The Search For Anti Inflammatory Drugs
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The Search For Anti Inflammatory Drugs
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Author : Vincent J. Merluzzi
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Search For Anti Inflammatory Drugs written by Vincent J. Merluzzi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Perspectives on Anti-Inflammatory Drugs Inflammation is a very complicated process of interrelated events and cas cades that does not allow for an easily defined, focused attack for drug discovery. It is evident from years of research and development that certain classes of compounds (e.g., NSAIDs, steroids, and so on) have had a meas ure of success in alleviating pain and even dampening cellularlhormonal mechanisms involved in the process. Clear, mechanism-related therapies (e.g., for arthritis) and targeted drugs (e.g., for transplantation) have not been available in the past and, in reality, research in inflammation has re lied on more phenomenological approaches for resolving symptoms or on blatant cytoreductive approaches in cases like organ transplantation. In the last decade, approaches that have revealed novel cellular pathways in which intervention is possible for lymphocyte regulation (for example, cyclosporine and FK506) and small molecular weight mediators (e.g., leu kotriene inhibitors) are now either standard therapy or will be in a short time. These latter approaches have been the result of research from the 1970s up to the present.
The Search For Anti Inflammatory Drugs
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Author : Vincent J. Merluzzi
language : en
Publisher: Birkhäuser
Release Date : 1995-07-01
The Search For Anti Inflammatory Drugs written by Vincent J. Merluzzi and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-07-01 with Medical categories.
Perspectives on Anti-Inflammatory Drugs Inflammation is a very complicated process of interrelated events and cas cades that does not allow for an easily defined, focused attack for drug discovery. It is evident from years of research and development that certain classes of compounds (e.g., NSAIDs, steroids, and so on) have had a meas ure of success in alleviating pain and even dampening cellularlhormonal mechanisms involved in the process. Clear, mechanism-related therapies (e.g., for arthritis) and targeted drugs (e.g., for transplantation) have not been available in the past and, in reality, research in inflammation has re lied on more phenomenological approaches for resolving symptoms or on blatant cytoreductive approaches in cases like organ transplantation. In the last decade, approaches that have revealed novel cellular pathways in which intervention is possible for lymphocyte regulation (for example, cyclosporine and FK506) and small molecular weight mediators (e.g., leu kotriene inhibitors) are now either standard therapy or will be in a short time. These latter approaches have been the result of research from the 1970s up to the present.
Anti Inflammatory Drugs
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Author :
language : en
Publisher:
Release Date : 1979
Anti Inflammatory Drugs written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with categories.
Non Steroidal Anti Inflammatory Drugs In Water
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Author : Leobardo Manuel Gómez-Oliván
language : en
Publisher: Springer Nature
Release Date : 2020-10-14
Non Steroidal Anti Inflammatory Drugs In Water written by Leobardo Manuel Gómez-Oliván and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-14 with Science categories.
This book gathers the main international research findings on non-steroidal anti-inflammatory drugs (NSAIDs) as emerging contaminants in water. It focuses on the major routes of exposure, and the destinations and life cycles of NSAIDs in water, as well as the manifestations of toxicity in different organisms. It also reviews the methods used in the detection, analysis and quantification of NSAIDs in water as well as the biological and chemical methods of removing them. Lastly, the book offers an overview of the legal frameworks in place and provides conclusions and recommendations for the future. Given its scope, the book is an indispensable resource for scientists in academia and industry, as well as for decision-makers involved in contamination assessment and environmental analysis and NGOs interested in the problem of water contamination by NSAIDs.
Improved Non Steroid Anti Inflammatory Drugs Cox 2 Enzyme Inhibitors
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Author : Sir John R. Vane
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Improved Non Steroid Anti Inflammatory Drugs Cox 2 Enzyme Inhibitors written by Sir John R. Vane and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
In 1971, Vane proposed that the mechanism of action of the aspirin-like drugs was through their inhibition of prostaglandin biosynthesis. Since then, there has been intense interest in the interaction between this diverse group of inhibitors and the enzyme known as cyclooxygenase (COX). It exists in two isoforms, COX-l and COX-2 (discovered some 5 years ago). Over the last two decades several new drugs have reached the market based on COX-l enzyme screens. Elucidation of the three-dimensional structure of COX-l has provided a new understanding for the actions of COX inhibitors. The constitutive isoform of COX, COX-l has clear physiological functions. Its activation leads, for instance, to the production of prostacyclin which when released by the endothelium is anti-thrombogenic and anti-atherosclerotic, and in the gastric mucosa is cyto protective. COX-l also generates prostaglandins in the kidney, where they help to maintain blood flow and promote natriuresis. The inducible isoform, COX-2, was discovered through its activity being increased in a number of cells by pro inflammatory stimuli. A year or so later, COX-2 was identified as a distinct isoform encoded by a different gene from COX-I. COX-2 is induced by inflammatory stimuli and by cytokines in migratory and other cells. Thus the anti-inflammatory actions of non-steroid anti-inflammatory drugs (NSAIDs) may be due to the inhibition of COX-2, whereas the unwanted side-effects such as irritation of the stomach lining and toxic effects on the kidney are due to inhibition of the constitutive enzyme, COX-I.
Anti Inflammatory Agents Part I
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Author : Robert Scherrer
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Anti Inflammatory Agents Part I written by Robert Scherrer and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.
Medicinal Chemistry: A Series of Monographs, Volume 13–I explores the development in the treatment of some severely debilitating chronic inflammatory diseases, including arthritis, gout, rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus, psoriasis, conjunctivitis, episcleritis, and uveitis. This volume examines the anti-inflammatory drugs used to alter the inflammatory response in diseases of unknown cause. This book is comprised of two parts encompassing 11 chapters. Part I discusses the factors that cause the inflammation and explores the interaction of these causative agents with those therapies found to be clinically effective. This text also presents an illustrative classification of some debilitating inflammatory conditions and the available therapy. Part II explores the nonsteroidal anti-inflammatory agents that are peripheral analgesics and anti-pyretic. Other chapters review colchicine and allopurinol as anti-inflammatory drugs for gout. Finally, this volume ends with a discussion on the anti-inflammatory activity of some proteolytic enzymes of vegetable, animal, fungal, and bacterial origin. Physicians, chemists, and experimental biologists will find this book extremely useful.
Handbook Of Experimental Pharmacology
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Author : John R. Vane
language : en
Publisher:
Release Date : 1979
Handbook Of Experimental Pharmacology written by John R. Vane and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with categories.
Nsaids And Aspirin
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Author : Angel Lanas
language : en
Publisher: Springer
Release Date : 2016-08-26
Nsaids And Aspirin written by Angel Lanas and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-26 with Medical categories.
This volume is a state-of-the art resource on the recent advances and clinical management of NSAIDs and aspirin. The text provides a thorough overview of NSAIDS and aspirin, reviewing such topics as pharmacology and mechanisms, clinical effects, and the safety and efficacy of these drugs. It also focuses on the effect of the drugs on the cardiovascular system and in the prevention of GI cancer. Practical recommendations for a safe prescription of NSAIDs are also included. Written by experts in the field, NSAIDs and Aspirin: Recent Advances and Implications for Clinical Management is a comprehensive text of great value to gastroenterologists, rheumatologists, cardiologists, oncologists, orthopedists, trauma and internal medicine specialists.
Drug Induced Liver Injury
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Author :
language : en
Publisher: Academic Press
Release Date : 2019-07-13
Drug Induced Liver Injury written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-13 with Medical categories.
Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series
Anti Inflammatory Nutraceuticals And Chronic Diseases
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Author : Subash Chandra Gupta
language : en
Publisher: Springer
Release Date : 2016-09-26
Anti Inflammatory Nutraceuticals And Chronic Diseases written by Subash Chandra Gupta and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-26 with Medical categories.
This comprehensive volume focuses on anti-inflammatory nutraceuticals and their role in various chronic diseases. Food and Drug Administration (FDA) approved drugs such as steroids, non-steroidal anti-inflammatory drugs (NSAIDS), statins and metformin have been shown to modulate inflammatory pathways, but their long-term intake has been associated with numerous side effects. This means that there is enormous potential for dietary agents that can modulate inflammatory pathways in humans. Leading experts describe the latest research on the role of anti-inflammatory nutraceuticals in preventing and treating chronic diseases.