Multi Omics Application In Exploring Potential Biomarkers Targeting Resistance Of Anti Cancer Drugs
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Multi Omics Application In Exploring Potential Biomarkers Targeting Resistance Of Anti Cancer Drugs
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Author : Hailin Tang
language : en
Publisher: Frontiers Media SA
Release Date : 2025-04-30
Multi Omics Application In Exploring Potential Biomarkers Targeting Resistance Of Anti Cancer Drugs written by Hailin Tang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-30 with Science categories.
Cancer remains a critical concern in global health due to its high prevalence and mortality rates. Despite significant advancements in the development of anti-cancer drugs, drug resistance continues to pose a major challenge in clinical treatments. Drug resistance may be either intrinsic i.e., pre-existent resistance present in the tumor cells even before exposure to chemotherapy, or acquired resistance i.e., induced by drugs during or after treatment of tumors with anticancer compounds. Anti-cancer treatments such as chemotherapy, targeted therapy, and immunotherapy are highly genotype-related interventions. Coding and Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), lncRNAs, circular RNAs (circRNAs), and PIWI-RNA (piRNA) have been shown to play important roles in tumor formation and therapeutic resistance. lncRNAs can activate DNA damage repair, silence tumor suppressor genes, and modulate cancer-related epigenetic changes at the chromatin level in terms of histone modifications, DNA methylation, and altering chromatin architecture.
Multi Omics In Studying The Mechanisms Of Anti Cancer Drugs Resistance And Toxicity
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Author : Jian Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-18
Multi Omics In Studying The Mechanisms Of Anti Cancer Drugs Resistance And Toxicity written by Jian Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-18 with Science categories.
Exploring The Impact Of Genetics On New Drugs And Potential Drug Targets A Multi Omics Approach To Improve Personalized Therapeutics
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Author : Shaoqiu Chen
language : en
Publisher: Frontiers Media SA
Release Date : 2024-07-08
Exploring The Impact Of Genetics On New Drugs And Potential Drug Targets A Multi Omics Approach To Improve Personalized Therapeutics written by Shaoqiu Chen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-08 with Science categories.
In recent years, significant advancements have been made in the field of new drug development. With the advent of high-throughput sequencing technologies, the identification of new drug targets has become more efficient and precise. In addition, multi-omics approaches, including genomics, transcriptomics, proteomics, and metabolomics, have emerged as a powerful tool for understanding the complexity of diseases and identifying new therapeutic targets.
Multi Targeted Tyrosine Kinase Inhibitors In The Treatment Of Cancer And Neurodegenerative Disorders
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Author : Halilibrahim Ciftci
language : en
Publisher: Frontiers Media SA
Release Date : 2024-08-07
Multi Targeted Tyrosine Kinase Inhibitors In The Treatment Of Cancer And Neurodegenerative Disorders written by Halilibrahim Ciftci and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-07 with Science categories.
Tyrosine kinases, which catalyze the transfer of a phosphate from ATP to a hydroxyl group of a tyrosine residue, play a plethora of roles in the regulation of diverse functions in normal cells including cell growth, motility, differentiation, and metabolism. Moreover, they are also associated with oncogenesis. Tyrosine kinases are mainly classified as receptor tyrosine kinases and non-receptor tyrosine kinases, including crucial members. Epidermal growth factor receptor (EGFR) belongs to the ERBB family of receptor tyrosine kinases along with three other closely related receptors, namely HER-2, HER-3 and HER-4. EGFR and HER-2, lead to autophosphorylation of the intracellular domain through tyrosine kinase activity and subsequent stimulation of downstream cascade that may result in proliferation, suppression of apoptosis, metastasis and angiogenesis. On the other hand, c-Abl (Abl-1) is a non-receptor tyrosine kinase, which is also essential in the regulation of several antiapoptotic and proliferative signal transduction pathways. They have mainly been identified as important targets for several types of cancer such as EGFR for non-small-cell lung cancer, glioma and colorectal cancer, HER-2 for breast and colorectal cancers and Abl for chronic myeloid leukemia. One of the major platforms that they have participated in is neurodegenerative disorders such as Parkinson’s disease, Alzheimer’s disease and amyotrophic lateral sclerosis. Aberrant activity of tyrosine kinases, in particular EGFR and Abl, have been reported to induce apoptosis and cell cycle arrest in response to a wide range of stimuli resulting in neurodegeneration and neuroinflammation. The main goal of this Research Topic is to identify new and potent effective tyrosine kinase inhibitors to be effective in cancer and neurodegenerative disorders.
Epigenetic Drugs And Therapeutic Resistance For Epithelial Malignancies
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Author : Zhiqian Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-05
Epigenetic Drugs And Therapeutic Resistance For Epithelial Malignancies written by Zhiqian Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-05 with Science categories.
Prediction And Explanation In Biomedicine Using Network Based Approaches
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Author : Alessio Martino
language : en
Publisher: Frontiers Media SA
Release Date : 2022-10-12
Prediction And Explanation In Biomedicine Using Network Based Approaches written by Alessio Martino and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-12 with Medical categories.
Computational Methods For Multi Omics Data Analysis In Cancer Precision Medicine
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Author : Ehsan Nazemalhosseini-Mojarad
language : en
Publisher: Frontiers Media SA
Release Date : 2023-08-02
Computational Methods For Multi Omics Data Analysis In Cancer Precision Medicine written by Ehsan Nazemalhosseini-Mojarad and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-02 with Science categories.
Cancer is a complex and heterogeneous disease often caused by different alterations. The development of human cancer is due to the accumulation of genetic and epigenetic modifications that could affect the structure and function of the genome. High-throughput methods (e.g., microarray and next-generation sequencing) can investigate a tumor at multiple levels: i) DNA with genome-wide association studies (GWAS), ii) epigenetic modifications such as DNA methylation, histone changes and microRNAs (miRNAs) iii) mRNA. The availability of public datasets from different multi-omics data has been growing rapidly and could facilitate better knowledge of the biological processes of cancer. Computational approaches are essential for the analysis of big data and the identification of potential biomarkers for early and differential diagnosis, and prognosis.
Functional Screening For Cancer Drug Discovery From Experimental Approaches To Data Integration
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Author : Wenyu Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-28
Functional Screening For Cancer Drug Discovery From Experimental Approaches To Data Integration written by Wenyu Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-28 with Science categories.
Journal Of The National Cancer Institute
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Author :
language : en
Publisher:
Release Date : 1990
Journal Of The National Cancer Institute written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Cancer categories.
Advances In Targeted Therapy And Biomarker Research For Endocrine Related Cancers
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Author : Zili Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-12-27
Advances In Targeted Therapy And Biomarker Research For Endocrine Related Cancers written by Zili Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-27 with Medical categories.
The field of endocrine-related cancers is rapidly evolving, driven by significant advancements in understanding the molecular and genetic underpinnings of these diseases. These cancers, which include various malignancies affecting the endocrine system, pose unique challenges due to their complex interactions with hormonal pathways. The development of targeted therapies has skyrocketed in recent years, bringing hope for more effective and personalized treatment options. Concurrently, the discovery and validation of biomarkers have become pivotal in diagnosis, prognostication, and guidance on therapy decision-making, marking a shift towards precision oncology. Additionally, innovative research methodologies, such as organoid and organ-on-a-chip technologies, have emerged and provided more accurate models of tumor biology and drug response. These advancements underscore the importance of translational medicine in bridging the gap between laboratory research and clinical application, offering new avenues for understanding and combating endocrine-related cancers. This dynamic landscape calls for a comprehensive exploration of current trends and future directions in the research and treatment of these complex malignancies.