The Secretory And Endocytic Paths
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Vesicular Transport In The Secretory And Endocytic Pathways
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Author : Anne Müsch
language : en
Publisher: Biota Publishing
Release Date : 2014-09-01
Vesicular Transport In The Secretory And Endocytic Pathways written by Anne Müsch and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-01 with Science categories.
The concept of vesicular traffic as a means of protein transport in and out of cells and between membrane compartments has been established since the 1960s. Its basic principles are beautifully simple, yet the details of protein transport are complex enough to find novel classes of transport vesicles, and trafficking itineraries still being described to date. In this treatise, the reader will be introduced to mechanisms of vesicle sculpting, cargo selection, vesicle targeting, and vesicle consumption that have emerged as common characteristics of multiple transport steps in the exocytic and endocytic pathways. These fundamentals also reveal the basis for the specificity and selectivity of individual transport steps. We will further discuss how protein transport might lead to the establishment and maintenance of the endomembrane system of eukaryotic cells. The concepts for these mechanisms are based on experimental evidence combined with mathematical modeling that can disclose the minimal requirements for the generation of the distinct membrane compartments. Table of Contents: Compartmentalization Is a Hallmark of Eukaryotic Cells / Organelles Can Be Classified Based on Their Origin / There Are Multiple Entry Points Into the Endomembrane System and a Network of Connecting Trafficking Routes / There Are Exceptions and Extensions to the Classic Trafficking Itineraries / A Mathematical Model Can Explain How Organelle Size Is Established and Maintained / Coats and SNAREs Constitute the Core Machinery for Vesicle Budding and Fusion / A Mathematical Model Explains How Coats and SNAREs Are Sufficient to Generate Organelle Identity / How Vesicle Formation Is Linked to Cargo Incorporation / RabGTPases Are the Master Regulators of Vesicular Traffic / The Mechanisms and Physiological Roles of Endocytosis / Models for Protein Transport in the Golgi Apparatus / Summary / Acknowledgments / References / Author Biography
The Secretory And Endocytic Paths
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Author : Alan Michael Tartakoff
language : en
Publisher: Wiley-Interscience
Release Date : 1987
The Secretory And Endocytic Paths written by Alan Michael Tartakoff and has been published by Wiley-Interscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Science categories.
A broadly-based, highly readable account of the intracellular transport of macromolecules along the secretory and endocytic paths, emphasizing basic concepts and essential methods of cell biology and challenges for future research. Adopting an interdisciplinary approach that spans the fields of anatomy, biochemistry and molecular biology, it methodically juxtaposes and compares the information and concepts relating to the two paths. The major sections on these topics are further divided into sections discussing composition of each of the two compartments, how they participate in intracellular transport, and specificity of transport. The focus throughout is on the need for input from molecular biology to deepen the knowledge of cell biological issues. Also included is a current bibliography, along with ample illustrations and line drawings of electron micrographs.
Protein And Lipid Sorting In The Secretory And Endocytic Pathways
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Author : Noriyuki Sagata
language : en
Publisher:
Release Date : 1998
Protein And Lipid Sorting In The Secretory And Endocytic Pathways written by Noriyuki Sagata and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.
Laboratory Methods In Vesicular And Vectorial Transport
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Author : Alan Tartakoff
language : en
Publisher: Academic Press
Release Date : 2012-12-02
Laboratory Methods In Vesicular And Vectorial Transport written by Alan Tartakoff and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Laboratory Methods in Vesicular and Vectorial Transport describes the procedures used to study the mechanisms of vesicular transport along the secretory and endocytic paths, including electron microscopy, autoradiography, and methods associated with cyto- and immunocytochemistry, genetics, and biochemistry. It investigates vectorial transport to the cisternal space of the rough endoplasmic reticulum (ER), as well as protein translocation across the ER, strategies for gaining access to the cytoplasm, cell-free analysis of vesicle fusion, the structure of glycoproteins, and the use of cell systems for analysis of vesicular traffic. Organized into seven parts encompassing 20 chapters, this volume begins with an overview of protein topology in the ER and the use of cross-linking methods to probe the molecular environment of translocating polypeptide chains. It then discusses the reconstitution of secretory protein translocation from detergent-solubilized rough microsomes; the use of anti-idiotype antibodies to characterize protein-protein interactions; the use of perforated cells to elucidate intracellular membrane transport; delivery of macromolecules into cells expressing a viral membrane fusion protein; and digitonin permeabilization procedures for studying endosome acidification and function. The reader is also introduced to reconstitution of intracellular vesicle fusion in a cell-free system after receptor-mediated endocytosis; immunoisolation using magnetic solid supports; endosome and lysosome purification by free-flow electrophoresis; remodeling of glycoprotein oligosaccharides after endocytosis; and replica plating of animal cells. This book will interest students, researchers, geneticists, biochemists, and cell biologists.
Trafficking Inside Cells
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Author : Nava Segev
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-05-30
Trafficking Inside Cells written by Nava Segev and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-30 with Science categories.
This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.
Processing And Trafficking Of Proteins Traversing The Secretory And Endocytic Pathways In Saccharomyces Cerevisiae
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Author : Xiang Zhao
language : en
Publisher:
Release Date : 2006
Processing And Trafficking Of Proteins Traversing The Secretory And Endocytic Pathways In Saccharomyces Cerevisiae written by Xiang Zhao and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Interactions Between Proteins Involved In Mammalian Endocytic And Secretory Pathways
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Author :
language : en
Publisher:
Release Date : 2004
Interactions Between Proteins Involved In Mammalian Endocytic And Secretory Pathways written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Mechanisms Of Localization For Resident Organelle Proteins In The Exocytic And Endocytic Secretory Pathways
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Author : Kenneth Robert Teter
language : en
Publisher:
Release Date : 1998
Mechanisms Of Localization For Resident Organelle Proteins In The Exocytic And Endocytic Secretory Pathways written by Kenneth Robert Teter and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.
Interaction Of Chlamydia Trachomatis With The Endocytic And Secretory Pathways Of Its Eukaryotic Host Cells
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Author : Christiaan Van Ooij
language : en
Publisher:
Release Date : 1998
Interaction Of Chlamydia Trachomatis With The Endocytic And Secretory Pathways Of Its Eukaryotic Host Cells written by Christiaan Van Ooij and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Chlamydia infections categories.