The Role Of The Tumor Microenvironment Tme And Relevant Novel Biomarkers In Oncogenesis 2nd Edition
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The Role Of The Tumor Microenvironment Tme And Relevant Novel Biomarkers In Oncogenesis 2nd Edition
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Author : Zhouxiao Li
language : en
Publisher: Frontiers Media SA
Release Date : 2025-06-25
The Role Of The Tumor Microenvironment Tme And Relevant Novel Biomarkers In Oncogenesis 2nd Edition written by Zhouxiao Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-25 with Science categories.
Tumors and their surroundings are closely related and constantly interact. Tumors can influence their microenvironment by releasing cell signaling molecules that promote neoplasm angiogenesis and induce immune tolerance, while immune cells in the microenvironment can influence cancer cell growth and development. The tumor microenvironment (TME), a complex biological ecosystem for cancer cells to survive and develop refers to the surrounding circumstances of cancer cells, including surrounding blood vessels, immune cells, fibroblasts, bone marrow inflammatory cells, various signaling molecules and extracellular matrix (ECM). The immune cells and their regulation mode in TME have tumor-antagonizing or tumor-promoting functions. TME has been gradually recognized as a key contributor to cancer progression and drug resistance, with cellular components in the TME able to enhance tumor resistance by recruiting and secreting multiple protective cytokines. The acellular components of TME can mediate drug resistance by building physical barriers, affecting tumor cell growth and metabolism, etc. Knowledge of the above is paving the way for identifying new targets and discovering new therapies. Studying the dynamic relationship between tumor surroundings and neoplasm, and clarifying the molecular mechanism of different factors refers to TME in the process of tumor progression, are the key elements of cancer inhibition. Currently, there is a proliferation of publicly available tumor genomic databases. Such as the Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Surveillance, Epidemiology, and EndResults Program (SEER), International Cancer Genome Consortium (ICGC) and National Cancer Database (NCDB). These abundant public database resources enable researchers to mine multi-omics cancer data to better understand the interactions between tumors and their microenvironment and to discover biomarkers and therapeutic targets in TME that are associated with tumorigenesis. This provides new targets for early diagnosis and precise treatment of tumors. In this research topic, we would like to demonstrate the function and mechanism of tumor microenvironment in tumorigenesis and development through various methods, including sequencing, bioassay, experimental models such as PDX and organoids. We welcome original research articles and reviews dedicated to: 1) Mechanisms of tumor microenvironment involvement in tumor progression. 2) Bioinformatics or big data demonstrating the role of the tumor microenvironment in tumor progression 3) Molecular therapeutic mechanisms and clinical studies related to the tumor microenvironment 4) Biomarkers and therapeutic targets related to tumor microenvironment 5) Drug resistance mechanism related to tumor microenvironment
The Role Of The Tumor Microenvironment Tme And Relevant Novel Biomarkers In Oncogenesis
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Author : Zhouxiao Li
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-15
The Role Of The Tumor Microenvironment Tme And Relevant Novel Biomarkers In Oncogenesis written by Zhouxiao Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-15 with Science categories.
Novel Biomarkers In Tumor Immunity And Immunotherapy
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Author : Takaji Matsutani
language : en
Publisher: Frontiers Media SA
Release Date : 2024-07-26
Novel Biomarkers In Tumor Immunity And Immunotherapy written by Takaji Matsutani and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-26 with Science categories.
Immune checkpoint inhibitors (ICIs) such as anti-PD-1 and anti-PD-L1 antibodies are highly effective against many types of cancer, yet durable responses are limited to a subset of patients highlighting the need for the development of effective biomarkers to predict prognosis and efficacy. Currently, PD-L1 expression in tumors, microsatellite instability (MSI) or mismatch repair deficiency (dMMR), and tumor mutation burden (TMB) are known as biomarkers for cancer immunotherapy but are not sufficient. Combination therapy with immune checkpoint inhibitors and chemotherapy or radiation therapy, as well as diverse therapies targeting intra-tumoral regulatory T cells have been described, but there are currently no unifying biomarkers that are applicable to clinically, a simple, fast, non-invasive method that can yield biomarkers of disease with a minimal adverse effect on patients is desirable. Recent findings suggest that the balancing of effector T cells and regulatory cells in the tumor microenvironment is associated with cancer progression and prognosis. Cells and molecules involved in the control of cancer are complex, and a better understanding of the tumor immune environment will lead to the development of truly effective biomarkers. This topic will focus on novel biomarkers that predict efficacy, prognosis, or the development of adverse events in various cancer immunotherapies, and extensive basic research leading to the development of biomarkers. Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic. We expect a wide range of research, not only in serology, genetics, and immunocytochemistry but also in bacterial flora. Research on the development of novel assays and bioinformatics methods is also welcome: • Non-invasive biomarkers for cancer immunotherapy. • Bulk RNA-seq, scRNA-seq, or Rep-seq methods. • Correlation of tumor immune cells with gut microbiota in tumor immunotherapy. • Impact of Teff and Treg balance in the tumor microenvironment on tumor prognosis. • Inflammatory and immune signatures associated with drug response versus resistance in cancer.
Novel Targets And Biomarkers In Solid Tumors 2nd Edition
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Author : Dong-Hua Yang
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-16
Novel Targets And Biomarkers In Solid Tumors 2nd Edition written by Dong-Hua Yang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-16 with categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Molecular Biomarkers For Gastric Cancer 2nd Edition
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Author : Kecheng Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-07-31
Molecular Biomarkers For Gastric Cancer 2nd Edition written by Kecheng Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-31 with Science categories.
Gastric cancer (GC) represents a serious health problem on a global scale. Despite some recent advances in the field, the prognosis in GC remains poor. A better understanding of molecular biology, which would lead to improved treatment options, is needed. Many potential biomarkers of prognostic significance have been identified. However, inhibition of only HER2 protein has led to a modest survival benefit. A deeper understanding of the pathogenesis and biological features of gastric cancer, including the identification and characterization of diagnostic, prognostic, predictive, and therapeutic biomarkers, hopefully will provide improved clinical outcomes. This Research Topic aims to provide a comprehensive overview on recent progress in emerging molecular biomarkers for gastric cancer. We welcome the submission of Review and Original Research articles covering, but not limited to, the following topics: 1)Novel diagnostic molecules to improve the early detection rate for gastric cancer 2)Novel prognostic molecules to stratify gastric cancer patients into different risk 3)Novel therapeutic biomarker which could serve as target for treating gastric cancer 4)Novel biomarker to predict chemotherapy response of gastric cancer patients
Cancer Immunotherapy Principles And Practice Second Edition
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Author : Lisa H. Butterfield
language : en
Publisher: Springer Publishing Company
Release Date : 2021-08-25
Cancer Immunotherapy Principles And Practice Second Edition written by Lisa H. Butterfield and has been published by Springer Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-25 with Medical categories.
Thoroughly updated to reflect major advances in the field of immuno-oncology, this second edition of Cancer Immunotherapy Principles and Practice, from the Society for Immunotherapy of Cancer (SITC), remains the definitive resource for information on tumor immunology and cancer immunotherapy treatments. An essential reference for both novice and experienced cancer researchers, oncologists, and related practitioners alike, the book not only guides readers through the fundamental scientific principles of the field all the way to translational and practical clinical applications for treating and managing oncologic disease, but also provides a comprehensive understanding of the regulatory processes that support the safe and effective delivery of immunotherapy to patients with cancer. The expanded and updated second edition now spans 68 chapters, including 12 new chapters, covering major topics and innovations that have shaped the rapid development of immunotherapy and its ascension into the standard of care as first-line treatment for a growing number of disease settings. New to this edition are chapters with deeper insight into our understanding of cancer genomics and determinants of response, immunogenic cell death, cancer and stromal cell-intrinsic pathways of immune resistance, cancer immune exclusion, adoptive cell therapy, metabolomics, tumor mutation burden, immunotherapy in combination with radiation therapy, synthetic biology, and more. Complete with detailed illustrations, tables, and key points for targeted reference, Cancer Immunotherapy Principles and Practice, Second Edition is the most comprehensive and authoritative resource for scientists and clinicians looking to expand their knowledge base of this dynamic field. Key Features: Offers key insights and perspectives on cancer immunology and immunotherapy treatments from renowned experts in the field Covers the basic principles and science behind cancer immunotherapy and tumor immunology Includes treatment strategies for a vast array of available immunotherapy classes and agents, such as cytokine therapies, oncolytic viruses, cancer vaccines, CAR T therapies, and combination immunotherapies Provides essential information on FDA-approved immunotherapies, including clinical management and outcome data related to response rates, risks, and toxicities Discusses special considerations for immunotherapy in the context of specific disease settings, including skin cancers, genitourinary cancers, gastrointestinal cancers, hepatocellular carcinomas, gynecologic malignancies, breast cancers, lung cancers, head and neck cancers, brain tumors, sarcomas, pediatric cancers, and treatments combined with radiation therapy Clarifies the complex regulatory aspects behind the development and approval of immunotherapy drugs
Exploring The Breast Tumor Microenvironment Association To Metastasis Novel Risk Factors And Novel Treatments And Immunotherapies
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Author : Jorge Morales-Montor
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-10
Exploring The Breast Tumor Microenvironment Association To Metastasis Novel Risk Factors And Novel Treatments And Immunotherapies written by Jorge Morales-Montor and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-10 with Medical categories.
Novel Biomarkers For Anticancer Therapy
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Author : Hongtao Xiao
language : en
Publisher: Frontiers Media SA
Release Date : 2023-02-07
Novel Biomarkers For Anticancer Therapy written by Hongtao Xiao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-07 with Science categories.
Multi Omics Application In Exploring Potential Biomarkers Targeting Resistance Of Anti Cancer Drugs
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Author : Hailin Tang
language : en
Publisher: Frontiers Media SA
Release Date : 2025-04-30
Multi Omics Application In Exploring Potential Biomarkers Targeting Resistance Of Anti Cancer Drugs written by Hailin Tang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-30 with Science categories.
Cancer remains a critical concern in global health due to its high prevalence and mortality rates. Despite significant advancements in the development of anti-cancer drugs, drug resistance continues to pose a major challenge in clinical treatments. Drug resistance may be either intrinsic i.e., pre-existent resistance present in the tumor cells even before exposure to chemotherapy, or acquired resistance i.e., induced by drugs during or after treatment of tumors with anticancer compounds. Anti-cancer treatments such as chemotherapy, targeted therapy, and immunotherapy are highly genotype-related interventions. Coding and Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), lncRNAs, circular RNAs (circRNAs), and PIWI-RNA (piRNA) have been shown to play important roles in tumor formation and therapeutic resistance. lncRNAs can activate DNA damage repair, silence tumor suppressor genes, and modulate cancer-related epigenetic changes at the chromatin level in terms of histone modifications, DNA methylation, and altering chromatin architecture.
Systematic Identification Of Novel Diagnostic And Prognostic Tumor Biomarkers Based On Multi Omics Data Analysis Of Solid Tumors
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Author : Ming Jun Zheng
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-08
Systematic Identification Of Novel Diagnostic And Prognostic Tumor Biomarkers Based On Multi Omics Data Analysis Of Solid Tumors written by Ming Jun Zheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-08 with Science categories.