The Pharmacology Of Inflammation
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The Pharmacology Of Inflammation
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Author : Iwan L. Bonta
language : en
Publisher: Elsevier Science & Technology
Release Date : 1985
The Pharmacology Of Inflammation written by Iwan L. Bonta and has been published by Elsevier Science & Technology this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Anti-inflammatory agents categories.
The Pharmacology Of Inflammation
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Author : Walter G. Spector
language : en
Publisher:
Release Date : 1968
The Pharmacology Of Inflammation written by Walter G. Spector and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1968 with Inflammation (Pathologie) categories.
10 Years Of Inflammation Pharmacology
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Author : Paola Patrignani
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-07
10 Years Of Inflammation Pharmacology written by Paola Patrignani and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-07 with categories.
The past and future of inflammatory pharmacology research: a hot topic in health and disease Inflammation is a physiological response to a traumatic injury, bacterial, or viral infection. However, if not appropriately controlled, it contributes to a long list of diseases, including asthma, atherosclerosis, multiple sclerosis, arthritis, and cancer. Different are the types of inflammatory responses. Acute inflammation is an immediate body response to the cellular damage induced by pathogens, noxious stimuli, or physical injury – it is a short-term response resulting in healing via time-dependent changes of leukocyte functions. First, a leukocytes infiltration happens within the damaged region with the purpose of eliminating the stimulus and repairing the tissue. Chronic inflammation, by contrast, is a prolonged and dysregulated response where the active inflammation contributes both to tissue destruction and to the development of many chronic human conditions and diseases. In the context of exaggerated inflammation, which occurs as a consequence of severe burns or trauma, the body response called sepsis can be associated with fatal outcome. Increased knowledge of the cellular and molecular mechanisms taking part in the different types of inflammation is a central requirement to develop more effective and safer treatments. This is a necessary step to prevent potential severe consequences, i.e., organ failure associated with tissue fibrosis. The mission of Inflammation Pharmacology (section of Frontiers in Pharmacology) is to publish scientifically sound studies that advance our knowledge on different aspects of inflammation and contribute to the development of more effective and safer anti-inflammatory agents. Within the present eBook are collected the top articles published in the Inflammation Pharmacology section in the last 10 years. Some articles explored the roles played by different lipid mediators generated from arachidonic acid, including leukotrienes and prostanoids [such as prostacylin and prostaglandin(PG)F2a], in inflammatory conditions. Moreover, the protectin (PD) family of specialized pro-resolving mediators biosynthesized from the two omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and n–3 docosapentaenoic acid (n–3 DPA) were described for their biological effects, the G-coupled protein receptors pharmacology, biosynthesis, and medicinal chemistry. Some other articles focused on the development of novel strategies to counteract inflammation or to induce its resolution. The current concepts and controversies on classification, pathogenesis, and clinical management of cutaneous adverse events induced by biologic agents used in the treatment of rheumatologic conditions were discussed in another article. The whole-exome and whole-genome sequencing data identifying new and old loci associated with atherosclerosis will lead to discovering new molecular targets for blocking atherosclerosis even in its early stages. This critical issue was reviewed in another paper. Numerous information on an individual clinical condition is held in their platelet-derived microparticles (MPs); the assessment of their number and size together with their content can represent the signature to acquire diagnostic information and to monitor the efficacy of therapeutic agents. Some other articles discussed the role of fibroblasts in the development of fibrosis and potential therapies under investigation. It was enlightened the role of the activation and transdifferentiation of hepatic stellate cells (HSCs) into contractile, matrix-producing myofibroblasts (MFBs) as central events in hepatic fibrogenesis, and summarized the current strategies for targeted delivery of drugs to pro-fibrogenic liver cells, including the development of therapeutics specifically targeting HSCs. (Continued in eBook)
The Pharmacology Of Inflammation
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Author : Ivan L. Bonta
language : en
Publisher:
Release Date : 1985
The Pharmacology Of Inflammation written by Ivan L. Bonta and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with categories.
Recent Developments In The Pharmacology Of Inflammatory Mediators
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Author : Iwan L. Bonta
language : en
Publisher: Agents and Actions Supplements
Release Date : 1977
Recent Developments In The Pharmacology Of Inflammatory Mediators written by Iwan L. Bonta and has been published by Agents and Actions Supplements this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with Juvenile Nonfiction categories.
In previous studies (1,2) we demonstrated the occurrence of a foetal protein after injury in the rat. This protein, behaving as an acute phase protein, proved to be already known as slow a2 glo bulin (3), or reproduction associated protein (4). Furthermore it is identical to aM foetoprotein (also known as a2FP or aMFP (5) ). This protein is quite different to the well-known a-foetoprotein (aFP), occurring in man and other species during liver carcinoge nesis and some other tumours. aMfoetoprotein (aMFP) is a glycoprotein with a mol.w. of 800.000. It is produced in the liver (6,2) and in the normal adult rat the plasma concentrations are rather low, about 0 - 40 ~g/ml. During fetal development the plasma level in the fetus is much higher (about 6000 ~g/ml), diminishing rapidly after birth to adult levels. But after injury (laparotomy, deep incision, partial hepatectomy followed by regeneration, BaS04 or CdS04 intraperitoneally), plasma levels increase fastly, reaching peak values of 1000 - 8000 ~g/ml after 24 - 48 hrs, declining thereafter gradually. Also very small lesions, as orbital punction, venasection, cannulations, small infections and so on, cause moderate rises of plasma levels up to 80 - 120 ~g/ml. During fetal stage the inflammatory reaction often lacks some of its characteristic features: oedema and infiltration of leucocytes are often rather scanty (7). Also is known that in exudates proteins occur, inhibiting experimen tal inflammations (8,9).
Immunopharmacology And Inflammation
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Author : Carlo Riccardi
language : en
Publisher: Springer
Release Date : 2018-06-09
Immunopharmacology And Inflammation written by Carlo Riccardi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-09 with Medical categories.
A comprehensive overview of the current research on inflammation and immunopharmacology, with particular attention to the use of anti-inflammatory drugs, this book discusses future trends in this area of pharmacological research. It addresses an audience with basic knowledge in the inflammatory process, immune system and pharmacology. The book meets the needs of graduate students, junior and senior researchers and is useful as a source of the most current information for those already working in these fields.
Anti Inflammatory Agents Part I
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Author : Robert Scherrer
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Anti Inflammatory Agents Part I written by Robert Scherrer and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.
Medicinal Chemistry: A Series of Monographs, Volume 13–I explores the development in the treatment of some severely debilitating chronic inflammatory diseases, including arthritis, gout, rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus, psoriasis, conjunctivitis, episcleritis, and uveitis. This volume examines the anti-inflammatory drugs used to alter the inflammatory response in diseases of unknown cause. This book is comprised of two parts encompassing 11 chapters. Part I discusses the factors that cause the inflammation and explores the interaction of these causative agents with those therapies found to be clinically effective. This text also presents an illustrative classification of some debilitating inflammatory conditions and the available therapy. Part II explores the nonsteroidal anti-inflammatory agents that are peripheral analgesics and anti-pyretic. Other chapters review colchicine and allopurinol as anti-inflammatory drugs for gout. Finally, this volume ends with a discussion on the anti-inflammatory activity of some proteolytic enzymes of vegetable, animal, fungal, and bacterial origin. Physicians, chemists, and experimental biologists will find this book extremely useful.
Inflammation
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Author :
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-27
Inflammation written by and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-27 with Medical categories.
Throughout the centuries, inflammation has been considered as a disease in itself. This misconception arose from the inability to distinguish between inflammatory changes and the insults which induce them. The understanding of the distinction between the genesis of inflammation and the tissue reactions that follow is attributed to JOHN HUNTER, who, at the end of the 18th century, substantially contributed to the analysis of inflammation in objective terms. Today, however, we are still trying to find explanations for Celsus' Signs in terms of structural and functional changes occurring in the inflamed tissue. There are drugs which modulate these signs but, without a detailed knowledge of the basic physiopathological events, it is impossible to understand their mechanism of action. Notwithstanding, the effects of anti inflammatory drugs provided new knowledge of the relevance of the signs and symptoms to the sequence of biochemical and morphological changes occurring in inflammation. When we accepted the invitation to edit a Handbook on Inflammation and Anti Inflammatory Drugs, we were aware of the magnitude of the task. We knew the impossibility of covering the whole field in detail, especially taking into account the rapid accumulation of experimental knowledge which would, in all likelihood, overtake the process of publication.
Recent Developments In The Pharmacology Of Inflammatory Mediators
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Author : Iwan L. Bonta
language : en
Publisher:
Release Date : 1977
Recent Developments In The Pharmacology Of Inflammatory Mediators written by Iwan L. Bonta and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with categories.
Resolution Pharmacology Innovative Therapeutic Approaches Based On The Biology Of Resolution To Control Chronic Diseases Of Western Societies
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Author : Mauro Perretti
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-04
Resolution Pharmacology Innovative Therapeutic Approaches Based On The Biology Of Resolution To Control Chronic Diseases Of Western Societies written by Mauro Perretti and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-04 with categories.
In this eBook, we have grouped together 16 original contributions which have addressed the translational potential for therapeutics developed on the conceptual framework of the resolution of inflammation. The take home message of our effort, and the efforts of our colleagues who wrote these pieces, is that completely different drugs can be designed and modelled on the mediators and targets of resolution. By implementing this 180° shift in the way we plan the drug development programme (that is by focusing on agonists and/or promoting the actions of pro-resolution agonists) we can offer a fresh approach to the clinical management of chronic diseases that affect the modern society. With this series of articles we foresee the birth of Resolution Pharmacology. The 16 contributions presented herein confirm the broad relevance of pro-resolving physio-pharmacology with the description of pro-resolving mechanisms in distinct diseases, from atherosclerosis and heart infarct, to cystic fibrosis and diabetes. This testifies on one hand the fundamental role that inflammatory mechanisms play in virtually all pathological settings and, on the other hand, the great potential that a novel approach to anti-inflammatory therapy by exploiting resolution mediators and targets may have. Thus, while there is broad recognition that evidence-based interventions have transformed cardiovascular, inflammation and endocrine care, new therapies are still needed for growing numbers of patients with unmet needs. As an example, an estimated 17 million people world-wide die annually of cardiovascular diseases, particularly heart attacks and strokes. Cardiovascular diseases occur almost equally in men and women and are the leading cause of death and morbidity worldwide. It is estimated that only 1/1,000 compounds entering preclinical testing are then trialled in man and the actual cost of developing a new therapeutic into clinical practice has grown exponentially over the past two decades (estimated $1.2B). Over the last 20 years or more, scientists have appreciated the biology of the resolution of inflammation, which provides a new paradigm in our understanding of the inflammatory process with the appreciation of genetic, molecular and cellular mechanisms that are engaged to actively resolve inflammation. The ‘resolution of acute inflammation’ is enabled by counter-regulatory checkpoints to terminate the host reaction while at the same time promoting healing and repair. The potential of lipid mediators to enact pro-resolving effects in the context of cystic fibrosis is presented by Recchiuti et al., while Fredman reasons on the potential for these molecules in atherosclerosis. This resonates well with the contributions from Bäck and colleagues who have focused on pro-resolving receptors to offer vasculo-protection in intimal hyperplasia and more generally in cardiovascular disease. On the same vein is the scholar contribution of Leoni and Soehnlein who focus on heart disease, with Qin et al. presenting the latest findings on the effect of an Annexin A1-derived peptide in myocardial infarction. Hansen et al. and de Gaetano et al. bring in the complexity of diabetes and associated morbidity with a focus on specialised pro-resolving lipid mediators but also introducing the potential of dietary approaches. As the western diet favours disease, an omega-3 rich diet can lead to higher availability of lipid mediators to afford tissue protection if not reverting its pathological status. Docosahexaenoic acid and its bioactive derivatives are endowed with potent anti-nociceptive properties following bone fracture, as shown by Zhang et al. The broad relevance of the pharmacological approach reaches the skin with Resolvin D1 protecting against UV irradiation (Saito et al.). Reduced skin inflammation is also achieved with an Annexin A1 peptide that impacts on the outcome of heterologous transplantation (Lacerda et al.). Indeed, modulating the phenotype of immune cells can provide long lasting beneficial outcomes, as attained with CDK inhibitors (Cartwright et al.) and PI3K inhibitors in experimental gout (Galvao et al.). Such an effect is also achieved with a third group of pro-resolving therapeutics, the melanocortin receptor agonists, with important modulation of macrophage reactivity (Patruno et al.) with Spana et al., providing new pharmacology following selective activation of the MC1 receptor. Finally, Hopkin et al. discuss the potential for targeting immune cell trafficking as a way to control immune mediated diseases, bringing in not only pro-resolving mediator agonists, but also approaches to reduce chemo/cytokine gradients or modulating S1P and 11-beta hydroxysteroid dehydrogenase. Finally, we wish to highlight that this wealth of science has also bought to the forefront specific pro-resolving receptors (including FPR2/ALX, GPR32, ChemR23 and MC1), all G protein coupled receptors that are therefore amenable to pharmacological exploitation for drug discovery programmes. We see that not only agonists to the receptors can be developed, some of them modelled on the natural ligands (e.g. resolvins, lipoxins, Annexin A1-derived peptides or melanocortin peptides), but also that the creativity of this pharmacology can be attained through biased ligands and positive allosteric modulators. Deep knowledge of pro-resolving receptor biology and their cell-specific signalling can accelerate the generation of novel anti-inflammatory depicted on the resolution of inflammation. In conclusion, with this eBook, we propose time is ready to exploit the concepts of resolution and use its targets and mediators for the identification of better drugs to establish ‘Resolution Pharmacology’. We predict Resolution Pharmacology will represent an important innovation in the way common diseases will be treated in the next decades of this millennium.