The Unlikely Chaperone
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The Unlikely Chaperone
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Author : Dorothy Mack
language : en
Publisher:
Release Date : 2020
The Unlikely Chaperone written by Dorothy Mack and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
The Unlikely Chaperone
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Author : Dorothy Mack
language : en
Publisher: Signet Book
Release Date : 1991-02
The Unlikely Chaperone written by Dorothy Mack and has been published by Signet Book this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-02 with Fiction categories.
The Chaperone
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Author : Laura Moriarty
language : en
Publisher: Penguin
Release Date : 2012-06-05
The Chaperone written by Laura Moriarty and has been published by Penguin this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-05 with Fiction categories.
Soon to be a feature film from the creators of Downton Abbey starring Elizabeth McGovern, The Chaperone is a New York Times-bestselling novel about the woman who chaperoned an irreverent Louise Brooks to New York City in the 1920s and the summer that would change them both. Only a few years before becoming a famous silent-film star and an icon of her generation, a fifteen-year-old Louise Brooks leaves Wichita, Kansas, to study with the prestigious Denishawn School of Dancing in New York. Much to her annoyance, she is accompanied by a thirty-six-year-old chaperone, who is neither mother nor friend. Cora Carlisle, a complicated but traditional woman with her own reasons for making the trip, has no idea what she’s in for. Young Louise, already stunningly beautiful and sporting her famous black bob with blunt bangs, is known for her arrogance and her lack of respect for convention. Ultimately, the five weeks they spend together will transform their lives forever. For Cora, the city holds the promise of discovery that might answer the question at the core of her being, and even as she does her best to watch over Louise in this strange and bustling place she embarks on a mission of her own. And while what she finds isn’t what she anticipated, she is liberated in a way she could not have imagined. Over the course of Cora’s relationship with Louise, her eyes are opened to the promise of the twentieth century and a new understanding of the possibilities for being fully alive. Drawing on the rich history of the 1920s, ’30s, and beyond—from the orphan trains to Prohibition, flappers, and the onset of the Great Depression to the burgeoning movement for equal rights and new opportunities for women—Laura Moriarty’s The Chaperone illustrates how rapidly everything, from fashion and hemlines to values and attitudes, was changing at this time and what a vast difference it all made for Louise Brooks, Cora Carlisle, and others like them.
The Hsp70 Molecular Chaperone Machines
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Author : Matthias P. Mayer
language : en
Publisher: Frontiers Media SA
Release Date : 2017-03-24
The Hsp70 Molecular Chaperone Machines written by Matthias P. Mayer and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-24 with Electronic book categories.
Members of the HSP70 family form a central hub of the molecular chaperone network, controlling protein homeostasis in prokaryotes and in the ATP-containing compartments of the eukaryotic cells. The heat-inducible form HSPA1A (HSP70), its constitutive cytosolic cognate HSPA8 (Hsc70), its endoplasmic reticulum form HSPA5 (BiP), and its mitochondrial form HSPA9 (Mortalin), as well as the more distantly related HSPHs (HSP110s), make up 1-2 % of the total mass of proteins in human cells. They use the energy of ATP-hydrolysis to prevent and forcefully revert the process of protein misfolding and aggregation during and following various stresses, presumably by working as unfoldases to lift aberrant conformers out of kinetic traps. As such, HSP70s, in cooperation with their J-domain co-chaperones and nucleotide exchange factors (NEFs) and co-disaggregases, form an efficient network of cellular defenses against the accumulation of cytotoxic misfolded protein conformers, which may cause degenerative diseases such as Parkinson's and Alzheimer's disease, diabetes, and aging in general. In addition to their function in repair of stress-induced damage, HSP70s fulfill many housekeeping functions, including assisting the de novo folding and maturation of proteins, driving the translocation of protein precursors across narrow membrane pores into organelles, and by controlling the oligomeric state of key regulator protein complexes involved in signal transduction and vesicular trafficking. For reasons not well understood, HSP70s are also found on the surface of some animal cells, in particular cancer cells where they may serve as specific targets for cancer immunotherapy. Here, we gathered seven mini reviews, each presenting a complementary aspect of HSP70’s structure and function in bacteria and eukaryotes, under physiological and stressful conditions. These articles highlight how, the various members of this conserved family of molecular chaperones, assisted by their various J-domain and NEF cochaperones and co-disaggregases, harness ATP hydrolysis to perform a great diversity of life-sustaining cellular functions using a similar molecular mechanism.
The Networking Of Chaperones By Co Chaperones
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Author : Adrienne L. Edkins
language : en
Publisher: Springer Nature
Release Date : 2022-12-15
The Networking Of Chaperones By Co Chaperones written by Adrienne L. Edkins and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-15 with Science categories.
Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is the dynamic integration of the processes of protein folding, degradation and translocation to ensure that cellular function is finely tuned in space and time. This third edition of the book The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by co-chaperones, a diverse cohort of non-client proteins. Since the second edition was released, not only has knowledge deepened on how co-chaperones act as nodes to network and functionalise chaperones, but an understanding of their broader biological function has started to emerge. The third edition provides new and updated chapters highlighting recent developments and emerging themes on co-chaperones, such as their extracellular functions, their role in human disease and their status as putative drug targets. The book is a useful resource for both newcomers and established researchers in the field of cell stress and chaperones, as well as those interested in cross-cutting disciplines such as cellular networks and systems biology.
The Unlikely Lady
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Author : Valerie Bowman
language : en
Publisher: St. Martin's Paperbacks
Release Date : 2015-05-05
The Unlikely Lady written by Valerie Bowman and has been published by St. Martin's Paperbacks this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-05 with Fiction categories.
FOR THE BACHELOR AND THE BLUESTOCKING... Certain that no man wants a bluestocking for a wife, Miss Jane Lowndes is careful to wield her books and her spectacles as weapons against matrimony. Convincing her ambitious mama that she's content to stay a spinster is easier said than done, however. It's a good thing Jane is not above a bit of manufactured scandal if it will keep her from the altar, and the argumentative, contrary Lord Garrett Upton... ROMANCE IS NEVER BY THE BOOK With the war over, Garrett is determined to enjoy his bachelor's life while he can, even when it means attending a house party in celebration of a friend's wedding—and suffering Jane's notorious disdain. But when a masquerade ball leads to a mistaken kiss, he's surprised to learn that Jane's bookish exterior hides a truly passionate soul. When two such headstrong people are determined to remain unattached, can love lead to a happy ending?
Molecular Chaperones
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Author : R.J. Ellis
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular Chaperones written by R.J. Ellis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Currently one of the hottest topics in biochemistry, the concept of molecular chaperones has challenged the paradigm of protein self-assembly. Key figures in many disciplines review all aspects of molecular chaperones in this volume, which arises from a Royal Society discussion meeting. Overview chapters discuss the significance of chaperones in biochemistry, molecular genetics and cell biology. Each chapter is well referenced providing access to the literature.
Evolutionary Cell Biology
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Author : Michael R. Lynch
language : en
Publisher: Oxford University Press
Release Date : 2024-02-22
Evolutionary Cell Biology written by Michael R. Lynch and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-22 with Science categories.
Establishes the foundations of the emerging field of evolutionary cell biology, providing a deep and broad coverage of the literature, with many ideas synthesised and presented for the first time.
Molecular Chaperones In The Cell
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Author : Peter A. Lund
language : en
Publisher: Oxford University Press, USA
Release Date : 2001
Molecular Chaperones In The Cell written by Peter A. Lund and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Science categories.
In this text, leading experts synthesise our body of knowledge , and the reader gains not only a fuller understanding of the roles of chaperones in the context of cellular processes, but also an insight into the nature of these proteins.
Molecular Chaperones
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Author : Sophie Jackson
language : en
Publisher: Springer
Release Date : 2012-12-15
Molecular Chaperones written by Sophie Jackson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-15 with Science categories.
Assisting Oxidative Protein Folding: How Do Protein Disulphide-Isomerases Couple Conformational and Chemical Processes in Protein Folding?, by A. Katrine Wallis and Robert B. Freedman Peptide Bond cis/trans Isomerases: A Biocatalysis Perspective of Conformational Dynamics in Proteins, by Cordelia Schiene-Fischer, Tobias Aumüller and Gunter Fischer Small Heat-Shock Proteins: Paramedics of the Cell, by Gillian R. Hilton, Hadi Lioe, Florian Stengel, Andrew J. Baldwin und Justin L. P. Benesch Allostery in the Hsp70 Chaperone Proteins, by Erik R. P. Zuiderweg, Eric B. Bertelsen, Aikaterini Rousaki, Matthias P. Mayer, Jason E. Gestwicki and Atta Ahmad Hsp90: Structure and Function, by Sophie E. Jackson Extracellular Chaperones, by Rebecca A. Dabbs, Amy R. Wyatt, Justin J. Yerbury, Heath Ecroyd and Mark R. Wilson