iain J. McEwan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-20 with Medical categories.
Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. It brings together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity. The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors.
Nuclear Receptors
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Author : Mostafa Z. Badr
language : en
Publisher: Springer Nature
Release Date : 2021-09-28
Nuclear Receptors written by Mostafa Z. Badr and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-28 with Medical categories.
Nuclear receptors are ligand activated transcription factors that control numerous biological functions. Consequently, altering activity of these receptors is proposed, and indeed documented, to affect many physiological and pathological conditions in experimental animals and humans. Thus, nuclear receptors have become a major target in the effort to treat numerous diseases. This book will shed light on and emphasize intricate processes involved in designing as well as discovering physiological and pharmacological modulators of these important proteins. World-renowned scientists will share with the reader their professional expertise and extensive experience acquired through decades working with nuclear receptors. Chapters address the various means and consequences of modulating nuclear receptor activity will be presented and discussed. These modulators cover a wide span of moieties ranging from synthetic chemicals to natural products. In addition, the classification of these chemicals ranges from pan agonists to selective agonists and inverse agonists to antagonists. They also include proteolytic means to obliterate the receptor in the event that modulating its activity through canonical pharmacological agents becomes less effective and/or less desirable due to anticipated or experienced toxicities. Modulation of receptor activity may also take place in the absence of a ligand or through manipulating the structure of the receptor itself by controlling posttranslational events.
Nuclear Receptors In Development And Disease
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Author :
language : en
Publisher: Academic Press
Release Date : 2017-05-17
Nuclear Receptors In Development And Disease written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-17 with Science categories.
Nuclear Receptors in Development and Disease, Volume 125, the latest volume in the Current Topics in Developmental Biology series, covers nuclear receptors in development and disease, and includes contributions from an international board of authors. The book's chapters provide a comprehensive set of reviews that cover such topics as nuclear differentiation and remodeling, evolution of receptors, ligand signaling and neural development. Covers the area of nuclear receptors in development and disease Includes contributions from an International board of authors Provides a comprehensive set of reviews on topics as nuclear differentiation and remodeling, evolution of receptors, ligand signaling and neural developments
Nuclear Receptors In Development
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Author :
language : en
Publisher: Elsevier
Release Date : 2006-11-07
Nuclear Receptors In Development written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-11-07 with Science categories.
A superb compilation of reviews from leading experts in the field of nuclear receptors, volume 16 in the Advances in Developmental Biology series covers the role of different nuclear receptor subfamilies in development, physiology and metabolism. This volume brilliantly reviews how genetic defects in the function of nuclear receptors leads to various developmental defects. Receptors discussed include: thyroid receptors, peroxisome proliferators activated receptors, and retinoic acid receptors. Additionaly, this volume offers an indespesable chapter on the orphan receptors Ftz-F1, COUPs, and RORs in embryonic and postnatal development. * Provides a compilation of reviews of several nuclear receptor subfamilies - such as TRs, PPARs, RARs, the orphan receptors COUP-TFs, RORs, and Ftz-F1 in embryonic and postnatal development. * Offers a detailed section on retinoid receptor signaling * Covers the role of co-repressors and co-activators in modulation of nuclear receptor functions
The Cytokine Factsbook And Webfacts
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Author : Katherine A. Fitzgerald
language : en
Publisher: Elsevier
Release Date : 2001-09-03
The Cytokine Factsbook And Webfacts written by Katherine A. Fitzgerald and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-09-03 with Medical categories.
Completely revised and expanded, this second edition of The Cytokine FactsBook is the most up-to-date reference manual available for all current well-characterized interleukins, cytokines, and their receptors. An additional 52 cytokines are included, doubling the number of entries from the previous edition. The key properties of each cytokine are described and presented in a very accessible format with diagrams for each of the receptors. The Cytokine FactsBook includes free online access to the regularly updated Cytokine Webfacts. Cytokine Webfacts is a web-based comprehensive compendium of facts about cytokines and their receptors that includes a variety of data representations, such as text, signal pathway diagrams and 3D images. This exciting resource is integrated into other databases via hypertext links to provide a unique network, and contains a web-enabled version of RasMol for viewing structures.
Constitutive Activity In Receptors And Other Proteins
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Author :
language : en
Publisher: Academic Press
Release Date : 2010-11-24
Constitutive Activity In Receptors And Other Proteins written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-24 with Science categories.
This volume of Methods in Enzymology covers the current methodology for the detection and assessment of constitutively active proteins. The chapters written by expert authors who are leaders in the field, provide hints and tricks not available in primary research publications.It is extensively referenced, with useful figures and tables throughout the volume. Expert authors who are leaders in the field Extensively referenced and useful figures and tables Provides hints and tricks to facilitate reproduction of methods