Exploring The Impact Of Genetics On New Drugs And Potential Drug Targets A Multi Omics Approach To Improve Personalized Therapeutics
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Exploring The Impact Of Genetics On New Drugs And Potential Drug Targets A Multi Omics Approach To Improve Personalized Therapeutics
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Author : Shaoqiu Chen
language : en
Publisher: Frontiers Media SA
Release Date : 2024-07-08
Exploring The Impact Of Genetics On New Drugs And Potential Drug Targets A Multi Omics Approach To Improve Personalized Therapeutics written by Shaoqiu Chen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-08 with Science categories.
In recent years, significant advancements have been made in the field of new drug development. With the advent of high-throughput sequencing technologies, the identification of new drug targets has become more efficient and precise. In addition, multi-omics approaches, including genomics, transcriptomics, proteomics, and metabolomics, have emerged as a powerful tool for understanding the complexity of diseases and identifying new therapeutic targets.
Gliomas Microenvironment New Drug Entities Mechanisms Of Action Molecular Biomarkers And Drug Delivery Strategies
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Author : Célia Cabral
language : en
Publisher: Frontiers Media SA
Release Date : 2024-07-26
Gliomas Microenvironment New Drug Entities Mechanisms Of Action Molecular Biomarkers And Drug Delivery Strategies written by Célia Cabral and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-26 with Science categories.
Gliomas are neoplasms originating in glial cells, the most malignant and frequent primary tumors of the Central Nervous System (CNS), representing approximately 40-50% of all intracranial tumors. Following the World Health Organization (WHO) guidelines, gliomas are classified into grades I-IV, regarding their malignancy degree. The latest report from WHO on CNS tumors considers that glioblastoma (GB), a grade IV adult-type diffuse glioma comprising isocitrate dehydrogenase (IDH)-wildtype tumors. Despite all efforts to improve patient survival and quality of life, the median survival remains lower due to the lack of effective diagnostic tools, poor prognosis, and limited therapeutic options. Regarding this, the design of novel treatment strategies is of the utmost importance. This can be by either the discovery of new medicines (for example synthetic compounds), repurposing known drugs or exploring novel strategies of drug delivery by nanotechnological platforms to improve treatment response and long-term survival of patients. Inter and intra-tumor heterogeneity mainly contribute to the poor prognosis and treatment efficacy. Therefore, exploiting tumor microenvironment (TME) and understanding GB’s cellular and molecular aspects are fundamental to developing more effective and better-tolerated personalized therapies. Thus, addressing physiological mechanisms involved in cancer development, progression and recurrence is crucial. Concerning this, our goal with this research topic is to share the latest advances in tumor-specific therapies for gliomas, especially GB, as well as to provide experimental validation of new bioactive molecules and their antitumor mechanism of action. Authors are invited to submit original research, review articles and systematic reviews covering, but not restricted to, the following topics: 1) Novel targeted therapies; 2) Mechanism of action and affected signaling pathways; 3) Repurposing drugs; 5) New chemical entities; 6) Pharmaceutical nanotechnology; 7) Drug delivery systems; 8) Preclinical and clinical studies of therapeutic molecules; 9) Potential molecular biomarkers to targeted therapies using proteomics or transcriptomics.
Immunological Precision Therapeutics Integrating Multi Omics Technologies And Comprehensive Approaches For Personalized Immune Intervention
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Author : Wenyi Jin
language : en
Publisher: Frontiers Media SA
Release Date : 2025-03-20
Immunological Precision Therapeutics Integrating Multi Omics Technologies And Comprehensive Approaches For Personalized Immune Intervention written by Wenyi Jin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-20 with Medical categories.
In the realm of modern immunology, the pursuit of precision therapeutics has emerged as a paramount endeavor. This research field harnesses the power of advanced multi-omics technologies and comprehensive methodologies to revolutionize personalized immune interventions. Immunotherapy, a cornerstone of precision medicine, targets the intricate dynamics of the immune system to combat diseases ranging from cancer to autoimmune disorders. Integrating multi-omics analyses, including genomics, transcriptomics, proteomics, and metabolomics, enables a holistic understanding of immune responses at various molecular levels. Immune signatures derived from these analyses unveil individualized patterns, offering crucial insights into disease susceptibility and treatment efficacy. Leveraging this wealth of data through sophisticated computational models and machine learning algorithms enhances our ability to predict immune responses and identify optimal therapeutic strategies. By amalgamating diverse approaches, from single-cell profiling to spatial transcriptomics, we delve deeper into the complexities of immune regulation and cellular interactions within the microenvironment. Through collaborative efforts, the pursuit of immunological precision therapeutics aims to tailor interventions precisely to each patient's immune landscape, ushering in a new era of personalized immune modulation.
Multi Omics Application In Exploring Potential Biomarkers Targeting Resistance Of Anti Cancer Drugs
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Author : Hailin Tang
language : en
Publisher: Frontiers Media SA
Release Date : 2025-04-30
Multi Omics Application In Exploring Potential Biomarkers Targeting Resistance Of Anti Cancer Drugs written by Hailin Tang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-30 with Science categories.
Cancer remains a critical concern in global health due to its high prevalence and mortality rates. Despite significant advancements in the development of anti-cancer drugs, drug resistance continues to pose a major challenge in clinical treatments. Drug resistance may be either intrinsic i.e., pre-existent resistance present in the tumor cells even before exposure to chemotherapy, or acquired resistance i.e., induced by drugs during or after treatment of tumors with anticancer compounds. Anti-cancer treatments such as chemotherapy, targeted therapy, and immunotherapy are highly genotype-related interventions. Coding and Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), lncRNAs, circular RNAs (circRNAs), and PIWI-RNA (piRNA) have been shown to play important roles in tumor formation and therapeutic resistance. lncRNAs can activate DNA damage repair, silence tumor suppressor genes, and modulate cancer-related epigenetic changes at the chromatin level in terms of histone modifications, DNA methylation, and altering chromatin architecture.
Omics For Personalized Medicine
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Author : Debmalya Barh
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-10-14
Omics For Personalized Medicine written by Debmalya Barh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-14 with Medical categories.
“Omics for Personalized Medicine” will give to its prospective readers the insight of both the current developments and the future potential of personalized medicine. The book brings into light how the pharmacogenomics and omics technologies are bringing a revolution in transforming the medicine and the health care sector for the better. Students of biomedical research and medicine along with medical professionals will benefit tremendously from the book by gaining from the diverse fields of knowledge of new age personalized medicine presented in the highly detailed chapters of the book. The book chapters are divided into two sections for convenient reading with the first section covering the general aspects of pharmaocogenomic technology that includes latest research and development in omics technologies. The first section also highlights the role of omics in modern clinical trials and even discusses the ethical consideration in pharmocogenomics. The second section is focusing on the development of personalized medicine in several areas of human health. The topics covered range from metabolic and neurological disorders to non-communicable as well as infectious diseases, and even explores the role of pharmacogenomics in cell therapy and transplantation technology. Thirty-four chapters of the book cover several aspects of pharmacogenomics and personalized medicine and have taken into consideration the varied interest of the readers from different fields of biomedical research and medicine. Advent of pharmacogenomics is the future of modern medicine, which has resulted from culmination of decades of research and now is showing the way forward. The book is an honest endeavour of researchers from all over the world to disseminate the latest knowledge and knowhow in personalized medicine to the community health researchers in particular and the educated public in general.
Multidisciplinary Research In Arts Science Commerce Volume 21
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Author : Chief Editor- Biplab Auddya, Editor- Dr. Jay Prakash Rajak, Dr. Akheel Mohammed, Dr. (Mrs) Shirley Bless Agwuocha, Andriya Mallick, Dr. Sandip R. Kelode, Chalamalasetti Vana Venkata Madhur
language : en
Publisher: The Hill Publication
Release Date : 2025-03-27
Multidisciplinary Research In Arts Science Commerce Volume 21 written by Chief Editor- Biplab Auddya, Editor- Dr. Jay Prakash Rajak, Dr. Akheel Mohammed, Dr. (Mrs) Shirley Bless Agwuocha, Andriya Mallick, Dr. Sandip R. Kelode, Chalamalasetti Vana Venkata Madhur and has been published by The Hill Publication this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-27 with Antiques & Collectibles categories.
Integrative Omics
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Author : Manish Kumar Gupta
language : en
Publisher: Elsevier
Release Date : 2024-05-03
Integrative Omics written by Manish Kumar Gupta and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-03 with Science categories.
Integrative Omics: Concepts, Methodology and Applications provides a holistic and integrated view of defining and applying network approaches, integrative tools, and methods to solve problems for the rationalization of genotype to phenotype relationships. The reference includes a range of chapters in a systemic 'step by step' manner, which begins with the basic concepts from Omic to Multi Integrative Omics approaches, followed by their full range of approaches, applications, emerging trends, and future trends. All key areas of Omics are covered including biological databases, sequence alignment, pharmacogenomics, nutrigenomics and microbial omics, integrated omics for Food Science and Identification of genes associated with disease, clinical data integration and data warehousing, translational omics as well as omics technology policy and society research. Integrative Omics: Concepts, Methodology and Applications highlights the recent concepts, methodologies, advancements in technologies and is also well-suited for researchers from both academic and industry background, undergraduate and graduate students who are mainly working in the area of computational systems biology, integrative omics and translational science. The book bridges the gap between biological sciences, physical sciences, computer science, statistics, data science, information technology and mathematics by presenting content specifically dedicated to mathematical models of biological systems. - Provides a holistic, integrated view of a defining and applying network approach, integrative tools, and methods to solve problems for rationalization of genotype to phenotype relationships - Offers an interdisciplinary approach to Databases, data analytics techniques, biological tools, network construction, analysis, modeling, prediction and simulation of biological systems leading to 'translational research', i.e., drug discovery, drug target prediction, and precision medicine - Covers worldwide methods, concepts, databases, and tools used in the construction of integrated pathways
Multidisciplinary Research In Arts Science Commerce Volume 15
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Author : Chief Editor- Biplab Auddya, Editor- Dr. Bijikumary P, Dr. Pravin Vivek Kaslikar, Prof. Rohit Kulkarni, Mr. Enock I, Dr. J.Sathish Kumar, Dr. Balaji Shivraj Hokarne
language : en
Publisher: The Hill Publication
Release Date : 2024-12-19
Multidisciplinary Research In Arts Science Commerce Volume 15 written by Chief Editor- Biplab Auddya, Editor- Dr. Bijikumary P, Dr. Pravin Vivek Kaslikar, Prof. Rohit Kulkarni, Mr. Enock I, Dr. J.Sathish Kumar, Dr. Balaji Shivraj Hokarne and has been published by The Hill Publication this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-19 with Antiques & Collectibles categories.
Revolutionizing Healthcare 5 0 The Power Of Generative Ai
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Author : Pronaya Bhattacharya
language : en
Publisher: Springer Nature
Release Date : 2025-02-18
Revolutionizing Healthcare 5 0 The Power Of Generative Ai written by Pronaya Bhattacharya and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-18 with Technology & Engineering categories.
This book serves as a critical resource that bridges the gap between burgeoning technology and its practical implementation. The book starts with an in-depth exploration of healthcare 5.0 principles, laying the foundation for the reader to understand the current shifts in healthcare paradigms. Then, it dives into the intricacies of generative models in healthcare, detailing how these algorithms work and the applications they serve. The book further delves into the subsets of generative machine learning and deep learning techniques in healthcare. As we move towards more complex applications, the book takes a turn to address the critical subject of interpretability and explainability in generative models, a topic that resonates profoundly given the life-critical nature of medical decisions. Finally, the book concludes with a robust discussion on the security and privacy concerns that accompany the deployment of GAI in real healthcare settings. By offering a multidimensional viewpoint—coupled with case studies, statistical analyses, and expert insights—the book ensures that the reader is left with a nuanced understanding of how GAI can be both a boon and a challenge in healthcare. As such, the proposed book serves as an indispensable resource for healthcare professionals, data scientists, researchers, and anyone invested in the future of healthcare and AI.
Multi Omics Approaches For Decoding Heterogeneity In Cancer Immunotherapy
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Author : Lin Qi
language : en
Publisher: Frontiers Media SA
Release Date : 2023-11-22
Multi Omics Approaches For Decoding Heterogeneity In Cancer Immunotherapy written by Lin Qi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-22 with Science categories.