The Small Gtpase Ran
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The Small Gtpase Ran
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Author : Mark Rush
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Small Gtpase Ran written by Mark Rush and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The Ras-related nuclear protein Ran is a member of the so-called Ras-superfamily of small GTP-binding proteins and hydrolyzing proteins. A variety of edited anthologies related to the Ras-superfamily have appeared over the last decade, but Ran has been under-represented in all of them. This under-representation is not due to the fact that Ran is unimportant or non-abundant. It is almost certainly because Ran was discovered and its functions elucidated only recently, and that some of these functions may not follow the typical Ras-superfamily paradign. Even workers in the field have difficulty keeping up with the Ran literature, and most outsiders rarely try even though they may be aware that major breakthroughs regarding the mechanisms of nuclear-cytosolic transport, mitosis and the maintenance of nuclear structure have depended upon an understanding of Ran function. The Small GTPase Ran is meant to provide specialists with a concise summary of some of the recent research in this area, along with background describing its initial identification and early characterization.
Nuclear Pore Complexes And Nucleocytoplasmic Transport Methods
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Author :
language : en
Publisher: Elsevier
Release Date : 2014-05-20
Nuclear Pore Complexes And Nucleocytoplasmic Transport Methods written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-20 with Science categories.
Volume 122 of Methods in Cell Biology describes modern tools and techniques used to study nuclear pore complexes and nucleocytoplasmic transport in diverse eukaryotic model systems (including mammalian cells, Xenopus, C. elegans, yeast). The volume enables investigators to analyze nuclear pore complex structure, assembly, and dynamics; to evaluate protein and RNA trafficking through the nuclear envelope; and to design in vivo or in vitro assays appropriate to their research needs. Beyond the study of nuclear pores and transport as such, these protocols will also be helpful to scientists characterizing gene regulation, signal transduction, cell cycle, viral infections, or aging. The NPC being one of the largest multiprotein complexes in the cell, some protocols will also be of interest for people currently characterizing other macromolecular assemblies. This book is thus designed for laboratory use by graduate students, technicians, and researchers in many molecular and cellular disciplines. Describes modern tools and techniques used to study nuclear pore complexes and nucleocytoplasmic transport in diverse eukaryotic model systems (mammalian cells, Xenopus, C. elegans, yeast) Chapters are written by experts in the field Cutting-edge material
Nuclear Transport
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Author : Karsten Weis
language : en
Publisher: Springer Science & Business Media
Release Date : 2002
Nuclear Transport written by Karsten Weis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Gardening categories.
Bidirectional traffic of macromolecules across the nuclear envelope is an active and essential transport process in all eukaryotic cells. Work on various model systems has led to a tremendous increase in our understanding of nuclear transport in recent years. This volume summarizes our current knowledge of protein and RNA transport into and out of the nucleus. It contains nine up-to-date reviews which cover various aspects of nucleocytoplasmic transport, including the structure and function of the nuclear pore complex, the role of soluble transport factors in protein and RNA transport, and the regulation of protein transport through the nuclear pore.
Ras Superfamily Small G Proteins Biology And Mechanisms 2
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Author : Alfred Wittinghofer
language : en
Publisher: Springer
Release Date : 2014-09-26
Ras Superfamily Small G Proteins Biology And Mechanisms 2 written by Alfred Wittinghofer and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-26 with Science categories.
This second of two volumes discusses subfamily proteins which function in molecular and vesicular transport mechanisms inside the cell. In this volume the focus lies on the Rab, Ran and Arf subfamily members. As in Volume 1, the book is written by international renowned scientists in the field of small G-proteins. In elaborate reviews, biochemistry, structure, function and G-protein - effector interactions are described. Together with Volume 1 this book provides an comprehensive state-of-the-art work on small G-proteins (GTPases). It is written for Graduates and Professors in Biochemistry and Cell Biology interested in the mechanism and function of small G-proteins but are extremely valuable for those who want to move into the field.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Arf Family Gtpases
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Author : Richard A. Kahn
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-02-29
Arf Family Gtpases written by Richard A. Kahn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-02-29 with Science categories.
For the first time experts in the area of signalling research with a focus on the ARF family have contributed to the production of a title devoted to ARF biology. A comprehensive phylogenetic analysis of the ARF family, tables of the ARF GEFs and ARF GAPs, and more than a dozen chapters describing them in detail are provided. The impact of the ARF proteins on widely diverse aspects of cell biology and cell signalling can be clearly seen from the activities described; including membrane traffic, lipid metabolism, receptor desensitization, mouse development, microtubule dynamics, and bacterial pathogenesis. Anyone interested in understanding the complexities of cell signalling and the integration of signalling networks will benefit from this volume.
Gtpase Protocols
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Author : Ed Manser
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-03
Gtpase Protocols written by Ed Manser and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-03 with Science categories.
In the last 10 years researchers have firmly established key roles for R- related GTPases in almost every aspect of cell biology. In the 1980s the pro- oncogene Ras itself was the focus of interest, though in the 1990s this shifted to the increasing variety of Ras-related proteins. In this new decade much yet needs to be done to establish the role for all the small GTPases now uncovered by the human genome project. In particular, these GTPases need to be und- stood in the appropriate biochemical and cellular contexts. In the process of trying to uncover the role of these versatile proteins, a variety of novel te- niques and methodologies has been developed. These now enable investi- tors to move easily within a diversity of fields ranging from structural studies to real-time in vivo analysis of a GTPase. In recognition of the need for access to key background methodologies, GTPase Protocols: The Ras Superfamily is devoted to techniques that are pr- ently widely used and that will continue to be the standard for researchers worldwide. Each chapter is aimed at supplying detailed methodologies to allow reproduction in any laboratory, while also providing the general pr- ciples on which the methods are based. Some of the techniques grouped in the first section apply broadly to small GTPases, whereas others in Part II are more applicable within each GTPase subfamily.
Gtpases In Biology I
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Author :
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Gtpases In Biology I written by and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The GTPase switch appears to be almost as old as life itself, and nature has adapted it to a variety of purposes. This two-volume work surveys the major classes of GTPases, including their role in ensuring accuracy during protein translation, a new look at the trimeric G-protein cycle, the molecular function of ARF in vesicle coating, the emerging role of the dynamin family in vesicle transfer, GTPases which activate GTPases during nascent protein translocation, and the many roles of ras-related proteins in growth, cytoskeletal polymerization, and vesicle transfer. 80 chapters contain much previously unpublished data and, at the rate the extended family of GTPases is growing, it is unlikely that it will again sit for a group portrait such as this. Thus, this could well become the standard reference work.
Gtpases
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Author : Alan Hall
language : en
Publisher: Oxford University Press, USA
Release Date : 2000
Gtpases written by Alan Hall and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Language Arts & Disciplines categories.
GTPases are molecular switches that are used to control biochemical pathways. This book describes the properties and cellular roles of all the major families of GTPases. All cells use GTPases to regulate the delivery of amino acids to the ribosome during protein synthesis, but eukaryotes, with their complex and compartmentalized environment, have exploited the versatility of GTPases to a much greater extent. In particular, GTPases play a central role in regulating signal transduction pathways activated by extracellular signals and in regulating the trafficking of proteins beetween different organelles. It is not surprising, therefore, that GTPases have become a center of attention for those studying the control of proliferation, differentiation, cell polarity, cell movement, and vesicle and protein trafficking. This book provides a complete guide to this area and should be essential reading for cell and molecular biologists, biochemists and geneticists interested in these contemporary problems.
Ras Family Gtpases
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Author : Channing Der
language : en
Publisher: Springer
Release Date : 2006-09-13
Ras Family Gtpases written by Channing Der and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-09-13 with Medical categories.
Since 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. The wide interest in Ras has been stimulated for three key reasons. This book features chapters contributed by leading investigators in the field that highlight the current state-of-the art in Ras biochemistry, structure and biology. This book is an excellent reference for students in the biomedical sciences and for investigators in the field.