The Role Of P2 Pruinergic Receptors In Lipopolysaccharide Mediated Macrophage Activation And Pathophysiology
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The Role Of P2 Pruinergic Receptors In Lipopolysaccharide Mediated Macrophage Activation And Pathophysiology
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Author : Alma N. Guerra
language : en
Publisher:
Release Date : 2002
The Role Of P2 Pruinergic Receptors In Lipopolysaccharide Mediated Macrophage Activation And Pathophysiology written by Alma N. Guerra and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
Dissertation Abstracts International
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Author :
language : en
Publisher:
Release Date : 2003
Dissertation Abstracts International written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Dissertations, Academic categories.
Glutathione System And Oxidative Stress In Health And Disease
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Author :
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-08-26
Glutathione System And Oxidative Stress In Health And Disease written by and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-26 with Science categories.
The imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses determines a state known as oxidative stress. Higher levels of pro-oxidants compared to antioxidant defenses may generate oxidative damage, which, in turn, may lead to modifications in cellular proteins, lipids, and DNA, reducing functional capacity and increasing the risk of diseases. Nevertheless, the clearance of harmful reactive chemical species is achieved by the antioxidant defense systems. These protection systems are referred to as the first and second lines of defense and comprise the classic antioxidants, enzymatic and nonenzymatic defenses, including glutathione. This book presents and discusses the advancement of research on health and diseases and their underlying mechanisms, exploring mainly aspects related to the glutathione antioxidant system.
Sphingosine 1 Phosphate Signaling In Immunology And Infectious Diseases
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Author : Michael B. A. Oldstone
language : en
Publisher: Springer
Release Date : 2016-08-23
Sphingosine 1 Phosphate Signaling In Immunology And Infectious Diseases written by Michael B. A. Oldstone and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-23 with Medical categories.
This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations of acute respiratory influenza virus infection (in the lung), and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system, including the beginning of treatments in multiple sclerosis. One chapter reveals the possible involvement of other lipid molecules, their use for better understanding lipid signaling, and their potential in the modulation of immune responses.
Receptors P1 And P2 As Targets For Drug Therapy In Humans
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Author : Robson Faria
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-03-11
Receptors P1 And P2 As Targets For Drug Therapy In Humans written by Robson Faria and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-11 with Medical categories.
This book aims to provide a brief update on the functions of purinergic receptors in various systems, in addition to the signaling pathway activated to mediate these functions. We address the influence of hypoxia by modulating the activity of these receptors under physiological and pathophysiological conditions. Additionally, we describe the mechanisms of induction of pain and inflammation in different systems. Finally, the book discusses some of the main bioinformatics tools currently used to improve or discover new prototypes capable of selectively acting on these receptors with estimated parameters of satisfactory solubility and toxicity for possible commercial implementation.
Myeloid Cells In Health And Disease
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Author : Siamon Gordon
language : en
Publisher: John Wiley & Sons
Release Date : 2020-07-10
Myeloid Cells In Health And Disease written by Siamon Gordon and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-10 with Science categories.
The structure, functions, and interactions of myeloid cells have long been the focus of research and therapeutics development. Yet, much more remains to be discovered about the complex web of relationships that makes up the immune systems of animals. Scientists today are applying genome-wide analyses, single-cell methods, gene editing, and modern imaging techniques to reveal new subclasses of differentiated myeloid cells, new receptors and cytokines, and important interactions among immune cells. In Myeloid Cells in Health and Disease: A Synthesis, Editor Siamon Gordon has assembled an international team of esteemed scientists to provide their perspectives of myeloid cells during innate and adaptive immunity. The book begins by presenting the foundational research of Paul Ehrlich, Elie Metchnikoff, and Donald Metcalf. The following chapters discuss evolution and the life cycles of myeloid cells; specific types of differentiated myeloid cells, including macrophage differentiation; and antigen processing and presentation. The rest of the book is organized by broad topics in immunology, including the recruitment of myeloid and other immune cells following microbial infection the role of myeloid cells in the inflammation process and the repair of damaged tissue the vast arsenal of myeloid cell secretory molecules, including metalloproteinases, tumor necrosis factor, histamine, and perforin receptors and downstream signaling pathways that are activated following ligand-receptor binding roles of myeloid cells during microbial and parasite infections contributions of myeloid cells in atherosclerosis myeloid-derived suppressor cells in tumor development and cancer Myeloid Cells in Health and Disease: A Synthesis will benefit graduate students and researchers in immunology, hematology, microbial pathogenesis, infectious disease, pathology, and pharmacology. Established scientists and physicians in these and related fields will enjoy the book's rich history of myeloid cell research and suggestions for future research directions and potential therapies.
Cell Membrane Receptors For Drugs And Hormones
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Author : Ralph W. Straub
language : en
Publisher:
Release Date : 1978
Cell Membrane Receptors For Drugs And Hormones written by Ralph W. Straub and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Medical categories.
Role Of The P2x7 Nucleotide Receptor In Lipopolysaccharide Stimulated Macrophage Activation
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Author : Philip L. Fisette
language : en
Publisher:
Release Date : 1999
Role Of The P2x7 Nucleotide Receptor In Lipopolysaccharide Stimulated Macrophage Activation written by Philip L. Fisette and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.
Autonomic Neuroimmunology
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Author : John Bienenstock
language : en
Publisher: CRC Press
Release Date : 2003-02-13
Autonomic Neuroimmunology written by John Bienenstock and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-02-13 with Medical categories.
While it may appear that the nervous and immune systems exist as two separate entities, groundbreaking observations have positively identified anatomic connections between elements of the nervous system and cells of adaptive immunity. Building on this research, Autonomic Neuroimmunology presents a scientific discussion of the current understanding of these vital neuroimmunological interactions and their implications for normal psychology and disease states. Contributors document the cell biological mechanisms for the neuropeptide activation of mast cells, and analyze how one or more adrenergenic and peptidergic messengers modulate immunity. They also explain the pathways by which cholinergic factors may suppress immunological inflammation. The potential implications of organ system-selective neuroimmunology for host defense and diseases are thoroughly discussed for the skin, the intestines, the bladder, and the lungs. With modern neuroimmunology now firmly established as a scientific discipline, this volume supports this promising science as a pathway to novel diagnostic and therapeutic techniques for diseases of the neural, immune, and endocrine systems.
Purinergic Signaling 2020 The State Of The Art Commented By The Members Of The Italian Purine Club
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Author : Francesco Caciagli
language : en
Publisher: Frontiers Media SA
Release Date : 2021-10-29
Purinergic Signaling 2020 The State Of The Art Commented By The Members Of The Italian Purine Club written by Francesco Caciagli and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-29 with Science categories.